IT1255802B - Derivati imidazolici ad attivita' a ii antagonista - Google Patents

Derivati imidazolici ad attivita' a ii antagonista

Info

Publication number
IT1255802B
IT1255802B ITMI921951A ITMI921951A IT1255802B IT 1255802 B IT1255802 B IT 1255802B IT MI921951 A ITMI921951 A IT MI921951A IT MI921951 A ITMI921951 A IT MI921951A IT 1255802 B IT1255802 B IT 1255802B
Authority
IT
Italy
Prior art keywords
antagonist
activity
derivatives
imidazolic
formula
Prior art date
Application number
ITMI921951A
Other languages
English (en)
Inventor
Aldo Salimbeni
Fabio Paleari
Jacques Mizrahi
Carlo Scolastico
Original Assignee
Luso Farmaco Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luso Farmaco Inst filed Critical Luso Farmaco Inst
Publication of ITMI921951A0 publication Critical patent/ITMI921951A0/it
Priority to ITMI921951A priority Critical patent/IT1255802B/it
Priority to US08/379,468 priority patent/US5587390A/en
Priority to CA002141853A priority patent/CA2141853A1/en
Priority to ES93917692T priority patent/ES2095662T3/es
Priority to PCT/EP1993/002024 priority patent/WO1994003449A1/en
Priority to AU47041/93A priority patent/AU4704193A/en
Priority to EP93917692A priority patent/EP0654030B1/en
Priority to DE69306792T priority patent/DE69306792T2/de
Publication of ITMI921951A1 publication Critical patent/ITMI921951A1/it
Application granted granted Critical
Publication of IT1255802B publication Critical patent/IT1255802B/it
Priority to GR970400533T priority patent/GR3022858T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Si descrivono derivati imidazolici ad attività A II antagonista di formula (I) (FORMULA I) dei procedimenti per la loro preparazione, composizioni farmaceutiche che li contengono e il loro uso come agenti terapeutici.I composti descritti sono dotati di proprietà A II antagonista e quindi utilizzabili in varie patologie cardiovascolari.
ITMI921951A 1992-08-07 1992-08-07 Derivati imidazolici ad attivita' a ii antagonista IT1255802B (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ITMI921951A IT1255802B (it) 1992-08-07 1992-08-07 Derivati imidazolici ad attivita' a ii antagonista
PCT/EP1993/002024 WO1994003449A1 (en) 1992-08-07 1993-07-29 Imidazole derivatives having a ii antagonist activity
CA002141853A CA2141853A1 (en) 1992-08-07 1993-07-29 Imidazole derivatives having a ii antagonist activity
ES93917692T ES2095662T3 (es) 1992-08-07 1993-07-29 Derivados de imidazol con actividad antagonista de la angiotensina ii.
US08/379,468 US5587390A (en) 1992-08-07 1993-07-29 Imidazole derivatives having a II antagonist activity
AU47041/93A AU4704193A (en) 1992-08-07 1993-07-29 Imidazole derivatives having a ii antagonist activity
EP93917692A EP0654030B1 (en) 1992-08-07 1993-07-29 Imidazole derivatives having angiotensin ii antagonist activity
DE69306792T DE69306792T2 (de) 1992-08-07 1993-07-29 Imidazol-derivate mit angiotensin ii antagonistischer wirkung
GR970400533T GR3022858T3 (en) 1992-08-07 1997-03-18 Imidazole derivatives having a ii antagonist activity.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI921951A IT1255802B (it) 1992-08-07 1992-08-07 Derivati imidazolici ad attivita' a ii antagonista

Publications (3)

Publication Number Publication Date
ITMI921951A0 ITMI921951A0 (it) 1992-08-07
ITMI921951A1 ITMI921951A1 (it) 1994-02-07
IT1255802B true IT1255802B (it) 1995-11-16

Family

ID=11363850

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI921951A IT1255802B (it) 1992-08-07 1992-08-07 Derivati imidazolici ad attivita' a ii antagonista

Country Status (9)

