ATE289997T1 - Herstellung von warfarin-natrium aus warfarin- säure - Google Patents
Herstellung von warfarin-natrium aus warfarin- säureInfo
- Publication number
- ATE289997T1 ATE289997T1 AT01991574T AT01991574T ATE289997T1 AT E289997 T1 ATE289997 T1 AT E289997T1 AT 01991574 T AT01991574 T AT 01991574T AT 01991574 T AT01991574 T AT 01991574T AT E289997 T1 ATE289997 T1 AT E289997T1
- Authority
- AT
- Austria
- Prior art keywords
- warfarin
- sodium
- acid
- production
- low temperature
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
- C07D311/44—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3
- C07D311/46—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 unsubstituted in the carbocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/794,212 US6673944B2 (en) | 2001-02-28 | 2001-02-28 | Preparation of warfarin sodium from warfarin acid |
PCT/US2001/050512 WO2002070505A1 (en) | 2001-02-28 | 2001-12-28 | Preparation of warfarin sodium from warfarin acid |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE289997T1 true ATE289997T1 (de) | 2005-03-15 |
Family
ID=25162028
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01991574T ATE289997T1 (de) | 2001-02-28 | 2001-12-28 | Herstellung von warfarin-natrium aus warfarin- säure |
Country Status (13)
Country | Link |
---|---|
US (1) | US6673944B2 (de) |
EP (1) | EP1363894B1 (de) |
JP (1) | JP2004520427A (de) |
CN (1) | CN1492862A (de) |
AT (1) | ATE289997T1 (de) |
BR (1) | BR0116918A (de) |
CA (1) | CA2438407A1 (de) |
DE (1) | DE60109212T2 (de) |
ES (1) | ES2239169T3 (de) |
IL (1) | IL157553A0 (de) |
MX (1) | MXPA03007768A (de) |
RU (1) | RU2003129001A (de) |
WO (1) | WO2002070505A1 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8327137B1 (en) * | 2005-03-25 | 2012-12-04 | Advanced Micro Devices, Inc. | Secure computer system with service guest environment isolated driver |
WO2006138534A2 (en) * | 2005-06-15 | 2006-12-28 | Morton Grove Pharmaceuticals, Inc. | Stable warfarin sodium liquid formulation and method of making same |
WO2008044246A2 (en) * | 2006-10-10 | 2008-04-17 | Matrix Laboratories Ltd | A process for the preparation of warfarin sodium |
ES2363964B1 (es) | 2009-11-20 | 2012-08-22 | Gp Pharm, S.A. | Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados. |
WO2011145007A1 (en) | 2010-05-20 | 2011-11-24 | Alembic Pharmaceuticals Limited | A process for the preparation of amorphous warfarin sodium |
CA2800016A1 (en) * | 2010-05-20 | 2011-11-24 | Apotex Pharmachem Inc. | Polymorphic forms of warfarin potassium and preparations thereof |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2427578A (en) | 1945-04-02 | 1947-09-16 | Wisconsin Alumni Res Found | 3-substituted 4-hydroxycoumarin and process of making it |
US2777859A (en) | 1953-02-05 | 1957-01-15 | Wisconsin Alumni Res Found | Warfarin-alkali metal derivatives and processes of preparing the same |
US2752360A (en) | 1953-03-23 | 1956-06-26 | S B Penick & Company Inc | Improvement in the manufacture of 3-substituted 4-hydroxycoumarins |
US2765321A (en) | 1955-05-27 | 1956-10-02 | Wisconsin Alumni Res Found | Process of making crystalline warfarin sodium |
USRE25866E (en) | 1961-02-21 | 1965-09-21 | Warfarin sodium | |
US3192232A (en) | 1961-02-21 | 1965-06-29 | Wisconsin Alumni Res Found | Warfarin alkali metal derivative process |
US3239529A (en) | 1962-03-01 | 1966-03-08 | Wisconsin Alumni Res Found | Resolution of warfarin and marcoumar |
US3246013A (en) | 1963-02-15 | 1966-04-12 | Wisconsin Alumni Res Found | Preparation of crystalline warfarin sodium-isopropyl alcohol complex |
FR1397213A (fr) * | 1963-05-14 | 1965-04-30 | Frosst & Co Charles E | Nouveau procédé de préparation de la warfarine-sodium |
US4113744A (en) | 1974-08-13 | 1978-09-12 | Nasri W. Badran | Microcrystalline 3-(alpha-acetonylbenzyl)-4-hydroxycoumarin (warfarin) and methods of making |
DE3142985A1 (de) | 1981-10-29 | 1983-05-11 | Gebrüder Lödige Maschinenbau-Gesellschaft mbH, 4790 Paderborn | Verfahren und vorrichtung zum entfernen von loesungsmitteln aus schuettguetern |
US4826689A (en) | 1984-05-21 | 1989-05-02 | University Of Rochester | Method for making uniformly sized particles from water-insoluble organic compounds |
