IL79176A - Process for the recovery of erythropoietin from a fluid - Google Patents
Process for the recovery of erythropoietin from a fluidInfo
- Publication number
- IL79176A IL79176A IL79176A IL7917686A IL79176A IL 79176 A IL79176 A IL 79176A IL 79176 A IL79176 A IL 79176A IL 7917686 A IL7917686 A IL 7917686A IL 79176 A IL79176 A IL 79176A
- Authority
- IL
- Israel
- Prior art keywords
- recombinant
- erythropoietin
- biologically active
- chromatographic procedures
- elution
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Detergent Compositions (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Cephalosporin Compounds (AREA)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL9713586A IL97135A (en) | 1985-06-20 | 1986-06-20 | Process for the recovery of erythropoietin from a fluid |
IL9197136A IL97136A0 (en) | 1985-06-20 | 1991-02-03 | Purified recombinant erythropoietin composition |
IL9197135A IL97135A0 (en) | 1985-06-20 | 1991-02-03 | Process for the recovery of erythropoetin from a fluid |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/747,119 US4667016A (en) | 1985-06-20 | 1985-06-20 | Erythropoietin purification |
US87215286A | 1986-06-13 | 1986-06-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL79176A0 IL79176A0 (en) | 1986-09-30 |
IL79176A true IL79176A (en) | 1992-06-21 |
Family
ID=27114696
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL79176A IL79176A (en) | 1985-06-20 | 1986-04-20 | Process for the recovery of erythropoietin from a fluid |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0228452B1 (ja) |
JP (1) | JPH0698019B2 (ja) |
KR (1) | KR930003665B1 (ja) |
AT (1) | ATE120208T1 (ja) |
AU (1) | AU606578B2 (ja) |
CA (1) | CA1297635C (ja) |
DE (1) | DE3650276T2 (ja) |
DK (1) | DK175251B1 (ja) |
ES (1) | ES8801381A1 (ja) |
GR (1) | GR861624B (ja) |
IE (1) | IE69343B1 (ja) |
IL (1) | IL79176A (ja) |
PT (1) | PT82811B (ja) |
WO (1) | WO1986007594A1 (ja) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5179199A (en) * | 1986-10-20 | 1993-01-12 | Genzyme Corporation | Protein purification |
IL118201A (en) * | 1995-05-11 | 2004-12-15 | Roche Diagnostics Gmbh | Preparation comprising a protein with human erythropoietin activity which is free of serum and non-recombinant mammalian protein and process for the preparation thereof |
KR100374308B1 (ko) * | 1995-07-27 | 2003-12-18 | 주식회사 엘지생명과학 | 재조합차이니스햄스터오바리세포로부터발현된수두바이러스의지피i당단백질의정제방법 |
PT1023442E (pt) * | 1997-10-16 | 2011-02-25 | Synageva Biopharma Corp | Vectores compreendendo um promotor específico do magno para transgénese aviária |
US6210924B1 (en) | 1998-08-11 | 2001-04-03 | Amgen Inc. | Overexpressing cyclin D 1 in a eukaryotic cell line |
BR9917606A (pt) * | 1998-11-06 | 2002-12-31 | Bio Sidus S A | Procedimento para a purificação de eritropoetina humana recombinante a partir de sobrenadantes de cultivo de células e eritropoetina humana recombinante obtida com tal procedimento |
ATE405644T1 (de) * | 2002-12-13 | 2008-09-15 | Bioceuticals Arzneimittel Ag | Verfahren zur herstellung und reinigung von erythropoietin |
US7423139B2 (en) | 2004-01-20 | 2008-09-09 | Insight Biopharmaceuticals Ltd. | High level expression of recombinant human erythropoietin having a modified 5′-UTR |
DE102004027816A1 (de) * | 2004-06-08 | 2006-01-05 | Bioceuticals Arzneimittel Ag | Verfahren zur Reinigung von Erythropoietin |
IL165484A0 (en) | 2004-11-30 | 2006-01-15 | Applied Research Systems | Production of proteins |
JP5401097B2 (ja) | 2005-12-23 | 2014-01-29 | ノボ・ノルデイスク・エー/エス | 分取逆相クロマトグラフィー(rpc)を使用するタンパク質精製 |
KR100900033B1 (ko) * | 2007-11-21 | 2009-06-01 | 한국생명공학연구원 | 인간 에리스로포이에틴의 정제방법 |
DE102008002209A1 (de) * | 2008-06-04 | 2009-12-10 | Evonik Degussa Gmbh | Verfahren zur Aufreinigung von Erythropoietin |
ES2435272T3 (es) | 2008-09-23 | 2013-12-17 | F. Hoffmann-La Roche Ag | Purificación de la eritropoyetina |
DE102008054716A1 (de) | 2008-12-16 | 2010-06-17 | Evonik Degussa Gmbh | Inprozesskontrolle in einem Verfahren zur Herstellung von EPO |
AU2010241154A1 (en) * | 2009-04-22 | 2011-10-27 | Bayer Bioscience N.V. | Production of multi-antennary N-glycan structures in plants |
CN102712688B (zh) | 2009-09-23 | 2015-06-24 | 通益制药有限公司 | 重组人红细胞生成素(epo)的纯化方法、由此纯化的epo以及包含纯化的epo的药物组合物 |
SG187834A1 (en) | 2010-08-20 | 2013-03-28 | Boehringer Ingelheim Int | Method for inactivating proteases by ph change in a liquid obtained from a cell culture |
EP2727930B1 (en) * | 2011-06-29 | 2019-12-25 | Kyowa Kirin Co., Ltd. | Method for purifying antithrombin |
EP3153522A1 (en) | 2015-10-09 | 2017-04-12 | Hetero Drugs Limited | Process for the purification of erythropoietin and darbepoetin alfa |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN150740B (ja) * | 1978-11-24 | 1982-12-04 | Hoffmann La Roche | |
JPS5616496A (en) * | 1979-07-20 | 1981-02-17 | Sumitomo Chem Co Ltd | Recovery of erythropoietin |
JPS5653696A (en) * | 1979-10-09 | 1981-05-13 | Ajinomoto Co Inc | Isolation of erythropoietin by adsorption |
JPS57149228A (en) * | 1981-03-11 | 1982-09-14 | Ajinomoto Co Inc | Novel erythropoietin and its preparation |
US4558005A (en) * | 1982-09-13 | 1985-12-10 | University Patents, Inc. | Monoclonal anti-erythropoietin |
JPH0686480B2 (ja) * | 1983-02-21 | 1994-11-02 | 雪印乳業株式会社 | エリスロポエチン製造用モノクローナル抗体 |
NZ210501A (en) * | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
US4568488A (en) * | 1984-01-11 | 1986-02-04 | Lee Huang Sylvia | Reverse immunoaffinity chromatography purification method |
US4677195A (en) * | 1985-01-11 | 1987-06-30 | Genetics Institute, Inc. | Method for the purification of erythropoietin and erythropoietin compositions |
-
1986
- 1986-04-20 IL IL79176A patent/IL79176A/xx not_active IP Right Cessation
- 1986-06-18 IE IE162886A patent/IE69343B1/en not_active IP Right Cessation
- 1986-06-18 CA CA000511855A patent/CA1297635C/en not_active Expired - Lifetime
- 1986-06-19 ES ES556257A patent/ES8801381A1/es not_active Expired
- 1986-06-20 JP JP61503570A patent/JPH0698019B2/ja not_active Expired - Lifetime
- 1986-06-20 DE DE3650276T patent/DE3650276T2/de not_active Expired - Lifetime
- 1986-06-20 AU AU61230/86A patent/AU606578B2/en not_active Expired
- 1986-06-20 EP EP86904556A patent/EP0228452B1/en not_active Expired - Lifetime
- 1986-06-20 AT AT86904556T patent/ATE120208T1/de not_active IP Right Cessation
- 1986-06-20 WO PCT/US1986/001342 patent/WO1986007594A1/en active IP Right Grant
- 1986-06-20 PT PT82811A patent/PT82811B/pt unknown
- 1986-06-20 GR GR861624A patent/GR861624B/el unknown
- 1986-10-04 KR KR1019860008331A patent/KR930003665B1/ko not_active IP Right Cessation
-
1987
- 1987-02-18 DK DK198700813A patent/DK175251B1/da not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IE69343B1 (en) | 1996-09-04 |
KR930003665B1 (ko) | 1993-05-08 |
JPH0698019B2 (ja) | 1994-12-07 |
ATE120208T1 (de) | 1995-04-15 |
EP0228452A4 (en) | 1989-05-16 |
EP0228452A1 (en) | 1987-07-15 |
AU606578B2 (en) | 1991-02-14 |
CA1297635C (en) | 1992-03-17 |
ES8801381A1 (es) | 1988-01-01 |
GR861624B (en) | 1986-10-21 |
WO1986007594A1 (en) | 1986-12-31 |
IE861628L (en) | 1986-12-20 |
DK81387D0 (da) | 1987-02-18 |
EP0228452B1 (en) | 1995-03-22 |
KR880000464A (ko) | 1988-03-26 |
DE3650276D1 (de) | 1995-04-27 |
DE3650276T2 (de) | 1995-07-27 |
PT82811A (en) | 1986-07-01 |
DK175251B1 (da) | 2004-07-19 |
ES556257A0 (es) | 1988-01-01 |
DK81387A (da) | 1987-02-18 |
AU6123086A (en) | 1987-01-13 |
PT82811B (pt) | 1988-04-21 |
JPS63503352A (ja) | 1988-12-08 |
IL79176A0 (en) | 1986-09-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB | Patent renewed | ||
KB | Patent renewed | ||
EXP | Patent expired |