IL98881A - Esters of 2-amino-6-alkoxyl-9-(beta-d-arabinofuranosyl)-9h-purine derivatives their preparation and immunomodulating compositions containing them - Google Patents
Esters of 2-amino-6-alkoxyl-9-(beta-d-arabinofuranosyl)-9h-purine derivatives their preparation and immunomodulating compositions containing themInfo
- Publication number
- IL98881A IL98881A IL9888191A IL9888191A IL98881A IL 98881 A IL98881 A IL 98881A IL 9888191 A IL9888191 A IL 9888191A IL 9888191 A IL9888191 A IL 9888191A IL 98881 A IL98881 A IL 98881A
- Authority
- IL
- Israel
- Prior art keywords
- amino
- purine
- mmol
- methoxy
- arabinofuranosyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Earth Drilling (AREA)
- Stereophonic System (AREA)
- Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909015914A GB9015914D0 (en) | 1990-07-19 | 1990-07-19 | Heterocyclic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
IL98881A0 IL98881A0 (en) | 1992-07-15 |
IL98881A true IL98881A (en) | 1996-01-19 |
Family
ID=10679359
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL9888191A IL98881A (en) | 1990-07-19 | 1991-07-18 | Esters of 2-amino-6-alkoxyl-9-(beta-d-arabinofuranosyl)-9h-purine derivatives their preparation and immunomodulating compositions containing them |
Country Status (23)
Country | Link |
---|---|
US (3) | US5492897A (pt) |
EP (1) | EP0539479B1 (pt) |
JP (1) | JP2873086B2 (pt) |
KR (1) | KR100187326B1 (pt) |
AT (1) | ATE151637T1 (pt) |
CA (1) | CA2087543C (pt) |
CY (1) | CY2165B1 (pt) |
DE (1) | DE69125715T2 (pt) |
DK (1) | DK0539479T3 (pt) |
ES (1) | ES2103311T3 (pt) |
GB (1) | GB9015914D0 (pt) |
GR (1) | GR3023776T3 (pt) |
HU (2) | HU9300115D0 (pt) |
IE (1) | IE912513A1 (pt) |
IL (1) | IL98881A (pt) |
MC (1) | MC2289A1 (pt) |
MY (1) | MY111871A (pt) |
NZ (1) | NZ239025A (pt) |
PT (1) | PT98371B (pt) |
RU (1) | RU2114860C1 (pt) |
TW (1) | TW208655B (pt) |
WO (1) | WO1992001456A1 (pt) |
ZA (1) | ZA915656B (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9015914D0 (en) * | 1990-07-19 | 1990-09-05 | Wellcome Found | Heterocyclic compounds |
WO1998042352A1 (en) * | 1997-03-24 | 1998-10-01 | Glaxo Group Ltd. | Method for treating b-cell tumors with ara-g nucleoside derivatives |
US6489331B1 (en) * | 1998-07-02 | 2002-12-03 | Kyowa Hakko Kogyo Co., Ltd. | Remedies for diabetes |
US6753322B2 (en) * | 2000-06-06 | 2004-06-22 | Pfizer Inc | 2-aminocarbonyl-9H-purine derivatives |
US6924271B2 (en) * | 2001-11-27 | 2005-08-02 | Anadys Pharmaceuticals, Inc. | 3-β-D-ribofuranosylthiazolo[4-5-d]pyridimine nucleosides and uses thereof |
US7321033B2 (en) * | 2001-11-27 | 2008-01-22 | Anadys Pharmaceuticals, Inc. | 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof |
US20040127435A1 (en) * | 2002-08-02 | 2004-07-01 | Regents Of The University Of California | Uses for inhibitors of inosine monophosphate dehydrogenase |
GEP20084545B (en) | 2003-09-05 | 2008-11-25 | Anadys Pharmaceuticals Inc | Introducing tlr7 ligands and prodrugs thereof for the treatment of hepatitis c viral infection |
GB0321613D0 (en) * | 2003-09-15 | 2003-10-15 | Drug Discovery Lab As | Compounds |
EP1804838A2 (en) * | 2004-09-15 | 2007-07-11 | Drug Discovery Laboratory AS | Drug conjugates of long chain fatty acid or ester moieties as protein binding prodrugs |
EP1814390A4 (en) * | 2004-11-12 | 2009-07-01 | Univ Northwestern | METHOD FOR THE TREATMENT OF MOLECULAR BLOOD DISEASES WITH NUCLEOSIDE ANALOGUE |
KR101320008B1 (ko) * | 2004-12-17 | 2013-10-18 | 애나디스 파마슈티칼스, 인코포레이티드 | 3,5-이치환 및 3,5,7-삼치환된-3H-옥사졸로 및3H-티아졸로 〔4,5-d〕피리미딘-2-온 화합물 및 이의전구약물 |
US20060189543A1 (en) * | 2005-02-23 | 2006-08-24 | Rosenbloom Richard A | Compositions and methods for the treatment of leukemia |
TWI383987B (zh) | 2005-11-21 | 2013-02-01 | Anadys Pharmaceuticals Inc | 製備5-胺基-3H-噻唑并〔4,5-d〕嘧啶-2-酮之新穎方法 |
JP5345527B2 (ja) * | 2006-06-22 | 2013-11-20 | アナディス ファーマシューティカルズ インク | プロドラッグである5−アミノ−3−(3’−デオキシ−β−D−リボフラノシル)−チアゾロ[4,5−d]ピリミジン−2,7−ジオン |
WO2008011406A2 (en) | 2006-07-18 | 2008-01-24 | Anadys Pharmaceuticals, Inc. | Carbonate and carbamate prodrugs of thiazolo [4,5-d] pyrimidines |
CN101768197A (zh) * | 2008-12-29 | 2010-07-07 | 北京德众万全药物技术开发有限公司 | 一种奈拉滨的制备方法 |
US9351989B2 (en) | 2010-12-29 | 2016-05-31 | Inhibitex, Inc. | Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections |
WO2018230479A1 (ja) * | 2017-06-13 | 2018-12-20 | 大原薬品工業株式会社 | ヌクレオシド系抗がん剤又は抗ウィルス剤の5'位シリルエーテル誘導体 |
KR20230127294A (ko) * | 2020-12-30 | 2023-08-31 | 서던 유니버시티 오브 사이언스 앤드 테크놀로지 | 코로나 바이러스 감염을 치료하기 위한 방법 및 변형된뉴클레오사이드 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2152486A1 (de) * | 1970-11-20 | 1972-06-29 | Akad Wissenschaften Ddr | Verfahren zur Herstellung von 5'-Desoxy-5'-fluor-6-methyl-mercaptopurinribosid |
US3872084A (en) * | 1972-10-10 | 1975-03-18 | Syntex Inc | Purine nucleoside 3,5-cyclicphosphate compounds |
US4081534A (en) * | 1973-09-11 | 1978-03-28 | Burroughs Wellcome Co. | Amino purine nucleosides as autoimmune suppressant agents |
GB1573777A (en) * | 1977-11-03 | 1980-08-28 | Wellcome Found | 9-d-arabinonucleosides and an enzymatic process for their preparation |
JPS61233696A (ja) * | 1985-04-08 | 1986-10-17 | Kanegafuchi Chem Ind Co Ltd | 7−ヒドロキシグアニン誘導体及びその製造方法並びにそれを有効成分とする抗腫瘍剤 |
GB8712745D0 (en) * | 1987-05-30 | 1987-07-01 | Wellcome Found | Antiviral compounds |
CA1317291C (en) * | 1987-12-14 | 1993-05-04 | Naeem Botros Hanna | Antitumor 6-sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides and related compounds |
US5352669A (en) * | 1990-03-13 | 1994-10-04 | The Of The United States Of America As Represented By The Department Of Health And Human Services | O6 -benzylated guanine, guanosine and 2'-deoxyguanosine compounds possessing O6 -alkylguanine-DNA alkyltransferase depleting activity |
GB9015914D0 (en) * | 1990-07-19 | 1990-09-05 | Wellcome Found | Heterocyclic compounds |
-
1990
- 1990-07-19 GB GB909015914A patent/GB9015914D0/en active Pending
-
1991
