BRPI0408501A
(pt)
|
2003-03-19 |
2006-03-14 |
Biogen Idec Inc |
proteìna de ligação ao receptor nogo
|
US7288638B2
(en)
*
|
2003-10-10 |
2007-10-30 |
Bristol-Myers Squibb Company |
Fully human antibodies against human 4-1BB
|
PL1776136T3
(pl)
|
2004-06-24 |
2013-03-29 |
Biogen Ma Inc |
Leczenie stanów związanych z demielinizacją
|
US20080019905A9
(en)
*
|
2005-02-18 |
2008-01-24 |
Strome Scott E |
Method of using an anti-CD137 antibody as an agent for radioimmunotherapy or radioimmunodetection
|
US20060182744A1
(en)
*
|
2005-02-15 |
2006-08-17 |
Strome Scott E |
Anti-CD137 antibody as an agent in the treatment of cancer and glycosylation variants thereof
|
RS53058B
(en)
|
2005-07-08 |
2014-04-30 |
Biogen Idec Ma Inc. |
SP35 ANTIBODIES AND THEIR APPLICATIONS
|
CA2626542C
(en)
*
|
2005-10-21 |
2018-07-03 |
Gtc Biotherapeutics, Inc. |
Antibodies with enhanced antibody-dependent cellular cytotoxicity activity, methods of their production and use
|
US20090196877A1
(en)
*
|
2005-12-02 |
2009-08-06 |
The Johns Hopkins University |
Novel Method to Increase Memory T Lymphocytes and Enhance Their Functions
|
WO2007110249A1
(de)
*
|
2006-03-24 |
2007-10-04 |
Deutsches Rheuma-Forschungszentrum Berlin |
Verwendung des 4-1bb rezeptors zur identifizierung und/oder separation aktivierter regulatorischer th-zellen (treg)
|
US8128926B2
(en)
|
2007-01-09 |
2012-03-06 |
Biogen Idec Ma Inc. |
Sp35 antibodies and uses thereof
|
US20110229460A1
(en)
*
|
2008-05-01 |
2011-09-22 |
Gtc Biotherapeutics, Inc. |
anti-cd137 antibody as an agent in the treatment of inflammatory conditions
|
EP2982695B1
(en)
|
2008-07-09 |
2019-04-03 |
Biogen MA Inc. |
Compositions comprising antibodies to lingo or fragments thereof
|
WO2010042433A1
(en)
*
|
2008-10-06 |
2010-04-15 |
Bristol-Myers Squibb Company |
Combination of cd137 antibody and ctla-4 antibody for the treatment of proliferative diseases
|
WO2011071871A1
(en)
|
2009-12-07 |
2011-06-16 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods for enhancing anti-tumor antibody therapy
|
AU2013201617B2
(en)
*
|
2010-09-09 |
2014-10-09 |
Pfizer Inc. |
4-1BB binding molecules
|
EP2614082B1
(en)
*
|
2010-09-09 |
2018-10-03 |
Pfizer Inc |
4-1bb binding molecules
|
EP2647707B1
(en)
|
2010-11-30 |
2018-09-12 |
Chugai Seiyaku Kabushiki Kaisha |
Cytotoxicity-inducing therapeutic agent
|
US9173887B2
(en)
|
2010-12-22 |
2015-11-03 |
Abbvie Inc. |
Hepatitis C inhibitors and uses thereof
|
CA2860170C
(en)
|
2010-12-22 |
2022-06-14 |
The Board Of Trustees Of The Leland Stanford Junior University |
Superagonists and antagonists of interleukin-2
|
WO2012145183A2
(en)
*
|
2011-04-19 |
2012-10-26 |
Pfizer Inc. |
Combinations of anti-4-1bb antibodies and adcc-inducing antibodies for the treatment of cancer
|
AU2013262934B2
(en)
|
2012-05-14 |
2018-02-01 |
Biogen Ma Inc. |
LINGO-2 antagonists for treatment of conditions involving motor neurons
|
CN107964042B
(zh)
|
2012-05-30 |
2022-04-19 |
中外制药株式会社 |
靶组织特异性抗原结合分子
|
EP3404116B1
(en)
|
2013-03-15 |
2022-10-19 |
The University of Chicago |
Methods and compositions related to t-cell activity
|
EP2982689B1
(en)
|
2013-04-02 |
2020-08-26 |
Chugai Seiyaku Kabushiki Kaisha |
Fc region variant
|
WO2014169078A2
(en)
|
2013-04-09 |
2014-10-16 |
Boston Biomedical, Inc. |
Methods for treating cancer
|
DK3444271T3
(da)
|
2013-08-08 |
2022-01-10 |
Cytune Pharma |
Il-15- og il-15r-alfa-sushi-domænebaserede modulokiner
|
CA2925421C
(en)
|
2013-09-24 |
2023-08-29 |
Medicenna Therapeutics, Inc. |
Interleukin-2 fusion proteins and uses thereof
|
EA201690746A1
(ru)
|
2013-10-25 |
2016-12-30 |
Фармасайкликс Элэлси |
Лечение с применением ингибиторов тирозинкиназы брутона и иммунотерапии
|
EP3066127A1
(en)
|
2013-11-06 |
2016-09-14 |
Bristol-Myers Squibb Company |
Immunotherapeutic dosing regimens and combinations thereof
|
KR102284503B1
(ko)
|
2013-12-04 |
2021-07-30 |
추가이 세이야쿠 가부시키가이샤 |
화합물의 농도에 따라 항원 결합능이 변화되는 항원 결합 분자 및 그의 라이브러리
|
EP3102604B1
(en)
|
2014-02-04 |
2020-01-15 |
Pfizer Inc |
Combination of a pd-1 antagonist and a 4-1bb agonist for treating cancer
|
KR101503341B1
(ko)
|
2014-03-12 |
2015-03-18 |
국립암센터 |
자가암항원 특이적 cd8+ t 세포의 분리 및 증식방법
|
TWI726842B
(zh)
|
2014-04-07 |
2021-05-11 |
日商中外製藥股份有限公司 |
免疫活化抗原結合分子
|
JP6592505B2
(ja)
|
2014-04-24 |
2019-10-16 |
ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー |
インターロイキン−2のスーパーアンタゴニスト、パーシャルアゴニスト及びアンタゴニスト
|
US11505605B2
(en)
|
2014-05-13 |
2022-11-22 |
Chugai Seiyaku Kabushiki Kaisha |
T cell-redirected antigen-binding molecule for cells having immunosuppression function
|
US11111284B2
(en)
|
2014-08-21 |
2021-09-07 |
The General Hospital Corporation |
Tumor necrosis factor superfamily and TNF-like ligand muteins and methods of preparing
|
CN115040532A
(zh)
|
2014-10-10 |
2022-09-13 |
伊黛拉制药有限公司 |
使用tlr9激动剂与检查点抑制剂对癌症的治疗
|
JP2018504400A
(ja)
|
2015-01-08 |
2018-02-15 |
バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. |
Lingo‐1拮抗薬及び脱髄障害の治療のための使用
|
AU2016219772A1
(en)
|
2015-02-22 |
2017-09-21 |
Sorrento Therapeutics, Inc. |
Antibody therapeutics that bind CD137
|
EP3283107B1
(en)
|
2015-04-17 |
2020-05-27 |
Bristol-Myers Squibb Company |
Compositions comprising a combination of ipilimumab and nivolumab
|
CN114573680A
(zh)
|
2015-05-04 |
2022-06-03 |
皮里斯制药有限公司 |
Cd137特异性的蛋白
|
SG11201708334RA
(en)
|
2015-05-04 |
2017-11-29 |
Pieris Pharmaceuticals Gmbh |
Anti-cancer fusion polypeptide
|
MX2017014716A
(es)
*
|
2015-05-18 |
2018-06-28 |
Pieris Pharmaceuticals Gmbh |
Polipeptido de fusion anti-cancer.
|
MX2017015618A
(es)
|
2015-06-03 |
2018-08-15 |
Boston Biomedical Inc |
Composiciones que comprenden un inhibidor de la autorrenovación y diferenciación de células madre cancerosas y un agente inmunoterapéutico para su uso en el tratamiento del cáncer.
|
EP3305322A4
(en)
*
|
2015-06-05 |
2018-12-26 |
Chugai Seiyaku Kabushiki Kaisha |
Combined use of immune activators
|
WO2017009843A2
(en)
|
2015-07-16 |
2017-01-19 |
Biokine Therapeutics Ltd. |
Compositions, articles of manufacture and methods for treating cancer
|
WO2017025871A1
(en)
|
2015-08-07 |
2017-02-16 |
Glaxosmithkline Intellectual Property Development Limited |
Combination therapy comprising anti ctla-4 antibodies
|
EP3344656A1
(en)
|
2015-09-01 |
2018-07-11 |
Agenus Inc. |
Anti-pd-1 antibodies and methods of use thereof
|
WO2017046746A1
(en)
|
2015-09-15 |
2017-03-23 |
Acerta Pharma B.V. |
Therapeutic combinations of a btk inhibitor and a gitr binding molecule, a 4-1bb agonist, or an ox40 agonist
|
CN113214398B
(zh)
*
|
2015-09-22 |
2022-04-08 |
苏州丁孚靶点生物技术有限公司 |
抗人cd137的完全人抗体及其应用
|
AR106188A1
(es)
|
2015-10-01 |
2017-12-20 |
Hoffmann La Roche |
Anticuerpos anti-cd19 humano humanizados y métodos de utilización
|
JP2019500893A
(ja)
|
2015-11-03 |
2019-01-17 |
ヤンセン バイオテツク,インコーポレーテツド |
Pd−1及びtim−3に特異的に結合する抗体及びそれらの使用
|
GB201519481D0
(en)
|
2015-11-04 |
2015-12-16 |
Cancer Rec Tech Ltd |
Immunomodulatory antibodies
|
WO2017086419A1
(ja)
|
2015-11-18 |
2017-05-26 |
中外製薬株式会社 |
液性免疫応答の増強方法
|
US11660340B2
(en)
|
2015-11-18 |
2023-05-30 |
Chugai Seiyaku Kabushiki Kaisha |
Combination therapy using T cell redirection antigen binding molecule against cell having immunosuppressing function
|
US10947317B2
(en)
|
2016-03-15 |
2021-03-16 |
Mersana Therapeutics, Inc. |
NaPi2b-targeted antibody-drug conjugates and methods of use thereof
|
US11104739B2
(en)
|
2016-04-14 |
2021-08-31 |
Bristol-Myers Squibb Company |
Combination therapy using an anti-fucosyl-GM1 antibody and an anti-CD137 antibody
|
