IT1284661B1 - Uso di alcanoil l-carnitine nel trattamento terapeutico di malattie infiammatorie croniche intestinali. - Google Patents

Uso di alcanoil l-carnitine nel trattamento terapeutico di malattie infiammatorie croniche intestinali.

Info

Publication number
IT1284661B1
IT1284661B1 IT96RM000396A ITRM960396A IT1284661B1 IT 1284661 B1 IT1284661 B1 IT 1284661B1 IT 96RM000396 A IT96RM000396 A IT 96RM000396A IT RM960396 A ITRM960396 A IT RM960396A IT 1284661 B1 IT1284661 B1 IT 1284661B1
Authority
IT
Italy
Prior art keywords
alcanoil
carnitine
inflammatory diseases
therapeutic treatment
chronic intestinal
Prior art date
Application number
IT96RM000396A
Other languages
English (en)
Inventor
Claudio Cavazza
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of ITRM960396A0 publication Critical patent/ITRM960396A0/it
Priority to IT96RM000396A priority Critical patent/IT1284661B1/it
Priority to TW086107648A priority patent/TW585763B/zh
Priority to DE69716341T priority patent/DE69716341T2/de
Priority to ES97830270T priority patent/ES2185897T3/es
Priority to PT97830270T priority patent/PT811376E/pt
Priority to AT97830270T priority patent/ATE226069T1/de
Priority to DK97830270T priority patent/DK0811376T3/da
Priority to EP97830270A priority patent/EP0811376B1/en
Priority to US08/868,627 priority patent/US6013670A/en
Priority to CA002206995A priority patent/CA2206995C/en
Priority to ZA9704946A priority patent/ZA974946B/xx
Priority to MX9704150A priority patent/MX9704150A/es
Priority to KR1019970023288A priority patent/KR100450293B1/ko
Priority to JP14907397A priority patent/JP4171085B2/ja
Publication of ITRM960396A1 publication Critical patent/ITRM960396A1/it
Application granted granted Critical
Publication of IT1284661B1 publication Critical patent/IT1284661B1/it
Priority to US09/441,328 priority patent/US6143785A/en
Priority to US09/626,151 priority patent/US6348495B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
IT96RM000396A 1996-06-06 1996-06-06 Uso di alcanoil l-carnitine nel trattamento terapeutico di malattie infiammatorie croniche intestinali. IT1284661B1 (it)

Priority Applications (16)

Application Number Priority Date Filing Date Title
IT96RM000396A IT1284661B1 (it) 1996-06-06 1996-06-06 Uso di alcanoil l-carnitine nel trattamento terapeutico di malattie infiammatorie croniche intestinali.
TW086107648A TW585763B (en) 1996-06-06 1997-05-31 Use of alkanoyl L-carnitines for the therapeutical treatment of chronic inflammatory bowel diseases
DE69716341T DE69716341T2 (de) 1996-06-06 1997-06-03 Verwendung von Alkanoyl-L-Carnitinen zur Herstellung eines Arzneimittels zur Behandlung von entzündlichen Darmerkrankungen
ES97830270T ES2185897T3 (es) 1996-06-06 1997-06-03 Uso de 2-carnitinas de alcanoilo para la fabricacion de un medicamento para el tratamiento de enfermedades inflamatorias del intestino.
PT97830270T PT811376E (pt) 1996-06-06 1997-06-03 Utilizacao de alcanoil l-carnitinas para o fabrico de um medicamento para o tratamento de doencas inflamatorias dos intestinos
AT97830270T ATE226069T1 (de) 1996-06-06 1997-06-03 Verwendung von alkanoyl-l-carnitinen zur herstellung eines arzneimittels zur behandlung von entzündlichen darmerkrankungen
DK97830270T DK0811376T3 (da) 1996-06-06 1997-06-03 Anvendelse af alkanoyl-L-carnitiner til fremstilling af et lægemiddel til behandling af inflammatoriske tarmsygdomme
EP97830270A EP0811376B1 (en) 1996-06-06 1997-06-03 Use of alkanoyl L-carnitines for the manufacture of a medicament for the treatment of inflammatory bowel diseases
US08/868,627 US6013670A (en) 1996-06-06 1997-06-04 Use of alkanoyl L-carnitines for the therapeutical treatment of chronic inflammatory bowel diseases
CA002206995A CA2206995C (en) 1996-06-06 1997-06-04 Use of alkanoyl l-carnitines for the therapeutical treatment of chronic inflammatory bowel diseases
ZA9704946A ZA974946B (en) 1996-06-06 1997-06-05 Use of alkanoyl L-carnitines for the therapeutical treatment of chronic inflammatory bowel diseases.
MX9704150A MX9704150A (es) 1996-06-06 1997-06-05 Uso de l-carnitinas de alcanoilo para el tratamiento de enfermedades del intestino cronicas, inflamatorias.
KR1019970023288A KR100450293B1 (ko) 1996-06-06 1997-06-05 만성장염의치료에유용한알카노일l-카르니틴의용도
JP14907397A JP4171085B2 (ja) 1996-06-06 1997-06-06 慢性炎症腸疾患の治療のためのアルカノイル ｌ−カルニチンの使用
US09/441,328 US6143785A (en) 1996-06-06 1999-11-16 Use of alkanoyl L-carnitines for the therapeutical treatment of chronic inflammatory bowel disease
US09/626,151 US6348495B1 (en) 1996-06-06 2000-07-26 Method for treating celiac disease

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96RM000396A IT1284661B1 (it) 1996-06-06 1996-06-06 Uso di alcanoil l-carnitine nel trattamento terapeutico di malattie infiammatorie croniche intestinali.

