IL149840A0 - New aminopropylphosphinic acids - Google Patents

New aminopropylphosphinic acids

Info

Publication number
IL149840A0
IL149840A0 IL14984000A IL14984000A IL149840A0 IL 149840 A0 IL149840 A0 IL 149840A0 IL 14984000 A IL14984000 A IL 14984000A IL 14984000 A IL14984000 A IL 14984000A IL 149840 A0 IL149840 A0 IL 149840A0
Authority
IL
Israel
Prior art keywords
new
aminopropylphosphinic acids
acids
new aminopropylphosphinic
aminopropylphosphinic
Prior art date
Application number
IL14984000A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0003640A external-priority patent/SE0003640D0/xx
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of IL149840A0 publication Critical patent/IL149840A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/30Phosphinic acids R2P(=O)(OH); Thiophosphinic acids, i.e. R2P(=X)(XH) (X = S, Se)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/48Phosphonous acids R—P(OH)2; Thiophosphonous acids including RHP(=O)(OH); Derivatives thereof
    • C07F9/4808Phosphonous acids R—P(OH)2; Thiophosphonous acids including RHP(=O)(OH); Derivatives thereof the acid moiety containing a substituent or structure which is considered as characteristic
    • C07F9/4816Acyclic saturated acids or derivatices which can have further substituents on alkyl
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
IL14984000A 1999-12-09 2000-12-04 New aminopropylphosphinic acids IL149840A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9904508A SE9904508D0 (sv) 1999-12-09 1999-12-09 New compounds
SE0003640A SE0003640D0 (sv) 2000-10-09 2000-10-09 New compounds
PCT/SE2000/002426 WO2001042252A1 (en) 1999-12-09 2000-12-04 New aminopropylphosphinic acids

Publications (1)

Publication Number Publication Date
IL149840A0 true IL149840A0 (en) 2002-11-10

Family

ID=26655259

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14984000A IL149840A0 (en) 1999-12-09 2000-12-04 New aminopropylphosphinic acids
IL149840A IL149840A (en) 1999-12-09 2004-01-01 Aminopropylphosphinic acids

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL149840A IL149840A (en) 1999-12-09 2004-01-01 Aminopropylphosphinic acids

Country Status (33)

Country Link
US (5) US6576626B2 (is)
EP (2) EP1484333A1 (is)
JP (2) JP3914435B2 (is)
KR (1) KR100689144B1 (is)
CN (1) CN1198832C (is)
AR (1) AR030541A1 (is)
AT (1) ATE282043T1 (is)
AU (1) AU780459B2 (is)
BR (1) BR0016253A (is)
CA (1) CA2397583C (is)
CZ (1) CZ20021983A3 (is)
DE (1) DE60015796T2 (is)
DK (1) DK1240172T3 (is)
EE (1) EE05067B1 (is)
ES (1) ES2230174T3 (is)
HK (2) HK1048321B (is)
HU (1) HUP0300301A3 (is)
IL (2) IL149840A0 (is)
IS (1) IS2231B (is)
MX (1) MXPA02005536A (is)
MY (1) MY125414A (is)
NO (1) NO329595B1 (is)
NZ (1) NZ519376A (is)
PL (1) PL201789B1 (is)
PT (1) PT1240172E (is)
RU (1) RU2260595C2 (is)
SE (1) SE9904508D0 (is)
SI (1) SI1240172T1 (is)
SK (1) SK286904B6 (is)
TW (1) TWI228510B (is)
UA (1) UA71649C2 (is)
WO (1) WO2001042252A1 (is)
ZA (1) ZA200204127B (is)

