IT1165509B - Composti guanidino tiazolici particolarmente utili come inibitori di secrezione di acidi gastrici e procedimento per la loro preparazione - Google Patents
Composti guanidino tiazolici particolarmente utili come inibitori di secrezione di acidi gastrici e procedimento per la loro preparazioneInfo
- Publication number
- IT1165509B IT1165509B IT67346/80A IT6734680A IT1165509B IT 1165509 B IT1165509 B IT 1165509B IT 67346/80 A IT67346/80 A IT 67346/80A IT 6734680 A IT6734680 A IT 6734680A IT 1165509 B IT1165509 B IT 1165509B
- Authority
- IT
- Italy
- Prior art keywords
- thiazolic
- guanidino
- inhibitors
- compounds
- procedure
- Prior art date
Links
- -1 COMPOUNDS GUANIDINO Chemical class 0.000 title 1
- 230000027119 gastric acid secretion Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2574579A JPS55118476A (en) | 1979-03-06 | 1979-03-06 | Novel amidine derivative and its preparation |
| JP7950879A JPS565469A (en) | 1979-06-23 | 1979-06-23 | Novel amidine derivative and its preparation |
| KR1019800000932A KR830002478B1 (ko) | 1979-03-06 | 1980-03-06 | 구아니디노 티아졸 화합물의 제조방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8067346A0 IT8067346A0 (it) | 1980-03-05 |
| IT1165509B true IT1165509B (it) | 1987-04-22 |
Family
ID=27285138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT67346/80A IT1165509B (it) | 1979-03-06 | 1980-03-05 | Composti guanidino tiazolici particolarmente utili come inibitori di secrezione di acidi gastrici e procedimento per la loro preparazione |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4362736A (it) |
| CA (1) | CA1145345A (it) |
| CH (1) | CH644114A5 (it) |
| DE (1) | DE3008056A1 (it) |
| ES (1) | ES489222A0 (it) |
| FR (1) | FR2450827A1 (it) |
| GB (1) | GB2052478B (it) |
| IT (1) | IT1165509B (it) |
| NL (1) | NL8001361A (it) |
| PH (1) | PH16099A (it) |
| SE (1) | SE447253B (it) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ196923A (en) * | 1980-04-29 | 1983-12-16 | Shionogi & Co | 2-guanidino-4-(-acylaminoalkyl(thio)methyl)thiazoles and analogs |
| CA1233818A (en) * | 1981-03-09 | 1988-03-08 | David J. Gilman | Guanidine derivatives as histamine h-2 receptor antagonists |
| CA1209998A (en) * | 1981-03-09 | 1986-08-19 | David J. Gilman | Amide derivatives as histamine h-2 receptor antagonists |
| IN158869B (it) * | 1981-03-18 | 1987-02-07 | Ici Plc | |
| US4451463A (en) * | 1981-03-24 | 1984-05-29 | Imperial Chemical Industries Plc | Alcohol derivatives |
| DE3267110D1 (de) * | 1981-05-18 | 1985-12-05 | Ici Plc | Amidine derivatives |
| JPS5872571A (ja) * | 1981-10-27 | 1983-04-30 | Shionogi & Co Ltd | ２−グアニジノ−４−〔２−（ホルムアミド）エチルチオメチル〕チアゾ−ルの製法 |
| US4808589A (en) * | 1982-02-20 | 1989-02-28 | Smith Kline & French Laboratories Limited | Pyrimidone derivatives |
| EP0103390A3 (en) * | 1982-08-13 | 1986-02-26 | Imperial Chemical Industries Plc | Guanidine-containing esters as histamine h2 receptor blockers |
| DE3238867A1 (de) * | 1982-10-20 | 1984-04-26 | Ludwig Heumann & Co GmbH, 8500 Nürnberg | Heterocyclische verbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| JPS59104370A (ja) * | 1982-12-03 | 1984-06-16 | Kotobuki Seiyaku Kk | チアゾ−ル誘導体及びその製造方法 |
| JPS59227870A (ja) * | 1983-06-07 | 1984-12-21 | Yamanouchi Pharmaceut Co Ltd | 新規２−グアニジノチアゾリン誘導体ならびにその製造法 |
| US4663347A (en) | 1983-10-31 | 1987-05-05 | Merck Frosst Canada, Inc. | Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis |
| GB8401751D0 (en) * | 1984-01-24 | 1984-02-29 | Ici Plc | Guanidine derivatives |
