IT1277898B1 - Uso di amminoacidi basici, di acil derivati di amminoacidi basici e di loro sali farmaceuticamente accettabili per la profilassi di malattie - Google Patents

Uso di amminoacidi basici, di acil derivati di amminoacidi basici e di loro sali farmaceuticamente accettabili per la profilassi di malattie

Info

Publication number
IT1277898B1
IT1277898B1 IT95RM000545A ITRM950545A IT1277898B1 IT 1277898 B1 IT1277898 B1 IT 1277898B1 IT 95RM000545 A IT95RM000545 A IT 95RM000545A IT RM950545 A ITRM950545 A IT RM950545A IT 1277898 B1 IT1277898 B1 IT 1277898B1
Authority
IT
Italy
Prior art keywords
amino acids
basic amino
pharmaceutically acceptable
acceptable salts
acyl derivatives
Prior art date
Application number
IT95RM000545A
Other languages
English (en)
Inventor
Sonia Moretti
Original Assignee
Mendes Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mendes Srl filed Critical Mendes Srl
Publication of ITRM950545A0 publication Critical patent/ITRM950545A0/it
Priority to IT95RM000545A priority Critical patent/IT1277898B1/it
Priority to DK96924125T priority patent/DK0844875T3/da
Priority to KR10-1998-0700816A priority patent/KR100423760B1/ko
Priority to CNB961965282A priority patent/CN1138539C/zh
Priority to AU64691/96A priority patent/AU713207B2/en
Priority to CA002228281A priority patent/CA2228281C/en
Priority to PCT/IT1996/000147 priority patent/WO1997005862A2/en
Priority to ES96924125T priority patent/ES2279523T3/es
Priority to JP9508283A priority patent/JPH11510182A/ja
Priority to PT96924125T priority patent/PT844875E/pt
Priority to BR9610106A priority patent/BR9610106A/pt
Priority to DE69636792T priority patent/DE69636792T2/de
Priority to EP96924125A priority patent/EP0844875B1/en
Priority to RU98103503/14A priority patent/RU2179850C2/ru
Priority to AT96924125T priority patent/ATE349206T1/de
Priority to US09/000,203 priority patent/US6114385A/en
Priority to TW085108859A priority patent/TW434011B/zh
Priority to ARP960103845A priority patent/AR003473A1/es
Publication of ITRM950545A1 publication Critical patent/ITRM950545A1/it
Application granted granted Critical
Publication of IT1277898B1 publication Critical patent/IT1277898B1/it
Priority to MXPA/A/1998/000916A priority patent/MXPA98000916A/xx
Priority to HK99100418A priority patent/HK1015274A1/xx
Priority to US09/558,860 priority patent/US6350782B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
IT95RM000545A 1995-08-03 1995-08-03 Uso di amminoacidi basici, di acil derivati di amminoacidi basici e di loro sali farmaceuticamente accettabili per la profilassi di malattie IT1277898B1 (it)

Priority Applications (21)

Application Number Priority Date Filing Date Title
IT95RM000545A IT1277898B1 (it) 1995-08-03 1995-08-03 Uso di amminoacidi basici, di acil derivati di amminoacidi basici e di loro sali farmaceuticamente accettabili per la profilassi di malattie
BR9610106A BR9610106A (pt) 1995-08-03 1996-07-19 Uso de aminoácidos básicos e derivados para diminuir níveis de ceramida
EP96924125A EP0844875B1 (en) 1995-08-03 1996-07-19 Use of basic l-carnitine and acyl derivatives for lowering ceramide levels
CNB961965282A CN1138539C (zh) 1995-08-03 1996-07-19 用于降低神经酰胺水平的碱性氨基酸和衍生物的应用
AU64691/96A AU713207B2 (en) 1995-08-03 1996-07-19 Use of basic aminoacids and derivatives for lowering ceramide levels
CA002228281A CA2228281C (en) 1995-08-03 1996-07-19 Use of l-carnitine and acyl l-carnitines for lowering ceramide levels
PCT/IT1996/000147 WO1997005862A2 (en) 1995-08-03 1996-07-19 Use of basic amino acids and derivatives for lowering ceramide levels
ES96924125T ES2279523T3 (es) 1995-08-03 1996-07-19 Nuevo uso terapeutico de la l-carnitina o sus derivados acilados.
JP9508283A JPH11510182A (ja) 1995-08-03 1996-07-19 セラミドのレベルを下げるための塩基性アミノ酸および誘導体の使用
PT96924125T PT844875E (pt) 1995-08-03 1996-07-19 Utilização de derivados básicos de l-carnitina e acilo para a redução dos níveis de ceramida
DK96924125T DK0844875T3 (da) 1995-08-03 1996-07-19 Anvendelse af L-carnitin og acylderivater til nedsættelse af ceramidniveauer
DE69636792T DE69636792T2 (de) 1995-08-03 1996-07-19 Verwendung von l-carnitine und acyl derivaten zur senkung des ceramidspiegels
KR10-1998-0700816A KR100423760B1 (ko) 1995-08-03 1996-07-19 세라미드레벨을경감시키는염기성아미노산과그유도체의용도
RU98103503/14A RU2179850C2 (ru) 1995-08-03 1996-07-19 Применение основных аминокислот и их производных для снижения содержания церамидов, фармацевтическая композиция
AT96924125T ATE349206T1 (de) 1995-08-03 1996-07-19 Verwendung von l-carnitine und acyl derivaten zur senkung des ceramidspiegels
US09/000,203 US6114385A (en) 1995-08-03 1996-07-19 Use of basic amino acids and derivatives for lowering ceramide levels
TW085108859A TW434011B (en) 1995-08-03 1996-07-20 Use of basic aminoacids, acylated basic aminoacids and their pharmacologically acceptable salts for the prophylaxis of diseases or the therapeutic treatment of cellular disorders accompanied by high levels of ceramide
ARP960103845A AR003473A1 (es) 1995-08-03 1996-08-02 Uso de la l-carnitina o una acil l-carnitina en donde el acilo es seleccionado del grupo que comprende acetilo, propionilo, butirilo, valerilo e isovalerilo, o de una sal farmacologicamente aceptable de las mismas para la produccion de un medicamento
MXPA/A/1998/000916A MXPA98000916A (en) 1995-08-03 1998-02-02 Use of basic amino acids and derivatives to decrease ceram levels
HK99100418A HK1015274A1 (en) 1995-08-03 1999-02-02 Use of basic amino acids and derivatives for lowering ceramide levels.
US09/558,860 US6350782B1 (en) 1995-08-03 2000-04-27 Use of basic amino acids derivatives for lowering ceramide levels