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* Cited by examiner, † Cited by third party
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SE9904508D0 (sv) * 1999-12-09 1999-12-09 Astra Ab New compounds
US7319095B2 (en) * 1999-12-09 2008-01-15 Astrazeneca Ab Use of GABAB receptor agonists
WO2002062324A2 (en) * 2001-02-05 2002-08-15 Michael Albert Kamm A treatment of oesophageal motility disorders and gastro-oesophageal reflux disease
AR033779A1 (es) * 2001-06-08 2004-01-07 Astrazeneca Ab Compuestos utiles en la enfermedad de reflujo
SE0201940D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New combination II
SE0201939D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New combination
SE0401653D0 (sv) 2004-06-24 2004-06-24 Astrazeneca Ab New compounds
SE0402462D0 (sv) * 2004-10-08 2004-10-08 Astrazeneca Ab New process
US7494985B2 (en) 2004-11-03 2009-02-24 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use
US7566738B2 (en) 2004-11-03 2009-07-28 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
US20060160777A1 (en) * 2004-12-27 2006-07-20 Anders Lehmann New use of GABAbeta receptor agonists
CA2632021A1 (en) 2005-12-23 2007-06-28 Astrazeneca Ab Gaba-b receptor modulators
WO2007073298A1 (en) 2005-12-23 2007-06-28 Astrazeneca Ab Imidazole derivatives for the treatment of gastrointestinal disorders
WO2008033572A1 (en) 2006-09-15 2008-03-20 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
EP2155762B1 (en) * 2007-05-04 2011-10-12 AstraZeneca AB Process for the synthesis of alkyl phosphinic acids by initiation of an amine and an amineoxide
US20100317626A1 (en) * 2007-07-25 2010-12-16 Astrazeneca Ab The Use Of (3-Amino-2-Fluoropropyl) Phosphinic Acid For Treatment Of NERD
WO2009082345A1 (en) * 2007-12-21 2009-07-02 Astrazeneca Ab Novel crystalline form b of (2r)-(3-amino-2-fluoropropyl)phosphinic acid
WO2009082344A1 (en) * 2007-12-21 2009-07-02 Astrazeneca Ab Novel process for making (2r)-(3-amino-2-fluoropropyl)phosphinic acid form a
WO2009082348A1 (en) * 2007-12-21 2009-07-02 Astrazeneca Ab Novel crystalline form c of (2r)-(3-amino-2-fluoropropyl)phosphinic acid
WO2009145716A1 (en) * 2008-05-28 2009-12-03 Astrazeneca Ab New pharmaceutical formulation useful in gerd therapy
EP2346885B1 (de) 2008-11-05 2013-08-28 Clariant International Ltd. Verfahren zur herstellung von monocarboxyfunktionaslisierten dialkylphosphinsäuren, -estern und -salzen mittels allylalkoholen/acroleinen und ihre verwendung
WO2010051893A1 (de) 2008-11-07 2010-05-14 Clariant International Ltd Verfahren zur herstellung von dialkylphosphinsäuren, -estern und -salzen mittels acrylsäurederivaten und ihre verwendung
DE102008056341A1 (de) 2008-11-07 2010-05-12 Clariant International Limited Verfahren zur Herstellung von monoaminofunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Acrylnitrilen und ihre Verwendung
CN102171226B (zh) 2008-11-11 2015-02-11 科莱恩金融(Bvi)有限公司 利用烯丙基化合物制备单烯丙基官能化的二烷基次膦酸、其盐或酯的方法以及它们的用途
DE102008060035A1 (de) 2008-12-02 2010-06-10 Clariant International Limited Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylester einer Carbonsäure und ihre Verwendung
DE102008060535A1 (de) 2008-12-04 2010-06-10 Clariant International Limited Verfahren zur Herstellung von mono-carboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylether und ihre Verwendung
DE102008063642A1 (de) 2008-12-18 2010-06-24 Clariant International Limited Verfahren zur Herstellung von monocarboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Alkylenoxiden und ihre Verwendung
DE102008063668A1 (de) 2008-12-18 2010-07-01 Clariant International Limited Verfahren zur Herstellung von Alkylphosponsäuren, -estern und -salzen mittels Oxidation von Alkylphosphonigsäuren und ihre Verwendung
EP2379573B1 (de) 2008-12-18 2013-12-11 Clariant Finance (BVI) Limited Verfahren zur herstellung von ethylendialkylphosphinsäuren, -estern und -salzen mittels acetylen und ihre verwendung
DE102008063627A1 (de) 2008-12-18 2010-06-24 Clariant International Limited Verfahren zur Herstellung von monohydroxyfunktionalisierten Dialkylphosphinsäuren,-estern und -salzen mittels Ethylenoxid und ihre Verwendung
DE102008064003A1 (de) 2008-12-19 2010-06-24 Clariant International Limited Verfahren zur Herstellung von mono-funktionalisierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung
WO2011113904A1 (en) 2010-03-17 2011-09-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Medicaments for the prevention and treatment of a disease associated with retinal ganglion cell degeneration
US20120016021A1 (en) 2010-07-15 2012-01-19 Xenoport, Inc. Methods of treating fragile x syndrome, down's syndrome, autism and related disorders