IL122924A0 (en) | 1995-07-13 | 1998-08-16 | Du Pont Merck Pharma | A novel asymmetric synthesis of r and s warfarin and its analogs |
ZA965853B (en) | 1995-07-13 | 1998-01-12 | Du Pont Merck Pharma | Asymmetric synthesis of r and s warfarin and its analogs. |
US5696274A (en) | 1995-12-28 | 1997-12-09 | Hoechst Celanese Corporation | Syntheses based on 2-hydroxyacetophenone |
-
2001
- 2001-02-28 US US09/794,212 patent/US6673944B2/en not_active Expired - Fee Related
- 2001-12-28 WO PCT/US2001/050512 patent/WO2002070505A1/en active IP Right Grant
- 2001-12-28 BR BR0116918-1A patent/BR0116918A/pt not_active IP Right Cessation
- 2001-12-28 RU RU2003129001/04A patent/RU2003129001A/ru unknown
- 2001-12-28 CA CA002438407A patent/CA2438407A1/en not_active Abandoned
- 2001-12-28 JP JP2002569825A patent/JP2004520427A/ja not_active Withdrawn
- 2001-12-28 ES ES01991574T patent/ES2239169T3/es not_active Expired - Lifetime
- 2001-12-28 AT AT01991574T patent/ATE289997T1/de not_active IP Right Cessation
- 2001-12-28 EP EP01991574A patent/EP1363894B1/de not_active Expired - Lifetime
- 2001-12-28 DE DE60109212T patent/DE60109212T2/de not_active Expired - Fee Related
- 2001-12-28 MX MXPA03007768A patent/MXPA03007768A/es unknown
- 2001-12-28 IL IL15755301A patent/IL157553A0/xx unknown
- 2001-12-28 CN CNA018229026A patent/CN1492862A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2004520427A (ja) | 2004-07-08 |
IL157553A0 (en) | 2004-03-28 |
US20020120157A1 (en) | 2002-08-29 |
CA2438407A1 (en) | 2002-09-12 |
DE60109212T2 (de) | 2006-01-12 |
BR0116918A (pt) | 2004-04-27 |
US6673944B2 (en) | 2004-01-06 |
ES2239169T3 (es) | 2005-09-16 |
MXPA03007768A (es) | 2004-11-12 |
CN1492862A (zh) | 2004-04-28 |
RU2003129001A (ru) | 2005-02-27 |
EP1363894A1 (de) | 2003-11-26 |
DE60109212D1 (de) | 2005-04-07 |
WO2002070505A1 (en) | 2002-09-12 |
EP1363894B1 (de) | 2005-03-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60332776D1 (de) | Herstellung von Delta-9-Tetrahydrocannabinol | |
CY1109568T1 (el) | Ενωσεις βενζο(d)ισοξαζολ-3-υλαμινης και η χρησιμοποιηση τους σαν προσδεματα υποδοχεα βανιλλοειδων | |
NO20062092L (no) | Nye fremgangsmater for fremstilling av N-desmetylzopiklon og optisk rent (+)-N-desmetylzopiklon og optisk rent (-)-N-desmetylzopiklon | |
DE69919599D1 (de) | Verfahren zur herstellung von 4-trifluormethylsulfinylpyrazolderivat | |
CA2325919A1 (en) | Processes for the preparation of threo-1,2-epoxy-3-amino-4-phenylbutane derivatives | |
AR032249A1 (es) | Metodo para tratar mezclas con contenido de fosfatidos | |
ATE289997T1 (de) | Herstellung von warfarin-natrium aus warfarin- säure | |
DE60315839D1 (de) | Teebaumöl enthaltende fungizide zusammensetzung | |
CY1108804T1 (el) | Μεθοδος παρασκευης της 4β-αμινο-4'-δεμεθυλ-4- δεσοξυποδοφυλλοτοξινης. | |
DE50211983D1 (de) | Ganischem material | |
ATE517857T1 (de) | Herstellung von 4-phenylbutansäure | |
MXPA04006803A (es) | Derivados de acidos alfa-feniltiocarboxilicos y alfa-feniloxi-carboxilicos para tratamiento de enfermedades que responden a activacion del receptor alfa activado del proliferador de peroxisoma. | |
DE60211758D1 (de) | Verfahren zur herstellung von sulfinylderivaten mittels oxidation der entsprechenden sulfide | |
AR051386A1 (es) | Proceso para compuestos triciclicos que contienen atomos heterogeneos | |
ATE304001T1 (de) | Verfahren zur herstellung von 2-alkyl-3-aryl- und heteroaryloxaziridinen und neue 2-alkyl-3- aryloxaziridine | |
EA200501125A1 (ru) | Способ получения метил-2-дифенилметилсульфинилацетата | |
AU2003266093A1 (en) | Cyclooct-(en-)yl derivatives for use as fragrances | |
DK1678129T3 (da) | Forbedret fremgangsmåde til fremstilling af benzhydrylthioacetamid | |
NO20064273L (no) | Fremgangsmate for semisyntese av deserpidin | |
HUP0400825A2 (hu) | Eljárás amorf cilastatin nátrium előállítására | |
SE9802939D0 (sv) | New process | |
ATE323172T1 (de) | Herstellung von l-ascorbinsäure und d- erythorbinsäure | |
AR046987A1 (es) | Procedimiento para la preparacion de triazolopirimidinas | |
DE60105216D1 (de) | Verfahren zur Herstellung von aromatischen Acylthiocarbonsäurederivaten | |
ATE356118T1 (de) | Moexipril-magnesium enthaltende arzneimittel |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |