IT1261230B - Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione. - Google Patents

Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione.

Info

Publication number
IT1261230B
IT1261230B ITRM930226A ITRM930226A IT1261230B IT 1261230 B IT1261230 B IT 1261230B IT RM930226 A ITRM930226 A IT RM930226A IT RM930226 A ITRM930226 A IT RM930226A IT 1261230 B IT1261230 B IT 1261230B
Authority
IT
Italy
Prior art keywords
carnitina
precursors
starting
preparation
improved procedure
Prior art date
Application number
ITRM930226A
Other languages
English (en)
Inventor
Fabio Giannessi
Maria Ornella Tinti
Domenico Misiti
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of ITRM930226A0 publication Critical patent/ITRM930226A0/it
Priority to ITRM930226A priority Critical patent/IT1261230B/it
Priority to DK94830152.8T priority patent/DK0623588T3/da
Priority to EP94830152A priority patent/EP0623588B1/en
Priority to AT94830152T priority patent/ATE150003T1/de
Priority to ES94830152T priority patent/ES2099563T3/es
Priority to DE69401979T priority patent/DE69401979T2/de
Priority to US08/224,522 priority patent/US5491260A/en
Priority to CA002120811A priority patent/CA2120811C/en
Priority to JP06928994A priority patent/JP3502657B2/ja
Priority to KR1019940007343A priority patent/KR100301951B1/ko
Priority to ZA942428A priority patent/ZA942428B/xx
Priority to TW083103475A priority patent/TW275613B/zh
Publication of ITRM930226A1 publication Critical patent/ITRM930226A1/it
Application granted granted Critical
Publication of IT1261230B publication Critical patent/IT1261230B/it
Priority to GR970401237T priority patent/GR3023594T3/el
Priority to HK98104946A priority patent/HK1005867A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Processing Of Solid Wastes (AREA)
  • Switches Operated By Changes In Physical Conditions (AREA)
  • Lighting Device Outwards From Vehicle And Optical Signal (AREA)
  • Fertilizers (AREA)
ITRM930226A 1993-04-08 1993-04-08 Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione. IT1261230B (it)

Priority Applications (14)

Application Number Priority Date Filing Date Title
ITRM930226A IT1261230B (it) 1993-04-08 1993-04-08 Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione.
DK94830152.8T DK0623588T3 (da) 1993-04-08 1994-03-31 Forbedret fremgangsmåde til fremstilling af L-(-)-carnitin fra affaldsprodukter med modsat konfigur ation
EP94830152A EP0623588B1 (en) 1993-04-08 1994-03-31 Improved process for manufacturing L-(-)-carnitine from waste products having opposite configuration
AT94830152T ATE150003T1 (de) 1993-04-08 1994-03-31 Verfahren zur herstellung von l-(-)-carnitin aus abfallprodukten mit entgegengesetzter konfiguration
ES94830152T ES2099563T3 (es) 1993-04-08 1994-03-31 Procedimiento mejorado para preparar l-(-)-carnitina a partir de productos de desecho que tienen configuracion opuesta.
DE69401979T DE69401979T2 (de) 1993-04-08 1994-03-31 Verfahren zur Herstellung von L-(-)-Carnitin aus Abfallprodukten mit entgegengesetzter Konfiguration
US08/224,522 US5491260A (en) 1993-04-08 1994-04-07 Process for manufacturing L-(-)-carnitine from derivatives having a configuration opposite to that of L-(-)-carnitine
CA002120811A CA2120811C (en) 1993-04-08 1994-04-07 Improved process for manufacturing l-(-)-carnitine from waste products having opposite configuration
JP06928994A JP3502657B2 (ja) 1993-04-08 1994-04-07 反対立体配置の廃棄物からのｌ−（−）−カルニチンの改良製造法
KR1019940007343A KR100301951B1 (ko) 1993-04-08 1994-04-08 반대배치를갖는폐물질로부터l-(-)-카르니틴의제조방법
ZA942428A ZA942428B (en) 1993-04-08 1994-04-08 Improved process for manufacturing L-(-)-carnitine from waste products having opposite configuration
TW083103475A TW275613B (it) 1993-04-08 1994-04-19
GR970401237T GR3023594T3 (en) 1993-04-08 1997-05-30 Improved process for manufacturing L-(-)-carnitine from waste products having opposite configuration.
HK98104946A HK1005867A1 (en) 1993-04-08 1998-06-05 Improved process for manufacturing l-(-)carnitine from waste products having opposite configuration

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM930226A IT1261230B (it) 1993-04-08 1993-04-08 Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione.

Publications (3)

Publication Number Publication Date
ITRM930226A0 ITRM930226A0 (it) 1993-04-08
ITRM930226A1 ITRM930226A1 (it) 1994-10-08
IT1261230B true IT1261230B (it) 1996-05-09

Family

ID=11401703

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM930226A IT1261230B (it) 1993-04-08 1993-04-08 Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione.

