ATE68182T1 - Thiophensulfonamide zur behandlung von glaukom. - Google Patents

Thiophensulfonamide zur behandlung von glaukom.

Info

Publication number
ATE68182T1
ATE68182T1 AT88305178T AT88305178T ATE68182T1 AT E68182 T1 ATE68182 T1 AT E68182T1 AT 88305178 T AT88305178 T AT 88305178T AT 88305178 T AT88305178 T AT 88305178T AT E68182 T1 ATE68182 T1 AT E68182T1
Authority
AT
Austria
Prior art keywords
treatment
glaucoma
thiophene
sulphone amides
sulphone
Prior art date
Application number
AT88305178T
Other languages
English (en)
Inventor
John J Baldwin
Wasyl Halczenko
Charles M Habecker
George D Hartman
Samuel L Graham
Harvey Schwam
Gerald S Ponticello
Kenneth L Shepard
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE68182T1 publication Critical patent/ATE68182T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
AT88305178T 1987-06-08 1988-06-06 Thiophensulfonamide zur behandlung von glaukom. ATE68182T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/059,084 US4847289A (en) 1987-06-08 1987-06-08 Thiophene sulfonamide antiglaucoma agents
EP88305178A EP0295049B1 (de) 1987-06-08 1988-06-06 Thiophensulfonamide zur Behandlung von Glaukom

Publications (1)

Publication Number Publication Date
ATE68182T1 true ATE68182T1 (de) 1991-10-15

Family

ID=22020751

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88305178T ATE68182T1 (de) 1987-06-08 1988-06-06 Thiophensulfonamide zur behandlung von glaukom.

Country Status (16)

Country Link
US (1) US4847289A (de)
EP (1) EP0295049B1 (de)
JP (1) JPH0637488B2 (de)
KR (1) KR960005954B1 (de)
AT (1) ATE68182T1 (de)
AU (1) AU606165B2 (de)
CA (1) CA1328261C (de)
DE (1) DE3865368D1 (de)
DK (1) DK308588A (de)
ES (1) ES2037829T3 (de)
GR (1) GR3002957T3 (de)
IE (1) IE62107B1 (de)
IL (1) IL86550A (de)
NZ (1) NZ224830A (de)
PT (1) PT87620B (de)
ZA (1) ZA884039B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5153192A (en) * 1990-04-09 1992-10-06 Alcon Laboratories, Inc. Thiophene sulfonamides useful as carbonic anhydrase inhibitors
US5585377A (en) * 1990-04-09 1996-12-17 Alcon Laboratories, Inc. Sulfonamides useful as carbonic anhydrase inhibitors
US5378703A (en) * 1990-04-09 1995-01-03 Alcon Laboratories, Inc. Sulfonamides useful as carbonic anhydrase inhibitors
US5932572A (en) * 1992-02-21 1999-08-03 Alcon Laboratories, Inc. Topical anti-glaucoma compositions
US5300499A (en) * 1992-09-02 1994-04-05 Allergan, Inc. 5-substituted 3-thiophene sulfonamides as antiglaucoma agents
US5629345A (en) * 1993-07-23 1997-05-13 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US5555804A (en) * 1993-06-25 1996-09-17 Akiyama Printing Machine Manufacturing Company Ltd. Perfecting sheet rotary offset press
US5965620A (en) * 1993-07-23 1999-10-12 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
JP4776113B2 (ja) 2001-08-02 2011-09-21 三菱重工印刷紙工機械株式会社 枚葉両面多色刷り印刷機用印刷ユニットおよび枚葉両面多色刷り印刷機ならびに製造方法
CA2611376C (en) * 2005-06-13 2013-09-10 Merck Sharp & Dohme Limited Therapeutic agents
JP5207964B2 (ja) 2006-03-31 2013-06-12 武田薬品工業株式会社 酸分泌抑制薬
LT5504B (lt) 2006-08-02 2008-06-25 Biotechnologijos Institutas Benzimidazo[1,2-c][1,2,3]tiadiazolo sulfonamidai - karboanhidrazių slopikliai ir tarpiniai junginiai jiems gauti
WO2008017932A2 (en) * 2006-08-09 2008-02-14 Pfizer Products Inc. Heterocycles useful as inhibitors of carbonic anhydrase
CA2756086A1 (en) 2009-03-26 2010-09-30 Takeda Pharmaceutical Company Limited Pyrazole compound
EA030535B1 (ru) 2013-10-17 2018-08-31 Сентисс Фарма Прайвет Лимитед Не содержащий консерванта офтальмологический фармацевтический состав
GB201602934D0 (en) 2016-02-19 2016-04-06 Cancer Res Inst Royal Compounds
WO2021262878A1 (en) * 2020-06-24 2021-12-30 Oregon Health & Science University Novel molecule for modulation of innate immune responses controlled by sting protein

