IT1203721B - Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono - Google Patents
Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengonoInfo
- Publication number
- IT1203721B IT1203721B IT24430/83A IT2443083A IT1203721B IT 1203721 B IT1203721 B IT 1203721B IT 24430/83 A IT24430/83 A IT 24430/83A IT 2443083 A IT2443083 A IT 2443083A IT 1203721 B IT1203721 B IT 1203721B
- Authority
- IT
- Italy
- Prior art keywords
- preparation
- antitosse
- procedure
- optically active
- active compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/20—Free hydroxyl or mercaptan
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT24430/83A IT1203721B (it) | 1983-12-29 | 1983-12-29 | Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono |
DE8484116334T DE3481510D1 (de) | 1983-12-29 | 1984-12-27 | Optisch aktive verbindungen mit antitassiver und zentral-sedativer wirkung, ein verfahren zu deren herstellung und diese enthaltende zusammensetzungen. |
JP59281944A JPS60252474A (ja) | 1983-12-29 | 1984-12-27 | (−)―3―(4―フェニル―1―ピペラジニル)―1,2―プロパンジオールを有効成分とする鎮咳剤 |
AT84116334T ATE50767T1 (de) | 1983-12-29 | 1984-12-27 | Optisch aktive verbindungen mit antitassiver und zentral-sedativer wirkung, ein verfahren zu deren herstellung und diese enthaltende zusammensetzungen. |
EP84116334A EP0147847B1 (en) | 1983-12-29 | 1984-12-27 | Optically active compounds with antitussive and central sedative activity, a process for the preparation thereof and compositions containing the same |
US06/906,698 US4699911A (en) | 1983-12-29 | 1986-09-11 | Levo and dextro dropropizine having antitussive activity |
US07/069,242 US4764515A (en) | 1983-12-29 | 1987-07-02 | Antitussive and central sedative composition of d-isomer of 3-(4-phenyl-1-piperazinyl)-1,2-propanediol |
JP3007235A JPH0670027B2 (ja) | 1983-12-29 | 1991-01-24 | 3−(4−フェニル−1−ピペラジニル)−1,2−プロパンジオールの光学対掌体の製法 |
JP3007236A JPH0662416B2 (ja) | 1983-12-29 | 1991-01-24 | (+)−3−(4−フェニル−1−ピペラジニル)−1,2−プロパンジオールを有効成分とする鎮静剤 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT24430/83A IT1203721B (it) | 1983-12-29 | 1983-12-29 | Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8324430A0 IT8324430A0 (it) | 1983-12-29 |
IT1203721B true IT1203721B (it) | 1989-02-23 |
Family
ID=11213495
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT24430/83A IT1203721B (it) | 1983-12-29 | 1983-12-29 | Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono |
Country Status (6)
Country | Link |
---|---|
US (2) | US4699911A (it) |
EP (1) | EP0147847B1 (it) |
JP (3) | JPS60252474A (it) |
AT (1) | ATE50767T1 (it) |
DE (1) | DE3481510D1 (it) |
IT (1) | IT1203721B (it) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4837025A (en) * | 1988-03-25 | 1989-06-06 | Laboratoires D'hygiene Et De Dietetique | Self-adhesive device for the percutaneous administration of an active ingredient |
NL8801622A (nl) * | 1988-06-25 | 1990-01-16 | Stamicarbon | Bereiding van enantiomeren van dropropizine. |
IT1226570B (it) * | 1988-08-01 | 1991-01-24 | Bidachem Spa | Procedimento di preparazione della levo- e destro-dropropizina |
