IN2014DN09417A - - Google Patents
Info
- Publication number
- IN2014DN09417A IN2014DN09417A IN9417DEN2014A IN2014DN09417A IN 2014DN09417 A IN2014DN09417 A IN 2014DN09417A IN 9417DEN2014 A IN9417DEN2014 A IN 9417DEN2014A IN 2014DN09417 A IN2014DN09417 A IN 2014DN09417A
- Authority
- IN
- India
- Prior art keywords
- present
- specific antibodies
- antibodies
- specificity
- affinity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261645302P | 2012-05-10 | 2012-05-10 | |
| PCT/US2013/040575 WO2013170168A1 (en) | 2012-05-10 | 2013-05-10 | Multi-specific monoclonal antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN09417A true IN2014DN09417A (es) | 2015-07-17 |
Family
ID=49551307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN9417DEN2014 IN2014DN09417A (es) | 2012-05-10 | 2013-05-10 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9969813B2 (es) |
| EP (2) | EP3553089A1 (es) |
| JP (3) | JP6267689B2 (es) |
| KR (3) | KR101951641B1 (es) |
| CN (2) | CN108690132B (es) |
| AU (3) | AU2013259276B2 (es) |
| CA (3) | CA3051210A1 (es) |
| DK (1) | DK2847231T3 (es) |
| ES (1) | ES2749200T3 (es) |
| HK (1) | HK1210620A1 (es) |
| IN (1) | IN2014DN09417A (es) |
| MX (2) | MX2019001355A (es) |
| WO (1) | WO2013170168A1 (es) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2847231T3 (da) | 2012-05-10 | 2019-10-14 | Bioatla Llc | Multispecifikke monoklonale antistoffer |
| KR102207770B1 (ko) | 2013-08-05 | 2021-01-26 | 트위스트 바이오사이언스 코포레이션 | 드 노보 합성된 유전자 라이브러리 |
| US10329556B2 (en) | 2014-05-13 | 2019-06-25 | Bioatla, Llc | Conditionally active biological proteins |
| JP7286267B2 (ja) | 2014-08-28 | 2023-06-05 | バイオアトラ インコーポレイテッド | 修飾ｔ細胞に対する条件的活性型キメラ抗原受容体 |
| US11111288B2 (en) | 2014-08-28 | 2021-09-07 | Bioatla, Inc. | Conditionally active chimeric antigen receptors for modified t-cells |
| CA2975852A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| WO2016172377A1 (en) | 2015-04-21 | 2016-10-27 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| CN108368482A (zh) * | 2015-09-18 | 2018-08-03 | 特韦斯特生物科学公司 | 寡核酸变体文库及其合成 |
| WO2017053450A1 (en) | 2015-09-22 | 2017-03-30 | Twist Bioscience Corporation | Flexible substrates for nucleic acid synthesis |
| US10697972B2 (en) | 2016-01-12 | 2020-06-30 | Bioatla, Llc | Diagnostics using conditionally active antibodies |
| AU2017207263B2 (en) | 2016-01-12 | 2021-01-07 | Bioatla, Llc | Diagnostics using conditionally active antibodies |
| US11291721B2 (en) | 2016-03-21 | 2022-04-05 | Marengo Therapeutics, Inc. | Multispecific and multifunctional molecules and uses thereof |
| TW201805307A (zh) | 2016-05-13 | 2018-02-16 | 美商拜奧亞特拉公司 | 抗-ror2抗體、抗體片段、其免疫結合物及其用途 |
| WO2018057526A2 (en) | 2016-09-21 | 2018-03-29 | Twist Bioscience Corporation | Nucleic acid based data storage |
| US20200291089A1 (en) | 2017-02-16 | 2020-09-17 | Elstar Therapeutics, Inc. | Multifunctional molecules comprising a trimeric ligand and uses thereof |
| WO2018156792A1 (en) | 2017-02-22 | 2018-08-30 | Twist Bioscience Corporation | Nucleic acid based data storage |
| EP3630836A1 (en) | 2017-05-31 | 2020-04-08 | Elstar Therapeutics, Inc. | Multispecific molecules that bind to myeloproliferative leukemia (mpl) protein and uses thereof |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| GB2578844A (en) | 2017-06-12 | 2020-05-27 | Twist Bioscience Corp | Methods for seamless nucleic acid assembly |
| EP3661555A4 (en) * | 2017-08-01 | 2021-07-14 | Ab Studio Inc. | SPECIFIC ANTIBODIES AND USES THEREOF |
| GB2581620A (en) | 2017-09-11 | 2020-08-26 | Twist Bioscience Corp | GPCR binding proteins and synthesis thereof |
| US10894242B2 (en) | 2017-10-20 | 2021-01-19 | Twist Bioscience Corporation | Heated nanowells for polynucleotide synthesis |
| WO2019178362A1 (en) | 2018-03-14 | 2019-09-19 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| WO2019178364A2 (en) | 2018-03-14 | 2019-09-19 | Elstar Therapeutics, Inc. | Multifunctional molecules and uses thereof |
| CN112639130A (zh) | 2018-05-18 | 2021-04-09 | 特韦斯特生物科学公司 | 用于核酸杂交的多核苷酸、试剂和方法 |
| WO2019241315A1 (en) | 2018-06-12 | 2019-12-19 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
| MX2020013606A (es) * | 2018-06-14 | 2021-05-27 | Bioatla Inc | Constructos de anticuerpos multiespecificos. |
| CA3105448A1 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| KR20210041604A (ko) * | 2018-08-21 | 2021-04-15 | 바이오아트라, 인코퍼레이티드 | pH 선택성을 보이는 조건부 활성 단백질 |
| US20210386788A1 (en) | 2018-10-24 | 2021-12-16 | Obsidian Therapeutics, Inc. | Er tunable protein regulation |
| SG11202108955QA (en) | 2019-02-21 | 2021-09-29 | Marengo Therapeutics Inc | Antibody molecules that bind to nkp30 and uses thereof |
| WO2020172571A1 (en) | 2019-02-21 | 2020-08-27 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
| CA3131014A1 (en) | 2019-02-21 | 2020-08-27 | Andreas Loew | Anti-tcr antibody molecules and uses thereof |
| JP2022522662A (ja) | 2019-02-21 | 2022-04-20 | マレンゴ・セラピューティクス，インコーポレーテッド | Ｔ細胞に結合する多機能性分子および自己免疫障害を処置するためのその使用 |
| WO2020172601A1 (en) | 2019-02-21 | 2020-08-27 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| CN113785057A (zh) | 2019-02-26 | 2021-12-10 | 特韦斯特生物科学公司 | 用于抗体优化的变异核酸文库 |
| MX2021010840A (es) | 2019-03-08 | 2022-01-19 | Obsidian Therapeutics Inc | Composiciones de anhidrasa carbónica 2 (ca2) humana y métodos de regulación ajustable. |
| US20240124889A1 (en) | 2019-05-07 | 2024-04-18 | Voyager Therapeutics, Inc. | Compositions and methods for the vectored augmentation of protein destruction, expression and/or regulation |
| US11332738B2 (en) | 2019-06-21 | 2022-05-17 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
| WO2021046451A1 (en) | 2019-09-06 | 2021-03-11 | Obsidian Therapeutics, Inc. | Compositions and methods for dhfr tunable protein regulation |
| WO2021084104A1 (en) | 2019-10-30 | 2021-05-06 | Bioinvent International Ab | Tetravalent antibody molecules |
| WO2021138407A2 (en) | 2020-01-03 | 2021-07-08 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to cd33 and uses thereof |
| CN115843312A (zh) | 2020-04-24 | 2023-03-24 | 马伦戈治疗公司 | 结合至t细胞相关癌细胞的多功能性分子及其用途 |
| WO2022047046A1 (en) | 2020-08-26 | 2022-03-03 | Marengo Therapeutics, Inc. | Methods of detecting trbc1 or trbc2 |
| KR20230074144A (ko) | 2020-08-26 | 2023-05-26 | 마렝고 테라퓨틱스, 인크. | NKp30에 결합하는 항체 분자 및 이의 용도 |
| WO2022046920A2 (en) | 2020-08-26 | 2022-03-03 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| WO2022076474A2 (en) * | 2020-10-07 | 2022-04-14 | Amgen Inc. | Rational selection of building blocks for the assembly of multispecific antibodies |
| AU2022255506A1 (en) | 2021-04-08 | 2023-11-09 | Marengo Therapeutics, Inc. | Multifunctional molecules binding to tcr and uses thereof |
| WO2023023055A1 (en) | 2021-08-16 | 2023-02-23 | Renagade Therapeutics Management Inc. | Compositions and methods for optimizing tropism of delivery systems for rna |
| CA3231523A1 (en) | 2021-09-14 | 2023-03-23 | Renagade Therapeutics Management Inc. | Acyclic lipids and methods of use thereof |
| CA3232386A1 (en) | 2021-09-14 | 2023-03-23 | Renagade Therapeutics Management Inc. | Cyclic lipids and methods of use thereof |
| WO2023122752A1 (en) | 2021-12-23 | 2023-06-29 | Renagade Therapeutics Management Inc. | Constrained lipids and methods of use thereof |
| WO2023196931A1 (en) | 2022-04-07 | 2023-10-12 | Renagade Therapeutics Management Inc. | Cyclic lipids and lipid nanoparticles (lnp) for the delivery of nucleic acids or peptides for use in vaccinating against infectious agents |
Family Cites Families (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4196265A (en) | 1977-06-15 | 1980-04-01 | The Wistar Institute | Method of producing antibodies |
| US4704362A (en) | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4361549A (en) | 1979-04-26 | 1982-11-30 | Ortho Pharmaceutical Corporation | Complement-fixing monoclonal antibody to human T cells, and methods of preparing same |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| WO1993012227A1 (en) | 1991-12-17 | 1993-06-24 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| ES2199935T3 (es) | 1991-03-15 | 2004-03-01 | Amgen Inc. | Pegilacion de polipeptidos. |
| EP0672145B1 (en) | 1992-11-24 | 2003-04-23 | G.D. Searle & Co. | Interleukin-3 (il-3) multiple mutation polypeptides |
| DK0672142T3 (da) | 1992-12-04 | 2001-06-18 | Medical Res Council | Multivalente og multispecifikke bindingsproteiner samt fremstilling og anvendelse af disse |
| GB9225453D0 (en) | 1992-12-04 | 1993-01-27 | Medical Res Council | Binding proteins |
| ATE173740T1 (de) | 1993-09-22 | 1998-12-15 | Medical Res Council | Antikoerper mit geaenderter zielrichtung |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US6562594B1 (en) | 1999-09-29 | 2003-05-13 | Diversa Corporation | Saturation mutagenesis in directed evolution |
| US6171820B1 (en) | 1995-12-07 | 2001-01-09 | Diversa Corporation | Saturation mutagenesis in directed evolution |
| US7011812B1 (en) | 1996-05-03 | 2006-03-14 | Immunomedics, Inc. | Targeted combination immunotherapy of cancer and infectious diseases |
| WO1997041898A1 (en) | 1996-05-03 | 1997-11-13 | Immunomedics, Inc. | Targeted combination immunotherapy of cancer |
| US5922845A (en) | 1996-07-11 | 1999-07-13 | Medarex, Inc. | Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies |
| US20030207346A1 (en) | 1997-05-02 | 2003-11-06 | William R. Arathoon | Method for making multispecific antibodies having heteromultimeric and common components |
| US20020062010A1 (en) * | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| US7951917B1 (en) | 1997-05-02 | 2011-05-31 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| DE69830901T2 (de) | 1997-05-02 | 2006-05-24 | Genentech Inc., San Francisco | ein verfahren zur herstellung multispezifischer antikörper die heteromultimere und gemeinsame komponenten besitzen |
| WO1999048527A1 (en) | 1998-03-27 | 1999-09-30 | Genentech, Inc. | Apo-2 ligand-anti-her-2 antibody synergism |
| US7833528B2 (en) | 1998-06-22 | 2010-11-16 | Immunomedics, Inc. | Use of multispecific, non-covalent complexes for targeted delivery of therapeutics |
| ATE368477T1 (de) | 2000-06-20 | 2007-08-15 | Immunomedics Inc | Zielgerichtete kombinationsimmuntherapie für krebs und infektionskrankheiten |
| US6902734B2 (en) * | 2000-08-07 | 2005-06-07 | Centocor, Inc. | Anti-IL-12 antibodies and compositions thereof |
| KR20030055274A (ko) | 2000-10-20 | 2003-07-02 | 츄가이 세이야꾸 가부시키가이샤 | 저분자화 트롬보포에틴 아고니스트 항체 |