| JPS6160673A (ja) * | 1984-08-30 | 1986-03-28 | Yamanouchi Pharmaceut Co Ltd | グアニジノチアゾ−ル誘導体の製造法 |
| CA1309557C (en) | 1985-06-18 | 1992-10-27 | Robert N. Young | Leukotriene antagonists |
| ATE90076T1 (de) | 1986-03-27 | 1993-06-15 | Merck Frosst Canada Inc | Tetrahydrocarbazole ester. |
| EP0284536A1 (en) * | 1987-02-20 | 1988-09-28 | Centro Marga Para La Investigacion S.A. | A process for the preparation of 3-(2-guanidinothiazol-4-yl-methylthio)propionitrile |
| US5428033A (en) | 1990-10-12 | 1995-06-27 | Merck Frosst Canada, Inc. | Saturated hydroxyalkylquinoline acids as leukotriene antagonists |
| US5410054A (en) * | 1993-07-20 | 1995-04-25 | Merck Frosst Canada, Inc. | Heteroaryl quinolines as inhibitors of leukotriene biosynthesis |
| TW200517114A (en) | 2003-10-15 | 2005-06-01 | Combinatorx Inc | Methods and reagents for the treatment of immunoinflammatory disorders |
| EP1956906A4 (en) | 2005-11-09 | 2009-12-30 | Combinatorx Inc | METHODS, COMPOSITIONS AND KITS FOR THE TREATMENT OF PATHOLOGIES |
| JP6378179B2 (ja) | 2013-07-03 | 2018-08-22 | 株式会社新日本科学 | 新規化合物，有機カチオントランスポーター３の検出剤及び活性阻害剤 |
| WO2015155297A1 (en) | 2014-04-11 | 2015-10-15 | Sanovel Ilac Sanayi Ve Ticaret A.S. | Pharmaceutical combinations of dabigatran and h2-receptor antagonists |
| WO2015169957A1 (en) | 2014-05-09 | 2015-11-12 | Sanovel Ilac Sanayi Ve Ticaret A.S. | Pharmaceutical combinations of rivaroxaban and h2-receptor antagonists |
| WO2021183259A1 (en) * | 2020-03-12 | 2021-09-16 | Nanopharmaceutics, Inc. | Famotidine and famotidine analogs for corona virus treatment |
| EP4196793A1 (en) | 2020-08-11 | 2023-06-21 | Université de Strasbourg | H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ186965A (en) * | 1977-04-20 | 1980-02-21 | Ici Ltd | Guanidino derivatives and pharmaceutical compositions |
| DE2817078C2 (de) * | 1977-04-20 | 1995-06-14 | Zeneca Ltd | Guanidinderivate |
| US4165378A (en) * | 1977-04-20 | 1979-08-21 | Ici Americas Inc. | Guanidine derivatives of imidazoles and thiazoles |
| JPS6056143B2 (ja) * | 1979-08-02 | 1985-12-09 | 山之内製薬株式会社 | アミジン誘導体ならびにその製造法 |
-
1980
- 1980-02-26 PH PH23689A patent/PH16099A/en unknown
- 1980-03-03 DE DE19803008056 patent/DE3008056A1/de active Granted
- 1980-03-03 FR FR8004690A patent/FR2450827A1/fr active Granted
- 1980-03-04 CH CH171680A patent/CH644114A5/de not_active IP Right Cessation
- 1980-03-04 CA CA000346986A patent/CA1145345A/en not_active Expired
- 1980-03-05 IT IT67346/80A patent/IT1165509B/it active
- 1980-03-05 ES ES489222A patent/ES489222A0/es active Granted
- 1980-03-05 SE SE8001691A patent/SE447253B/sv not_active IP Right Cessation
- 1980-03-06 NL NL8001361A patent/NL8001361A/nl not_active Application Discontinuation
- 1980-03-06 US US06/127,902 patent/US4362736A/en not_active Expired - Lifetime
- 1980-03-06 GB GB8007702A patent/GB2052478B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE3008056A1 (de) | 1980-09-18 |
| PH16099A (en) | 1983-06-24 |
| DE3008056C2 (it) | 1988-07-21 |
| GB2052478A (en) | 1981-01-28 |
| ES8103070A1 (es) | 1981-02-16 |
| NL8001361A (nl) | 1980-09-09 |
| CA1145345A (en) | 1983-04-26 |
| CH644114A5 (de) | 1984-07-13 |
| FR2450827B1 (it) | 1983-03-25 |
| GB2052478B (en) | 1983-04-07 |
| FR2450827A1 (fr) | 1980-10-03 |
| IT8067346A0 (it) | 1980-03-05 |
| SE447253B (sv) | 1986-11-03 |
| ES489222A0 (es) | 1981-02-16 |
| SE8001691L (sv) | 1980-09-07 |
| US4362736A (en) | 1982-12-07 |
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