ES8302671A1 - "procedimiento de preparacion de nuevos derivados 3,4-dihidro-5h-2,3-benzodiazepinos y de sus sales de adicion acidas farmaceuticamente aceptables". - Google Patents

"procedimiento de preparacion de nuevos derivados 3,4-dihidro-5h-2,3-benzodiazepinos y de sus sales de adicion acidas farmaceuticamente aceptables".

Info

Publication number
ES8302671A1
ES8302671A1 ES510348A ES510348A ES8302671A1 ES 8302671 A1 ES8302671 A1 ES 8302671A1 ES 510348 A ES510348 A ES 510348A ES 510348 A ES510348 A ES 510348A ES 8302671 A1 ES8302671 A1 ES 8302671A1
Authority
ES
Spain
Prior art keywords
general formula
group
dihydro
alkoxy
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES510348A
Other languages
English (en)
Other versions
ES510348A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of ES8302671A1 publication Critical patent/ES8302671A1/es
Publication of ES510348A0 publication Critical patent/ES510348A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 3,4-DIHIDRO-5H-2,3-BENZODIAZEPINOS Y DE SUS SALES DE ADICION ACIDAS FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R ES HIDROGENO O ALQUILO C <003> ; Y R, R Y R PUEDEN SER VARIOS RADICALES. CONSISTE EN LA REACCION DE REDUCCION DEL COMPUESTO DE FORMULA (II), EN LA QUE R, R , R Y R TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO CON UN AGENTE REDUCTOR CONVENCIONAL, EN UN DISOLVENTE O MEZCLA DE DISOLVENTES INERTES, A UNA TEMPERATURA ENTRE 10<025>C Y 100<025>C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS, POR SUS EFECTOS SOBRE EL SISTEMA NERVIOSO CENTRAL.
ES510348A 1981-03-12 1982-03-11 "procedimiento de preparacion de nuevos derivados 3,4-dihidro-5h-2,3-benzodiazepinos y de sus sales de adicion acidas farmaceuticamente aceptables". Granted ES510348A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU81620A HU186760B (en) 1981-03-12 1981-03-12 Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives

Publications (2)

Publication Number Publication Date
ES8302671A1 true ES8302671A1 (es) 1983-02-01
ES510348A0 ES510348A0 (es) 1983-02-01

Family

ID=10950496

Family Applications (1)

Application Number Title Priority Date Filing Date
ES510348A Granted ES510348A0 (es) 1981-03-12 1982-03-11 "procedimiento de preparacion de nuevos derivados 3,4-dihidro-5h-2,3-benzodiazepinos y de sus sales de adicion acidas farmaceuticamente aceptables".

Country Status (23)