IT1231158B (it) * | 1989-07-20 | 1991-11-19 | Dompe Farmaceutici Spa | Procedimento per la risoluzione ottica della dropropizina. |
EP0591434A4 (en) * | 1991-06-26 | 1994-09-14 | Sepracor Inc | Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron |
EP1013275A3 (en) * | 1991-11-26 | 2001-01-10 | Sepracor, Inc. | Method and compositions for treating hypertension, angina and other disorders using optically pure (-) amlodipine |
IT1254452B (it) * | 1992-02-14 | 1995-09-25 | Dompe Farmaceutici Spa | N-ossidi ed n,n'-diossidi di 3-(piperazin-1-il)-propan-1,2-dioli |
IT1254993B (it) * | 1992-06-24 | 1995-10-11 | Procedimento per la preparazione degli enantiomeri della dropropizina | |
WO2000051582A2 (en) | 1999-03-01 | 2000-09-08 | Sepracor Inc. | Methods for treating apnea and apnea disorders using optically pure r(+)ondansetron |
IT1318650B1 (it) * | 2000-07-28 | 2003-08-27 | Dompe Spa | 1,3-diossolani ad attivita' antitosse. |
IT1318651B1 (it) * | 2000-07-28 | 2003-08-27 | Dompe Spa | Sintesi di (+-)1,3-diossolani e loro risoluzione ottica. |
CN102805746B (zh) * | 2011-06-02 | 2016-02-10 | 湖南九典制药股份有限公司 | 一种作用于呼吸***疾病的复方化学药及其制备工艺与应用 |
MX2017014725A (es) * | 2017-11-16 | 2019-05-17 | Productos Farm S A De C V | Dropropizina en combinacion con ambroxol en la forma farmaceutica de jarabe y tabletas. |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3163649A (en) * | 1964-12-29 | Substituteb phenyl-piperazine | ||
BE601394A (it) * | ||||
BE601794A (fr) * | 1960-03-24 | 1961-09-25 | Gabriel Co | Mécanisme distributeur |
GB938646A (en) * | 1961-03-16 | 1963-10-02 | Henri Morren | New piperazine derivatives |
NL275711A (it) * | 1962-03-15 | |||
IT1210639B (it) * | 1981-02-25 | 1989-09-14 | Menarini Sas | Prodotto: 3(4-fenil1piperazinio-1-il)-1,2-propandiolo 3(teofillin-7-il)-1propansolfonato,utilizzabile in terapia,e relativo procedimento di fabbricazione |
-
1983
- 1983-12-29 IT IT24430/83A patent/IT1203721B/it active
-
1984
- 1984-12-27 AT AT84116334T patent/ATE50767T1/de not_active IP Right Cessation
- 1984-12-27 EP EP84116334A patent/EP0147847B1/en not_active Expired - Lifetime
- 1984-12-27 JP JP59281944A patent/JPS60252474A/ja active Granted
- 1984-12-27 DE DE8484116334T patent/DE3481510D1/de not_active Expired - Lifetime
-
1986
- 1986-09-11 US US06/906,698 patent/US4699911A/en not_active Expired - Lifetime
-
1987
- 1987-07-02 US US07/069,242 patent/US4764515A/en not_active Expired - Lifetime
-
1991
- 1991-01-24 JP JP3007235A patent/JPH0670027B2/ja not_active Expired - Lifetime
- 1991-01-24 JP JP3007236A patent/JPH0662416B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE3481510D1 (de) | 1990-04-12 |
JPH05222019A (ja) | 1993-08-31 |
EP0147847A3 (en) | 1986-11-26 |
JPS60252474A (ja) | 1985-12-13 |
JPH0662416B2 (ja) | 1994-08-17 |
IT8324430A0 (it) | 1983-12-29 |
US4699911A (en) | 1987-10-13 |
EP0147847B1 (en) | 1990-03-07 |
US4764515A (en) | 1988-08-16 |
JPH058688B2 (it) | 1993-02-02 |
JPH05221864A (ja) | 1993-08-31 |
JPH0670027B2 (ja) | 1994-09-07 |
ATE50767T1 (de) | 1990-03-15 |
EP0147847A2 (en) | 1985-07-10 |
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