IL162052A0 - Inhibitors of cytosolic phospholipase a2 - Google Patents

Inhibitors of cytosolic phospholipase a2

Info

Publication number: IL162052A0
Authority: IL; Israel
Prior art keywords: inhibitors; cytosolic phospholipase; cytosolic; phospholipase
Prior art date: 2001-12-03

Application number

IL16205202A

Other languages

English (en)

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-03

Filing date

2002-12-02

Publication date

2005-11-20

2002-12-02 Application filed by Wyeth Corp filed Critical Wyeth Corp

2005-11-20 Publication of IL162052A0 publication Critical patent/IL162052A0/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

IL16205202A 2001-12-03 2002-12-02 Inhibitors of cytosolic phospholipase a2 IL162052A0 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US33459101P	2001-12-03	2001-12-03
US33458801P	2001-12-03	2001-12-03
US33460501P	2001-12-03	2001-12-03
US41966402P	2002-10-18	2002-10-18
PCT/US2002/038311 WO2003048122A2 (en)	2001-12-03	2002-12-02	Inhibitors of cytosolic phospholipase a2

Publications (1)

Publication Number	Publication Date
IL162052A0 true IL162052A0 (en)	2005-11-20

Family

ID=27502498

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL16205202A IL162052A0 (en)	2001-12-03	2002-12-02	Inhibitors of cytosolic phospholipase a2
IL162052A IL162052A (en)	2001-12-03	2004-05-19	Indole compounds that inhibit phospholipase a2 cytosolic, methods for their preparation and uses

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL162052A IL162052A (en)	2001-12-03	2004-05-19	Indole compounds that inhibit phospholipase a2 cytosolic, methods for their preparation and uses

Country Status (25)

Country	Link
EP (1)	EP1451154B1 (de)
JP (1)	JP4657605B2 (de)
KR (1)	KR100973665B1 (de)
CN (1)	CN100503566C (de)
AR (1)	AR037684A1 (de)
AT (1)	ATE384045T1 (de)
AU (1)	AU2002351182B2 (de)
BR (1)	BR0214672A (de)
CA (1)	CA2469138C (de)
CO (1)	CO5580763A2 (de)
CY (1)	CY1107383T1 (de)
DE (1)	DE60224707T2 (de)
DK (2)	DK1451154T3 (de)
EC (1)	ECSP045131A (de)
ES (2)	ES2300490T3 (de)
HK (2)	HK1065799A1 (de)
HU (1)	HUP0402577A3 (de)
IL (2)	IL162052A0 (de)
IN (1)	IN2005KO00312A (de)
NO (1)	NO327256B1 (de)
NZ (1)	NZ533269A (de)
PL (1)	PL370445A1 (de)
PT (1)	PT1451154E (de)
TW (1)	TWI334778B (de)
WO (1)	WO2003048122A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7605156B2 (en)	2001-12-03	2009-10-20	Wyeth	Methods for the use of inhibitors of cytosolic phospholipase A2
US7713964B2 (en)	2001-12-03	2010-05-11	Wyeth Llc	Methods for treating asthmatic conditions
TW200510305A (en)	2003-07-25	2005-03-16	Wyeth Corp	Process for the preparation of CPLA2 inhibitors
ATE382035T1 (de)	2003-11-17	2008-01-15	Wyeth Corp	Verfahren zur herstellung von n-substituierten phthalimiden
HN2004000536A (es) *	2003-12-16	2009-02-18	Wyeth Corp	Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles
AR048239A1 (es)	2004-02-25	2006-04-12	Wyeth Corp	Procesos para la preparacion de haluros de aril- y heteroaril-alquilsulfonilo e intermediarios de sintesis de los mismos
US20050244367A1 (en) *	2004-05-03	2005-11-03	Ilypsa, Inc.	Phospholipase inhibitors localized in the gastrointestinal lumen
AR053410A1 (es) *	2004-08-19	2007-05-09	Wyeth Corp	Proceso para la sintesis de indoles n-alquilados c-2, c-3 sustituidos. compuestos intermediarios
WO2006108424A2 (en)	2005-04-13	2006-10-19	Astion Pharma A/S	Beta-2 adrenoceptor agonists for treating connective tissue diseases of the skin
TW200718687A (en)	2005-05-27	2007-05-16	Wyeth Corp	Inhibitors of cytosolic phospholipase A2
KR20080027868A (ko)	2005-07-21	2008-03-28	와이어쓰	설폰산염으로부터 설포닐 할라이드 및 설폰아미드의 합성방법
MX2008005666A (es)	2005-11-03	2009-03-02	Ilypsa Inc	Compuestos multivalentes de indol y uso de los mismos como inhibidores de fosfolipasa-a2.
FR2899471A1 (fr) *	2006-04-06	2007-10-12	Pasteur Institut	Utilisation d'au moins un inhibiteur de la phospholipase a2 cytosolique comme medicament pour le traitement des maladies respiratoires
WO2007140317A2 (en) *	2006-05-26	2007-12-06	Wyeth	Use of inhibitors of cytosolic ph0sph0lipase a2 in the treatment of thrombosis
JP2010508303A (ja) *	2006-10-31	2010-03-18	ワイスエルエルシー	ホスホリパーゼ酵素阻害剤の液体製剤
US20100056520A1 (en) *	2006-10-31	2010-03-04	Frances Anne Donahue	Formulations of phospholipase enzyme inhibitors
JP5164972B2 (ja) *	2007-03-29	2013-03-21	第一三共株式会社	ｃＰＬＡ２阻害活性を有するインドール誘導体およびその用途並びに製造方法
CN102015656A (zh)	2008-04-28	2011-04-13	旭化成制药株式会社	苯丙酸衍生物及其用途
EP2488025A4 (de) *	2009-10-15	2013-04-03	Childrens Medical Center	Sepiapterinreduktasehemmer für schmerzbehandlung
EP2614144B1 (de)	2010-09-08	2015-07-22	Twincore Zentrum für Experimentelle und Klinische Infektionsforschung GmbH	Verwendung von phospholipase-a2-hemmern zur behandlung oder prävention einer flavivirus-infektion