- 1991-07-18 NZ NZ239025A patent/NZ239025A/en not_active IP Right Cessation
- 1991-07-18 MY MYPI91001298A patent/MY111871A/en unknown
- 1991-07-18 HU HU93115A patent/HU9300115D0/hu unknown
- 1991-07-18 JP JP3512249A patent/JP2873086B2/ja not_active Expired - Lifetime
- 1991-07-18 IE IE251391A patent/IE912513A1/en unknown
- 1991-07-18 IL IL9888191A patent/IL98881A/en not_active IP Right Cessation
- 1991-07-18 ZA ZA915656A patent/ZA915656B/xx unknown
- 1991-07-18 RU RU93004860A patent/RU2114860C1/ru active Protection Beyond IP Right Term
- 1991-07-18 HU HU93115D patent/HUT62911A/hu unknown
- 1991-07-18 AT AT91913553T patent/ATE151637T1/de not_active IP Right Cessation
- 1991-07-18 DE DE69125715T patent/DE69125715T2/de not_active Expired - Lifetime
- 1991-07-18 CA CA002087543A patent/CA2087543C/en not_active Expired - Lifetime
- 1991-07-18 EP EP91913553A patent/EP0539479B1/en not_active Expired - Lifetime
- 1991-07-18 DK DK91913553.3T patent/DK0539479T3/da active
- 1991-07-18 PT PT98371A patent/PT98371B/pt not_active IP Right Cessation
- 1991-07-18 KR KR1019930700144A patent/KR100187326B1/ko not_active IP Right Cessation
- 1991-07-18 WO PCT/GB1991/001196 patent/WO1992001456A1/en active IP Right Grant
- 1991-07-18 MC MC91@@D patent/MC2289A1/xx unknown
- 1991-07-18 ES ES91913553T patent/ES2103311T3/es not_active Expired - Lifetime
- 1991-07-27 TW TW080105920A patent/TW208655B/zh not_active IP Right Cessation
-
1994
- 1994-04-07 US US08/224,343 patent/US5492897A/en not_active Expired - Lifetime
-
1995
- 1995-05-24 US US08/449,078 patent/US5821236A/en not_active Expired - Lifetime
- 1995-05-31 US US08/456,186 patent/US5747472A/en not_active Expired - Lifetime
-
1997
- 1997-06-12 GR GR970401414T patent/GR3023776T3/el unknown
-
2000
- 2000-04-10 CY CY0000009A patent/CY2165B1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP0539479B1 (en) | 1997-04-16 |
IE912513A1 (en) | 1992-01-29 |
CA2087543C (en) | 1998-08-25 |
ATE151637T1 (de) | 1997-05-15 |
DE69125715D1 (de) | 1997-05-22 |
ES2103311T3 (es) | 1997-09-16 |
AU8196091A (en) | 1992-02-18 |
AU641533B2 (en) | 1993-09-23 |
DK0539479T3 (da) | 1997-08-25 |
CA2087543A1 (en) | 1992-01-20 |
MC2289A1 (fr) | 1993-07-14 |
ZA915656B (en) | 1993-03-31 |
HUT62911A (en) | 1993-06-28 |
JPH05508649A (ja) | 1993-12-02 |
PT98371A (pt) | 1992-06-30 |
GB9015914D0 (en) | 1990-09-05 |
CY2165B1 (en) | 2002-08-23 |
RU2114860C1 (ru) | 1998-07-10 |
DE69125715T2 (de) | 1997-08-07 |
EP0539479A1 (en) | 1993-05-05 |
US5492897A (en) | 1996-02-20 |
US5747472A (en) | 1998-05-05 |
NZ239025A (en) | 1993-08-26 |
WO1992001456A1 (en) | 1992-02-06 |
IL98881A0 (en) | 1992-07-15 |
JP2873086B2 (ja) | 1999-03-24 |
US5821236A (en) | 1998-10-13 |
GR3023776T3 (en) | 1997-09-30 |
PT98371B (pt) | 1999-01-29 |
HU9300115D0 (en) | 1993-04-28 |
MY111871A (en) | 2001-02-28 |
KR100187326B1 (ko) | 1999-05-01 |
TW208655B (pt) | 1993-07-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
EXP | Patent expired |