IL160682A0 - Spirocyclic-6, 7-dihydro-5h-pyrazolo [1,2a] pyrazol-1-ones which control inflammatory cytokines - Google Patents

Spirocyclic-6, 7-dihydro-5h-pyrazolo [1,2a] pyrazol-1-ones which control inflammatory cytokines

Info

Publication number
IL160682A0
IL160682A0 IL16068202A IL16068202A IL160682A0 IL 160682 A0 IL160682 A0 IL 160682A0 IL 16068202 A IL16068202 A IL 16068202A IL 16068202 A IL16068202 A IL 16068202A IL 160682 A0 IL160682 A0 IL 160682A0
Authority
IL
Israel
Prior art keywords
spirocyclic
pyrazolo
pyrazol
dihydro
ones
Prior art date
Application number
IL16068202A
Other languages
English (en)
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of IL160682A0 publication Critical patent/IL160682A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20Spiro-condensed systems
IL16068202A 2001-09-20 2002-09-20 Spirocyclic-6, 7-dihydro-5h-pyrazolo [1,2a] pyrazol-1-ones which control inflammatory cytokines IL160682A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32362501P 2001-09-20 2001-09-20
PCT/US2002/030133 WO2003024973A1 (en) 2001-09-20 2002-09-20 Spirocyclic-6,7-dihydro-5h-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines

Publications (1)

Publication Number Publication Date
IL160682A0 true IL160682A0 (en) 2004-08-31

Family

ID=23259997

Family Applications (3)

Application Number Title Priority Date Filing Date
IL16074102A IL160741A0 (en) 2001-09-20 2002-09-20 Compounds which inhibit the release of inflammatory cytokines
IL16074202A IL160742A0 (en) 2001-09-20 2002-09-20 6,7-dihydro-5h-pyrazolo[1,2-a] pyrazol-1-ones which control inflammatory cytokines
IL16068202A IL160682A0 (en) 2001-09-20 2002-09-20 Spirocyclic-6, 7-dihydro-5h-pyrazolo [1,2a] pyrazol-1-ones which control inflammatory cytokines

Family Applications Before (2)

Application Number Title Priority Date Filing Date
IL16074102A IL160741A0 (en) 2001-09-20 2002-09-20 Compounds which inhibit the release of inflammatory cytokines
IL16074202A IL160742A0 (en) 2001-09-20 2002-09-20 6,7-dihydro-5h-pyrazolo[1,2-a] pyrazol-1-ones which control inflammatory cytokines

Country Status (33)

