IN2014CN03130A - - Google Patents

Info

Publication number
IN2014CN03130A
IN2014CN03130A IN3130CHN2014A IN2014CN03130A IN 2014CN03130 A IN2014CN03130 A IN 2014CN03130A IN 3130CHN2014 A IN3130CHN2014 A IN 3130CHN2014A IN 2014CN03130 A IN2014CN03130 A IN 2014CN03130A
Authority
IN
India
Prior art keywords
represent
npt
preventive
formula
iib
Prior art date
Application number
Other languages
English (en)
Inventor
Masanori Miura
Daisuke Kaga
Susumu Watanuki
Shunichiro Hachiya
Takao Okuda
Ippei Sato
Mai Isomura
Kazuhiro Terai
Yoh Terada
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of IN2014CN03130A publication Critical patent/IN2014CN03130A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C07D333/80Seven-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D453/00Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655345Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
    • C07F9/655354Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
IN3130CHN2014 2011-10-27 2012-10-25 IN2014CN03130A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011236533 2011-10-27
PCT/JP2012/077660 WO2013062065A1 (fr) 2011-10-27 2012-10-25 Dérivé de n-thiényl benzamide substitué avec un aminoalkyle

Publications (1)

Publication Number Publication Date
IN2014CN03130A true IN2014CN03130A (fr) 2015-07-03

Family

ID=48167891

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3130CHN2014 IN2014CN03130A (fr) 2011-10-27 2012-10-25

Country Status (16)

Country Link
US (1) US9062032B2 (fr)
EP (1) EP2772490B1 (fr)
JP (2) JP2013107880A (fr)
KR (1) KR101941048B1 (fr)
CN (1) CN103906741B (fr)
AR (1) AR088563A1 (fr)
AU (1) AU2012329913A1 (fr)
CA (1) CA2853688C (fr)
EA (1) EA023955B1 (fr)
ES (1) ES2585415T3 (fr)
IL (1) IL232230A0 (fr)
IN (1) IN2014CN03130A (fr)
MX (1) MX342521B (fr)
PL (1) PL2772490T3 (fr)
TW (1) TW201323419A (fr)
WO (1) WO2013062065A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2903968T (lt) 2012-10-02 2017-02-27 Gilead Sciences, Inc. Histondemetilazių inhibitoriai
US9499553B2 (en) 2013-03-13 2016-11-22 Chugai Seiyaku Kabushiki Kaisha Dihydropyridazine-3,5-dione derivative and pharmaceuticals containing the same
SI2975030T1 (sl) 2013-03-13 2020-10-30 Chugai Seiyaku Kabushiki Kaisha Derivat dihidropiridazin-3,5-diona
TWI594975B (zh) * 2013-04-24 2017-08-11 第一三共股份有限公司 二羧酸化合物
CN105658655B (zh) 2013-08-08 2018-11-13 加拉佩格斯股份有限公司 作为CFTR调节剂的噻吩并[2,3-c]吡喃
WO2015064532A1 (fr) * 2013-10-30 2015-05-07 第一三共株式会社 Composé de morpholine
EP3126345A1 (fr) * 2014-03-31 2017-02-08 Gilead Sciences, Inc. Inhibiteurs d'histones déméthylases
CN105658635B (zh) * 2014-08-22 2019-03-08 江苏恒瑞医药股份有限公司 噻吩并环烷基或噻吩并杂环基类衍生物、其制备方法及其在医药上的应用
ES2881611T3 (es) 2014-09-12 2021-11-30 Chugai Pharmaceutical Co Ltd Producto farmacéutico que contiene inhibidor del transportador de fosfato dependiente de sodio
CN107074793B (zh) 2014-09-26 2019-08-23 第一三共株式会社 二羧酸化合物的盐
CN105524053B (zh) * 2014-10-19 2020-06-05 广东东阳光药业有限公司 四氢苯并噻吩化合物
TW201700458A (zh) 2015-04-24 2017-01-01 第一三共股份有限公司 二羧酸化合物之製法
CN107082773B (zh) * 2016-02-16 2020-07-28 江苏恒瑞医药股份有限公司 一种肠2b型磷酸钠协同转运蛋白抑制剂的硫酸盐及其结晶形式
WO2018034883A1 (fr) * 2016-08-15 2018-02-22 Eli Lilly And Company Dérivés de thiophène condensés utiles en tant qu'inhibiteurs de napi-iib
JOP20190080A1 (ar) 2016-10-14 2019-04-11 Bayer Pharma AG مركبات مشتقة من 6-(1h-بيرازول-1-يل) بيريميدين-4- أمين مستبدل واستخداماتها
CN109422723B (zh) * 2017-08-25 2021-02-23 江苏恒瑞医药股份有限公司 一种肠2b型磷酸钠协同转运蛋白抑制剂的晶型及其制备方法
AR126060A1 (es) 2021-06-08 2023-09-06 Chugai Pharmaceutical Co Ltd Método para producir derivado de dihidropiridazin-3,5-diona
TW202317118A (zh) 2021-06-08 2023-05-01 日商中外製藥股份有限公司 含有二氫嗒-3,5-二酮衍生物的製劑
WO2023203254A2 (fr) 2022-04-22 2023-10-26 Fundamental Pharma Gmbh Moyens efficaces pour moduler la toxicité médiée par le récepteur nmda

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002213048A1 (en) * 2000-10-05 2002-04-15 Smith Kline Beecham Corporation Phosphate transport inhibitors
JP2007131532A (ja) 2001-09-28 2007-05-31 Kirin Brewery Co Ltd 生体内リン輸送を阻害する化合物およびそれを含んでなる医薬
WO2003048134A1 (fr) * 2001-12-05 2003-06-12 Japan Tobacco Inc. Compose de triazole et son utilisation therapeutique
WO2004085382A1 (fr) * 2003-03-27 2004-10-07 Kirin Beer Kabushiki Kaisha Compose inhibiteur in vivo de transport de phosphore et medicament en contenant
WO2006093518A2 (fr) 2004-06-25 2006-09-08 Apath, Llc Composes thienyle pour traiter des etats pathologiques lies a un virus
CA2579089A1 (fr) 2004-08-30 2006-03-09 Government Of The United States Of America As Represented By The Secreta Ry Department Of Health And Human Services Methodes et compositions ayant trait a l'inhibition de virus utilisant des inhibiteurs de rnase h
WO2006044826A2 (fr) 2004-10-20 2006-04-27 Compass Pharmaceuticals Llc Compositions et leur utilisation en tant qu'agents antitumoraux
CN101910126B (zh) * 2008-01-08 2014-04-30 普渡制药公司 作为***素受体之配体的脯氨酸类似物
US20130029973A1 (en) 2010-04-28 2013-01-31 Astellas Pharma Inc. Tetrahydrobenzothiophene compound
EP2590655B1 (fr) 2010-07-07 2015-06-24 Ardelyx, Inc. Composés et procédés pour l'inhibition du transport de phosphate
WO2012006477A1 (fr) 2010-07-07 2012-01-12 Ardelyx, Inc. Composés et procédés pour l'inhibition du transport de phosphate
EP2591354B1 (fr) 2010-07-07 2016-09-07 Ardelyx, Inc. Composés et procédés pour l'inhibition du transport de phosphate
WO2012006474A2 (fr) * 2010-07-07 2012-01-12 Ardelyx, Inc. Composés et procédés pour l'inhibition du transport de phosphate
EP2590656B1 (fr) 2010-07-07 2017-11-15 Ardelyx, Inc. Composés et procédés permettant d'inhiber le transport du phosphate

Also Published As

Publication number Publication date
TW201323419A (zh) 2013-06-16
CA2853688C (fr) 2018-06-12
US20150031727A1 (en) 2015-01-29
US9062032B2 (en) 2015-06-23
AU2012329913A1 (en) 2014-05-22
WO2013062065A1 (fr) 2013-05-02
EA023955B1 (ru) 2016-07-29
EA201490875A1 (ru) 2014-09-30
JP6020460B2 (ja) 2016-11-02
EP2772490A4 (fr) 2015-01-21
EP2772490B1 (fr) 2016-04-06
KR20140096322A (ko) 2014-08-05
CA2853688A1 (fr) 2013-05-02
ES2585415T3 (es) 2016-10-05
IL232230A0 (en) 2014-06-30
EP2772490A1 (fr) 2014-09-03
AR088563A1 (es) 2014-06-18
MX342521B (es) 2016-10-03
KR101941048B1 (ko) 2019-01-22
PL2772490T3 (pl) 2016-11-30
CN103906741B (zh) 2016-01-20
JP2013107880A (ja) 2013-06-06
BR112014010169A2 (pt) 2017-04-25
JPWO2013062065A1 (ja) 2015-04-02
CN103906741A (zh) 2014-07-02
MX2014005090A (es) 2015-02-12

Similar Documents

Publication Publication Date Title
IN2014CN03130A (fr)
RS53301B (en) TIOACETATE COMPOUNDS, COMPOSITIONS AND USE PROCEDURES
IN2015MN00405A (fr)
TN2011000400A1 (en) Inhibitors of beta-secretase
BR112014017749A8 (pt) Composto alquinilbenzeno 3,5-dissubstituído e sal do mesmo
MX356342B (es) Agente de control de endoparásitos y método para usarlo.
MX348422B (es) Inhibidores de arginasa y sus aplicaciones terapeuticas.
MX336381B (es) Boronatos como inhibidores de arginasa.
IN2014CN00712A (fr)
MX2013001805A (es) Derivados de 2-(arilamino)-3h-imidazo [4,5-b] piridina-6-carboxamida y su uso como inhibidores de mpges-1.
AU2012214029A8 (en) Rorgammat inhibitors
TN2014000122A1 (en) 1 - arylcarbonyl - 4 - oxy - piperidine compounds useful for the treatment of neurodegenerative diseases
CL2009000650A1 (es) Compuestos derivados de amino-pirazina, inhibidores de cinasa-pi 3; composicion farmaceutica; y uso para el tratamiento de condiciones inflamatorias o alérgicas, tales como enfermedades respiratorias, artritis reumatoide, colitis ulcerativa, entre otras
TN2015000245A1 (en) Heterocyclic compound
GEP20146197B (en) New compounds
EA201291121A1 (ru) Соединения тетрагидробензотиофена
MX351812B (es) Derivados de piridona.
MA35402B1 (fr) Compositions pesticides et procédés associés
UA108926C2 (ru) LibreOffice? [2,3-D] +" +" !+
MY172924A (en) Neprilysin inhibitors
IN2014CN04204A (fr)
MY167898A (en) Co-crystals and salts of ccr3-inhibitors
IN2012DN02502A (fr)
IN2014CN04449A (fr)
IN2013CN01335A (fr)