NO20042679L - Inhibitorer av cytosolisk fosfolipase A2 - Google Patents
Inhibitorer av cytosolisk fosfolipase A2Info
- Publication number
- NO20042679L NO20042679L NO20042679A NO20042679A NO20042679L NO 20042679 L NO20042679 L NO 20042679L NO 20042679 A NO20042679 A NO 20042679A NO 20042679 A NO20042679 A NO 20042679A NO 20042679 L NO20042679 L NO 20042679L
- Authority
- NO
- Norway
- Prior art keywords
- inhibitors
- cytosolic phospholipase
- cytosolic
- phospholipase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33459101P | 2001-12-03 | 2001-12-03 | |
| US33458801P | 2001-12-03 | 2001-12-03 | |
| US33460501P | 2001-12-03 | 2001-12-03 | |
| US41966402P | 2002-10-18 | 2002-10-18 | |
| PCT/US2002/038311 WO2003048122A2 (en) | 2001-12-03 | 2002-12-02 | Inhibitors of cytosolic phospholipase a2 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20042679L true NO20042679L (no) | 2004-06-25 |
| NO327256B1 NO327256B1 (no) | 2009-05-25 |
Family
ID=27502498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20042679A NO327256B1 (no) | 2001-12-03 | 2004-06-25 | Inhibitorer av cytosolisk fosfolipase A2, fremgangsmate for fremstilling av og mellomprodukter ved fremstilling av slike forbindelser, farmasoytiske preparater inneholdende slike forbindelser samt anvendelse av slike forbindelser for fremstilling av farmasoytiske preparater for behandling av lidelser |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1451154B1 (no) |
| JP (1) | JP4657605B2 (no) |
| KR (1) | KR100973665B1 (no) |
| CN (1) | CN100503566C (no) |
| AR (1) | AR037684A1 (no) |
| AT (1) | ATE384045T1 (no) |
| AU (1) | AU2002351182B2 (no) |
| BR (1) | BR0214672A (no) |
| CA (1) | CA2469138C (no) |
| CO (1) | CO5580763A2 (no) |
| CY (1) | CY1107383T1 (no) |
| DE (1) | DE60224707T2 (no) |
| DK (2) | DK1451154T3 (no) |
| EC (1) | ECSP045131A (no) |
| ES (2) | ES2300490T3 (no) |
| HK (2) | HK1065799A1 (no) |
| HU (1) | HUP0402577A3 (no) |
| IL (2) | IL162052A0 (no) |
| IN (1) | IN2005KO00312A (no) |
| NO (1) | NO327256B1 (no) |
| NZ (1) | NZ533269A (no) |
| PL (1) | PL370445A1 (no) |
| PT (1) | PT1451154E (no) |
| TW (1) | TWI334778B (no) |
| WO (1) | WO2003048122A2 (no) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7605156B2 (en) | 2001-12-03 | 2009-10-20 | Wyeth | Methods for the use of inhibitors of cytosolic phospholipase A2 |
| US7713964B2 (en) | 2001-12-03 | 2010-05-11 | Wyeth Llc | Methods for treating asthmatic conditions |
| TW200510305A (en) | 2003-07-25 | 2005-03-16 | Wyeth Corp | Process for the preparation of CPLA2 inhibitors |
| ATE382035T1 (de) | 2003-11-17 | 2008-01-15 | Wyeth Corp | Verfahren zur herstellung von n-substituierten phthalimiden |
| HN2004000536A (es) * | 2003-12-16 | 2009-02-18 | Wyeth Corp | Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles |
| AR048239A1 (es) | 2004-02-25 | 2006-04-12 | Wyeth Corp | Procesos para la preparacion de haluros de aril- y heteroaril-alquilsulfonilo e intermediarios de sintesis de los mismos |
| US20050244367A1 (en) * | 2004-05-03 | 2005-11-03 | Ilypsa, Inc. | Phospholipase inhibitors localized in the gastrointestinal lumen |
| AR053410A1 (es) * | 2004-08-19 | 2007-05-09 | Wyeth Corp | Proceso para la sintesis de indoles n-alquilados c-2, c-3 sustituidos. compuestos intermediarios |
| WO2006108424A2 (en) | 2005-04-13 | 2006-10-19 | Astion Pharma A/S | Beta-2 adrenoceptor agonists for treating connective tissue diseases of the skin |
| TW200718687A (en) | 2005-05-27 | 2007-05-16 | Wyeth Corp | Inhibitors of cytosolic phospholipase A2 |
| KR20080027868A (ko) | 2005-07-21 | 2008-03-28 | 와이어쓰 | 설폰산염으로부터 설포닐 할라이드 및 설폰아미드의 합성방법 |
| MX2008005666A (es) | 2005-11-03 | 2009-03-02 | Ilypsa Inc | Compuestos multivalentes de indol y uso de los mismos como inhibidores de fosfolipasa-a2. |