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GB8425872D0 (en) * 1984-10-12 1984-11-21 Ciba Geigy Ag Chemical compounds
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US5567840A (en) 1989-05-13 1996-10-22 Ciba-Geigy Corporation Substituted aminoalkylphosphinic acids
US5281747A (en) 1989-05-13 1994-01-25 Ciba-Geigy Corporation Substituted aminoalkylphosphinic acids
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US5006560A (en) 1989-12-20 1991-04-09 Schering Corporation Use of GABA-B selective agonists as anti-tussive agents
IL114631A (en) * 1990-06-22 1998-12-06 Novartis Ag Anti-epileptic preparations containing antagonists of BABAG
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GB9125615D0 (en) * 1991-12-02 1992-01-29 Wyeth John & Brother Ltd Amines
AU662404B2 (en) * 1992-05-08 1995-08-31 Novartis Ag Novel N-aralkyl- and N-heteroaralkyl-aminoalkanephosphinic acids
FR2722192A1 (fr) 1994-07-06 1996-01-12 Adir Nouveaux derives de l'acide 4-amino butyrique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB9420784D0 (en) 1994-10-14 1994-11-30 Glaxo Group Ltd Medicaments
SE9603408D0 (sv) * 1996-09-18 1996-09-18 Astra Ab Medical use
US7319095B2 (en) * 1999-12-09 2008-01-15 Astrazeneca Ab Use of GABAB receptor agonists
SE9904507D0 (sv) * 1999-12-09 1999-12-09 Astra Ab New compounds
SE9904508D0 (sv) * 1999-12-09 1999-12-09 Astra Ab New compounds

Also Published As

Publication number Publication date
US20080146836A1 (en) 2008-06-19
NO329595B1 (no) 2010-11-22
CN1409716A (zh) 2003-04-09
BR0016253A (pt) 2002-08-27
TWI228510B (en) 2005-03-01
US20050137414A1 (en) 2005-06-23
MXPA02005536A (es) 2004-09-10
NZ519376A (en) 2003-11-28
EP1240172A1 (en) 2002-09-18
SK7642002A3 (en) 2002-12-03
RU2002113909A (ru) 2004-01-10
HK1048321B (zh) 2005-09-30
AU780459B2 (en) 2005-03-24
PL201789B1 (pl) 2009-05-29
CN1198832C (zh) 2005-04-27
CA2397583C (en) 2010-11-09
DE60015796D1 (de) 2004-12-16
AR030541A1 (es) 2003-08-27
SI1240172T1 (en) 2005-02-28
EE200200286A (et) 2003-08-15
DK1240172T3 (da) 2005-02-14
SE9904508D0 (sv) 1999-12-09
EP1240172B1 (en) 2004-11-10
NO20022728L (no) 2002-08-07
ATE282043T1 (de) 2004-11-15
WO2001042252A1 (en) 2001-06-14
RU2260595C2 (ru) 2005-09-20
IL149840A (en) 2006-04-10
UA71649C2 (en) 2004-12-15
ES2230174T3 (es) 2005-05-01
US7034176B2 (en) 2006-04-25
US20070021393A1 (en) 2007-01-25
EE05067B1 (et) 2008-08-15
ZA200204127B (en) 2003-08-25
HK1053125A1 (en) 2003-10-10
US7807658B2 (en) 2010-10-05
JP2006306885A (ja) 2006-11-09
IS2231B (is) 2007-04-15
US20020156053A1 (en) 2002-10-24
CA2397583A1 (en) 2001-06-14
AU2036401A (en) 2001-06-18
PL364795A1 (en) 2004-12-13
US6841698B2 (en) 2005-01-11
EP1484333A1 (en) 2004-12-08
JP2003516407A (ja) 2003-05-13
NO20022728D0 (no) 2002-06-07
PT1240172E (pt) 2005-02-28
SK286904B6 (sk) 2009-07-06
KR100689144B1 (ko) 2007-03-08
HUP0300301A3 (en) 2008-12-29
KR20020060992A (ko) 2002-07-19
HK1048321A1 (en) 2003-03-28
IS6408A (is) 2002-06-06
JP3914435B2 (ja) 2007-05-16
CZ20021983A3 (cs) 2002-11-13
DE60015796T2 (de) 2005-11-03
US6576626B2 (en) 2003-06-10
HUP0300301A2 (hu) 2003-06-28
MY125414A (en) 2006-07-31
US20030220303A1 (en) 2003-11-27

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