IT1318651B1 - Sintesi di (+-)1,3-diossolani e loro risoluzione ottica. - Google Patents

Sintesi di (+-)1,3-diossolani e loro risoluzione ottica.

Info

Publication number: IT1318651B1
Authority: IT; Italy
Prior art keywords: optical resolution; diossolans; piperazinyl; phenyl; propanediol
Prior art date: 2000-07-28

Application number

IT2000MI001735A

Other languages

English (en)

Inventor

Marcello Allegretti

Maria Candida Cesta

Roberto Curti

Luca Nicolini

Original Assignee

Dompe Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-28

Filing date

2000-07-28

Publication date

2003-08-27

2000-07-28 Application filed by Dompe Spa filed Critical Dompe Spa

2000-07-28 Publication of ITMI20001735A0 publication Critical patent/ITMI20001735A0/it

2000-07-28 Priority to IT2000MI001735A priority Critical patent/IT1318651B1/it

2001-07-18 Priority to YUP-31/03A priority patent/RS50862B/sr

2001-07-18 Priority to ES01960513T priority patent/ES2237589T3/es

2001-07-18 Priority to SK90-2003A priority patent/SK286795B6/sk

2001-07-18 Priority to DK01960513T priority patent/DK1307440T3/da

2001-07-18 Priority to EP01960513A priority patent/EP1307440B1/en

2001-07-18 Priority to JP2002515881A priority patent/JP5015403B2/ja

2001-07-18 Priority to EEP200300035A priority patent/EE05159B1/xx

2001-07-18 Priority to BR0112802-7A priority patent/BR0112802A/pt

2001-07-18 Priority to PCT/EP2001/008305 priority patent/WO2002010150A1/en

2001-07-18 Priority to UA2003021768A priority patent/UA73790C2/uk

2001-07-18 Priority to PT01960513T priority patent/PT1307440E/pt

2001-07-18 Priority to AT01960513T priority patent/ATE290533T1/de

2001-07-18 Priority to MXPA02012922A priority patent/MXPA02012922A/es

2001-07-18 Priority to SI200120037A priority patent/SI21041B/sl

2001-07-18 Priority to RU2003105692/04A priority patent/RU2269522C2/ru

2001-07-18 Priority to HU0301473A priority patent/HU229801B1/hu

2001-07-18 Priority to DE60109299T priority patent/DE60109299T2/de

2001-07-18 Priority to AU2001281992A priority patent/AU2001281992A1/en

2001-07-18 Priority to IL15350201A priority patent/IL153502A0/xx

2001-07-18 Priority to SI200130321T priority patent/SI1307440T1/xx

2001-07-18 Priority to CN018134572A priority patent/CN1216053C/zh

2001-07-18 Priority to CZ20030269A priority patent/CZ301039B6/cs

2001-07-18 Priority to US10/312,290 priority patent/US6916926B2/en

2001-07-18 Priority to PL361173A priority patent/PL206308B1/pl

2001-07-18 Priority to KR1020037000943A priority patent/KR100788532B1/ko

2002-01-28 Publication of ITMI20001735A1 publication Critical patent/ITMI20001735A1/it

2002-12-17 Priority to IL153502A priority patent/IL153502A/en

2003-08-27 Application granted granted Critical

2003-08-27 Publication of IT1318651B1 publication Critical patent/IT1318651B1/it

2004-03-05 Priority to HK04101654A priority patent/HK1058798A1/xx

Links

230000003287 optical effect Effects 0.000 title abstract 2
-1 (±) 3-(4-Phenyl-1-piperazinyl)-1,2-propanediol cyclic acetals Chemical class 0.000 abstract 1
PTVWPYVOOKLBCG-UHFFFAOYSA-N 3-(4-phenyl-1-piperazinyl)propane-1,2-diol Chemical compound C1CN(CC(O)CO)CCN1C1=CC=CC=C1 PTVWPYVOOKLBCG-UHFFFAOYSA-N 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
PTVWPYVOOKLBCG-ZDUSSCGKSA-N levodropropizine Chemical compound C1CN(C[C@H](O)CO)CCN1C1=CC=CC=C1 PTVWPYVOOKLBCG-ZDUSSCGKSA-N 0.000 abstract 1
229960002265 levodropropizine Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pulmonology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Holo Graphy (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
Secondary Cells (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Fats And Perfumes (AREA)
Liquid Crystal Substances (AREA)
Glass Compositions (AREA)
Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)