US11623958B2
(en)
|
2016-05-20 |
2023-04-11 |
Harpoon Therapeutics, Inc. |
Single chain variable fragment CD3 binding proteins
|
JP7169195B2
(ja)
|
2016-05-20 |
2022-11-10 |
バイオヘイブン・ファーマシューティカル・ホールディング・カンパニー・リミテッド |
癌を処置するためのリルゾール、リルゾールプロドラッグまたはリルゾール類似体と免疫療法との併用
|
US10875921B2
(en)
|
2016-05-27 |
2020-12-29 |
Abbvie Biotherapeutics Inc. |
Anti-4-1BB antibodies and their uses
|
EP3464367B1
(en)
|
2016-05-27 |
2020-09-09 |
AbbVie Biotherapeutics Inc. |
Bispecific binding proteins binding an immunomodulatory protein and a tumor antigen
|
AU2017281830B2
(en)
|
2016-06-20 |
2023-04-06 |
Kymab Limited |
Anti-PD-L1 antibodies
|
CA3030841A1
(en)
|
2016-07-14 |
2018-01-18 |
Fred Hutchinson Cancer Research Center |
Multiple bi-specific binding domain constructs with different epitope binding to treat cancer
|
KR102632202B1
(ko)
|
2016-07-14 |
2024-02-02 |
젠맵 에이/에스 |
Cd40 및 cd137에 대한 다중특이적 항체
|
GB201612520D0
(en)
|
2016-07-19 |
2016-08-31 |
F-Star Beta Ltd |
Binding molecules
|
WO2018031258A1
(en)
|
2016-08-12 |
2018-02-15 |
Janssen Biotech, Inc. |
Engineered antibodies and other fc-domain containing molecules with enhanced agonism and effector functions
|
US20180044430A1
(en)
|
2016-08-12 |
2018-02-15 |
Janssen Biotech, Inc. |
FC Engineered Anti-TNFR Superfamily Member Antibodies Having Enhanced Atonistic Activity and Methods of Using Them
|
LT3347379T
(lt)
|
2016-08-17 |
2020-05-11 |
Compugen Ltd. |
Anti-tigit antikūnai, anti-pvrig antikūnai ir jų kombinacijos
|
MA46278A
(fr)
|
2016-09-23 |
2019-07-31 |
Merus Nv |
Molécules de liaison qui modulent une activité biologique exprimée par une cellule
|
TWI788307B
(zh)
|
2016-10-31 |
2023-01-01 |
美商艾歐凡斯生物治療公司 |
用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞
|
WO2018087108A1
(en)
|
2016-11-09 |
2018-05-17 |
Pieris Pharmaceuticals Gmbh |
Proteins specific for cd137
|
US11135307B2
(en)
|
2016-11-23 |
2021-10-05 |
Mersana Therapeutics, Inc. |
Peptide-containing linkers for antibody-drug conjugates
|
EP3544601B1
(en)
|
2016-11-23 |
2024-03-20 |
Translational Drug Development, LLC |
A composition comprising a benzamide and a tnfrsf agonist binding to 4-1bb or gitr, and the use thereof in the treatment of cancer.
|
WO2018098370A1
(en)
*
|
2016-11-23 |
2018-05-31 |
Immunoah Therapeutics, Inc. |
4-1bb binding proteins and uses thereof
|
WO2018102427A1
(en)
|
2016-11-29 |
2018-06-07 |
Boston Biomedical, Inc. |
Naphthofuran derivatives, preparation, and methods of use thereof
|
EP3554561B1
(en)
|
2016-12-14 |
2023-06-28 |
Janssen Biotech, Inc. |
Cd137 binding fibronectin type iii domains
|
EP3554535A4
(en)
|
2016-12-14 |
2020-10-21 |
Janssen Biotech, Inc. |
PD-L1 BINDING FIBRONECTIN TYPE III DOMAINS
|
EP3554562A4
(en)
|
2016-12-14 |
2020-11-04 |
Janssen Biotech, Inc. |
DOMAINS OF TYPE III FIBRONECTIN BINDING TO CD8A
|
US11512134B2
(en)
|
2017-08-01 |
2022-11-29 |
Eli Lilly And Company |
Anti-CD137 antibodies
|
US20230242876A1
(en)
|
2016-12-30 |
2023-08-03 |
Shanghai Sinobio Biotech Co., Ltd. |
Bifunctional molecule and use thereof
|
BR112019013189A2
(pt)
|
2017-01-03 |
2019-12-10 |
Hoffmann La Roche |
moléculas de ligação ao antígeno biespecífica, polinucleotídeo, célula hospedeira, método de produção da molécula de ligação ao antígeno biespecífica, composição farmacêutica, uso, métodos para inibir o crescimento de células tumorais em um indivíduo e para tratar o câncer ou uma doença infecciosa
|
KR102427192B1
(ko)
|
2017-01-06 |
2022-07-29 |
주식회사 유틸렉스 |
항-인간 4-1bb 항체 및 그의 용도
|
CN110462027A
(zh)
|
2017-01-06 |
2019-11-15 |
艾欧凡斯生物治疗公司 |
用肿瘤坏死因子受体超家族(tnfrsf)激动剂扩增肿瘤浸润淋巴细胞(til)及til和tnfrsf激动剂的治疗组合
|
MX2019008205A
(es)
|
2017-01-20 |
2020-01-23 |
Magenta Therapeutics Inc |
Composiciones y metodos para el agotamiento de células cd137+.
|
IL268836B2
(en)
|
2017-02-24 |
2024-04-01 |
Macrogenics Inc |
Bispecific molecules that bind CD137 and cancer antigens and their uses
|
TW201834697A
(zh)
|
2017-02-28 |
2018-10-01 |
美商梅爾莎納醫療公司 |
Her2標靶抗體-藥物結合物之組合療法
|
SG11201908396PA
(en)
|
2017-03-31 |
2019-10-30 |
Bristol Myers Squibb Co |
Methods of treating tumor
|
BR112019017241A2
(pt)
*
|
2017-04-13 |
2020-04-14 |
Agenus Inc |
anticorpos anti-cd137 e métodos de uso dos mesmos
|
SG10202107880XA
(en)
|
2017-05-12 |
2021-09-29 |
Harpoon Therapeutics Inc |
Mesothelin binding proteins
|
JP2020520923A
(ja)
|
2017-05-17 |
2020-07-16 |
ボストン バイオメディカル, インコーポレイテッド |
がんを処置するための方法
|
KR20200021474A
(ko)
|
2017-06-01 |
2020-02-28 |
컴퓨젠 엘티디. |
삼중 조합 항체 치료제
|
AR112072A1
(es)
|
2017-06-05 |
2019-09-18 |
Iovance Biotherapeutics Inc |
Métodos de uso de linfocitos infiltrantes de tumor en melanoma doble refractario
|
JP7433051B2
(ja)
|
2017-06-19 |
2024-02-19 |
メディシナ セラピューティクス インコーポレイテッド |
Il-2スーパーアゴニスト、アゴニスト、およびそれらの融合体の使用および方法
|
EP3652209A2
(en)
|
2017-07-11 |
2020-05-20 |
Compass Therapeutics LLC |
Agonist antibodies that bind human cd137 and uses thereof
|
MA49749A
(fr)
|
2017-08-01 |
2021-03-24 |
Lilly Co Eli |
Anticorps anti-cd137
|
SG11202000198QA
(en)
|
2017-08-04 |
2020-02-27 |
Genmab As |
Binding agents binding to pd-l1 and cd137 and use thereof
|
CN111511762A
(zh)
|
2017-08-21 |
2020-08-07 |
天演药业公司 |
抗cd137分子及其用途
|
EP3694871A4
(en)
|
2017-10-13 |
2021-11-10 |
Harpoon Therapeutics, Inc. |
B-CELL MATURATION ANTIG-BINDING PROTEINS
|
US20200239577A1
(en)
|
2017-10-15 |
2020-07-30 |
Bristol-Myers Squibb Company |
Methods of treating tumor
|
US11718679B2
(en)
|
2017-10-31 |
2023-08-08 |
Compass Therapeutics Llc |
CD137 antibodies and PD-1 antagonists and uses thereof
|
US20210324108A1
(en)
|
2017-11-01 |
2021-10-21 |
Hoffmann-La Roche Inc. |
Bispecific 2+1 contorsbodies
|
TWI701259B
(zh)
*
|
2017-11-09 |
2020-08-11 |
大陸商上海懷越生物科技有限公司 |
4﹘1bb抗體及其製備方法和應用
|
WO2019100023A1
(en)
|
2017-11-17 |
2019-05-23 |
Iovance Biotherapeutics, Inc. |
Til expansion from fine needle aspirates and small biopsies
|
US11851497B2
(en)
|
2017-11-20 |
2023-12-26 |
Compass Therapeutics Llc |
CD137 antibodies and tumor antigen-targeting antibodies and uses thereof
|
WO2019104289A1
(en)
|
2017-11-27 |
2019-05-31 |
Mersana Therapeutics, Inc. |
Pyrrolobenzodiazepine antibody conjugates
|
WO2019109238A1
(en)
*
|
2017-12-05 |
2019-06-13 |
Lyvgen Biopharma Co., Ltd. |
Anti-cd137 antibodies and uses thereof
|
TW201929908A
(zh)
|
2017-12-21 |
2019-08-01 |
美商梅爾莎納醫療公司 |
吡咯并苯并二氮呯抗體共軛物
|
WO2019136459A1
(en)
|
2018-01-08 |
2019-07-11 |
Iovance Biotherapeutics, Inc. |
Processes for generating til products enriched for tumor antigen-specific t-cells
|
US11713446B2
(en)
|
2018-01-08 |
2023-08-01 |
Iovance Biotherapeutics, Inc. |
Processes for generating TIL products enriched for tumor antigen-specific T-cells
|
AU2019205823A1
(en)
|
2018-01-08 |
2020-07-30 |
Iovance Biotherapeutics, Inc. |
Processes for generating TIL products enriched for tumor antigen-specific T-cells
|
WO2019141268A1
(zh)
|
2018-01-22 |
2019-07-25 |
江苏恒瑞医药股份有限公司 |
抗4-1bb抗体、其抗原结合片段及其医药用途
|
WO2019148445A1
(en)
|
2018-02-02 |
2019-08-08 |
Adagene Inc. |
Precision/context-dependent activatable antibodies, and methods of making and using the same
|
MA51875A
(fr)
|
2018-02-13 |
2020-12-23 |
Iovance Biotherapeutics Inc |
Expansion de lymphocytes infiltrant les tumeurs (til) avec des antagonistes du récepteur a2a de l'adénosine et combinaisons thérapeutiques de til et d'antagonistes du récepteur a2a de l'adénosine
|
US10875894B2
(en)
|
2018-02-23 |
2020-12-29 |
Bicycletx Limited |
Multimeric bicyclic peptide ligands
|
RU2020132924A
(ru)
|
2018-03-08 |
2022-04-11 |
Рубиус Терапьютикс, Инк. |
Терапевтические клеточные системы и способы лечения рака и инфекционных заболеваний
|
CA3094998C
(en)
|
2018-03-23 |
2023-05-09 |
Eli Lilly And Company |
Anti-cd137 antibodies for combination with anti-pd-1 antibodies
|
EP3768715A1
(en)
|
2018-03-23 |
2021-01-27 |
Bristol-Myers Squibb Company |
Antibodies against mica and/or micb and uses thereof
|
CN112020517A
(zh)
*
|
2018-03-23 |
2020-12-01 |
伊莱利利公司 |
用于与抗pd-l1抗体组合的抗cd137抗体
|
MX2020010264A
(es)
|
2018-03-29 |
2020-11-06 |
Iovance Biotherapeutics Inc |
Procesos para la produccion de linfocitos infiltrantes en tumor y usos de los mismos en inmunoterapia.
|
US20210032344A1
(en)
|
2018-03-30 |
2021-02-04 |
Bristol-Myers Squibb Company |
Methods of treating tumor
|
BR112020020349A2
(pt)
|
2018-04-04 |
2021-01-05 |
Bicycletx Limited |
Complexos de peptídeos bicíclicos em heterotandem
|
AR114284A1
(es)
|
2018-04-13 |
2020-08-12 |
Hoffmann La Roche |
Moléculas de unión a antígeno dirigidas a her2 que comprenden 4-1bbl
|
WO2019210131A1
(en)
|
2018-04-27 |
2019-10-31 |
Iovance Biotherapeutics, Inc. |
Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
|
WO2019217753A1
(en)
|
2018-05-10 |
2019-11-14 |
Iovance Biotherapeutics, Inc. |
Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy
|
WO2019225787A1
(ko)
|
2018-05-24 |
2019-11-28 |
에이비엘바이오 주식회사 |
항-b7-h3 항체 및 그 용도
|
US20210251994A1
(en)
|
2018-06-15 |
2021-08-19 |
Flagship Pioneering Innovations V, Inc. |
Increasing immune activity through modulation of postcellular signaling factors
|
EP3818082A1
(en)
*
|
2018-07-04 |
2021-05-12 |
F. Hoffmann-La Roche AG |
Novel bispecific agonistic 4-1bb antigen binding molecules
|
GB201811450D0
(en)
|
2018-07-12 |
2018-08-29 |
F Star Delta Ltd |
Mesothelin and CD137 binding molecules
|
EP3820569A1
(en)
|
2018-07-12 |
2021-05-19 |
F-Star Beta Limited |
Antibody molecules that bind pd-l1 and cd137
|
JP7397055B2
(ja)
|
2018-07-12 |
2023-12-12 |
エフ-スター セラピューティクス リミテッド |
Cd137及びox40に結合する抗体分子
|
GB201811404D0
(en)
|
2018-07-12 |
2018-08-29 |
F Star Beta Ltd |
Anti-CD137 Antibodies
|
GB201811408D0
(en)
|
2018-07-12 |
2018-08-29 |
F Star Beta Ltd |
CD137 Binding Molecules
|
JP7090204B2
(ja)
|
2018-07-19 |
2022-06-23 |
イーライ リリー アンド カンパニー |
免疫チェックポイントを標的とする二重特異性抗体
|
TWI837156B
(zh)
|
2018-07-31 |
2024-04-01 |
德商皮里斯製藥有限公司 |
新穎的cd137及pd-l1特異性融合蛋白
|
CN112839960A
(zh)
|
2018-08-10 |
2021-05-25 |
中外制药株式会社 |
抗cd137抗原结合分子及其应用
|
TW202031273A
(zh)
|
2018-08-31 |
2020-09-01 |
美商艾歐凡斯生物治療公司 |
抗pd-1抗體難治療性之非小細胞肺癌(nsclc)病患的治療
|
EP3856216A4
(en)
*
|
2018-09-10 |
2022-10-05 |
Genesail Biotech (Shanghai) Co. Ltd. |
MODIFIED ONCOLYTIC VIRUS, COMPOSITION AND USE THEREOF
|
IL281423B1
(en)
|
2018-09-20 |
2024-04-01 |
Iovance Biotherapeutics Inc |
Expansion of TILS from cryopreserved tumor samples
|
AU2019346466A1
(en)
|
2018-09-25 |
2021-05-20 |
Harpoon Therapeutics, Inc. |
DLL3 binding proteins and methods of use
|
US20210355216A1
(en)
|
2018-10-05 |
2021-11-18 |
INSERM (Institut National de la Santé et de la Recherche Médicale |
Methods and systems for controlling the agonistic properties of antibody variable domains by light
|
US11208485B2
(en)
|
2018-10-11 |
2021-12-28 |
Inhibrx, Inc. |
PD-1 single domain antibodies and therapeutic compositions thereof
|
WO2020077635A1
(zh)
*
|
2018-10-19 |
2020-04-23 |
苏州丁孚靶点生物技术有限公司 |
抗cd137抗体及其应用
|
EA202191175A1
(ru)
|
2018-10-29 |
2021-09-08 |
Мерсана Терапьютикс, Инк. |
Сконструированные с цистеином конъюгаты антитело-лекарственное средство, содержащие пептидсодержащие линкеры
|
US20230039976A1
(en)
|
2018-11-05 |
2023-02-09 |
Iovance Biotherapeutics, Inc. |
Selection of improved tumor reactive t-cells
|
SG11202104615VA
(en)
|
2018-11-05 |
2021-06-29 |
Iovance Biotherapeutics Inc |
Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
CA3118634A1
(en)
|
2018-11-05 |
2020-05-14 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients refractory for anti-pd-1 antibody
|
CA3118493A1
(en)
|
2018-11-05 |
2020-05-14 |
Iovance Biotherapeutics, Inc. |
Expansion of tils utilizing akt pathway inhibitors
|
KR20210124959A
(ko)
|
2018-11-06 |
2021-10-15 |
젠맵 에이/에스 |
항체 제제
|
EA202191457A1
(ru)
*
|
2018-11-30 |
2021-09-06 |
Эбиэл Био Инк. |
Анти-pd-l1/анти-4-1bb биспецифические антитела и их применения
|
EP3898949A1
(en)
|
2018-12-19 |
2021-10-27 |
Iovance Biotherapeutics, Inc. |
Methods of expanding tumor infiltrating lymphocytes using engineered cytokine receptor pairs and uses thereof
|
JP2022516301A
(ja)
*
|
2019-01-02 |
2022-02-25 |
キューエルエスエフ バイオセラピューティック インコーポレイテッド |
Cd137アゴニスト性抗体とその使用
|
MX2021010039A
(es)
|
2019-02-26 |
2021-09-21 |
Pieris Pharmaceuticals Gmbh |
Novedosas proteinas de fusion especificas para cd137 y gpc3.
|
AU2020256125A1
(en)
|
2019-03-29 |
2021-11-18 |
Turnstone Biologics Corp. |
Ex vivo methods for producing a T cell therapeutic and related compositions and methods
|
JP2022530026A
(ja)
|
2019-04-24 |
2022-06-27 |
ハイデルベルク ファルマ リサーチ ゲゼルシャフト ミット ベシュレンクテル ハフツング |
アマトキシン抗体薬物複合体及びその使用
|
EP3962493A2
(en)
|
2019-05-03 |
2022-03-09 |
Flagship Pioneering Innovations V, Inc. |
Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor
|
JP2022532173A
(ja)
|
2019-05-10 |
2022-07-13 |
リビジェン バイオファーマ カンパニー リミテッド |
ヒト化抗cd137抗体およびその使用
|
US20220249559A1
(en)
|
2019-05-13 |
2022-08-11 |
Iovance Biotherapeutics, Inc. |
Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
JP2022534982A
(ja)
|
2019-05-30 |
2022-08-04 |
ブリストル-マイヤーズ スクイブ カンパニー |
細胞局在化シグネチャーおよびその使用
|
WO2020243563A1
(en)
|
2019-05-30 |
2020-12-03 |
Bristol-Myers Squibb Company |
Multi-tumor gene signatures for suitability to immuno-oncology therapy
|
WO2020243570A1
(en)
|
2019-05-30 |
2020-12-03 |
Bristol-Myers Squibb Company |
Cell localization signature and combination therapy
|
KR20220016945A
(ko)
|
2019-06-04 |
2022-02-10 |
몰리큘라 파트너스 아게 |
다중특이적 단백질
|
US11466086B2
(en)
|
2019-10-11 |
2022-10-11 |
Nanjing Leads Biolabs Co., Ltd. |
Antibodies binding 4-1BB and uses thereof
|
WO2021076574A2
(en)
|
2019-10-14 |
2021-04-22 |
Aro Biotherapeutics Company |
Fn3 domain-sirna conjugates and uses thereof
|
JP2022551204A
(ja)
|
2019-10-14 |
2022-12-07 |
アロ・バイオセラピューティクス・カンパニー |
Cd71結合フィブロネクチンiii型ドメイン
|
JP2022553389A
(ja)
|
2019-10-25 |
2022-12-22 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
腫瘍浸潤リンパ球の遺伝子編集及び免疫療法におけるその使用
|
EP4055046A1
(en)
|
2019-11-06 |
2022-09-14 |
Genmab B.V. |
Antibody variant combinations and uses thereof
|
JP7432716B2
(ja)
|
2019-11-13 |
2024-02-16 |
合肥瀚科邁博生物技術有限公司 |
ヒト4-1bbに結合可能な分子及びその応用
|
AU2020391231A1
(en)
|
2019-11-27 |
2022-07-14 |
Turnstone Biologics Corp. |
Method of producing tumor-reactive T cell composition using modulatory agents
|
JP2023506734A
(ja)
|
2019-12-11 |
2023-02-20 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
腫瘍浸潤リンパ球(til)の産生のためのプロセス及びそれを使用する方法
|
EP4076434A1
(en)
|
2019-12-17 |
2022-10-26 |
Flagship Pioneering Innovations V, Inc. |
Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly
|
KR20220107251A
(ko)
|
2020-01-09 |
2022-08-02 |
에프. 호프만-라 로슈 아게 |
새로운 4-1bbl 삼량체-함유 항원 결합 분자
|
CN115135344A
(zh)
|
2020-02-04 |
2022-09-30 |
健玛保 |
在疗法中使用的抗体
|
WO2021155916A1
(en)
|
2020-02-04 |
2021-08-12 |
BioNTech SE |
Treatment involving antigen vaccination and binding agents binding to pd-l1 and cd137
|
US20230151109A1
(en)
|
2020-02-13 |
2023-05-18 |
UCB Biopharma SRL |
Bispecific antibodies against cd9
|
US20230151108A1
(en)
|
2020-02-13 |
2023-05-18 |
UCB Biopharma SRL |
Bispecific antibodies against cd9 and cd137
|
EP4107173A1
(en)
|
2020-02-17 |
2022-12-28 |
Board of Regents, The University of Texas System |
Methods for expansion of tumor infiltrating lymphocytes and use thereof
|
MX2022010517A
(es)
|
2020-02-27 |
2022-11-14 |
Myst Therapeutics Llc |
Metodos para la expansion y enriquecimiento ex vivo de celulas t reactivas a tumor y composiciones relacionadas de las mismas.
|
AU2021228078A1
(en)
|
2020-02-28 |
2022-09-22 |
Shanghai Henlius Biotech, Inc. |
Anti-CD137 constructs, multispecific antibody and uses thereof
|
KR20220148209A
(ko)
|
2020-02-28 |
2022-11-04 |
상하이 헨리우스 바이오테크, 인크. |
항cd137 작제물 및 그 용도
|
US20230293685A1
(en)
|
2020-05-04 |
2023-09-21 |
Iovance Biotherapeutics, Inc. |
Selection of improved tumor reactive t-cells
|
TW202208617A
(zh)
|
2020-05-04 |
2022-03-01 |
美商艾歐凡斯生物治療公司 |
用於產生腫瘤浸潤性淋巴球的過程及其在免疫療法中的用途
|
WO2021245240A1
(en)
|
2020-06-05 |
2021-12-09 |
Pieris Pharmaceuticals Gmbh |
Multimeric immunomodulator targeting 4-1bb
|
PE20230470A1
(es)
|
2020-06-19 |
2023-03-14 |
Hoffmann La Roche |
Moleculas de union al dominio fc de activacion inmunitaria
|
CN116096906A
(zh)
|
2020-06-29 |
2023-05-09 |
旗舰创业创新五公司 |
工程化以促进萨诺传递的病毒及其在治疗癌症中的用途
|
MX2023002326A
(es)
|
2020-08-31 |
2023-03-21 |
Bristol Myers Squibb Co |
Firma de localizacion celular e inmunoterapia.
|
CN114195894A
(zh)
|
2020-09-17 |
2022-03-18 |
普米斯生物技术(珠海)有限公司 |
一种靶向4-1bb的抗体及其应用
|
WO2022076606A1
(en)
|
2020-10-06 |
2022-04-14 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
JP2023546359A
(ja)
|
2020-10-06 |
2023-11-02 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
腫瘍浸潤リンパ球療法によるnsclc患者の治療
|
CN116368154A
(zh)
|
2020-10-08 |
2023-06-30 |
阿菲姆德股份有限公司 |
三特异性结合剂
|
US20230399403A1
(en)
|
2020-11-11 |
2023-12-14 |
BioNTech SE |
Monoclonal antibodies directed against programmed death-1 protein and their use in medicine
|
WO2022120179A1
(en)
|
2020-12-03 |
2022-06-09 |
Bristol-Myers Squibb Company |
Multi-tumor gene signatures and uses thereof
|
WO2022122765A2
(en)
|
2020-12-07 |
2022-06-16 |
Genmab A/S |
Antibody and taxane combination therapy
|
TW202241468A
(zh)
|
2020-12-11 |
2022-11-01 |
美商艾歐凡斯生物治療公司 |
用腫瘤浸潤性淋巴球療法與braf抑制劑及/或mek抑制劑組合治療癌症患者
|
CN117603360A
(zh)
|
2020-12-16 |
2024-02-27 |
美勒斯公司 |
用于治疗癌症的多特异性抗体
|
AU2021401302A1
(en)
|
2020-12-17 |
2023-07-06 |
Iovance Biotherapeutics, Inc. |
Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors
|
US20240123067A1
(en)
|
2020-12-17 |
2024-04-18 |
Iovance Biotherapeutics, Inc. |
Treatment of cancers with tumor infiltrating lymphocyte therapies
|
US20220233689A1
(en)
|
2020-12-28 |
2022-07-28 |
Bristol-Myers Squibb Company |
Methods of treating tumors
|
EP4267105A1
(en)
|
2020-12-28 |
2023-11-01 |
Bristol-Myers Squibb Company |
Antibody compositions and methods of use thereof
|
CA3207359A1
(en)
|
2021-02-05 |
2022-08-11 |
Cecile Chartier-Courtaud |
Adjuvant therapy for cancer
|
TW202300014A
(zh)
|
2021-03-05 |
2023-01-01 |
美商艾歐凡斯生物治療公司 |
腫瘤儲存及細胞培養組成物
|
MX2023010512A
(es)
|
2021-03-09 |
2023-12-08 |
Genmab As |
Agentes de union multiespecificos contra cd40 y cd137 en terapia.
|
AU2022246895A1
(en)
|
2021-03-31 |
2023-10-19 |
Flagship Pioneering Innovations V, Inc. |
Thanotransmission polypeptides and their use in treating cancer
|
JP2024514530A
(ja)
|
2021-04-02 |
2024-04-02 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
切断型cdcp1に対する抗体およびその使用
|
AU2022258566A1
(en)
|
2021-04-14 |
2023-10-12 |
Aro Biotherapeutics Company |
Cd71 binding fibronectin type iii domains
|
AU2022263418A1
(en)
|
2021-04-19 |
2023-10-26 |
Iovance Biotherapeutics, Inc. |
Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies
|
CN117222672A
(zh)
|
2021-04-22 |
2023-12-12 |
安斯泰来制药株式会社 |
抗cldn4-抗cd137双特异性抗体
|
CA3219148A1
(en)
|
2021-05-17 |
2022-11-24 |
Frederick G. Vogt |
Pd-1 gene-edited tumor infiltrating lymphocytes and uses of same in immunotherapy
|
CA3223375A1
(en)
|
2021-06-21 |
2022-12-29 |
Ugur Sahin |
Combination dosage regime of cd137 and pd-l1 binding agents
|
EP4363059A1
(en)
|
2021-06-29 |
2024-05-08 |
Flagship Pioneering Innovations V, Inc. |
Immune cells engineered to promote thanotransmission and uses thereof
|
EP4370552A1
(en)
|
2021-07-13 |
2024-05-22 |
BioNTech SE |
Multispecific binding agents against cd40 and cd137 in combination therapy for cancer
|
EP4377446A1
(en)
|
2021-07-28 |
2024-06-05 |
Iovance Biotherapeutics, Inc. |
Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with kras inhibitors
|
WO2023007023A1
(en)
|
2021-07-30 |
2023-02-02 |
Affimed Gmbh |
Duplexbodies
|
WO2023049862A1
(en)
|
2021-09-24 |
2023-03-30 |
Iovance Biotherapeutics, Inc. |
Expansion processes and agents for tumor infiltrating lymphocytes
|
IL311771A
(en)
|
2021-10-06 |
2024-05-01 |
BioNTech SE |
Multispecific binding agents against PD-L1 and CD137 in combination
|
KR20240082397A
(ko)
|
2021-10-08 |
2024-06-10 |
젠맵 에이/에스 |
Cd30 및 cd3에 결합하는 항체
|
WO2023064958A1
(en)
|
2021-10-15 |
2023-04-20 |
Compugen Ltd. |
Combination therapy with anti-pvrig antibodies formulations, anti-tigit antibodies, and anti-pd-1 antibodies
|
TW202331735A
(zh)
|
2021-10-27 |
2023-08-01 |
美商艾歐凡斯生物治療公司 |
協調用於患者特異性免疫療法之細胞之製造的系統及方法
|
AU2022388729A1
(en)
|
2021-11-10 |
2024-05-16 |
Iovance Biotherapeutics, Inc. |
Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes
|
CN118339179A
(zh)
|
2021-11-29 |
2024-07-12 |
江苏恒瑞医药股份有限公司 |
经修饰的蛋白或多肽
|
WO2023147486A1
(en)
|
2022-01-28 |
2023-08-03 |
Iovance Biotherapeutics, Inc. |
Tumor infiltrating lymphocytes engineered to express payloads
|
WO2023174521A1
(en)
|
2022-03-15 |
2023-09-21 |
Genmab A/S |
Binding agents binding to epcam and cd137
|
WO2023178329A1
(en)
|
2022-03-18 |
2023-09-21 |
Bristol-Myers Squibb Company |
Methods of isolating polypeptides
|
WO2023198851A1
(en)
|
2022-04-14 |
2023-10-19 |
Institut National de la Santé et de la Recherche Médicale |
Methods for controlling the tumor cell killing by light
|
WO2023201369A1
(en)
|
2022-04-15 |
2023-10-19 |
Iovance Biotherapeutics, Inc. |
Til expansion processes using specific cytokine combinations and/or akti treatment
|
WO2023213763A1
(en)
|
2022-05-02 |
2023-11-09 |
Transgene |
Poxvirus encoding a binding agent comprising an anti- pd-l1 sdab
|
WO2023213764A1
(en)
|
2022-05-02 |
2023-11-09 |
Transgene |
Fusion polypeptide comprising an anti-pd-l1 sdab and a member of the tnfsf
|
WO2023217987A1
(en)
|
2022-05-12 |
2023-11-16 |
BioNTech SE |
Monoclonal antibodies directed against programmed death-1 protein and their use in medicine
|
WO2023225098A1
(en)
|
2022-05-18 |
2023-11-23 |
Regeneron Pharmaceuticals, Inc. |
Multispecific antigen binding molecules that bind cd38 and 4-1bb, and uses thereof
|
WO2023235847A1
(en)
|
2022-06-02 |
2023-12-07 |
Bristol-Myers Squibb Company |
Antibody compositions and methods of use thereof
|
WO2024003353A1
(en)
|
2022-07-01 |
2024-01-04 |
Transgene |
Fusion protein comprising a surfactant-protein-d and a member of the tnfsf
|
WO2024030758A1
(en)
|
2022-08-01 |
2024-02-08 |
Iovance Biotherapeutics, Inc. |
Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies
|
WO2024040194A1
(en)
|
2022-08-17 |
2024-02-22 |
Capstan Therapeutics, Inc. |
Conditioning for in vivo immune cell engineering
|
WO2024056861A1
(en)
|
2022-09-15 |
2024-03-21 |
Avidicure Ip B.V. |
Multispecific antigen binding proteins for stimulating nk cells and use thereof
|
US20240174732A1
(en)
|
2022-10-05 |
2024-05-30 |
Flagship Pioneering Innovations V, Inc. |
Nucleic acid molecules encoding trif and additional polypeptides and their use in treating cancer
|
WO2024115725A1
(en)
|
2022-12-01 |
2024-06-06 |
BioNTech SE |
Multispecific antibody against cd40 and cd137 in combination therapy with anti-pd1 ab and chemotherapy
|
WO2024151687A1
(en)
|
2023-01-09 |
2024-07-18 |
Flagship Pioneering Innovations V, Inc. |
Genetic switches and their use in treating cancer
|
WO2024151885A1
(en)
|
2023-01-13 |
2024-07-18 |
Iovance Biotherapeutics, Inc. |
Use of til as maintenance therapy for nsclc patients who achieved pr/cr after prior therapy
|