IL86550A - Derivatives of aryl-thiufen sulfonamides and ophthalmic preparations containing them - Google Patents
Derivatives of aryl-thiufen sulfonamides and ophthalmic preparations containing themInfo
- Publication number
- IL86550A IL86550A IL8655088A IL8655088A IL86550A IL 86550 A IL86550 A IL 86550A IL 8655088 A IL8655088 A IL 8655088A IL 8655088 A IL8655088 A IL 8655088A IL 86550 A IL86550 A IL 86550A
- Authority
- IL
- Israel
- Prior art keywords
- thiophene
- sulfonamide
- solution
- compound
- added
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/059,084 US4847289A (en) | 1987-06-08 | 1987-06-08 | Thiophene sulfonamide antiglaucoma agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL86550A0 IL86550A0 (en) | 1988-11-15 |
| IL86550A true IL86550A (en) | 1995-01-24 |
Family
ID=22020751
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL8655088A IL86550A (en) | 1987-06-08 | 1988-05-30 | Derivatives of aryl-thiufen sulfonamides and ophthalmic preparations containing them |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4847289A (de) |
| EP (1) | EP0295049B1 (de) |
| JP (1) | JPH0637488B2 (de) |
| KR (1) | KR960005954B1 (de) |
| AT (1) | ATE68182T1 (de) |
| AU (1) | AU606165B2 (de) |
| CA (1) | CA1328261C (de) |
| DE (1) | DE3865368D1 (de) |
| DK (1) | DK308588A (de) |
| ES (1) | ES2037829T3 (de) |
| GR (1) | GR3002957T3 (de) |
| IE (1) | IE62107B1 (de) |
| IL (1) | IL86550A (de) |
| NZ (1) | NZ224830A (de) |
| PT (1) | PT87620B (de) |
| ZA (1) | ZA884039B (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5378703A (en) * | 1990-04-09 | 1995-01-03 | Alcon Laboratories, Inc. | Sulfonamides useful as carbonic anhydrase inhibitors |
| US5153192A (en) * | 1990-04-09 | 1992-10-06 | Alcon Laboratories, Inc. | Thiophene sulfonamides useful as carbonic anhydrase inhibitors |
| US5585377A (en) * | 1990-04-09 | 1996-12-17 | Alcon Laboratories, Inc. | Sulfonamides useful as carbonic anhydrase inhibitors |
| US5932572A (en) * | 1992-02-21 | 1999-08-03 | Alcon Laboratories, Inc. | Topical anti-glaucoma compositions |
| US5300499A (en) * | 1992-09-02 | 1994-04-05 | Allergan, Inc. | 5-substituted 3-thiophene sulfonamides as antiglaucoma agents |
| US5629345A (en) * | 1993-07-23 | 1997-05-13 | Vide Pharmaceuticals | Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure |
| US5555804A (en) * | 1993-06-25 | 1996-09-17 | Akiyama Printing Machine Manufacturing Company Ltd. | Perfecting sheet rotary offset press |
| US5965620A (en) * | 1993-07-23 | 1999-10-12 | Vide Pharmaceuticals | Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure |
| JP4776113B2 (ja) | 2001-08-02 | 2011-09-21 | 三菱重工印刷紙工機械株式会社 | 枚葉両面多色刷り印刷機用印刷ユニットおよび枚葉両面多色刷り印刷機ならびに製造方法 |
| EP1899294B1 (de) * | 2005-06-13 | 2015-03-18 | Merck Sharp & Dohme Limited | Therapeutische mittel |
| CA2647862A1 (en) | 2006-03-31 | 2007-10-11 | Takeda Pharmaceutical Company Limited | Acid secretion inhibitor |
| LT5504B (lt) | 2006-08-02 | 2008-06-25 | Biotechnologijos Institutas | Benzimidazo[1,2-c][1,2,3]tiadiazolo sulfonamidai - karboanhidrazių slopikliai ir tarpiniai junginiai jiems gauti |
| WO2008017932A2 (en) * | 2006-08-09 | 2008-02-14 | Pfizer Products Inc. | Heterocycles useful as inhibitors of carbonic anhydrase |
| MA33214B1 (fr) | 2009-03-26 | 2012-04-02 | Takeda Pharmaceutical | Compose pyrazole |
| US9801813B2 (en) | 2013-10-17 | 2017-10-31 | Sentiss Pharma Private Limited | Preservative-free ophthalmic pharmaceutical formulation |
| GB201602934D0 (en) | 2016-02-19 | 2016-04-06 | Cancer Res Inst Royal | Compounds |
| WO2021262878A1 (en) * | 2020-06-24 | 2021-12-30 | Oregon Health & Science University | Novel molecule for modulation of innate immune responses controlled by sting protein |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1459571A (en) * | 1974-09-12 | 1976-12-22 | Pfizer Ltd | Thiophene-2-sulphonamide derivatives and their use as therapeutic agents sheet orienting apparatus |
| ZA813332B (en) * | 1980-06-21 | 1982-05-26 | Pfizer | Larvicides and isecticides |
| US4416890A (en) * | 1981-07-13 | 1983-11-22 | Merck & Co., Inc. | Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure |
| US4386098A (en) * | 1981-11-03 | 1983-05-31 | Merck & Co., Inc. | 6-Hydroxy-2-benzothiazolesulfonamide for the topical treatment of elevated intraocular pressure |
| US4426388A (en) * | 1982-04-02 | 1984-01-17 | Merck & Co., Inc. | 5-Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure |
| US4542152A (en) * | 1983-05-23 | 1985-09-17 | Merck & Co., Inc. | 5-[Phenylsulfonyl(or sulfinyl)]thiophene-2-sulfonamides for the topical treatment of elevated intraocular pressure |
| US4477466A (en) * | 1983-05-23 | 1984-10-16 | Merck & Co., Inc. | Acyloxy derivatives of [phenylsulfonyl(or sulfinyl)]thiophenesulfonamide for the topical treatment of elevated intraocular pressure |
| US4585787A (en) * | 1983-06-20 | 1986-04-29 | Merck & Co., Inc. | 5-[2(Or 3)-hydroxyphenylsulfonyl]thiophene-2-sulfonamides for the topical treatment of elevated intraocular pressure |
| ES533389A0 (es) * | 1983-06-20 | 1985-10-16 | Merck & Co Inc | Un procedimiento para la preparacion de nuevos derivados de tiosulfonamida. |
| US4486444A (en) * | 1983-06-20 | 1984-12-04 | Merck & Co., Inc. | (Hydroxybenzoyl)thiophenesulfonamide and acyl derivatives thereof for the topical treatment of elevated intraocular pressure |
| US4668697A (en) * | 1983-10-31 | 1987-05-26 | Merck & Co., Inc. | Elevated intraocular pressure lowering benzo-[b]-thiophene-2-sulfonamide derivatives, compositions, and method of use therefor |
| EP0182691B1 (de) * | 1984-11-02 | 1990-07-04 | Merck & Co. Inc. | Substituierte Thiophen-2-sulfonamide und ihre Herstellung |
| US4677115A (en) * | 1984-12-12 | 1987-06-30 | Merck & Co., Inc. | Antiglaucoma thieno-thiopyran and thieno-thiepin sulfonamide derivatives, compositions, and method of use thereof |
| US4665090A (en) * | 1985-10-09 | 1987-05-12 | Merck & Co., Inc. | Substituted thiophene-2-sulfonamide antiglaucoma agents |
-
1987
- 1987-06-08 US US07/059,084 patent/US4847289A/en not_active Expired - Fee Related
-
1988
- 1988-05-30 IL IL8655088A patent/IL86550A/en not_active IP Right Cessation
- 1988-05-30 NZ NZ224830A patent/NZ224830A/en unknown
- 1988-05-31 PT PT87620A patent/PT87620B/pt not_active IP Right Cessation
- 1988-06-06 EP EP88305178A patent/EP0295049B1/de not_active Expired - Lifetime
- 1988-06-06 AT AT88305178T patent/ATE68182T1/de not_active IP Right Cessation
- 1988-06-06 ES ES198888305178T patent/ES2037829T3/es not_active Expired - Lifetime
- 1988-06-06 DE DE8888305178T patent/DE3865368D1/de not_active Expired - Fee Related
- 1988-06-07 ZA ZA884039A patent/ZA884039B/xx unknown
- 1988-06-07 IE IE169188A patent/IE62107B1/en not_active IP Right Cessation
- 1988-06-07 KR KR1019880006786A patent/KR960005954B1/ko not_active IP Right Cessation
- 1988-06-07 DK DK308588A patent/DK308588A/da not_active Application Discontinuation
- 1988-06-07 CA CA000568886A patent/CA1328261C/en not_active Expired - Fee Related
- 1988-06-07 AU AU17453/88A patent/AU606165B2/en not_active Ceased
- 1988-06-08 JP JP63139590A patent/JPH0637488B2/ja not_active Expired - Lifetime
-
1991
- 1991-10-22 GR GR91401588T patent/GR3002957T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ224830A (en) | 1990-04-26 |
| AU606165B2 (en) | 1991-01-31 |
| KR890000458A (ko) | 1989-03-14 |
| IL86550A0 (en) | 1988-11-15 |
| US4847289A (en) | 1989-07-11 |
| JPH0637488B2 (ja) | 1994-05-18 |
| IE62107B1 (en) | 1994-12-14 |
| PT87620A (pt) | 1988-06-01 |
| DE3865368D1 (de) | 1991-11-14 |
| EP0295049A3 (en) | 1989-03-08 |
| KR960005954B1 (ko) | 1996-05-06 |
| DK308588D0 (da) | 1988-06-07 |
| GR3002957T3 (en) | 1993-01-25 |
| AU1745388A (en) | 1988-12-08 |
| ZA884039B (en) | 1989-01-25 |
| CA1328261C (en) | 1994-04-05 |
| ES2037829T3 (es) | 1993-07-01 |
| IE881691L (en) | 1988-12-08 |
| DK308588A (da) | 1988-12-09 |
| ATE68182T1 (de) | 1991-10-15 |
| JPS6456672A (en) | 1989-03-03 |
| EP0295049A2 (de) | 1988-12-14 |
| PT87620B (pt) | 1992-09-30 |
| EP0295049B1 (de) | 1991-10-09 |
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| WO1995019981A1 (en) | Thienothiazine sulfonamide derivatives process and intermediates for their preparation and their use as carbonic anhydrase inhibitors | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| RH | Patent void |