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2079374C (en) *	1991-09-30	2003-08-05	Merck Frosst Canada Incorporated	(bicyclic-azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5994398A (en) *	1996-12-11	1999-11-30	Elan Pharmaceuticals, Inc.	Arylsulfonamides as phospholipase A2 inhibitors
SK12742000A3 (sk) *	1998-02-25	2001-05-10	Genetics Institute, Inc.	Inhibítory fosfolipázových enzýmov, farmaceutický prostriedok s ich obsahom a ich použitie
NZ506329A (en) *	1998-02-25	2004-01-30	Inst Genetics Llc	Inhibitors of phospholipase enzymes

2002
- 2002-12-02 ES ES02786829T patent/ES2300490T3/es not_active Expired - Lifetime
- 2002-12-02 JP JP2003549314A patent/JP4657605B2/ja not_active Expired - Lifetime
- 2002-12-02 ES ES07023208T patent/ES2401454T3/es not_active Expired - Lifetime
- 2002-12-02 KR KR1020047008482A patent/KR100973665B1/ko active IP Right Grant
- 2002-12-02 NZ NZ533269A patent/NZ533269A/xx not_active IP Right Cessation
- 2002-12-02 CN CNB028276116A patent/CN100503566C/zh not_active Expired - Lifetime
- 2002-12-02 DK DK02786829T patent/DK1451154T3/da active
- 2002-12-02 TW TW091134928A patent/TWI334778B/zh not_active IP Right Cessation
- 2002-12-02 DE DE60224707T patent/DE60224707T2/de not_active Expired - Lifetime
- 2002-12-02 CA CA2469138A patent/CA2469138C/en not_active Expired - Lifetime
- 2002-12-02 AU AU2002351182A patent/AU2002351182B2/en not_active Expired
- 2002-12-02 WO PCT/US2002/038311 patent/WO2003048122A2/en active IP Right Grant
- 2002-12-02 IL IL16205202A patent/IL162052A0/xx unknown
- 2002-12-02 EP EP02786829A patent/EP1451154B1/de not_active Expired - Lifetime
- 2002-12-02 BR BR0214672-0A patent/BR0214672A/pt not_active Application Discontinuation
- 2002-12-02 DK DK07023208.7T patent/DK1892239T3/da active
- 2002-12-02 AT AT02786829T patent/ATE384045T1/de active
- 2002-12-02 PT PT02786829T patent/PT1451154E/pt unknown
- 2002-12-02 AR ARP020104643A patent/AR037684A1/es unknown
- 2002-12-02 PL PL02370445A patent/PL370445A1/xx not_active Application Discontinuation
- 2002-12-02 HU HU0402577A patent/HUP0402577A3/hu unknown
2004
- 2004-05-19 IL IL162052A patent/IL162052A/en active IP Right Grant
- 2004-05-31 CO CO04050432A patent/CO5580763A2/es not_active Application Discontinuation
- 2004-06-03 EC EC2004005131A patent/ECSP045131A/es unknown
- 2004-06-25 NO NO20042679A patent/NO327256B1/no not_active IP Right Cessation
- 2004-11-06 HK HK04108749A patent/HK1065799A1/xx not_active IP Right Cessation
2005
- 2005-04-12 IN IN312KO2005 patent/IN2005KO00312A/en unknown
2008
- 2008-03-31 CY CY20081100371T patent/CY1107383T1/el unknown
- 2008-08-20 HK HK08109339.3A patent/HK1113798A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO2003048122A2 (en)	2003-06-12
CO5580763A2 (es)	2005-11-30
JP4657605B2 (ja)	2011-03-23
CA2469138C (en)	2012-04-17
HUP0402577A3 (en)	2011-05-30
NO327256B1 (no)	2009-05-25
AU2002351182B2 (en)	2009-01-15
AU2002351182A1 (en)	2003-06-17
AR037684A1 (es)	2004-12-01
NO20042679L (no)	2004-06-25
HUP0402577A2 (hu)	2005-03-29
HK1113798A1 (en)	2008-10-17
HK1065799A1 (en)	2005-03-04
PL370445A1 (en)	2005-05-30
DE60224707D1 (de)	2008-03-06
CN1617855A (zh)	2005-05-18
TW200301695A (en)	2003-07-16
KR100973665B1 (ko)	2010-08-04
EP1451154B1 (de)	2008-01-16
JP2005515997A (ja)	2005-06-02
BR0214672A (pt)	2004-10-19
IN2005KO00312A (de)	2015-08-14
NZ533269A (en)	2006-03-31
ES2401454T3 (es)	2013-04-19
CN100503566C (zh)	2009-06-24
EP1451154A2 (de)	2004-09-01
TWI334778B (en)	2010-12-21
DK1892239T3 (da)	2013-03-25
CY1107383T1 (el)	2012-12-19
IL162052A (en)	2013-04-30
ECSP045131A (es)	2004-07-23
KR20050044661A (ko)	2005-05-12
PT1451154E (pt)	2008-04-21
DE60224707T2 (de)	2009-02-26
WO2003048122A3 (en)	2003-09-18
CA2469138A1 (en)	2003-06-12
DK1451154T3 (da)	2008-05-19
ES2300490T3 (es)	2008-06-16
ATE384045T1 (de)	2008-02-15

Publication	Publication Date	Title
HK1113798A1 (en)	2008-10-17	Inhibitors of cytosolic phospholipase a2
IL137540A0 (en)	2001-07-24	Inhibitors of phospholipase a2
HK1077762A1 (zh)	2006-02-24	TFGß[轉化生長因子]的抑制劑
HK1072545A1 (en)	2005-09-02	Novel inhibitors of kinases
HUP0401052A3 (en)	2007-05-29	Dna-pk inhibitors
IL157652A0 (en)	2004-03-28	Metalloproteinase inhibitors
IL157570A0 (en)	2004-03-28	Metalloproteinase inhibitors
IL157658A0 (en)	2004-03-28	Metalloproteinase inhibitors
IL165475A0 (en)	2006-01-15	Nitrooxyderivatives of eyclooxygenase-2 inhibitors
AU2002306734A1 (en)	2002-10-03	Inhibitors of plasmepsins
SI1451154T1 (sl)	2008-06-30	Zaviralci citosolne fosfolipaze a2
AU2002305868A1 (en)	2002-12-23	Inhibitors of reggamma
EP1430302A4 (de)	2007-08-22	Glycosaminoglycans-hemmer
EP1441034A4 (de)	2006-06-07	Verfahren zur auswertung von phosphatasehemmern
GB0109278D0 (en)	2001-05-30	Enzyme inhibitors
AU2002328906A1 (en)	2003-03-03	Inhibitors of polyq-aggregation
GB0121073D0 (en)	2001-10-24	Inhibitors of complement activation
AUPR974401A0 (en)	2002-01-24	Inhibitors of oligoribonuclease orthologues
GB2405870B (en)	2005-07-06	DNA-PK inhibitors
AU2002307351A1 (en)	2002-10-28	Prodrugs of cox-2 inhibitors
ZA200500492B (en)	2006-08-30	Novel inhibitors of kinases
GB0101134D0 (en)	2001-02-28	Inhibitors
GB0128453D0 (en)	2002-01-16	Inhibitors
GB0101135D0 (en)	2001-02-28	Inhibitors
GB0106564D0 (en)	2001-05-09	Enzyme inhibitors