IT1245699B - Derivati della l-carnitina quali agenti terapeutici per il trattamento delle miopatie, della degenarazione neuronale e per inibire la proteolisi - Google Patents
Derivati della l-carnitina quali agenti terapeutici per il trattamento delle miopatie, della degenarazione neuronale e per inibire la proteolisiInfo
- Publication number
- IT1245699B IT1245699B ITRM910363A ITRM910363A IT1245699B IT 1245699 B IT1245699 B IT 1245699B IT RM910363 A ITRM910363 A IT RM910363A IT RM910363 A ITRM910363 A IT RM910363A IT 1245699 B IT1245699 B IT 1245699B
- Authority
- IT
- Italy
- Prior art keywords
- myopathies
- neuronal
- degenaration
- treatment
- therapeutic agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Viene descritto l'uso di composti di formula generale (I) (FORMULA I) in cui:Y è idrogeno oppure metile e,R è un radicale alchilico non sostituito oppure sostituito scelto fra metile, etile e isopropile e dei loro sali farmacologicamente accettabili nel trattamento terapeutico di miopatie, della degenerazione neuronale, e di certe patologie epatiche, del muscolo scheletrico e del miocardio.I composti possono essere somministrati per via orale o parenterale.
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM910363A IT1245699B (it) | 1991-05-29 | 1991-05-29 | Derivati della l-carnitina quali agenti terapeutici per il trattamento delle miopatie, della degenarazione neuronale e per inibire la proteolisi |
CA002069520A CA2069520A1 (en) | 1991-05-29 | 1992-05-26 | L-carnitine derivatives as therapeutical agents for treating myopathies and neuronal degeneration and for inhibiting proteolysis |
EP92830259A EP0516594A1 (en) | 1991-05-29 | 1992-05-26 | L-carnitine derivatives as therapeutical agents for treating myopathies and neuronal degeneration and for inhibiting proteolysis |
ZA923829A ZA923829B (en) | 1991-05-29 | 1992-05-26 | L-carnitine derivatives as therapeutical agents for treating myopathies and neuronal degeneration and for inhibiting proteolysis |
JP4136886A JPH05148200A (ja) | 1991-05-29 | 1992-05-28 | 筋障害および神経退行変性の処置のためのアシル−l−カルニチン誘導体 |
US07/890,009 US5227518A (en) | 1991-05-29 | 1992-05-29 | L-carnitine derivatives as therapeutical agents for treating myopathies and neuronal degeneration and for inhibiting proteolysis |
IE169992A IE921699A1 (en) | 1991-05-29 | 1992-07-01 | L-carnitine derivatives as therapeutical agents for treating¹myopathies and neuronal degeneration and for inhibiting¹proteolysis |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM910363A IT1245699B (it) | 1991-05-29 | 1991-05-29 | Derivati della l-carnitina quali agenti terapeutici per il trattamento delle miopatie, della degenarazione neuronale e per inibire la proteolisi |
Publications (3)
Publication Number | Publication Date |
---|---|
ITRM910363A0 ITRM910363A0 (it) | 1991-05-29 |
ITRM910363A1 ITRM910363A1 (it) | 1992-11-29 |
IT1245699B true IT1245699B (it) | 1994-10-14 |
Family
ID=11400163
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITRM910363A IT1245699B (it) | 1991-05-29 | 1991-05-29 | Derivati della l-carnitina quali agenti terapeutici per il trattamento delle miopatie, della degenarazione neuronale e per inibire la proteolisi |
Country Status (7)
Country | Link |
---|---|
US (1) | US5227518A (it) |
EP (1) | EP0516594A1 (it) |
JP (1) | JPH05148200A (it) |
CA (1) | CA2069520A1 (it) |
IE (1) | IE921699A1 (it) |
IT (1) | IT1245699B (it) |
ZA (1) | ZA923829B (it) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1254314B (it) * | 1992-03-27 | 1995-09-14 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche conyenenti l-carnitina e acil- carnitine inassociazione con ace-inibitori per il trattamento di patologie cardiovascolari. |
IT1261230B (it) * | 1993-04-08 | 1996-05-09 | Sigma Tau Ind Farmaceuti | Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione. |
EP0681839A3 (en) * | 1994-05-12 | 1997-11-12 | Hirohiko Kuratsune | A pharmaceutical preparation comprising an acylcarnitine |
US5681739A (en) * | 1995-05-25 | 1997-10-28 | Lockheed Idaho Technologies Company | Method for in situ or ex situ bioremediation of hexavalent chromium contaminated soils and/or groundwater |
IT1276225B1 (it) * | 1995-10-17 | 1997-10-27 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per |
IT1276253B1 (it) | 1995-12-15 | 1997-10-27 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica contenente l-carnitina o alcanoil l-carnitine per la prevenzione ed il trattamento di stati morbosi |
IT1290801B1 (it) * | 1996-07-05 | 1998-12-11 | Mendes Srl | Uso della acetil l-carnitina, della isovaleril l-carnitina, della propionil l-carnitina o dei loro sali farmacologicamente accettabili |
IT1291113B1 (it) * | 1997-03-20 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Composizione nutritiva terapeutica per soggetti affetti da diabete mellito |
IT1291127B1 (it) * | 1997-04-01 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Integratore alimentare per soggetti dediti ad intensa e prolungata attivita' fisica |
US6090848A (en) * | 1997-12-01 | 2000-07-18 | Sigma-Tau Healthscience S.P.A. | Compositions and methods for increasing the concentration and/or motility of spermatozoa in humans |
US5863940A (en) | 1997-12-01 | 1999-01-26 | Sigma-Tau Healthscience S.P.A. | Medicament and therapeutical method for treating idiopathic asthenozoospermia |
SI0951909T2 (sl) | 1998-03-19 | 2010-11-30 | Sigma Tau Ind Farmaceuti | Kombinirana zmes ki vsebuje L karnitin ali alkanoil L karnitin glikozaminoglikan in ali njegov sestavni del |
ES2218155T3 (es) * | 1999-04-14 | 2004-11-16 | Shell Internationale Research Maatschappij B.V. | Metodo para la descontaminacion de acuiferos. |
IT1317042B1 (it) | 2000-06-14 | 2003-05-26 | Biosalts Srl | Fumarati doppi di una carnitina e creatina, e integratori alimentari,dietetici e farmaci che li contengono. |
IT1317062B1 (it) | 2000-07-14 | 2003-05-26 | Sigma Tau Healthscience Spa | Integratore alimentare utile per prevenire le disfunzioni epatiche ebiliari comprendente una alcanoil l-carnitina. |
US8173618B2 (en) | 2003-07-25 | 2012-05-08 | University Of Massachusetts | Formulations for reducing neuronal degeneration |
US20050232911A1 (en) * | 2004-04-19 | 2005-10-20 | Schreiber Brian D | Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid |
US8597640B2 (en) | 2007-10-31 | 2013-12-03 | University Of Massachusetts Lowell | Over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in alzheimer's disease and normal aging |
WO2020092243A1 (en) * | 2018-10-29 | 2020-05-07 | Lonza Inc. | Method and composition for increasing the bioavailability of carnitine |
CN109395084A (zh) * | 2018-11-14 | 2019-03-01 | 威海市千谷生物科技有限公司 | 一种溶脂线和溶脂液及利用其的埋线减肥方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4727151A (en) * | 1974-06-24 | 1988-02-23 | Interx Research Corporation | Labile quaternary ammonium salts as prodrugs |
IT1150396B (it) * | 1982-12-09 | 1986-12-10 | Sigma Tau Ind Farmaceuti | Impiego di alcanoil l-carnitine per il trattamento terapeutico di miopa tie e distrofie muscolari |
EP0150688B1 (en) * | 1983-12-28 | 1987-04-22 | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. | Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same |
DE3400514A1 (de) * | 1984-01-10 | 1985-07-18 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue carbonsaeure-derivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel |
IT1181682B (it) * | 1985-06-11 | 1987-09-30 | Sigma Tau Ind Farmaceuti | Impiego di alcanoil l-carnitine per il trattamento terapeutico del parkinsonismo idiopatico o indotto |
DE3623215A1 (de) * | 1986-07-10 | 1988-01-21 | Henkel Kgaa | Neue quartaere ammoniumverbindungen und deren verwendung |
IT1196564B (it) * | 1986-08-04 | 1988-11-16 | Sigma Tau Ind Farmaceuti | Impiego di acetil l-carnitina nel trattamento terapeutico delle neuropatie periferiche |
IT1224842B (it) * | 1988-12-27 | 1990-10-24 | Sigma Tau Ind Farmaceuti | Uso di derivati della l-carnitina nel trattamento terapeutico delle alterazioni degenerative del sistema nervoso |
-
1991
- 1991-05-29 IT ITRM910363A patent/IT1245699B/it active IP Right Grant
-
1992
- 1992-05-26 CA CA002069520A patent/CA2069520A1/en not_active Abandoned
- 1992-05-26 EP EP92830259A patent/EP0516594A1/en not_active Withdrawn
- 1992-05-26 ZA ZA923829A patent/ZA923829B/xx unknown
- 1992-05-28 JP JP4136886A patent/JPH05148200A/ja active Pending
- 1992-05-29 US US07/890,009 patent/US5227518A/en not_active Expired - Lifetime
- 1992-07-01 IE IE169992A patent/IE921699A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JPH05148200A (ja) | 1993-06-15 |
ITRM910363A0 (it) | 1991-05-29 |
US5227518A (en) | 1993-07-13 |
ITRM910363A1 (it) | 1992-11-29 |
EP0516594A1 (en) | 1992-12-02 |
CA2069520A1 (en) | 1992-11-30 |
IE921699A1 (en) | 1992-12-02 |
ZA923829B (en) | 1993-01-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970416 |