| WO2002064746A2 (en) | 2001-02-14 | 2002-08-22 | Uab Research Foundation | Combined transductional and transcriptional targeting system for improved gene delivery |
| PL362324A1 (en) | 2001-02-19 | 2004-10-18 | Merck Patent Gmbh | Artificial fusion proteins with reduced immunogenicity |
| US20050142539A1 (en) * | 2002-01-14 | 2005-06-30 | William Herman | Targeted ligands |
| ATE428778T1 (de) | 2002-04-26 | 2009-05-15 | Chugai Pharmaceutical Co Ltd | Verfahren zum screening auf agonistische antikörper |
| AU2013200009B2 (en) | 2002-07-18 | 2015-05-07 | Merus N.V. | Recombinant production of mixtures of antibodies |
| JP4836451B2 (ja) * | 2002-07-18 | 2011-12-14 | メルス ベー ヴェー | 抗体混合物の組換え生産 |
| US8337841B2 (en) | 2003-01-21 | 2012-12-25 | Chugai Seiyaku Kabushiki Kaisha | Methods of screening for antibody light chains |
| WO2004111233A1 (ja) | 2003-06-11 | 2004-12-23 | Chugai Seiyaku Kabushiki Kaisha | 抗体の製造方法 |
| US20090191213A9 (en) | 2003-07-02 | 2009-07-30 | Novo Nordisk A/S | Compositions and methods for regulating NK cell activity |
| EP1631315B1 (en) * | 2003-09-24 | 2014-07-30 | Millennium Pharmaceuticals, Inc. | Antibodies which bind human cxcr3 |
| GB0329825D0 (en) | 2003-12-23 | 2004-01-28 | Celltech R&D Ltd | Biological products |
| US20050266425A1 (en) | 2003-12-31 | 2005-12-01 | Vaccinex, Inc. | Methods for producing and identifying multispecific antibodies |
| WO2006063150A2 (en) | 2004-12-08 | 2006-06-15 | Immunomedics, Inc. | Methods and compositions for immunotherapy and detection of inflammatory and immune-dysregulatory disease, infectious disease, pathologic angiogenesis and cancer |
| WO2006074399A2 (en) | 2005-01-05 | 2006-07-13 | Biogen Idec Ma Inc. | Multispecific binding molecules comprising connecting peptides |
| RS50752B (sr) | 2005-01-05 | 2010-08-31 | F-Star Biotechnologische Forschungs-Und Entwicklungsges M.B.H. | Domeni sintetskih imunoglobulina sa svojstvima vezivanja, konstruisani u regionima molekula, koji se razlikuju od regiona, koji određuju komplementarnost |
| EP1870459B1 (en) | 2005-03-31 | 2016-06-29 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
| EP2230256A1 (en) | 2005-09-23 | 2010-09-22 | Walter Reed Army Institute of Research (WRAIR) | Antibodies with simultaneous subsite specificities to protein and lipid epitopes |
| WO2008060645A2 (en) | 2006-03-21 | 2008-05-22 | Genentech, Inc. | Combinatorial therapy involving alpha5beta1 antagonists |
| DK2059533T3 (da) | 2006-08-30 | 2013-02-25 | Genentech Inc | Multispecifikke antistoffer |
| GB0620729D0 (en) | 2006-10-18 | 2006-11-29 | Ucb Sa | Biological products |
| CN101849001B (zh) | 2007-06-25 | 2014-07-16 | 艾斯巴技术-诺华有限责任公司 | 修饰抗体的方法和具有改善的功能性质的修饰抗体 |
| CA2694488A1 (en) | 2007-07-31 | 2009-02-05 | Medimmune, Llc | Multispecific epitope binding proteins and uses thereof |
| CA2697922A1 (en) | 2007-08-28 | 2009-03-12 | Biogen Idec Ma Inc. | Compositions that bind multiple epitopes of igf-1r |
| KR20100065162A (ko) | 2007-09-26 | 2010-06-15 | 제넨테크, 인크. | 신규한 항체 |
| EP2113255A1 (en) | 2008-05-02 | 2009-11-04 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Cytotoxic immunoglobulin |
| CA2727992C (en) | 2008-06-25 | 2017-10-17 | Esbatech, An Alcon Biomedical Research Unit Llc | Stable and soluble antibodies inhibiting tnf.alpha. |
| JP2011526792A (ja) | 2008-07-02 | 2011-10-20 | エマージェント プロダクト デベロップメント シアトル， エルエルシー | ＴＮＦ−αアンタゴニスト多重標的結合性タンパク質 |
