IN2012DN03129A - - Google Patents

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Publication number
IN2012DN03129A
IN2012DN03129A IN3129DEN2012A IN2012DN03129A IN 2012DN03129 A IN2012DN03129 A IN 2012DN03129A IN 3129DEN2012 A IN3129DEN2012 A IN 3129DEN2012A IN 2012DN03129 A IN2012DN03129 A IN 2012DN03129A
Authority
IN
India
Prior art keywords
group
optionally substituted
cis
indistinctly
atom
Prior art date
Application number
Other languages
English (en)
Inventor
Mora Fernando Pedro Cossio
Olascoaga Aizpea Zubia
Salazar Yosu Ion Vara
Sebastian Larzabal Eider San
Ansa Dorleta Otaegui
Margalef Maria Del Carmen Masdeu
Arevalo Eneko Aldaba
Original Assignee
Ikerchem S L
Univ Pais Vasco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ikerchem S L, Univ Pais Vasco filed Critical Ikerchem S L
Publication of IN2012DN03129A publication Critical patent/IN2012DN03129A/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
IN3129DEN2012 2009-10-02 2010-10-01 IN2012DN03129A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09382193A EP2305643A1 (en) 2009-10-02 2009-10-02 New histone deacetylase inhibitors based simultaneously on trisubstituted 1h-pyrroles and aromatic and heteroaromatic spacers
PCT/EP2010/064653 WO2011039353A1 (en) 2009-10-02 2010-10-01 New histone deacetylase inhibitors based simultaneously on trisubstituted 1h-pyrroles and aromatic and heteroaromatic spacers

Publications (1)

Publication Number Publication Date
IN2012DN03129A true IN2012DN03129A (es) 2015-09-18

Family

ID=41716282

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3129DEN2012 IN2012DN03129A (es) 2009-10-02 2010-10-01

Country Status (17)

Country Link
US (1) US8685992B2 (es)
EP (2) EP2305643A1 (es)
JP (1) JP5746185B2 (es)
KR (1) KR101754940B1 (es)
CN (1) CN102648177B (es)
AU (1) AU2010302572B2 (es)
BR (1) BR112012007411B8 (es)
CA (1) CA2776351C (es)
ES (1) ES2452868T3 (es)
HK (1) HK1173450A1 (es)
IL (1) IL218995A (es)
IN (1) IN2012DN03129A (es)
MX (1) MX2012003988A (es)
PL (1) PL2483242T3 (es)
PT (1) PT2483242E (es)
RU (1) RU2549885C2 (es)
WO (1) WO2011039353A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012051117A2 (en) * 2010-10-11 2012-04-19 The Board Of Trustees Of The Leland Stanford Junior University Substituted benzamides and their uses
AU2014260605B2 (en) 2013-04-29 2016-07-14 Chong Kun Dang Pharmaceutical Corp. Novel compounds for selective histone deacetylase inhibitors, and pharmaceutical composition comprising the same
AR103598A1 (es) 2015-02-02 2017-05-24 Forma Therapeutics Inc Ácidos bicíclicos[4,6,0]hidroxámicos como inhibidores de hdac
MX2020003488A (es) 2015-02-02 2022-05-24 Forma Therapeutics Inc Acidos 3-alquil-4-amido-biciclico [4,5,0] hidroxamicos como inhibidores de histona desacetilasas (hdac).
WO2017029684A1 (en) * 2015-08-17 2017-02-23 University Of Mysore 2,3,5 trisubstituted pyrrole derivatives as topoisomerase inhibitors and therapeutic uses thereof
EP3472131B1 (en) 2016-06-17 2020-02-19 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors
CN107793375A (zh) * 2016-08-31 2018-03-13 中国科学院上海药物研究所 一类芳基2,2’‑串联双噻唑类化合物及其制备方法和用途
EP3318256A1 (en) * 2016-11-08 2018-05-09 Quimatryx, S.L Compounds for the treatment of autoimmune diseases
GB201708457D0 (en) * 2017-05-26 2017-07-12 Univ Oxford Innovation Ltd Inhibitors of metallo-beta-lactamases
CN110938055A (zh) * 2018-09-21 2020-03-31 华东师范大学 六元环甲酰胺类化合物及其合成方法和应用
JP2022529695A (ja) 2019-04-17 2022-06-23 キマトリクス、エセ.エレ. ヒストン脱アセチル化酵素阻害剤としての1,3,4-オキサジアゾール誘導体
CN112225737B (zh) * 2020-12-11 2021-04-09 北京鑫开元医药科技有限公司 具有hdac抑制活性的化合物、制备方法、组合物及用途
CN112516142B (zh) * 2020-12-11 2021-10-15 北京华氏精恒医药科技有限公司 一种具有hdac抑制活性的药物组合物、制备方法及其用途
CN116813560A (zh) * 2022-03-28 2023-09-29 上海科技大学 ***酰胺类化合物及其制备方法和用途
CN114558004B (zh) * 2022-03-29 2023-08-11 奎马特里克斯有限公司 Qtx125药物制剂
CN114634489B (zh) * 2022-04-19 2023-07-04 奎马特里克斯有限公司 结晶形式
CN114652715B (zh) 2022-04-29 2023-04-25 奎马特里克斯有限公司 联合疗法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA76977C2 (en) * 2001-03-02 2006-10-16 Icos Corp Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers
JP5042626B2 (ja) 2003-09-22 2012-10-03 エス*バイオ プライベート リミティッド ベンズイミダゾール誘導体:製造及び医薬適用
BRPI0417138A (pt) * 2003-12-05 2007-02-21 Warner Lambert Co n-alquil-pirroles como inibidores de hmg-coa-redutase
WO2006108864A2 (en) * 2005-04-15 2006-10-19 Dominion Pharmakine S.L. New nitrogenated trans-stilbene analogs, method for the obtention and medical applications thereof
US7754717B2 (en) * 2005-08-15 2010-07-13 Amgen Inc. Bis-aryl amide compounds and methods of use
MX2008008470A (es) * 2005-12-27 2008-09-26 Univ Pais Vasco Nuevos derivados pirrolicos con actividad inhibidora de desacetilasa de histonas.
EP2217588A4 (en) * 2007-11-02 2013-12-04 Methylgene Inc INHIBITORS OF HISTONE DEACETYLASE

Also Published As

Publication number Publication date
KR101754940B1 (ko) 2017-07-06
AU2010302572A1 (en) 2012-05-17
MX2012003988A (es) 2012-07-23
IL218995A0 (en) 2012-06-28
JP2013506637A (ja) 2013-02-28
BR112012007411B8 (pt) 2021-05-25
PT2483242E (pt) 2014-03-17
IL218995A (en) 2016-11-30
CA2776351C (en) 2017-10-31
ES2452868T3 (es) 2014-04-03
BR112012007411A2 (pt) 2016-12-06
US20120196885A1 (en) 2012-08-02
KR20120091176A (ko) 2012-08-17
WO2011039353A1 (en) 2011-04-07
US8685992B2 (en) 2014-04-01
AU2010302572B2 (en) 2016-10-20
BR112012007411B1 (pt) 2020-12-15
EP2483242A1 (en) 2012-08-08
AU2010302572A8 (en) 2012-05-24
EP2305643A1 (en) 2011-04-06
PL2483242T3 (pl) 2014-05-30
RU2012117885A (ru) 2013-11-10
CA2776351A1 (en) 2011-04-07
JP5746185B2 (ja) 2015-07-08
HK1173450A1 (en) 2013-05-16
RU2549885C2 (ru) 2015-05-10
CN102648177A (zh) 2012-08-22
EP2483242B1 (en) 2013-12-11
CN102648177B (zh) 2015-01-07

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