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95RM000545A IT1277898B1 (it) 1995-08-03 1995-08-03 Uso di amminoacidi basici, di acil derivati di amminoacidi basici e di loro sali farmaceuticamente accettabili per la profilassi di malattie

Publications (3)

Publication Number Publication Date
ITRM950545A0 ITRM950545A0 (it) 1995-08-03
ITRM950545A1 ITRM950545A1 (it) 1997-02-03
IT1277898B1 true IT1277898B1 (it) 1997-11-12

Family

ID=11403513

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95RM000545A IT1277898B1 (it) 1995-08-03 1995-08-03 Uso di amminoacidi basici, di acil derivati di amminoacidi basici e di loro sali farmaceuticamente accettabili per la profilassi di malattie

Country Status (19)

Country Link
US (2) US6114385A (it)
EP (1) EP0844875B1 (it)
JP (1) JPH11510182A (it)
KR (1) KR100423760B1 (it)
CN (1) CN1138539C (it)
AR (1) AR003473A1 (it)
AT (1) ATE349206T1 (it)
AU (1) AU713207B2 (it)
BR (1) BR9610106A (it)
CA (1) CA2228281C (it)
DE (1) DE69636792T2 (it)
DK (1) DK0844875T3 (it)
ES (1) ES2279523T3 (it)
HK (1) HK1015274A1 (it)
IT (1) IT1277898B1 (it)
PT (1) PT844875E (it)
RU (1) RU2179850C2 (it)
TW (1) TW434011B (it)
WO (1) WO1997005862A2 (it)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1277898B1 (it) 1995-08-03 1997-11-12 Mendes Srl Uso di amminoacidi basici, di acil derivati di amminoacidi basici e di loro sali farmaceuticamente accettabili per la profilassi di malattie
IT1277897B1 (it) * 1995-08-03 1997-11-12 Mendes Srl Uso della l-carnitina,di suoi derivati e di loro sali farmaceuticamen- te accettabili in combinazione con farmaci antiretrovirali per ridurre
IT1284661B1 (it) * 1996-06-06 1998-05-21 Sigma Tau Ind Farmaceuti Uso di alcanoil l-carnitine nel trattamento terapeutico di malattie infiammatorie croniche intestinali.
FR2778562B1 (fr) * 1998-05-14 2000-08-04 Sephra Composition pharmaceutique, hygienique et/ou cosmetique contenant de l'eau de mer et de l'arginine
DE69923322T2 (de) 1998-07-30 2005-12-22 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Verwendung von propionyl-l-carnitin und acetyl-l-carnitin zur herstellung von arzneimittel mit antikrebs wirkung
IT1302289B1 (it) 1998-09-30 2000-09-05 Univ Catania Composizioni farmaceutiche ad attivita' antineoplastica
AU4013900A (en) * 1999-03-19 2000-10-09 Enos Pharmaceuticals, Inc. Increasing cerebral bioavailability of drugs
US20010025027A1 (en) * 2000-03-07 2001-09-27 Sonis Stephen T. Inhibition of ceramide for the prevention and treatment of oral mucositis induced by antineoplastic drugs or radiation
KR20030070147A (ko) * 2001-01-30 2003-08-27 아지노모토 가부시키가이샤 염증성 질환 치료 예방제
US20080145424A1 (en) * 2002-10-24 2008-06-19 Enos Phramaceuticals, Inc. Sustained release L-arginine formulations and methods of manufacture and use
WO2004037203A2 (en) * 2002-10-24 2004-05-06 Enos Pharmaceuticals, Inc. Sustained release l-arginine formulations and methods of manufacture and use
IL156670A0 (en) * 2003-06-26 2004-01-04 Zvi Zolotariov Aloe suppositories
JP2007521324A (ja) * 2003-09-29 2007-08-02 エノス ファーマシューティカルズ， インク． 徐放性ｌ−アルギニン調合物並びにその製造法及び使用法
JP2007055900A (ja) * 2003-12-15 2007-03-08 Ajinomoto Co Inc 炎症性疾患の治療及び予防用医薬組成物
US20050232911A1 (en) * 2004-04-19 2005-10-20 Schreiber Brian D Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid
EA019268B1 (ru) * 2010-12-01 2014-02-28 Общество С Ограниченной Ответственностью "Анвилаб" Комбинированное средство, обладающее гепатопротекторным действием
CN103142735B (zh) * 2013-03-09 2014-07-23 河北工程大学 一种治疗鸭病毒性肝炎的中药口服液
EP4125858A1 (en) * 2020-04-28 2023-02-08 Lonza Consumer Health Inc. Nutritional composition comprising carnitine and method for treating or preventing an infection in a mammal
WO2023244536A2 (en) * 2022-06-13 2023-12-21 Neubase Therapeutics, Inc. Oligonucleotide analogue formulations

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AU518617B2 (en) * 1977-04-29 1981-10-08 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Therapeutic application of acetyl-d, 1-carnitine
DE2946563A1 (de) * 1979-11-17 1981-05-21 B. Braun Melsungen Ag, 3508 Melsungen Aminosaeureloesung zur parenteralen infusion
JPH0247447B2 (ja) * 1982-05-27 1990-10-19 Teijin Ltd Kohotaikanohikuiigmsoseibutsu
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IT1244636B (it) * 1991-01-04 1994-08-08 Sigma Tau Ind Farmaceuti Uso dell'acetil l-carnitina nel trattamento terapeutico del coma e composizioni farmaceutiche utili in tale trattamento.
IT1248321B (it) * 1991-05-15 1995-01-05 Sigma Tau Ind Farmaceuti Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie
IT1254136B (it) * 1992-01-16 1995-09-08 Sigma Tau Ind Farmaceuti Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antimicotica.
WO1995000137A1 (de) * 1993-06-21 1995-01-05 Bernardini, Attilio Verwendung von acylcarnitin zur behandlund von aids-krankheiten
IT1277897B1 (it) 1995-08-03 1997-11-12 Mendes Srl Uso della l-carnitina,di suoi derivati e di loro sali farmaceuticamen- te accettabili in combinazione con farmaci antiretrovirali per ridurre
IT1277898B1 (it) 1995-08-03 1997-11-12 Mendes Srl Uso di amminoacidi basici, di acil derivati di amminoacidi basici e di loro sali farmaceuticamente accettabili per la profilassi di malattie
IT1283951B1 (it) * 1996-03-15 1998-05-07 Mendes Srl Uso della acetil l-carnitina o dei suoi sali farmacologicamente accettabili per il trattamento terapeutico o la profilassi di

Also Published As

Publication number Publication date
ITRM950545A0 (it) 1995-08-03
AU713207B2 (en) 1999-11-25
EP0844875A2 (en) 1998-06-03
AU6469196A (en) 1997-03-05
AR003473A1 (es) 1998-08-05
BR9610106A (pt) 1999-02-23
RU2179850C2 (ru) 2002-02-27
WO1997005862A2 (en) 1997-02-20
ES2279523T3 (es) 2007-08-16
KR19990036148A (ko) 1999-05-25
WO1997005862A3 (en) 1997-04-17
KR100423760B1 (ko) 2004-08-25
JPH11510182A (ja) 1999-09-07
PT844875E (pt) 2007-02-28
CN1138539C (zh) 2004-02-18
DE69636792T2 (de) 2007-10-04
DK0844875T3 (da) 2007-04-10
TW434011B (en) 2001-05-16
US6350782B1 (en) 2002-02-26
CN1193911A (zh) 1998-09-23
CA2228281C (en) 2008-03-25
ITRM950545A1 (it) 1997-02-03
CA2228281A1 (en) 1997-02-20
DE69636792D1 (de) 2007-02-08
ATE349206T1 (de) 2007-01-15
HK1015274A1 (en) 1999-10-15
EP0844875B1 (en) 2006-12-27
MX9800916A (es) 1998-10-31
US6114385A (en) 2000-09-05

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