IL157553A0 - Preparation of warfarin sodium from warfarin acid - Google Patents

Preparation of warfarin sodium from warfarin acid

Info

Publication number
IL157553A0
IL157553A0 IL15755301A IL15755301A IL157553A0 IL 157553 A0 IL157553 A0 IL 157553A0 IL 15755301 A IL15755301 A IL 15755301A IL 15755301 A IL15755301 A IL 15755301A IL 157553 A0 IL157553 A0 IL 157553A0
Authority
IL
Israel
Prior art keywords
warfarin
sodium
acid
preparation
low temperature
Prior art date
Application number
IL15755301A
Other languages
English (en)
Original Assignee
Taro Pharma Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taro Pharma Ind filed Critical Taro Pharma Ind
Publication of IL157553A0 publication Critical patent/IL157553A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/44—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3
    • C07D311/46—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 unsubstituted in the carbocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL15755301A 2001-02-28 2001-12-28 Preparation of warfarin sodium from warfarin acid IL157553A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/794,212 US6673944B2 (en) 2001-02-28 2001-02-28 Preparation of warfarin sodium from warfarin acid
PCT/US2001/050512 WO2002070505A1 (en) 2001-02-28 2001-12-28 Preparation of warfarin sodium from warfarin acid

Publications (1)

Publication Number Publication Date
IL157553A0 true IL157553A0 (en) 2004-03-28

Family

ID=25162028

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15755301A IL157553A0 (en) 2001-02-28 2001-12-28 Preparation of warfarin sodium from warfarin acid

Country Status (13)

Country Link
US (1) US6673944B2 (de)
EP (1) EP1363894B1 (de)
JP (1) JP2004520427A (de)
CN (1) CN1492862A (de)
AT (1) ATE289997T1 (de)
BR (1) BR0116918A (de)
CA (1) CA2438407A1 (de)
DE (1) DE60109212T2 (de)
ES (1) ES2239169T3 (de)
IL (1) IL157553A0 (de)
MX (1) MXPA03007768A (de)
RU (1) RU2003129001A (de)
WO (1) WO2002070505A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8327137B1 (en) * 2005-03-25 2012-12-04 Advanced Micro Devices, Inc. Secure computer system with service guest environment isolated driver
US7259185B2 (en) 2005-06-15 2007-08-21 Morton Grove Pharmaceuticals, Inc. Stable warfarin sodium liquid formulation and method of making same
WO2008044246A2 (en) * 2006-10-10 2008-04-17 Matrix Laboratories Ltd A process for the preparation of warfarin sodium
ES2363964B1 (es) 2009-11-20 2012-08-22 Gp Pharm, S.A. Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados.
WO2011145007A1 (en) 2010-05-20 2011-11-24 Alembic Pharmaceuticals Limited A process for the preparation of amorphous warfarin sodium
IN2012CN10302A (de) * 2010-05-20 2015-06-12 Apotex Pharmachem Inc

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2427578A (en) 1945-04-02 1947-09-16 Wisconsin Alumni Res Found 3-substituted 4-hydroxycoumarin and process of making it
US2777859A (en) 1953-02-05 1957-01-15 Wisconsin Alumni Res Found Warfarin-alkali metal derivatives and processes of preparing the same
US2752360A (en) 1953-03-23 1956-06-26 S B Penick & Company Inc Improvement in the manufacture of 3-substituted 4-hydroxycoumarins
US2765321A (en) 1955-05-27 1956-10-02 Wisconsin Alumni Res Found Process of making crystalline warfarin sodium
US3192232A (en) 1961-02-21 1965-06-29 Wisconsin Alumni Res Found Warfarin alkali metal derivative process
USRE25866E (en) 1961-02-21 1965-09-21 Warfarin sodium
US3239529A (en) 1962-03-01 1966-03-08 Wisconsin Alumni Res Found Resolution of warfarin and marcoumar
US3246013A (en) 1963-02-15 1966-04-12 Wisconsin Alumni Res Found Preparation of crystalline warfarin sodium-isopropyl alcohol complex
FR1397213A (fr) * 1963-05-14 1965-04-30 Frosst & Co Charles E Nouveau procédé de préparation de la warfarine-sodium
US4113744A (en) 1974-08-13 1978-09-12 Nasri W. Badran Microcrystalline 3-(alpha-acetonylbenzyl)-4-hydroxycoumarin (warfarin) and methods of making
DE3142985A1 (de) 1981-10-29 1983-05-11 Gebrüder Lödige Maschinenbau-Gesellschaft mbH, 4790 Paderborn Verfahren und vorrichtung zum entfernen von loesungsmitteln aus schuettguetern
US4826689A (en) 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
ZA965853B (en) 1995-07-13 1998-01-12 Du Pont Merck Pharma Asymmetric synthesis of r and s warfarin and its analogs.
CA2226752C (en) 1995-07-13 2002-02-19 The Dupont Merck Pharmaceutical Company A novel asymmetric synthesis of r and s warfarin and its analogs
US5696274A (en) 1995-12-28 1997-12-09 Hoechst Celanese Corporation Syntheses based on 2-hydroxyacetophenone

Also Published As

Publication number Publication date
WO2002070505A1 (en) 2002-09-12
ES2239169T3 (es) 2005-09-16
RU2003129001A (ru) 2005-02-27
JP2004520427A (ja) 2004-07-08
DE60109212D1 (de) 2005-04-07
DE60109212T2 (de) 2006-01-12
BR0116918A (pt) 2004-04-27
ATE289997T1 (de) 2005-03-15
US20020120157A1 (en) 2002-08-29
EP1363894B1 (de) 2005-03-02
EP1363894A1 (de) 2003-11-26
MXPA03007768A (es) 2004-11-12
CA2438407A1 (en) 2002-09-12
CN1492862A (zh) 2004-04-28
US6673944B2 (en) 2004-01-06

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