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1459571A (en) * 1974-09-12 1976-12-22 Pfizer Ltd Thiophene-2-sulphonamide derivatives and their use as therapeutic agents sheet orienting apparatus
ZA813332B (en) * 1980-06-21 1982-05-26 Pfizer Larvicides and isecticides
US4416890A (en) * 1981-07-13 1983-11-22 Merck & Co., Inc. Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
US4386098A (en) * 1981-11-03 1983-05-31 Merck & Co., Inc. 6-Hydroxy-2-benzothiazolesulfonamide for the topical treatment of elevated intraocular pressure
US4426388A (en) * 1982-04-02 1984-01-17 Merck & Co., Inc. 5-Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
US4542152A (en) * 1983-05-23 1985-09-17 Merck & Co., Inc. 5-[Phenylsulfonyl(or sulfinyl)]thiophene-2-sulfonamides for the topical treatment of elevated intraocular pressure
US4477466A (en) * 1983-05-23 1984-10-16 Merck & Co., Inc. Acyloxy derivatives of [phenylsulfonyl(or sulfinyl)]thiophenesulfonamide for the topical treatment of elevated intraocular pressure
ES533389A0 (es) * 1983-06-20 1985-10-16 Merck & Co Inc Un procedimiento para la preparacion de nuevos derivados de tiosulfonamida.
US4585787A (en) * 1983-06-20 1986-04-29 Merck & Co., Inc. 5-[2(Or 3)-hydroxyphenylsulfonyl]thiophene-2-sulfonamides for the topical treatment of elevated intraocular pressure
US4486444A (en) * 1983-06-20 1984-12-04 Merck & Co., Inc. (Hydroxybenzoyl)thiophenesulfonamide and acyl derivatives thereof for the topical treatment of elevated intraocular pressure
US4668697A (en) * 1983-10-31 1987-05-26 Merck & Co., Inc. Elevated intraocular pressure lowering benzo-[b]-thiophene-2-sulfonamide derivatives, compositions, and method of use therefor
EP0182691B1 (de) * 1984-11-02 1990-07-04 Merck & Co. Inc. Substituierte Thiophen-2-sulfonamide und ihre Herstellung
US4677115A (en) * 1984-12-12 1987-06-30 Merck & Co., Inc. Antiglaucoma thieno-thiopyran and thieno-thiepin sulfonamide derivatives, compositions, and method of use thereof
US4665090A (en) * 1985-10-09 1987-05-12 Merck & Co., Inc. Substituted thiophene-2-sulfonamide antiglaucoma agents

Also Published As

Publication number Publication date
KR890000458A (ko) 1989-03-14
NZ224830A (en) 1990-04-26
JPH0637488B2 (ja) 1994-05-18
DK308588D0 (da) 1988-06-07
DK308588A (da) 1988-12-09
PT87620B (pt) 1992-09-30
GR3002957T3 (en) 1993-01-25
AU606165B2 (en) 1991-01-31
US4847289A (en) 1989-07-11
IL86550A0 (en) 1988-11-15
ZA884039B (en) 1989-01-25
EP0295049A2 (de) 1988-12-14
AU1745388A (en) 1988-12-08
JPS6456672A (en) 1989-03-03
DE3865368D1 (de) 1991-11-14
IE881691L (en) 1988-12-08
PT87620A (pt) 1988-06-01
KR960005954B1 (ko) 1996-05-06
IL86550A (en) 1995-01-24
EP0295049B1 (de) 1991-10-09
CA1328261C (en) 1994-04-05
ES2037829T3 (es) 1993-07-01
IE62107B1 (en) 1994-12-14
EP0295049A3 (en) 1989-03-08

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee