IT1154663B - Procedimento per la risoluzione in antipodi ottici di miscele di acidi d- e l-2-(6-metossi-2-naftil)-propionico - Google Patents

Procedimento per la risoluzione in antipodi ottici di miscele di acidi d- e l-2-(6-metossi-2-naftil)-propionico

Info

Publication number
IT1154663B
IT1154663B IT03492/80A IT349280A IT1154663B IT 1154663 B IT1154663 B IT 1154663B IT 03492/80 A IT03492/80 A IT 03492/80A IT 349280 A IT349280 A IT 349280A IT 1154663 B IT1154663 B IT 1154663B
Authority
IT
Italy
Prior art keywords
naftil
methoxy
resolution
mixtures
procedure
Prior art date
Application number
IT03492/80A
Other languages
English (en)
Other versions
IT8003492A0 (it
Inventor
Vincenzo Cannata
Graziano Zagnoni
Original Assignee
Alfa Chimica Italiana Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Chimica Italiana Spa filed Critical Alfa Chimica Italiana Spa
Publication of IT8003492A0 publication Critical patent/IT8003492A0/it
Priority to IT03492/80A priority Critical patent/IT1154663B/it
Priority to AT81105355T priority patent/ATE6499T1/de
Priority to DE8181105355T priority patent/DE3162513D1/de
Priority to EP81105355A priority patent/EP0044984B1/en
Priority to ZA814679A priority patent/ZA814679B/xx
Priority to US06/282,440 priority patent/US4399284A/en
Priority to IL63313A priority patent/IL63313A/xx
Priority to KR1019810002695A priority patent/KR860001228B1/ko
Priority to YU1869/81A priority patent/YU42576B/xx
Priority to GR65651A priority patent/GR74968B/el
Priority to AR286265A priority patent/AR229029A1/es
Priority to FI812377A priority patent/FI64348C/fi
Priority to IE1724/81A priority patent/IE51531B1/en
Priority to ES504398A priority patent/ES8207495A1/es
Priority to CA000382748A priority patent/CA1159833A/en
Priority to NO812593A priority patent/NO155005C/no
Priority to DK337781A priority patent/DK337781A/da
Priority to HU812228A priority patent/HU185941B/hu
Priority to JP56120002A priority patent/JPS5764642A/ja
Priority to PT73452A priority patent/PT73452B/pt
Priority to HU833328A priority patent/HU187975B/hu
Priority to CA000425643A priority patent/CA1171089A/en
Priority to FI831784A priority patent/FI76782C/fi
Priority to YU01290/83A priority patent/YU129083A/xx
Priority to NO85854414A priority patent/NO155806B/no
Priority to JP61284103A priority patent/JPS62174037A/ja
Application granted granted Critical
Publication of IT1154663B publication Critical patent/IT1154663B/it
Priority to DK255489A priority patent/DK255489D0/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IT03492/80A 1980-07-30 1980-07-30 Procedimento per la risoluzione in antipodi ottici di miscele di acidi d- e l-2-(6-metossi-2-naftil)-propionico IT1154663B (it)

Priority Applications (27)

Application Number Priority Date Filing Date Title
IT03492/80A IT1154663B (it) 1980-07-30 1980-07-30 Procedimento per la risoluzione in antipodi ottici di miscele di acidi d- e l-2-(6-metossi-2-naftil)-propionico
AT81105355T ATE6499T1 (de) 1980-07-30 1981-07-09 Verfahren zur optischen trennung von mischungen aus d- und l-2-(6-methoxy-2-naphthyl)propions[uren, das cinchonidinsalz der d-2-(6- methoxy-2-naphthyl)-propionsaeure und verfahren zu dessen herstellung.
DE8181105355T DE3162513D1 (en) 1980-07-30 1981-07-09 Process for the optical resolution of mixtures of d- and l-2-(6-methoxy-2-naphthyl)-propionic acids, the cinchonidine salt of d-2-(6-methoxy-2-naphthyl)-propionic acid and the preparation thereof
EP81105355A EP0044984B1 (en) 1980-07-30 1981-07-09 Process for the optical resolution of mixtures of d- and l-2-(6-methoxy-2-naphthyl)-propionic acids, the cinchonidine salt of d-2-(6-methoxy-2-naphthyl)-propionic acid and the preparation thereof
ZA814679A ZA814679B (en) 1980-07-30 1981-07-09 A new process for the optical resolution of mixtures of d-and 1-2-(6-mehtoxy-2-naphtyl)-propionic acids
US06/282,440 US4399284A (en) 1980-07-30 1981-07-13 Process for the optical resolution of mixtures of D- and L-2-(6-methoxy-2-naphthyl)-propionic acids
IL63313A IL63313A (en) 1980-07-30 1981-07-15 Process for the optical resolution of mixtures of d-and 1-2-(6-methoxy-2-naphthyl)-propionic acids with cinchonidine
KR1019810002695A KR860001228B1 (ko) 1980-07-30 1981-07-24 d-및 l-2-(6-메톡시-2-나프틸)-프로피온산 혼합물의 광학적 분할방법
YU1869/81A YU42576B (en) 1980-07-30 1981-07-28 Process for separating of racemic mixture of d-and l-2-(6-methoxy-2-naphtyl)-propionic acid
GR65651A GR74968B (it) 1980-07-30 1981-07-28
IE1724/81A IE51531B1 (en) 1980-07-30 1981-07-29 A new process for the optical resolution of mixtures of d-and 1-2-(6-methoxy-2-naphthyl)-propionic acids
FI812377A FI64348C (fi) 1980-07-30 1981-07-29 Foerfarande foer uppdelning av en blandning av d- och 1-2-(6-metoxi-2-naftyl)-propionsyror i optiskt aktiva isomerer
AR286265A AR229029A1 (es) 1980-07-30 1981-07-29 Procedimiento para la resolucion en los isomeros opticamente activos de mezclas de acidos d-y 1-2-(6-metoxi-2-naftil)-propionicos
ES504398A ES8207495A1 (es) 1980-07-30 1981-07-29 Un procedimiento para la resolucion en los isomeros optica- mente activos de mezclas de acidos d- y l-2-(6-metoxi-2-naf-til)-propionicos
CA000382748A CA1159833A (en) 1980-07-30 1981-07-29 Process for the optical resolution of mixtures of d- and 1-2-(6methoxy-2-naphthyl)-propionic acids
NO812593A NO155005C (no) 1980-07-30 1981-07-29 Fremgangsmaate for separasjon av optisk aktive isomerer av blandinger av d- og 1-2-(6-metoksy-2-naftyl)-propionsyre.
DK337781A DK337781A (da) 1980-07-30 1981-07-29 Fremgangsmaade til optisk spaltning af blandinger af d- og l-2-(6-methoxy-2-naphthyl 1)-propionsyrer
PT73452A PT73452B (en) 1980-07-30 1981-07-30 A new process for the optical resolution of mixtures of d-and l-2-(6-methoxy-2-naphtyl)-propionic acids
JP56120002A JPS5764642A (en) 1980-07-30 1981-07-30 Novel optical resolution of d-and l-2-(6-methoxy-2-naphthyl)-propionic acid mixture
HU812228A HU185941B (en) 1980-07-30 1981-07-30 Process for optical separating mixture of d- and l-bracket-6-methoxy-2-naphtyl-bracket closed-propionic acids
HU833328A HU187975B (en) 1980-07-30 1981-07-30 Process for producing cinconidine salt of d-2-/6-methoxy-2-naphtyl/propionic acid
CA000425643A CA1171089A (en) 1980-07-30 1983-04-11 Process for the optical resolution of mixtures of d- and 1-2(6-methoxy-2-naphthyl)- propionic acids
FI831784A FI76782C (fi) 1980-07-30 1983-05-20 Amid innehaollande d-2-(6-metoxi-2- naftyl)-propionsyrans kinconidinsalt och foerfarande foer dess framstaellning.
YU01290/83A YU129083A (en) 1980-07-30 1983-06-09 Process for preparing the cinchonidine salt of d-2-(6-methoxy-2-naphthyl)-propionic acid
NO85854414A NO155806B (no) 1980-07-30 1985-11-06 Fremgangsmaate for fremstilling av kinkonidinsaltet av d-2-(6-metoksy-2-naftyl)-propionsyre som inneholder amider.
JP61284103A JPS62174037A (ja) 1980-07-30 1986-11-28 新規シンコニジン溶媒和塩およびその製法
DK255489A DK255489D0 (da) 1980-07-30 1989-05-25 Fremgangsmaade til fremstilling af chinchonidinsaltet af d-2-(6-methoxy-2-naphthyl)-propionsyre som indeholder amider

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT03492/80A IT1154663B (it) 1980-07-30 1980-07-30 Procedimento per la risoluzione in antipodi ottici di miscele di acidi d- e l-2-(6-metossi-2-naftil)-propionico

Publications (2)

Publication Number Publication Date
IT8003492A0 IT8003492A0 (it) 1980-07-30
IT1154663B true IT1154663B (it) 1987-01-21

Family

ID=11108380

Family Applications (1)

Application Number Title Priority Date Filing Date
IT03492/80A IT1154663B (it) 1980-07-30 1980-07-30 Procedimento per la risoluzione in antipodi ottici di miscele di acidi d- e l-2-(6-metossi-2-naftil)-propionico

Country Status (19)

Country Link
US (1) US4399284A (it)
EP (1) EP0044984B1 (it)
JP (2) JPS5764642A (it)
KR (1) KR860001228B1 (it)
AR (1) AR229029A1 (it)
AT (1) ATE6499T1 (it)
CA (1) CA1159833A (it)
DE (1) DE3162513D1 (it)
DK (2) DK337781A (it)
ES (1) ES8207495A1 (it)
GR (1) GR74968B (it)
HU (2) HU185941B (it)
IE (1) IE51531B1 (it)
IL (1) IL63313A (it)
IT (1) IT1154663B (it)
NO (2) NO155005C (it)
PT (1) PT73452B (it)
YU (2) YU42576B (it)
ZA (1) ZA814679B (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4520203A (en) * 1983-08-16 1985-05-28 American Home Products Corporation Resolution of (±)-1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid using cinchonine
IT1208109B (it) * 1983-11-23 1989-06-06 Alfa Chem Ital Procedimento per la risoluzione ottica di acidi arilpropionici
IT1196197B (it) * 1984-07-23 1988-11-10 Ravizza Spa Procedimento per la risoluzione dell'acido (+)(-) 2-(2'-(p-fluorofenil)--5'-benzossazolil)-propionico
IT1196332B (it) * 1984-11-20 1988-11-16 Secifarma Spa Procedimento per la risoluzione dell'acido (+)-6-metossi-alfa-metil-2-naftalen acetico nei corrispondenti antipodi ottici
IT1196334B (it) * 1984-11-22 1988-11-16 Alfa Chem Ital Processo per la risoluzione ottica di miscugli racemi di acidi alfanaftil-propionici
IT1203605B (it) * 1985-04-18 1989-02-15 Alfa Chem Ital Processo per la risoluzione ottica di miscigli racemi di acidi e naftilpropionici
ATE259807T1 (de) * 1996-06-05 2004-03-15 Lindner Wolfgang Prof Dr Auf cinchonan basierte chirale selektoren zur trennung von stereoisomeren
WO2012059797A1 (en) * 2010-11-04 2012-05-10 Lupin Limited Process for synthesis of (s) - pregabalin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3904682A (en) * 1967-01-13 1975-09-09 Syntex Corp 2-(6{40 -Methoxy-2{40 -naphthyl)acetic acid
US3686183A (en) * 1969-03-24 1972-08-22 Syntex Corp Preparation of optical isomers of arylalkylacetic acids
US3658863A (en) * 1969-09-30 1972-04-25 Syntex Corp 6-methoxy-2-naphthyl copper(i)
US3658858A (en) * 1969-09-30 1972-04-25 Syntex Corp Di-(6-methoxy-2-naphthyl) cadmium
US3683015A (en) * 1970-11-04 1972-08-08 Norman H Dyson Resolution of 2-(6-methoxy-2-naphthyl)propionic
US3988365A (en) * 1973-04-11 1976-10-26 Syntex Corporation Resolution of 2-(6-methoxy-2-napthyl)propionic acid
CH641432A5 (de) * 1978-07-19 1984-02-29 Syntex Pharma Int Verfahren zur aufspaltung von racemischer 6-methoxy-alpha-methyl-2-naphthalinessigsaeure in die optischen antipoden.

Also Published As

Publication number Publication date
KR830006141A (ko) 1983-09-17
EP0044984B1 (en) 1984-03-07
JPS62174037A (ja) 1987-07-30
NO155005B (no) 1986-10-20
IE51531B1 (en) 1987-01-07
GR74968B (it) 1984-07-12
US4399284A (en) 1983-08-16
YU42576B (en) 1988-10-31
IL63313A0 (en) 1981-10-30
IT8003492A0 (it) 1980-07-30
NO155806B (no) 1987-02-23
AR229029A1 (es) 1983-05-31
DK255489A (da) 1989-05-25
IE811724L (en) 1982-01-30
ZA814679B (en) 1982-07-28
HU185941B (en) 1985-04-28
DK255489D0 (da) 1989-05-25
ATE6499T1 (de) 1984-03-15
PT73452A (en) 1981-08-01
JPS6351135B2 (it) 1988-10-13
IL63313A (en) 1985-01-31
CA1159833A (en) 1984-01-03
NO854414L (no) 1982-02-01
JPS5764642A (en) 1982-04-19
ES504398A0 (es) 1982-10-01
ES8207495A1 (es) 1982-10-01
DK337781A (da) 1982-01-31
NO155005C (no) 1987-01-28
YU186981A (en) 1984-04-30
EP0044984A1 (en) 1982-02-03
YU129083A (en) 1984-06-30
KR860001228B1 (ko) 1986-08-30
DE3162513D1 (en) 1984-04-12
PT73452B (en) 1982-07-30
HU187975B (en) 1986-03-28
NO812593L (no) 1982-02-01

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