Country Link
US (1) US5587390A (it)
EP (1) EP0654030B1 (it)
AU (1) AU4704193A (it)
CA (1) CA2141853A1 (it)
DE (1) DE69306792T2 (it)
ES (1) ES2095662T3 (it)
GR (1) GR3022858T3 (it)
IT (1) IT1255802B (it)
WO (1) WO1994003449A1 (it)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9224144D0 (en) * 1992-11-18 1993-01-06 Erba Carlo Spa Phenyl-imidazolidinone derivatives and process for their preparation
IT1273790B (it) * 1994-02-18 1997-07-10 Guidotti & C Spa Labor Derivati eterociclici diazotati aventi attivita' aii antagonista
US5854265A (en) * 1996-04-03 1998-12-29 Merck & Co., Inc. Biheteroaryl inhibitors of farnesyl-protein transferase
US5883105A (en) * 1996-04-03 1999-03-16 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
JP2000507591A (ja) * 1996-04-03 2000-06-20 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質トランスフェラーゼ阻害剤
WO1997036896A1 (en) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
JP2000507590A (ja) * 1996-04-03 2000-06-20 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質トランスフェラーゼ阻害剤
WO1997036898A1 (en) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU714851B2 (en) * 1996-04-03 2000-01-13 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
KR20030092129A (ko) * 2001-05-09 2003-12-03 스미카 다케다 노야쿠 가부시키가이샤 아졸 화합물, 상기물의 제조 방법 및 이들의 용도
US7482366B2 (en) * 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
JP5498703B2 (ja) 2006-01-23 2014-05-21 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼのインヒビターとして有用なチオフェン−カルボキサミド
US7829590B2 (en) 2006-04-13 2010-11-09 Guy Brenchley Thiophene-carboxamides useful as inhibitors of protein kinases
CN101484447A (zh) 2006-05-23 2009-07-15 沃泰克斯药物股份有限公司 可用作蛋白激酶抑制剂的噻吩-甲酰胺类
CN101495474A (zh) 2006-05-23 2009-07-29 沃泰克斯药物股份有限公司 可用作蛋白激酶抑制剂的噻吩-甲酰胺类
ATE532770T1 (de) 2006-09-05 2011-11-15 Kyowa Hakko Kirin Co Ltd Imidazolderivat
CN101200455B (zh) * 2007-09-29 2010-08-18 泰兴市江神化工有限公司 沙坦类治疗高血压药物主环5-(4'-甲酰基联苯-2-基)-1h-四氮唑的制备方法
WO2011134019A1 (en) * 2010-04-30 2011-11-03 The University Of Melbourne Novel biphenyl sartans
CN102702117B (zh) * 2012-06-01 2016-04-13 浙江沙星医药化工有限公司 一种制备5-(4’-溴代甲基-2-联苯基)-1-三苯甲基四氮唑的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
KR0163595B1 (ko) * 1989-06-30 1998-12-01 미리암디, 메코너헤이 치환된 이미다졸
JP2568315B2 (ja) * 1989-06-30 1997-01-08 イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー 縮合環アリール置換イミダゾール
US5126342A (en) * 1990-10-01 1992-06-30 Merck & Co., Inc. Imidazole angiotensin ii antagonists incorporating acidic functional groups
AT395853B (de) * 1991-01-31 1993-03-25 Chem Pharm Forsch Gmbh Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung

Also Published As

Publication number Publication date
EP0654030B1 (en) 1996-12-18
CA2141853A1 (en) 1994-02-17
WO1994003449A1 (en) 1994-02-17
ES2095662T3 (es) 1997-02-16
ITMI921951A0 (it) 1992-08-07
US5587390A (en) 1996-12-24
EP0654030A1 (en) 1995-05-24
DE69306792T2 (de) 1997-05-07
GR3022858T3 (en) 1997-06-30
ITMI921951A1 (it) 1994-02-07
AU4704193A (en) 1994-03-03
DE69306792D1 (de) 1997-01-30

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19960826