IT2000MI001735A 2000-07-28 2000-07-28 Sintesi di (+-)1,3-diossolani e loro risoluzione ottica. IT1318651B1 (it)

Priority Applications (28)

Application Number	Priority Date	Filing Date	Title
IT2000MI001735A IT1318651B1 (it)	2000-07-28	2000-07-28	Sintesi di (+-)1,3-diossolani e loro risoluzione ottica.
SI200120037A SI21041B (en)	2000-07-28	2001-07-18	2,2-disubstituted 1,3-dioxolanes as antitussive agents
HU0301473A HU229801B1 (en)	2000-07-28	2001-07-18	2,2-disubstituted 1,3-dioxolanes as antitussive agents
ES01960513T ES2237589T3 (es)	2000-07-28	2001-07-18	1,3-dioxolanos 2,2-disustituidos como agentes antitusigenos.
DK01960513T DK1307440T3 (da)	2000-07-28	2001-07-18	2,2-disubstituerede 1,3-dioxolaner som antihostemidler
EP01960513A EP1307440B1 (en)	2000-07-28	2001-07-18	2,2-disubstituted 1,3-dioxolanes as antitussive agents
JP2002515881A JP5015403B2 (ja)	2000-07-28	2001-07-18	（−）３−（４−フェニル−１−ピペラジニル）−１，２−プロパンジオール及びその中間体の製造方法
EEP200300035A EE05159B1 (et)	2000-07-28	2001-07-18	2,2-asendatud-1,3-dioksolaanid, nende valmistamine, optiline lahutamine ning kasutamine vahehenditena
BR0112802-7A BR0112802A (pt)	2000-07-28	2001-07-18	l,3-dioxolanos 2,2-dissubstituìdos como agentes antitussivos
PCT/EP2001/008305 WO2002010150A1 (en)	2000-07-28	2001-07-18	2,2-disubstituted 1,3-dioxolanes as antitussive agents
UA2003021768A UA73790C2 (uk)	2000-07-28	2001-07-18	2,2-дизаміщені 1,3-діоксолани, спосіб одержання та застосування як проміжних продуктів для синтезу відповідних (s)-енантіомерів та (-)3-(4-феніл-1-піперазиніл)-1,2-пропандіолу
PT01960513T PT1307440E (pt)	2000-07-28	2001-07-18	1,3-dioxolanos dissubstituidos em 2,2 como agentes antitussicos
AT01960513T ATE290533T1 (de)	2000-07-28	2001-07-18	2,2-disubstituierte 1,3-dioxolane als hustenmittel
MXPA02012922A MXPA02012922A (es)	2000-07-28	2001-07-18	1,3 dioxolanos 2,2-disubstituidos como agentes antitusigenos.
YUP-31/03A RS50862B (sr)	2000-07-28	2001-07-18	2,2-disupstituisani 1,3-dioksolani kao sredstva protiv kašlja
RU2003105692/04A RU2269522C2 (ru)	2000-07-28	2001-07-18	1,3-диоксоланы и способ их получения
SK90-2003A SK286795B6 (sk)	2000-07-28	2001-07-18	2,2-Disubstituované 1,3-dioxolány, spôsob ich prípravy a ich použitie
DE60109299T DE60109299T2 (de)	2000-07-28	2001-07-18	2,2-disubstituierte 1,3-dioxolane als hustenmittel
AU2001281992A AU2001281992A1 (en)	2000-07-28	2001-07-18	2,2-disubstituted 1,3-dioxolanes as antitussive agents
IL15350201A IL153502A0 (en)	2000-07-28	2001-07-18	2,2-disubstituted 1,3-dioxolanes as antitussive agents
SI200130321T SI1307440T1 (it)	2000-07-28	2001-07-18
CN018134572A CN1216053C (zh)	2000-07-28	2001-07-18	用作镇咳药的2,2－二取代的1,3－二氧环戊烷
CZ20030269A CZ301039B6 (cs)	2000-07-28	2001-07-18	2,2-disubstituované 1,3-dioxolany
US10/312,290 US6916926B2 (en)	2000-07-28	2001-07-18	Process for the preparation of (±) 1-3-dioxolanes and the optical resolution thereof
PL361173A PL206308B1 (pl)	2000-07-28	2001-07-18	2,2-dipodstawione 1,3-dioksolany, sposób ich wytwarzania, sposób ich rozdzielania optycznego i ich zastosowanie oraz sposób syntezy lewodropropizyny
KR1020037000943A KR100788532B1 (ko)	2000-07-28	2001-07-18	항해수성 2,2-이중치환된 1,3-디옥솔란
IL153502A IL153502A (en)	2000-07-28	2002-12-17	1,3 - Dioxolanes - 2,2 - Imaging as cough suppressants
HK04101654A HK1058798A1 (en)	2000-07-28	2004-03-05	2,2-Disubstituted 1,3-dioxolanes as antitussive agents.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT2000MI001735A IT1318651B1 (it)	2000-07-28	2000-07-28	Sintesi di (+-)1,3-diossolani e loro risoluzione ottica.