Country Status (14)

Country Link
US (1) US5491260A (it)
EP (1) EP0623588B1 (it)
JP (1) JP3502657B2 (it)
KR (1) KR100301951B1 (it)
AT (1) ATE150003T1 (it)
CA (1) CA2120811C (it)
DE (1) DE69401979T2 (it)
DK (1) DK0623588T3 (it)
ES (1) ES2099563T3 (it)
GR (1) GR3023594T3 (it)
HK (1) HK1005867A1 (it)
IT (1) IT1261230B (it)
TW (1) TW275613B (it)
ZA (1) ZA942428B (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1261828B (it) 1993-07-14 1996-06-03 Sigma Tau Ind Farmaceuti Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
IT1276207B1 (it) * 1995-09-29 1997-10-27 Sigma Tau Ind Farmaceuti Procedimento per la preparazione del (s)-b-idrossi-gamma- butirrolattone
KR100255039B1 (ko) * 1997-07-28 2000-05-01 박영구 L-카르니틴의제조방법
IT1297120B1 (it) * 1997-12-16 1999-08-03 Sigma Tau Ind Farmaceuti Procedimento per la produzione di (r)-3-idrossi-4-butirrolattone utile nella preparazione della (r)-carnitina
DE10027391B4 (de) * 2000-06-02 2006-05-04 Wella Ag Oligomere und Polymere aus Crotonbetain oder Crotonbetainderivaten
EP2468739A1 (en) * 2010-12-22 2012-06-27 Lonza Ltd. A process for the production of carnitine from B-lactones
EP2595973B1 (en) * 2010-07-21 2017-07-12 Lonza Ltd. A process for the production of carnitine from beta-lactones
EP2409965A1 (en) * 2010-07-21 2012-01-25 Lonza Ltd. A process for the production of carnitine by cycloaddition
EP2409972A1 (en) * 2010-07-21 2012-01-25 Lonza Ltd. A process for the production of carnitine from B-lactones

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE664500A (it) *
ES332080A1 (es) * 1965-10-15 1967-10-01 Otsuka Pharma Co Ltd Procedimiento para obtencion de complejos de sales opticamente activas de hidroxido de nitrilo,carnitina y acidos glutamicos n-acilos.
IT1156852B (it) * 1978-07-10 1987-02-04 Sigma Tau Ind Farmaceuti Procedimento industriale per la preparazione del d'canforato della l carnitinammide e del d canforato della d carnitinammide e sue applicazioni
IT1136945B (it) * 1981-03-18 1986-09-03 Anic Spa Processo per la preparazione di l-carnitina
JPS59183694A (ja) * 1983-04-05 1984-10-18 Hamari Yakuhin Kogyo Kk 光学活性なカルニチンの生化学的製造法
JPS59192095A (ja) * 1983-04-13 1984-10-31 Ajinomoto Co Inc Ｌ−カルニチンの製造法
DD221905B1 (de) * 1983-11-03 1987-03-18 Univ Leipzig Verfahren zur herstellung von l(-)-carnitin und seinen derivaten
CH664374A5 (de) * 1985-02-27 1988-02-29 Lonza Ag Verfahren zur herstellung von l-carnitin auf mikrobiologischem weg.
US5200526A (en) * 1987-04-27 1993-04-06 The Governors Of The University Of Alberta Syntheses of optically pure α-amino acids from 3-amino-2-oxetanone salts
JPH0291049A (ja) * 1988-09-21 1990-03-30 Lonza Ag ｒ―ブチロベタインの製造方法
IT1231751B (it) * 1989-04-12 1991-12-21 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r(+) amminocarnitina e s(-) amminocarnitina
MX170707B (es) * 1989-07-28 1993-09-08 Lonza Ag Procedimiento para la produccion discontinua de l-carnitina por transformacion microbiologica de crotonobetaina y gama-butirobetaina
IT1240833B (it) * 1990-05-14 1993-12-17 Sigma Tau Ind Farmaceuti Procedimento biocatalitico per la produzione di l-(-)- carnitina da crotonilbetaina e ceppi di proteeae per l'uso in tale procedimento
IT1245699B (it) * 1991-05-29 1994-10-14 Sigma Tau Ind Farmaceuti Derivati della l-carnitina quali agenti terapeutici per il trattamento delle miopatie, della degenarazione neuronale e per inibire la proteolisi
IT1256705B (it) * 1992-12-21 1995-12-12 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.

Also Published As

Publication number Publication date
DK0623588T3 (da) 1997-07-21
ATE150003T1 (de) 1997-03-15
DE69401979T2 (de) 1997-06-26
JPH06311888A (ja) 1994-11-08
EP0623588A1 (en) 1994-11-09
HK1005867A1 (en) 1999-01-29
GR3023594T3 (en) 1997-08-29
JP3502657B2 (ja) 2004-03-02
CA2120811C (en) 2004-10-26
TW275613B (it) 1996-05-11
CA2120811A1 (en) 1994-10-09
EP0623588B1 (en) 1997-03-12
US5491260A (en) 1996-02-13
KR100301951B1 (ko) 2001-10-22
DE69401979D1 (de) 1997-04-17
ITRM930226A1 (it) 1994-10-08
ITRM930226A0 (it) 1993-04-08
ZA942428B (en) 1994-11-29
ES2099563T3 (es) 1997-05-16

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970304