| NZ590667A (en) | 2008-07-02 | 2013-01-25 | Emergent Product Dev Seattle | Tgf-b antagonist multi-target binding proteins |
| CN102264390A (zh) | 2008-07-02 | 2011-11-30 | 新兴产品开发西雅图有限公司 | Il6免疫治疗 |
| US20110130324A1 (en) * | 2008-07-14 | 2011-06-02 | Uchicago Argonne, Llc | Methods for systematic control of protein stability |
| WO2010014629A1 (en) | 2008-07-28 | 2010-02-04 | Trubion Pharmaceuticals, Inc. | Multi-specific binding proteins targeting b cell disorders |
| CN102227447A (zh) | 2008-10-02 | 2011-10-26 | 新兴产品开发西雅图有限公司 | Cd86拮抗物多靶点结合蛋白 |
| TW201544123A (zh) | 2009-03-20 | 2015-12-01 | Genentech Inc | 抗-ｈｅｒ抗體 |
| PE20120591A1 (es) | 2009-04-02 | 2012-05-23 | Roche Glycart Ag | Anticuerpos multiespecificos que comprenden anticuerpos de longitud completa y fragmentos fab de cadena sencilla |
| DK2483310T3 (da) | 2009-09-29 | 2014-09-01 | Roche Glycart Ag | Bispecifik dødsreceptor-agonistiske antistoffer |
| JP2013509200A (ja) | 2009-10-30 | 2013-03-14 | バイエル・ヘルスケア・エルエルシー | 抗体模倣足場 |
| RU2580038C2 (ru) | 2009-12-04 | 2016-04-10 | Дженентек, Инк. | Мультиспецифические антитела, аналоги антител, композиции и способы |
| LT2519543T (lt) | 2009-12-29 | 2016-10-10 | Emergent Product Development Seattle, Llc | Heterodimerus rišantys baltymai ir jų panaudojimas |
| ES2547142T5 (es) * | 2010-02-08 | 2021-12-09 | Regeneron Pharma | Cadena ligera común de ratón |
| WO2011109726A2 (en) | 2010-03-05 | 2011-09-09 | Bioatla Llc | Homologous multi-specific antibodies |
| MX346731B (es) * | 2010-04-23 | 2017-03-30 | Genentech Inc * | Producción de proteínas heteromultiméricas. |
| ES2966088T3 (es) | 2010-07-16 | 2024-04-18 | Bioatla Inc | Nuevos métodos de evolución de proteínas |
| US9834615B2 (en) | 2010-08-16 | 2017-12-05 | Novimmune Sa | Methods for the generation of multispecific and multivalent antibodies |
| SI2644698T1 (en) | 2010-11-17 | 2018-05-31 | Chugai Seiyaku Kabushiki Kaisha | MULTISPECIFIC ANTIGEN-TUBULAR MOLECULAR, WITH AN ALTERNATIVE FUNCTION TO THE FACTOR OF BLOOD VIOLATION VIII |
| EA037071B1 (ru) | 2011-01-14 | 2021-02-02 | Юсб Байофарма Срл | Молекулы антител, которые связываются с il-17a и il-17f |
| EP2500073A1 (en) | 2011-03-17 | 2012-09-19 | ChromaCon AG | Method for identification and purification of multi-specific polypeptides |
| CN107903325B (zh) | 2011-05-16 | 2021-10-29 | 埃泰美德(香港)有限公司 | 多特异性fab融合蛋白及其使用方法 |
| WO2013003647A2 (en) | 2011-06-28 | 2013-01-03 | Sea Lane Biotechnologies, Llc | Multispecific stacked variable domain binding proteins |
| UA117901C2 (uk) | 2011-07-06 | 2018-10-25 | Ґенмаб Б.В. | Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування |
| EP2543680A1 (en) | 2011-07-07 | 2013-01-09 | Centre National de la Recherche Scientifique | Multispecific mutated antibody Fab fragments |
| JP6205363B2 (ja) | 2011-09-26 | 2017-09-27 | ジェイエヌ バイオサイエンシーズ エルエルシー | ハイブリッド定常領域 |
| MY171761A (en) | 2012-03-14 | 2019-10-28 | Regeneron Pharma | Multispecific antigen-binding molecules and uses thereof |
| WO2013142255A2 (en) | 2012-03-22 | 2013-09-26 | University Of Miami | Multi-specific binding agents |
| DK2847231T3 (da) | 2012-05-10 | 2019-10-14 | Bioatla Llc | Multispecifikke monoklonale antistoffer |
| KR20150013188A (ko) | 2012-05-24 | 2015-02-04 | 에프. 호프만-라 로슈 아게 | 다중특이적 항체 |
| US9540442B2 (en) | 2012-08-02 | 2017-01-10 | Jn Biosciences Llc | Antibodies or fusion proteins multimerized via cysteine mutation and a mu tailpiece |
| KR20140036905A (ko) | 2012-09-18 | 2014-03-26 | 삼성전자주식회사 | 이중특이 항체를 포함하는 단백질 복합체 |
| GB201223276D0 (en) | 2012-12-21 | 2013-02-06 | Ucb Pharma Sa | Antibodies and methods of producing same |
-
2013
- 2013-05-10 DK DK13788439.1T patent/DK2847231T3/da active
- 2013-05-10 US US14/399,617 patent/US9969813B2/en active Active
- 2013-05-10 JP JP2015511761A patent/JP6267689B2/ja active Active
- 2013-05-10 ES ES13788439T patent/ES2749200T3/es active Active
- 2013-05-10 WO PCT/US2013/040575 patent/WO2013170168A1/en active Application Filing
- 2013-05-10 EP EP19174963.9A patent/EP3553089A1/en active Pending
- 2013-05-10 IN IN9417DEN2014 patent/IN2014DN09417A/en unknown
- 2013-05-10 CN CN201810258801.6A patent/CN108690132B/zh active Active
- 2013-05-10 CN CN201380035170.7A patent/CN104583239B/zh active Active
- 2013-05-10 MX MX2019001355A patent/MX2019001355A/es unknown
- 2013-05-10 AU AU2013259276A patent/AU2013259276B2/en active Active
- 2013-05-10 KR KR1020147033427A patent/KR101951641B1/ko active IP Right Grant
- 2013-05-10 CA CA3051210A patent/CA3051210A1/en active Pending
- 2013-05-10 MX MX2014013590A patent/MX362705B/es active IP Right Grant
- 2013-05-10 KR KR1020197017228A patent/KR102089526B1/ko active IP Right Grant
- 2013-05-10 EP EP13788439.1A patent/EP2847231B1/en active Active
- 2013-05-10 CA CA2872908A patent/CA2872908C/en active Active
- 2013-05-10 CA CA3202536A patent/CA3202536A1/en active Pending
- 2013-05-10 KR KR1020197004783A patent/KR102023401B1/ko active IP Right Grant
-
2015
- 2015-08-26 HK HK15108289.6A patent/HK1210620A1/xx unknown
-
2017
- 2017-12-22 JP JP2017246602A patent/JP6465953B2/ja active Active
-
2018
- 2018-02-16 AU AU2018201159A patent/AU2018201159B2/en active Active
- 2018-03-23 US US15/934,596 patent/US20180237543A1/en not_active Abandoned
-
2019
- 2019-01-07 JP JP2019000631A patent/JP6723392B2/ja active Active
- 2019-01-31 US US16/264,028 patent/US10696750B2/en active Active
-
2020
- 2020-03-25 AU AU2020202133A patent/AU2020202133B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IN2014DN09417A (es) | ||
| PH12017500915A1 (en) | Cd47 antibodies, methods, and uses | |
| PH12014501427B1 (en) | Anti-phf-tau antibodies and their uses | |
| MX360368B (es) | Regiones de anticuerpo modificado y sus usos. | |
| PH12015502565A1 (en) | Anti-transferrin receptor antibodies and methods of use | |
| PH12014501758A1 (en) | Cd47 antibodies and methods of use thereof | |
| WO2013064701A3 (en) | Specific antibodies and their isolation with anti-idiotypic antibodies | |
| MX364329B (es) | Conjugados del anticuerpo pirrolobenzodiazepina. | |
| EA201491947A1 (ru) | Антитела и иммуноконъюгаты к ly6e и способы применения | |
| NZ703423A (en) | Antibodies to tau | |
| EA201492101A1 (ru) | Антитела против fcrn | |
| TN2013000292A1 (en) | Antibody molecules which bind il-17a and il-17f | |
| EA201590993A1 (ru) | Гетеродимерные иммуноглобулины | |
| MX2015004421A (es) | Conjugados del anticuerpo pirrolobenzodiazepina. | |
| SG10201703798YA (en) | Antibodies with modified affinity to fcrn that promote antigen clearance | |
| MX347454B (es) | Anticuerpos monoclonales inhibidores anti-factor xii-xiia. | |
| WO2013021279A3 (en) | Highly galactosylated antibodies | |
| PH12015501059A1 (en) | Anti-hemagglutinin antibodies and methods of use | |
| WO2011109726A3 (en) | Homologous multi-specific antibodies | |
| IN2015DN00634A (es) | ||
| MX350335B (es) | Anticuerpos que enlazan alfa-v beta-8 integrina. | |
| WO2013186630A3 (en) | Humanized antibodies to ca215 | |
| NZ743971A (en) | Antibodies to tau |