Country Link
US (2) US6566357B1 (el)
EP (3) EP1427727B1 (el)
JP (3) JP2005504083A (el)
KR (4) KR100656126B1 (el)
CN (3) CN1257905C (el)
AR (3) AR037502A1 (el)
AT (3) ATE356126T1 (el)
AU (2) AU2002327690B2 (el)
BR (3) BR0212716A (el)
CA (3) CA2461073A1 (el)
CO (3) CO5560589A2 (el)
CY (1) CY1106398T1 (el)
CZ (3) CZ2004361A3 (el)
DE (3) DE60218704T2 (el)
DK (2) DK1427728T3 (el)
EG (2) EG24363A (el)
ES (3) ES2282459T3 (el)
HK (2) HK1071366A1 (el)
HU (3) HUP0402500A3 (el)
IL (3) IL160741A0 (el)
MA (3) MA27066A1 (el)
MX (3) MXPA04002570A (el)
MY (2) MY129329A (el)
NO (2) NO20041594L (el)
NZ (3) NZ531122A (el)
PE (3) PE20030474A1 (el)
PL (3) PL370351A1 (el)
PT (3) PT1427728E (el)
RU (3) RU2278864C2 (el)
SA (1) SA03230529B1 (el)
SK (3) SK1492004A3 (el)
WO (3) WO2003024971A1 (el)
ZA (3) ZA200401260B (el)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7087615B2 (en) 2001-09-20 2006-08-08 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia
US6730668B2 (en) * 2001-09-20 2004-05-04 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US6849627B2 (en) 2001-09-20 2005-02-01 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US7473695B2 (en) * 2001-10-22 2009-01-06 Mitsubishi Tanabe Pharma Corporation 4-imidazolin-2-one compounds
US6677337B2 (en) * 2002-03-19 2004-01-13 The Procter & Gamble Company 1,2-dihydropyrazol-3-ones which controls inflammatory cytokines
US6967254B2 (en) * 2002-09-09 2005-11-22 Amgen Inc. Substituted heterocyclic compounds and methods of use
MXPA05010445A (es) * 2003-04-03 2005-11-04 Merck Patent Gmbh Derivados de azaprolina.
GB0308466D0 (en) * 2003-04-11 2003-05-21 Novartis Ag Organic compounds
US7482356B2 (en) * 2003-11-10 2009-01-27 The Procter & Gamble Company Bicyclic pyrazolone cytokine inhibitors
NZ571706A (en) * 2006-04-18 2012-06-29 Abbott Lab Antagonists of the vanilloid receptor subtype 1 (VR1) and uses thereof
DE102008060549A1 (de) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
CA2760911A1 (en) * 2009-05-19 2010-11-25 George E. Davis Compounds and methods for controlling fungi
EP3308059B1 (en) 2015-06-15 2021-05-26 Cummins, Inc. Combustion chamber elasticity device
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods
CN107033090B (zh) * 2017-05-16 2019-05-07 无锡捷化医药科技有限公司 一种1,2,3,4-四氢噌啉的制备方法
RU2721684C1 (ru) * 2019-09-06 2020-05-21 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" Метил 2,3,8-триоксо-4-фенилтетрагидро-6Н-пиразоло[1,2-а]пирроло[2,3-c]пиразол-9а(1Н)-карбоксилаты
WO2023076133A1 (en) * 2021-10-27 2023-05-04 Merck Sharp & Dohme Llc Spirotricycle ripk1 inhibitors and methods of uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1054291A (el) 1963-02-26
GB1124982A (en) * 1965-02-09 1968-08-21 Lepetit Spa Diazabicyclo octanes and derivatives thereof
CH529154A (fr) 1969-10-27 1972-10-15 Lepetit Spa Procédé de préparation de pyrazolo (1,2-b) phtalazine-1,5 (10H)-diones
US5358924A (en) * 1991-03-21 1994-10-25 Bayer Aktiengesellschaft 3-hydroxy-4-aryl-5-oxo-pyrozoline derivatives, compositions and use
PT1210333E (pt) * 1999-09-07 2005-03-31 Syngenta Participations Ag P-tolil-heterociclos como herbicidas
US6730668B2 (en) * 2001-09-20 2004-05-04 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines

Also Published As

Publication number Publication date
DE60218704D1 (de) 2007-04-19
SK1492004A3 (en) 2004-11-03
ES2268154T3 (es) 2007-03-16
PT1427728E (pt) 2007-05-31
MY129329A (en) 2007-03-30
JP2005504083A (ja) 2005-02-10
NO20041605L (no) 2004-06-21
MY129069A (en) 2007-03-30
KR20060036125A (ko) 2006-04-27
CN1250551C (zh) 2006-04-12
JP2005504081A (ja) 2005-02-10
CZ2004345A3 (cs) 2004-06-16
CA2461073A1 (en) 2003-03-27
SK1482004A3 (en) 2004-08-03
ES2282459T3 (es) 2007-10-16
DK1427728T3 (da) 2007-07-09
PT1427727E (pt) 2005-06-30
RU2004111803A (ru) 2005-10-10
EP1427732A1 (en) 2004-06-16
KR20040035836A (ko) 2004-04-29
IL160742A0 (en) 2004-08-31
CY1106398T1 (el) 2011-10-12
MXPA04002569A (es) 2004-05-31
PE20030446A1 (es) 2003-07-21
CN1555379A (zh) 2004-12-15
PE20030430A1 (es) 2003-06-24
ZA200401260B (en) 2004-08-30
CN1257905C (zh) 2006-05-31
NZ531122A (en) 2005-09-30
BR0212905A (pt) 2004-10-13
MXPA04002574A (es) 2004-06-18
EP1427727B1 (en) 2005-01-26
ZA200401403B (en) 2004-08-30
BR0212716A (pt) 2004-08-03
EP1427728B1 (en) 2007-03-07
US6821971B2 (en) 2004-11-23
DE60202782D1 (de) 2005-03-03
SK1502004A3 (en) 2004-09-08
PL370415A1 (en) 2005-05-30
RU2272040C2 (ru) 2006-03-20
BR0212673A (pt) 2004-08-24
US6566357B1 (en) 2003-05-20
CO5560589A2 (es) 2005-09-30
ATE332901T1 (de) 2006-08-15
CZ2004358A3 (cs) 2004-07-14
HK1071565A1 (en) 2005-07-22
WO2003024970A1 (en) 2003-03-27
JP2005504082A (ja) 2005-02-10
CA2461072A1 (en) 2003-03-27
RU2004111806A (ru) 2005-03-27
MA27065A1 (fr) 2004-12-20
SA03230529B1 (ar) 2008-06-21
RU2299885C2 (ru) 2007-05-27
AR037145A1 (es) 2004-10-27
CN1555375A (zh) 2004-12-15
EP1427732B1 (en) 2006-07-12
AR037237A1 (es) 2004-11-03
HUP0402378A2 (hu) 2005-02-28
CA2461071A1 (en) 2003-03-27
NO20041594L (no) 2004-06-21
DE60213108T2 (de) 2007-02-08
PL370351A1 (en) 2005-05-16
EP1427727A1 (en) 2004-06-16
NZ531063A (en) 2007-08-31
CO5560579A2 (es) 2005-09-30
CN1556811A (zh) 2004-12-22
PT1427732E (pt) 2006-12-29
NZ531123A (en) 2006-08-31
EG24413A (en) 2009-05-25
IL160741A0 (en) 2004-08-31
DE60218704T2 (de) 2007-11-08
CZ2004361A3 (cs) 2004-07-14
DE60202782T2 (de) 2006-01-19
US20030105084A1 (en) 2003-06-05
HUP0500752A2 (en) 2006-01-30
AU2002334641B2 (en) 2007-03-29
KR20040035837A (ko) 2004-04-29
HUP0402500A2 (hu) 2005-03-29
ES2237691T3 (es) 2005-08-01
MA27064A1 (fr) 2004-12-20
WO2003024973A1 (en) 2003-03-27
ATE356126T1 (de) 2007-03-15
EP1427728A1 (en) 2004-06-16
EG24363A (en) 2009-03-04
WO2003024971A1 (en) 2003-03-27
HK1071366A1 (en) 2005-07-15
KR20040035835A (ko) 2004-04-29
KR100623879B1 (ko) 2006-09-19
AR037502A1 (es) 2004-11-17
CO5560590A2 (es) 2005-09-30
HUP0402378A3 (en) 2008-10-28
KR100656126B1 (ko) 2006-12-12
MXPA04002570A (es) 2004-05-31
DE60213108D1 (de) 2006-08-24
RU2278864C2 (ru) 2006-06-27
CN1249066C (zh) 2006-04-05
ATE287887T1 (de) 2005-02-15
RU2004111805A (ru) 2005-04-10
PL370362A1 (en) 2005-05-16
PE20030474A1 (es) 2003-07-22
DK1427732T3 (da) 2006-10-30
HUP0402500A3 (en) 2008-10-28
MA27066A1 (fr) 2004-12-20
ZA200401402B (en) 2004-08-27
AU2002327690B2 (en) 2006-07-20

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