IT8109343A0 - Prodotto: 3(4-fenil1piperazinio-1-il)-1,2-propandiolo 3(teofillin-7-il)-1propansolfonato,utilizzabile in terapia,e relativo procedimento di fabbricazione - Google Patents

Prodotto: 3(4-fenil1piperazinio-1-il)-1,2-propandiolo 3(teofillin-7-il)-1propansolfonato,utilizzabile in terapia,e relativo procedimento di fabbricazione

Info

Publication number
IT8109343A0
IT8109343A0 IT8109343A IT934381A IT8109343A0 IT 8109343 A0 IT8109343 A0 IT 8109343A0 IT 8109343 A IT8109343 A IT 8109343A IT 934381 A IT934381 A IT 934381A IT 8109343 A0 IT8109343 A0 IT 8109343A0
Authority
IT
Italy
Prior art keywords
theophyllin
propandiol
usable
therapy
product
Prior art date
Application number
IT8109343A
Other languages
English (en)
Other versions
IT1210639B (it
Inventor
Vittorio Pestellini
Mario Ghelardoni
Danilo Giannotti
Alberto Meli
Carlo Alberto Maggi
Original Assignee
Menarini Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Sas filed Critical Menarini Sas
Publication of IT8109343A0 publication Critical patent/IT8109343A0/it
Priority to IT8109343A priority Critical patent/IT1210639B/it
Priority to GB8115803A priority patent/GB2093445B/en
Priority to US06/272,281 priority patent/US4372958A/en
Priority to DE19823205149 priority patent/DE3205149A1/de
Priority to AT0059982A priority patent/AT380881B/de
Priority to PT74463A priority patent/PT74463B/pt
Priority to LU83962A priority patent/LU83962A1/fr
Priority to GR67396A priority patent/GR76060B/el
Priority to JP57027570A priority patent/JPS57188589A/ja
Priority to ES509850A priority patent/ES8302680A1/es
Priority to CA000397008A priority patent/CA1192549A/en
Priority to YU412/82A priority patent/YU44007B/xx
Priority to DK79982A priority patent/DK148687C/da
Priority to NL8200746A priority patent/NL8200746A/nl
Priority to CH1167/82A priority patent/CH651043A5/it
Priority to SE8201184A priority patent/SE440503B/sv
Priority to BE0/207403A priority patent/BE892271A/fr
Priority to FR8203164A priority patent/FR2500455A1/fr
Application granted granted Critical
Publication of IT1210639B publication Critical patent/IT1210639B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
IT8109343A 1981-02-25 1981-02-25 Prodotto: 3(4-fenil1piperazinio-1-il)-1,2-propandiolo 3(teofillin-7-il)-1propansolfonato,utilizzabile in terapia,e relativo procedimento di fabbricazione IT1210639B (it)

Priority Applications (18)

Application Number Priority Date Filing Date Title
IT8109343A IT1210639B (it) 1981-02-25 1981-02-25 Prodotto: 3(4-fenil1piperazinio-1-il)-1,2-propandiolo 3(teofillin-7-il)-1propansolfonato,utilizzabile in terapia,e relativo procedimento di fabbricazione
GB8115803A GB2093445B (en) 1981-02-25 1981-05-22 A piperazine derivative having antitussive activity
US06/272,281 US4372958A (en) 1981-02-25 1981-06-10 Compound having antitussive activity
DE19823205149 DE3205149A1 (de) 1981-02-25 1982-02-13 3-(4-phenyl-1-piperazinio-1-yl)-1,2-propandiol-3-(theophyllin-7-yl)-propansulfonat, verfahren zu seiner herstellung und es enthaltende arzneimittel
AT0059982A AT380881B (de) 1981-02-25 1982-02-17 Verfahren zur herstellung des neuen 3-(4-phenyl-1-piperazinio-1-yl)-1,2-propandiol-(theophyllin-7-yl)-1-propansulfonats
PT74463A PT74463B (en) 1981-02-25 1982-02-19 Process for the preparation of 3(4-phenyl-1-piperazinio-1-yl)- -1,2-propanediol 3(theophyllin-7-yl)-1-propanesulphonate having antitussive activity
LU83962A LU83962A1 (fr) 1981-02-25 1982-02-23 Nouveau compose utile comme medicament antitussif et son procede de preparation
GR67396A GR76060B (it) 1981-02-25 1982-02-23
JP57027570A JPS57188589A (en) 1981-02-25 1982-02-24 3(4-phenyl-1-piperazino-1-yl)-1,2-propanediol- 3-(theophyllin-7-yl)-1-propane sulfonate, manufacture and antitussive medicine containing same
ES509850A ES8302680A1 (es) 1981-02-25 1982-02-24 "un procedimiento para sintetizar 3(4-fenil-1-piperacinio-1-il)-1,2-propandiol 3(teofilin-7-il)-1-propansulfonato"
CA000397008A CA1192549A (en) 1981-02-25 1982-02-24 3-(4-phenyl-1-piperazino-1-yl)-1,2-propane-diol 3-(theophyllin-7-yl)-1-propane sulfphonate having anti-tussive activity
YU412/82A YU44007B (en) 1981-02-25 1982-02-24 Process for obtaining 3(4-phenyl-1-piperazino-1-yl)-1,2-propandiole-3-(theophilyne-7-yl)-1-propansulphonate
DK79982A DK148687C (da) 1981-02-25 1982-02-24 Analogifremgangsmaade til fremstilling af 3-(4-phenyl-1-piperazinio-1-yl)-1,2-propandiol-3-(theophyllin-7-yl)-1-propansulfonat
NL8200746A NL8200746A (nl) 1981-02-25 1982-02-24 Verbinding met antitussive activiteit, werkwijze ter bereiding daarvan en toepassing.
CH1167/82A CH651043A5 (it) 1981-02-25 1982-02-25 3(4-fenil-1-piperazinio-1-il)-1,2-propandiolo 3(teofillin-7-il)-1-propansolfonato e relativo procedimento di fabbricazione e farmaco comprendente questo composto.
SE8201184A SE440503B (sv) 1981-02-25 1982-02-25 3-(4-fenyl-1-piperazino-1-yl)-1,2-propandiol-3-(teofyllin-7-yl)-1-propansulfonat, forfarande for framstellning av denna samt lekemedel med antitussiv verkan
BE0/207403A BE892271A (fr) 1981-02-25 1982-02-25 Nouveau compose utile comme medicament antitussif et son procede de preparation
FR8203164A FR2500455A1 (fr) 1981-02-25 1982-02-25 Derive de 1,2-propanediol possedant une activite antitussive et son procede pour sa preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8109343A IT1210639B (it) 1981-02-25 1981-02-25 Prodotto: 3(4-fenil1piperazinio-1-il)-1,2-propandiolo 3(teofillin-7-il)-1propansolfonato,utilizzabile in terapia,e relativo procedimento di fabbricazione

