IL98881A - Esters of 2-amino-6-alkoxyl-9-(beta-d-arabinofuranosyl)-9h-purine derivatives their preparation and immunomodulating compositions containing them - Google Patents

Esters of 2-amino-6-alkoxyl-9-(beta-d-arabinofuranosyl)-9h-purine derivatives their preparation and immunomodulating compositions containing them

Info

Publication number
IL98881A
IL98881A IL9888191A IL9888191A IL98881A IL 98881 A IL98881 A IL 98881A IL 9888191 A IL9888191 A IL 9888191A IL 9888191 A IL9888191 A IL 9888191A IL 98881 A IL98881 A IL 98881A
Authority
IL
Israel
Prior art keywords
amino
purine
mmol
methoxy
arabinofuranosyl
Prior art date
Application number
IL9888191A
Other languages
English (en)
Other versions
IL98881A0 (en
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of IL98881A0 publication Critical patent/IL98881A0/xx
Publication of IL98881A publication Critical patent/IL98881A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Earth Drilling (AREA)
  • Stereophonic System (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Saccharide Compounds (AREA)
IL9888191A 1990-07-19 1991-07-18 Esters of 2-amino-6-alkoxyl-9-(beta-d-arabinofuranosyl)-9h-purine derivatives their preparation and immunomodulating compositions containing them IL98881A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909015914A GB9015914D0 (en) 1990-07-19 1990-07-19 Heterocyclic compounds

Publications (2)

Publication Number Publication Date
IL98881A0 IL98881A0 (en) 1992-07-15
IL98881A true IL98881A (en) 1996-01-19

Family

ID=10679359

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9888191A IL98881A (en) 1990-07-19 1991-07-18 Esters of 2-amino-6-alkoxyl-9-(beta-d-arabinofuranosyl)-9h-purine derivatives their preparation and immunomodulating compositions containing them

Country Status (23)

Country Link
US (3) US5492897A (pt)
EP (1) EP0539479B1 (pt)
JP (1) JP2873086B2 (pt)
KR (1) KR100187326B1 (pt)
AT (1) ATE151637T1 (pt)
CA (1) CA2087543C (pt)
CY (1) CY2165B1 (pt)
DE (1) DE69125715T2 (pt)
DK (1) DK0539479T3 (pt)
ES (1) ES2103311T3 (pt)
GB (1) GB9015914D0 (pt)
GR (1) GR3023776T3 (pt)
HU (2) HU9300115D0 (pt)
IE (1) IE912513A1 (pt)
IL (1) IL98881A (pt)
MC (1) MC2289A1 (pt)
MY (1) MY111871A (pt)
NZ (1) NZ239025A (pt)
PT (1) PT98371B (pt)
RU (1) RU2114860C1 (pt)
TW (1) TW208655B (pt)
WO (1) WO1992001456A1 (pt)
ZA (1) ZA915656B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9015914D0 (en) * 1990-07-19 1990-09-05 Wellcome Found Heterocyclic compounds
WO1998042352A1 (en) * 1997-03-24 1998-10-01 Glaxo Group Ltd. Method for treating b-cell tumors with ara-g nucleoside derivatives
US6489331B1 (en) * 1998-07-02 2002-12-03 Kyowa Hakko Kogyo Co., Ltd. Remedies for diabetes
US6753322B2 (en) * 2000-06-06 2004-06-22 Pfizer Inc 2-aminocarbonyl-9H-purine derivatives
US6924271B2 (en) * 2001-11-27 2005-08-02 Anadys Pharmaceuticals, Inc. 3-β-D-ribofuranosylthiazolo[4-5-d]pyridimine nucleosides and uses thereof
US7321033B2 (en) * 2001-11-27 2008-01-22 Anadys Pharmaceuticals, Inc. 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
US20040127435A1 (en) * 2002-08-02 2004-07-01 Regents Of The University Of California Uses for inhibitors of inosine monophosphate dehydrogenase
GEP20084545B (en) 2003-09-05 2008-11-25 Anadys Pharmaceuticals Inc Introducing tlr7 ligands and prodrugs thereof for the treatment of hepatitis c viral infection
GB0321613D0 (en) * 2003-09-15 2003-10-15 Drug Discovery Lab As Compounds
EP1804838A2 (en) * 2004-09-15 2007-07-11 Drug Discovery Laboratory AS Drug conjugates of long chain fatty acid or ester moieties as protein binding prodrugs
EP1814390A4 (en) * 2004-11-12 2009-07-01 Univ Northwestern METHOD FOR THE TREATMENT OF MOLECULAR BLOOD DISEASES WITH NUCLEOSIDE ANALOGUE
KR101320008B1 (ko) * 2004-12-17 2013-10-18 애나디스 파마슈티칼스, 인코포레이티드 ３，５-이치환 및 ３，５，７-삼치환된-３Ｈ-옥사졸로 및３Ｈ-티아졸로 〔４，５-ｄ〕피리미딘-2-온 화합물 및 이의전구약물
US20060189543A1 (en) * 2005-02-23 2006-08-24 Rosenbloom Richard A Compositions and methods for the treatment of leukemia
TWI383987B (zh) 2005-11-21 2013-02-01 Anadys Pharmaceuticals Inc 製備５-胺基-３Ｈ-噻唑并〔４，５-ｄ〕嘧啶-２-酮之新穎方法
JP5345527B2 (ja) * 2006-06-22 2013-11-20 アナディス ファーマシューティカルズ インク プロドラッグである５−アミノ−３−（３’−デオキシ−β−Ｄ−リボフラノシル）−チアゾロ［４，５−ｄ］ピリミジン−２，７−ジオン
WO2008011406A2 (en) 2006-07-18 2008-01-24 Anadys Pharmaceuticals, Inc. Carbonate and carbamate prodrugs of thiazolo [4,5-d] pyrimidines
CN101768197A (zh) * 2008-12-29 2010-07-07 北京德众万全药物技术开发有限公司 一种奈拉滨的制备方法
US9351989B2 (en) 2010-12-29 2016-05-31 Inhibitex, Inc. Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections
WO2018230479A1 (ja) * 2017-06-13 2018-12-20 大原薬品工業株式会社 ヌクレオシド系抗がん剤又は抗ウィルス剤の５'位シリルエーテル誘導体
KR20230127294A (ko) * 2020-12-30 2023-08-31 서던 유니버시티 오브 사이언스 앤드 테크놀로지 코로나 바이러스 감염을 치료하기 위한 방법 및 변형된뉴클레오사이드