Publications (3)

Publication Number Publication Date
ITRM960396A0 ITRM960396A0 (it) 1996-06-06
ITRM960396A1 ITRM960396A1 (it) 1997-12-06
IT1284661B1 true IT1284661B1 (it) 1998-05-21

Family

ID=11404269

Family Applications (1)

Application Number Title Priority Date Filing Date
IT96RM000396A IT1284661B1 (it) 1996-06-06 1996-06-06 Uso di alcanoil l-carnitine nel trattamento terapeutico di malattie infiammatorie croniche intestinali.

Country Status (14)

Country Link
US (2) US6013670A (it)
EP (1) EP0811376B1 (it)
JP (1) JP4171085B2 (it)
KR (1) KR100450293B1 (it)
AT (1) ATE226069T1 (it)
CA (1) CA2206995C (it)
DE (1) DE69716341T2 (it)
DK (1) DK0811376T3 (it)
ES (1) ES2185897T3 (it)
IT (1) IT1284661B1 (it)
MX (1) MX9704150A (it)
PT (1) PT811376E (it)
TW (1) TW585763B (it)
ZA (1) ZA974946B (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6348495B1 (en) * 1996-06-06 2002-02-19 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Method for treating celiac disease
EP0972516A1 (en) * 1998-06-25 2000-01-19 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Gastro-intestinal adverse effect-free composition comprising an L-carnitine replacement.
US20010025027A1 (en) * 2000-03-07 2001-09-27 Sonis Stephen T. Inhibition of ceramide for the prevention and treatment of oral mucositis induced by antineoplastic drugs or radiation
JP4104834B2 (ja) * 2001-04-13 2008-06-18 株式会社東芝 Ｍｉｓ型電界効果トランジスタの製造方法
ITRM20040168A1 (it) * 2004-04-01 2004-07-01 Sigma Tau Ind Farmaceuti Composizione a rilascio modificato ph dipendente.
US20050232911A1 (en) * 2004-04-19 2005-10-20 Schreiber Brian D Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid
CN100421648C (zh) * 2006-08-15 2008-10-01 苏州市立医院 氢化考的松灌肠剂及其制备方法
US20110015154A1 (en) * 2009-07-20 2011-01-20 Kellermann Gottfried H Supporting acetylcholine function
US20110098265A1 (en) * 2009-10-28 2011-04-28 Neuroscience, Inc. Methods for reducing cravings and impulses associated with addictive and compulsive behaviors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4537772A (en) * 1984-05-02 1985-08-27 Merck & Co., Inc. Enhancing absorption of drugs from gastrointestinal tract using acylcarnitines
IT1181682B (it) * 1985-06-11 1987-09-30 Sigma Tau Ind Farmaceuti Impiego di alcanoil l-carnitine per il trattamento terapeutico del parkinsonismo idiopatico o indotto
IT1258370B (it) * 1992-03-02 1996-02-26 Sigma Tau Ind Farmaceuti Esteri della l-carnitina e di acil l-carnitine dotati di attivita' miorilassante selettiva sull'apparato gastro-intestinale e composizioni farmaceutiche che li contengono.
IT1254314B (it) * 1992-03-27 1995-09-14 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche conyenenti l-carnitina e acil- carnitine inassociazione con ace-inibitori per il trattamento di patologie cardiovascolari.
IT1277898B1 (it) * 1995-08-03 1997-11-12 Mendes Srl Uso di amminoacidi basici, di acil derivati di amminoacidi basici e di loro sali farmaceuticamente accettabili per la profilassi di malattie
IT1283967B1 (it) * 1996-03-29 1998-05-07 Sigma Tau Ind Farmaceuti Uso di l-carnitina o derivati della l-carnitina ed antiossidanti nella prevenzione e trattamento di patologie derivanti da danni ossidativi

Also Published As

Publication number Publication date
DE69716341T2 (de) 2003-06-05
ES2185897T3 (es) 2003-05-01
DE69716341D1 (de) 2002-11-21
KR100450293B1 (ko) 2004-11-20
DK0811376T3 (da) 2003-03-10
CA2206995C (en) 2007-10-30
ATE226069T1 (de) 2002-11-15
JPH1059845A (ja) 1998-03-03
US6013670A (en) 2000-01-11
CA2206995A1 (en) 1997-12-06
MX9704150A (es) 1997-12-31
US6143785A (en) 2000-11-07
ZA974946B (en) 1997-12-18
TW585763B (en) 2004-05-01
EP0811376A1 (en) 1997-12-10
ITRM960396A1 (it) 1997-12-06
PT811376E (pt) 2003-03-31
JP4171085B2 (ja) 2008-10-22
ITRM960396A0 (it) 1996-06-06
EP0811376B1 (en) 2002-10-16
KR980000444A (ko) 1998-03-30

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Legal Events

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0001 Granted