Publications (3)

Publication Number	Publication Date
ITMI20001735A0 ITMI20001735A0 (it)	2000-07-28
ITMI20001735A1 ITMI20001735A1 (it)	2002-01-28
IT1318651B1 true IT1318651B1 (it)	2003-08-27

Family

ID=11445592

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT2000MI001735A IT1318651B1 (it)	2000-07-28	2000-07-28	Sintesi di (+-)1,3-diossolani e loro risoluzione ottica.

Country Status (25)

Country	Link
US (1)	US6916926B2 (it)
EP (1)	EP1307440B1 (it)
JP (1)	JP5015403B2 (it)
KR (1)	KR100788532B1 (it)
CN (1)	CN1216053C (it)
AT (1)	ATE290533T1 (it)
AU (1)	AU2001281992A1 (it)
BR (1)	BR0112802A (it)
CZ (1)	CZ301039B6 (it)
DE (1)	DE60109299T2 (it)
EE (1)	EE05159B1 (it)
ES (1)	ES2237589T3 (it)
HK (1)	HK1058798A1 (it)
HU (1)	HU229801B1 (it)
IL (2)	IL153502A0 (it)
IT (1)	IT1318651B1 (it)
MX (1)	MXPA02012922A (it)
PL (1)	PL206308B1 (it)
PT (1)	PT1307440E (it)
RS (1)	RS50862B (it)
RU (1)	RU2269522C2 (it)
SI (1)	SI21041B (it)
SK (1)	SK286795B6 (it)
UA (1)	UA73790C2 (it)
WO (1)	WO2002010150A1 (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1318650B1 (it) *	2000-07-28	2003-08-27	Dompe Spa	1,3-diossolani ad attivita' antitosse.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4049660A (en) *	1971-06-18	1977-09-20	Delalande S.A.	N-substituted derivatives of 4 (N-piperazinylmethyl) spiro dibenzocycloheptadi- (or tri-) ene-5, 2-dioxolane (1,3) their method of preparation and their application in therapeutics
IT1210639B (it) *	1981-02-25	1989-09-14	Menarini Sas	Prodotto: 3(4-fenil1piperazinio-1-il)-1,2-propandiolo 3(teofillin-7-il)-1propansolfonato,utilizzabile in terapia,e relativo procedimento di fabbricazione
IT1203721B (it) *	1983-12-29	1989-02-23	Dompe Farmaceutici Spa	Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono
SE449516B (sv) *	1984-10-16	1987-05-04	Skf Nova Ab	Klemring med reglerbar halomkrets
IT1254452B (it)	1992-02-14	1995-09-25	Dompe Farmaceutici Spa	N-ossidi ed n,n'-diossidi di 3-(piperazin-1-il)-propan-1,2-dioli
IL111730A (en) *	1993-11-29	1998-12-06	Fujisawa Pharmaceutical Co	Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them
IT1318650B1 (it) *	2000-07-28	2003-08-27	Dompe Spa	1,3-diossolani ad attivita' antitosse.