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2152486A1 (de) * 1970-11-20 1972-06-29 Akad Wissenschaften Ddr Verfahren zur Herstellung von 5'-Desoxy-5'-fluor-6-methyl-mercaptopurinribosid
US3872084A (en) * 1972-10-10 1975-03-18 Syntex Inc Purine nucleoside 3,5-cyclicphosphate compounds
US4081534A (en) * 1973-09-11 1978-03-28 Burroughs Wellcome Co. Amino purine nucleosides as autoimmune suppressant agents
GB1573777A (en) * 1977-11-03 1980-08-28 Wellcome Found 9-d-arabinonucleosides and an enzymatic process for their preparation
JPS61233696A (ja) * 1985-04-08 1986-10-17 Kanegafuchi Chem Ind Co Ltd ７−ヒドロキシグアニン誘導体及びその製造方法並びにそれを有効成分とする抗腫瘍剤
GB8712745D0 (en) * 1987-05-30 1987-07-01 Wellcome Found Antiviral compounds
CA1317291C (en) * 1987-12-14 1993-05-04 Naeem Botros Hanna Antitumor 6-sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides and related compounds
US5352669A (en) * 1990-03-13 1994-10-04 The Of The United States Of America As Represented By The Department Of Health And Human Services O6 -benzylated guanine, guanosine and 2'-deoxyguanosine compounds possessing O6 -alkylguanine-DNA alkyltransferase depleting activity
GB9015914D0 (en) * 1990-07-19 1990-09-05 Wellcome Found Heterocyclic compounds

Also Published As

Publication number Publication date
EP0539479B1 (en) 1997-04-16
IE912513A1 (en) 1992-01-29
CA2087543C (en) 1998-08-25
ATE151637T1 (de) 1997-05-15
DE69125715D1 (de) 1997-05-22
ES2103311T3 (es) 1997-09-16
AU8196091A (en) 1992-02-18
AU641533B2 (en) 1993-09-23
DK0539479T3 (da) 1997-08-25
CA2087543A1 (en) 1992-01-20
MC2289A1 (fr) 1993-07-14
ZA915656B (en) 1993-03-31
HUT62911A (en) 1993-06-28
JPH05508649A (ja) 1993-12-02
PT98371A (pt) 1992-06-30
GB9015914D0 (en) 1990-09-05
CY2165B1 (en) 2002-08-23
RU2114860C1 (ru) 1998-07-10
DE69125715T2 (de) 1997-08-07
EP0539479A1 (en) 1993-05-05
US5492897A (en) 1996-02-20
US5747472A (en) 1998-05-05
NZ239025A (en) 1993-08-26
WO1992001456A1 (en) 1992-02-06
IL98881A0 (en) 1992-07-15
JP2873086B2 (ja) 1999-03-24
US5821236A (en) 1998-10-13
GR3023776T3 (en) 1997-09-30
PT98371B (pt) 1999-01-29
HU9300115D0 (en) 1993-04-28
MY111871A (en) 2001-02-28
KR100187326B1 (ko) 1999-05-01
TW208655B (pt) 1993-07-01

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