Publications (2)

Publication Number Publication Date
IT8109343A0 true IT8109343A0 (it) 1981-02-25
IT1210639B IT1210639B (it) 1989-09-14

Family

ID=11128724

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8109343A IT1210639B (it) 1981-02-25 1981-02-25 Prodotto: 3(4-fenil1piperazinio-1-il)-1,2-propandiolo 3(teofillin-7-il)-1propansolfonato,utilizzabile in terapia,e relativo procedimento di fabbricazione

Country Status (18)

Country Link
US (1) US4372958A (it)
JP (1) JPS57188589A (it)
AT (1) AT380881B (it)
BE (1) BE892271A (it)
CA (1) CA1192549A (it)
CH (1) CH651043A5 (it)
DE (1) DE3205149A1 (it)
DK (1) DK148687C (it)
ES (1) ES8302680A1 (it)
FR (1) FR2500455A1 (it)
GB (1) GB2093445B (it)
GR (1) GR76060B (it)
IT (1) IT1210639B (it)
LU (1) LU83962A1 (it)
NL (1) NL8200746A (it)
PT (1) PT74463B (it)
SE (1) SE440503B (it)
YU (1) YU44007B (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1203721B (it) * 1983-12-29 1989-02-23 Dompe Farmaceutici Spa Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono
IT1217950B (it) * 1988-06-28 1990-03-30 Dott Formenti Ind Chimica E Fa Sali di (r,s) 3 (4 fenil 1 piperazinil) 1,2 propandtolo
IT1231158B (it) * 1989-07-20 1991-11-19 Dompe Farmaceutici Spa Procedimento per la risoluzione ottica della dropropizina.
DE3938123A1 (de) * 1989-11-16 1991-05-23 Diehl Gmbh & Co Treibladungsanzuender
IT1318651B1 (it) * 2000-07-28 2003-08-27 Dompe Spa Sintesi di (+-)1,3-diossolani e loro risoluzione ottica.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3163649A (en) * 1964-12-29 Substituteb phenyl-piperazine
GB938646A (en) * 1961-03-16 1963-10-02 Henri Morren New piperazine derivatives
FR1384693A (fr) * 1963-10-08 1965-01-08 Electrochimie Soc Procédé de préparation d'esters méthallyliques
FR1554628A (it) * 1967-05-23 1969-01-24

Also Published As

Publication number Publication date
NL8200746A (nl) 1982-09-16
IT1210639B (it) 1989-09-14
YU44007B (en) 1990-02-28
PT74463A (en) 1982-03-01
DK79982A (da) 1982-08-26
DE3205149C2 (it) 1991-04-18
BE892271A (fr) 1982-06-16
GB2093445A (en) 1982-09-02
YU41282A (en) 1987-10-31
DE3205149A1 (de) 1982-11-11
GB2093445B (en) 1985-02-27
SE440503B (sv) 1985-08-05
FR2500455A1 (fr) 1982-08-27
AT380881B (de) 1986-07-25
LU83962A1 (fr) 1982-07-08
FR2500455B1 (it) 1984-04-27
GR76060B (it) 1984-08-03
ATA59982A (de) 1985-12-15
DK148687B (da) 1985-09-02
CA1192549A (en) 1985-08-27
US4372958A (en) 1983-02-08
JPS57188589A (en) 1982-11-19
SE8201184L (sv) 1982-08-26
ES509850A0 (es) 1983-02-01
PT74463B (en) 1983-08-24
JPH0333715B2 (it) 1991-05-20
ES8302680A1 (es) 1983-02-01
DK148687C (da) 1986-04-28
CH651043A5 (it) 1985-08-30

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