2000
- 2000-07-28 IT IT2000MI001735A patent/IT1318651B1/it active
2001
- 2001-07-18 RS YUP-31/03A patent/RS50862B/sr unknown
- 2001-07-18 HU HU0301473A patent/HU229801B1/hu not_active IP Right Cessation
- 2001-07-18 CN CN018134572A patent/CN1216053C/zh not_active Expired - Fee Related
- 2001-07-18 BR BR0112802-7A patent/BR0112802A/pt not_active Application Discontinuation
- 2001-07-18 JP JP2002515881A patent/JP5015403B2/ja not_active Expired - Fee Related
- 2001-07-18 ES ES01960513T patent/ES2237589T3/es not_active Expired - Lifetime
- 2001-07-18 RU RU2003105692/04A patent/RU2269522C2/ru not_active IP Right Cessation
- 2001-07-18 PL PL361173A patent/PL206308B1/pl unknown
- 2001-07-18 DE DE60109299T patent/DE60109299T2/de not_active Expired - Lifetime
- 2001-07-18 US US10/312,290 patent/US6916926B2/en not_active Expired - Fee Related
- 2001-07-18 SI SI200120037A patent/SI21041B/sl not_active IP Right Cessation
- 2001-07-18 KR KR1020037000943A patent/KR100788532B1/ko not_active IP Right Cessation
- 2001-07-18 WO PCT/EP2001/008305 patent/WO2002010150A1/en active IP Right Grant
- 2001-07-18 UA UA2003021768A patent/UA73790C2/uk unknown
- 2001-07-18 SK SK90-2003A patent/SK286795B6/sk not_active IP Right Cessation
- 2001-07-18 CZ CZ20030269A patent/CZ301039B6/cs not_active IP Right Cessation
- 2001-07-18 AU AU2001281992A patent/AU2001281992A1/en not_active Abandoned
- 2001-07-18 EP EP01960513A patent/EP1307440B1/en not_active Expired - Lifetime
- 2001-07-18 EE EEP200300035A patent/EE05159B1/xx not_active IP Right Cessation
- 2001-07-18 PT PT01960513T patent/PT1307440E/pt unknown
- 2001-07-18 MX MXPA02012922A patent/MXPA02012922A/es active IP Right Grant
- 2001-07-18 AT AT01960513T patent/ATE290533T1/de active
- 2001-07-18 IL IL15350201A patent/IL153502A0/xx active IP Right Grant
2002
- 2002-12-17 IL IL153502A patent/IL153502A/en not_active IP Right Cessation
2004
- 2004-03-05 HK HK04101654A patent/HK1058798A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
CZ301039B6 (cs)	2009-10-21
US6916926B2 (en)	2005-07-12
JP5015403B2 (ja)	2012-08-29
PL206308B1 (pl)	2010-07-30
ITMI20001735A0 (it)	2000-07-28
MXPA02012922A (es)	2003-10-06
ATE290533T1 (de)	2005-03-15
CN1444579A (zh)	2003-09-24
EE200300035A (et)	2004-10-15
EP1307440A1 (en)	2003-05-07
PT1307440E (pt)	2005-05-31
CZ2003269A3 (cs)	2003-06-18
SK286795B6 (sk)	2009-05-07
ES2237589T3 (es)	2005-08-01
DE60109299T2 (de)	2005-07-21
YU3103A (sh)	2006-05-25
SK902003A3 (en)	2003-09-11
PL361173A1 (en)	2004-09-20
US20030176446A1 (en)	2003-09-18
ITMI20001735A1 (it)	2002-01-28
CN1216053C (zh)	2005-08-24
SI21041B (en)	2005-08-31
AU2001281992A1 (en)	2002-02-13
KR100788532B1 (ko)	2007-12-24
EE05159B1 (et)	2009-04-15
JP2004505074A (ja)	2004-02-19
RS50862B (sr)	2010-08-31
HK1058798A1 (en)	2004-06-04
IL153502A0 (en)	2003-07-06
RU2269522C2 (ru)	2006-02-10
SI21041A (sl)	2003-04-30
EP1307440B1 (en)	2005-03-09
UA73790C2 (uk)	2005-09-15
DE60109299D1 (de)	2005-04-14
HUP0301473A2 (hu)	2003-08-28
HU229801B1 (en)	2014-07-28
KR20030016424A (ko)	2003-02-26
IL153502A (en)	2006-12-10
BR0112802A (pt)	2003-07-01
WO2002010150A1 (en)	2002-02-07

Publication	Publication Date	Title
EA199900853A1 (ru)	2000-10-30	Замещенные производные бензопирана для лечения воспалительных процессов
CY1105836T1 (el)	2011-02-02	12, 13-τροποποιημενα παραγωγα εποθιλονης
DE69527072D1 (de)	2002-07-18	Endothelin antagoniste
BR0115501A (pt)	2003-10-21	Processo quìmico e novos intermediários
DK1140788T3 (da)	2004-06-07	Fremgangsmåde til fremstilling af arylethere
DE50101861D1 (de)	2004-05-06	Tocotrienolchinon- zyklisierungsprodukte mit antihypercholesterin wirkung
PT1204658E (pt)	2003-08-29	Agonistas benzofurilpiperazina de serotonina
IT1318651B1 (it)	2003-08-27	Sintesi di (+-)1,3-diossolani e loro risoluzione ottica.
NO20032401D0 (no)	2003-05-27	Fremgangsmåte ved fremstilling av taksanderivater
ATE266018T1 (de)	2004-05-15	1,3-dioxolanen mit hustenhemmender wirkung
AR032373A2 (es)	2003-11-05	Intermediarios para preparar 3-(1-piperazinil)-1,2-benzoisotiazol.
SE9701438D0 (sv)	1997-04-17	A new process
ATE298336T1 (de)	2005-07-15	Verfahren zur herstellung von thiazolidinedion- derivaten und zwischenprodukte
FI961793A0 (fi)	1996-04-26	Muistia parantavina aineina käyttökelpoiset 3-aryyli-4-alkyyli- ja 4,5-dialkyyli 4H-1,2,4-triatsolit
EA200001212A1 (ru)	2001-04-23	Усовершенствованный способ получения производных норбензоморфана с ценными фармацевтическими свойствами
EA200200741A1 (ru)	2002-12-26	Способ получения эфиров арилиминометилкарбаминовой кислоты
DE50110829D1 (de)	2006-10-05	Verfahren zur herstellung von 4-(17alpha-substituierten-3-oxoestra-4,9-dien-11beta-yl) benzaldehyd-(1e oder 1z)-oximen
EA200200090A1 (ru)	2002-06-27	Способ получения замещенных бензизотиазоловых соединений
EA200100528A1 (ru)	2002-04-25	1,4-диарил-2-фтор-1-бутен-3-ольные производные и их применение для получения 1,4-диарил-2-фтор-1,3-бутадиеновых и 1,4-диарил-2-фтор-2-бутеновых производных
ES2037667T3 (es)	1993-07-01	Procedimiento para la obtencion de indolinas.