Country Link
US (1) US4423044A (es)
JP (1) JPS57159772A (es)
AT (1) AT383120B (es)
AU (1) AU550388B2 (es)
BE (1) BE892395A (es)
CA (1) CA1178584A (es)
CH (1) CH648553A5 (es)
CS (1) CS224646B2 (es)
DD (1) DD204698A5 (es)
DE (1) DE3209100A1 (es)
DK (1) DK106882A (es)
ES (1) ES510348A0 (es)
FI (1) FI820839L (es)
FR (1) FR2501686A1 (es)
GB (1) GB2097387B (es)
GR (1) GR76111B (es)
HU (1) HU186760B (es)
IL (1) IL65076A (es)
IT (1) IT1190732B (es)
NL (1) NL8201005A (es)
NO (1) NO820798L (es)
SE (1) SE8201537L (es)
SU (1) SU1151206A3 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3971179A (en) * 1969-08-13 1976-07-27 Andrew Bodocsi Non-bonded framing system
DE3124013A1 (de) * 1981-06-19 1982-12-30 Kali-Chemie Pharma Gmbh, 3000 Hannover 2-acylaminomethyl-1,4-benzodiazepin-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
US5204339A (en) * 1986-01-31 1993-04-20 Whitby Research, Inc. Penetration enhancers for transdermal delivery of systemic agents
HU198494B (en) * 1986-08-15 1989-10-30 Gyogyszerkutato Intezet Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same
EP0322582A3 (en) * 1987-12-07 1989-09-13 Hoechst-Roussel Pharmaceuticals Incorporated 4-heteroaryl-1,3-benzodiazepines and 2-substituted-alpha-(heteroaryl)benzeneethanamines, a process for their preparation and their use us medicaments
HU206719B (en) * 1990-12-21 1992-12-28 Gyogyszerkutato Intezet Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them
HU224435B1 (hu) * 1995-02-09 2005-10-28 EGIS Gyógyszergyár Rt. Benzodiazepin-származékok, eljárás előállításukra, alkalmazásukra és ezeket tartalmazó gyógyászati készítmények
ATE200487T1 (de) * 1995-02-09 2001-04-15 Egyt Gyogyszervegyeszeti Gyar 1-(hetero)arylvinyl-5h-2,3- benzodiazepinderivative verwendbar zur behandlung von erkrankungen des zentralnervensystems, sowie benzopyrylium intermediate zu ihrer herstellung
SK283859B6 (sk) * 1995-02-09 2004-03-02 EGIS Gyógyszergyár Rt. 1-[2'-(Substituovaný)vinyl]-5H-2,3-benzodiazepínové deriváty, spôsob ich prípravy a medziprodukty na ich prípravu, liečivá ich obsahujúce a ich použitie
DE19604920A1 (de) 1996-02-01 1997-08-07 Schering Ag Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
ES2111493B1 (es) * 1996-02-08 1999-08-01 Egyt Gyogyszervegyeszeti Gyar Derivados de 1-(2- (vinilo substituido ) ) -5h-2,3-benzo-diazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizaciones correspondientes.
ZA972746B (en) * 1996-04-04 1998-10-09 Egyt Gyogyszervegyeszeti Gyar Novel 2,3-benzodiazepine derivatives
US6080736A (en) * 1999-10-27 2000-06-27 Janus Pharmaceuticals, Inc. Methods and compositions for treating and preventing anxiety and anxiety disorders using optically pure (R) tofisopam
US6649607B2 (en) * 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
CA2510275A1 (en) * 2002-12-03 2004-08-19 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5h-2,3-benzodiazepine and uses therof
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
JP2006510634A (ja) * 2002-12-03 2006-03-30 ヴェラ ファーマスーティカルズ インコーポレイテッド １−（３，４−ジメトキシフェニル）−４−メチル−５−エチル−７−メトキシ−８−ヒドロキシ−５ｈ−２，３−ベンゾジアゼピンの製薬組成物及びその用途
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20070021412A1 (en) * 2003-05-16 2007-01-25 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine
JP4611308B2 (ja) * 2003-05-16 2011-01-12 ヴェラ アクイジション コーポレイション 鏡像的に純粋な（ｒ）２，３−ベンゾジアゼピンを使用する胃腸の機能不全及び関連するストレスの治療
US20040254173A1 (en) * 2003-06-13 2004-12-16 Leventer Steven M. Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines
US7541355B2 (en) * 2005-05-23 2009-06-02 Vela Acquisition Corporation Conversion process for 2,3-benzodiazepine enantiomers
TW200902024A (en) * 2007-04-02 2009-01-16 Teva Pharma Novel 2,3-benzodiazepine derivatives and their use as antipsychotic agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK118660B (da) * 1966-12-09 1970-09-21 Egyt Gyogyszervegyeszeti Gyar Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid.
USRE30014E (en) 1966-12-09 1979-05-29 Egyesult Gyogyazer-es Tapozergyar 1-(3,4-Dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine
HU179018B (en) * 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives

Also Published As

Publication number Publication date
US4423044A (en) 1983-12-27
IT8220094A0 (it) 1982-03-11
GR76111B (es) 1984-08-03
BE892395A (fr) 1982-09-08
IL65076A (en) 1984-12-31
ES510348A0 (es) 1983-02-01
DD204698A5 (de) 1983-12-07
NO820798L (no) 1982-09-13
JPS57159772A (en) 1982-10-01
ATA96982A (de) 1986-10-15
FR2501686B1 (es) 1985-03-01
CS224646B2 (en) 1984-01-16
IT1190732B (it) 1988-02-24
GB2097387B (en) 1984-09-19
HU186760B (en) 1985-09-30
AT383120B (de) 1987-05-25
AU550388B2 (en) 1986-03-20
SE8201537L (sv) 1982-09-13
CH648553A5 (de) 1985-03-29
DK106882A (da) 1982-09-13
CA1178584A (en) 1984-11-27
DE3209100A1 (de) 1982-10-28
AU8130882A (en) 1982-09-16
FR2501686A1 (fr) 1982-09-17
FI820839L (fi) 1982-09-13
SU1151206A3 (ru) 1985-04-15
NL8201005A (nl) 1982-10-01
GB2097387A (en) 1982-11-03

Similar Documents

Publication Publication Date Title
ES8302671A1 (es) &#34;procedimiento de preparacion de nuevos derivados 3,4-dihidro-5h-2,3-benzodiazepinos y de sus sales de adicion acidas farmaceuticamente aceptables&#34;.
BG103195A (en) Substituted indazole derivatives and their application as inhibitors of phosphodiesterase (pde) type iv and of the production of a tumournecrotic factor (tnf)
ES8705393A1 (es) Un procedimiento para preparar un derivado de pirazol (como divisional de la solicitud de patente de invencion n 543.046, presentada el 10.5.85)
MY116915A (en) Substituted indazole analogs
IL62110A (en) Pharmaceutical compositions containing(substituted)phenyl alkyl imidazole derivatives,some new such compounds and their preparation
ES2004985A6 (es) Procedimiento de preparacion de 1-4aminofenil-4-metil-7,8-metilendioxi-3,4-dihidro-5h-2,3-benzodiazepina y sus sales de adicion acidas
ES8706608A1 (es) Un procedimiento para preparar derivados de arilciclobutilalquilamina
ES8500247A1 (es) Un procedimiento para la preparacion de un isomero optico en su forma (-) de un derivado de triazina.
IL67381A (en) N-substituted-4-aminomethyl-imidazole derivatives,their preparation and pharmaceutical compositions containing them
ES8203917A1 (es) Un procedimiento para la preparacion de un derivado de nu- cleosido de adenina
ES8304571A1 (es) &#34;procedimiento para la preparacion de nuevas 1,4,9,10-tetrahidro-pirazolo (4,3-e)pirido (3,2-b) (1,4)diazepin-10-onas&#34;.
ATE29251T1 (de) Aminopyridincarbonsaeure-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ES8406457A1 (es) Procedimiento de preparacion de derivados de piperacina
ES8403130A1 (es) Procedimiento para la preparacion de tienobenzodiazepinonas sustituidas.
ES2012567A6 (es) Procedimiento de preparacion de derivados de quinolinio e isoquinolinio condensados.
IL70552A (en) Aminoethoxybenzyl alcohol derivatives,their preparation and pharmaceutical compositions containing them
ES8103082A1 (es) Procedimiento de preparacion de nuevos derivados pirido (3,4-e)-as-triazinos acilados y de sus sales de acicion aci-da de los mismos
ES8205413A1 (es) Procedimiento para preparar nuevas benzotiopirano (2,3-c)pi-ridinas
ES485333A1 (es) Procedimiento para preparar derivados 5,6,7,8-tetrahidro-4 (3h)-quinazolinonicos y sus sales
ES8106518A1 (es) Procedimiento de preparacion de un nuevo derivado pirido (3,2-e)-as-triazino o de una sal de adicion acida del mismo, farmaceuticamente aceptable