| FR2899471A1 (fr) * | 2006-04-06 | 2007-10-12 | Pasteur Institut | Utilisation d'au moins un inhibiteur de la phospholipase a2 cytosolique comme medicament pour le traitement des maladies respiratoires |
| WO2007140317A2 (en) * | 2006-05-26 | 2007-12-06 | Wyeth | Use of inhibitors of cytosolic ph0sph0lipase a2 in the treatment of thrombosis |
| JP2010508303A (ja) * | 2006-10-31 | 2010-03-18 | ワイス エルエルシー | ホスホリパーゼ酵素阻害剤の液体製剤 |
| US20100056520A1 (en) * | 2006-10-31 | 2010-03-04 | Frances Anne Donahue | Formulations of phospholipase enzyme inhibitors |
| JP5164972B2 (ja) * | 2007-03-29 | 2013-03-21 | 第一三共株式会社 | ｃＰＬＡ２阻害活性を有するインドール誘導体およびその用途並びに製造方法 |
| CN102015656A (zh) | 2008-04-28 | 2011-04-13 | 旭化成制药株式会社 | 苯丙酸衍生物及其用途 |
| EP2488025A4 (en) * | 2009-10-15 | 2013-04-03 | Childrens Medical Center | SEPIAPTERIC INTREDUCTASE INHIBITION FOR PAIN TREATMENT |
| EP2614144B1 (en) | 2010-09-08 | 2015-07-22 | Twincore Zentrum für Experimentelle und Klinische Infektionsforschung GmbH | Use of inhibitors of phospholipase a2 for the treatment or prevention of flavivirus infection |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2079374C (en) * | 1991-09-30 | 2003-08-05 | Merck Frosst Canada Incorporated | (bicyclic-azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5994398A (en) * | 1996-12-11 | 1999-11-30 | Elan Pharmaceuticals, Inc. | Arylsulfonamides as phospholipase A2 inhibitors |
| SK12742000A3 (sk) * | 1998-02-25 | 2001-05-10 | Genetics Institute, Inc. | Inhibítory fosfolipázových enzýmov, farmaceutický prostriedok s ich obsahom a ich použitie |
| NZ506329A (en) * | 1998-02-25 | 2004-01-30 | Inst Genetics Llc | Inhibitors of phospholipase enzymes |
-
2002
- 2002-12-02 ES ES02786829T patent/ES2300490T3/es not_active Expired - Lifetime
- 2002-12-02 JP JP2003549314A patent/JP4657605B2/ja not_active Expired - Lifetime
- 2002-12-02 ES ES07023208T patent/ES2401454T3/es not_active Expired - Lifetime
- 2002-12-02 KR KR1020047008482A patent/KR100973665B1/ko active IP Right Grant
- 2002-12-02 NZ NZ533269A patent/NZ533269A/xx not_active IP Right Cessation
- 2002-12-02 CN CNB028276116A patent/CN100503566C/zh not_active Expired - Lifetime
- 2002-12-02 DK DK02786829T patent/DK1451154T3/da active
- 2002-12-02 TW TW091134928A patent/TWI334778B/zh not_active IP Right Cessation
- 2002-12-02 DE DE60224707T patent/DE60224707T2/de not_active Expired - Lifetime
- 2002-12-02 CA CA2469138A patent/CA2469138C/en not_active Expired - Lifetime
- 2002-12-02 AU AU2002351182A patent/AU2002351182B2/en not_active Expired
- 2002-12-02 WO PCT/US2002/038311 patent/WO2003048122A2/en active IP Right Grant
- 2002-12-02 IL IL16205202A patent/IL162052A0/xx unknown
- 2002-12-02 EP EP02786829A patent/EP1451154B1/en not_active Expired - Lifetime
- 2002-12-02 BR BR0214672-0A patent/BR0214672A/pt not_active Application Discontinuation
- 2002-12-02 DK DK07023208.7T patent/DK1892239T3/da active
- 2002-12-02 AT AT02786829T patent/ATE384045T1/de active
- 2002-12-02 PT PT02786829T patent/PT1451154E/pt unknown
- 2002-12-02 AR ARP020104643A patent/AR037684A1/es unknown
- 2002-12-02 PL PL02370445A patent/PL370445A1/xx not_active Application Discontinuation
- 2002-12-02 HU HU0402577A patent/HUP0402577A3/hu unknown
-
2004
- 2004-05-19 IL IL162052A patent/IL162052A/en active IP Right Grant
- 2004-05-31 CO CO04050432A patent/CO5580763A2/es not_active Application Discontinuation
- 2004-06-03 EC EC2004005131A patent/ECSP045131A/es unknown
- 2004-06-25 NO NO20042679A patent/NO327256B1/no not_active IP Right Cessation
- 2004-11-06 HK HK04108749A patent/HK1065799A1/xx not_active IP Right Cessation
-
2005
- 2005-04-12 IN IN312KO2005 patent/IN2005KO00312A/en unknown
-
2008
- 2008-03-31 CY CY20081100371T patent/CY1107383T1/el unknown
- 2008-08-20 HK HK08109339.3A patent/HK1113798A1/xx not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |