IL149617A0 - 4-pyrimidinyl-n-acyl-l-phenylalanines - Google Patents
4-pyrimidinyl-n-acyl-l-phenylalaninesInfo
- Publication number
- IL149617A0 IL149617A0 IL14961700A IL14961700A IL149617A0 IL 149617 A0 IL149617 A0 IL 149617A0 IL 14961700 A IL14961700 A IL 14961700A IL 14961700 A IL14961700 A IL 14961700A IL 149617 A0 IL149617 A0 IL 149617A0
- Authority
- IL
- Israel
- Prior art keywords
- phenylalanines
- pyrimidinyl
- acyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16908999P | 1999-12-06 | 1999-12-06 | |
PCT/EP2000/011884 WO2001042225A2 (en) | 1999-12-06 | 2000-11-28 | 4-pyrimidinyl-n-acyl-l-phenylalanines |
Publications (1)
Publication Number | Publication Date |
---|---|
IL149617A0 true IL149617A0 (en) | 2002-11-10 |
Family
ID=22614222
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14961700A IL149617A0 (en) | 1999-12-06 | 2000-11-28 | 4-pyrimidinyl-n-acyl-l-phenylalanines |
IL149617A IL149617A (en) | 1999-12-06 | 2002-05-13 | 4 – pyrimidinyl – N– noble – L– phenylalanines |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL149617A IL149617A (en) | 1999-12-06 | 2002-05-13 | 4 – pyrimidinyl – N– noble – L– phenylalanines |
Country Status (35)
Country | Link |
---|---|
EP (1) | EP1237878B1 (xx) |
JP (1) | JP3824935B2 (xx) |
KR (1) | KR100522344B1 (xx) |
CN (1) | CN1218943C (xx) |
AR (1) | AR034401A1 (xx) |
AT (1) | ATE357433T1 (xx) |
AU (1) | AU783348B2 (xx) |
BR (1) | BR0016195A (xx) |
CA (1) | CA2392570C (xx) |
CO (1) | CO5080772A1 (xx) |
CY (1) | CY1106626T1 (xx) |
CZ (1) | CZ303435B6 (xx) |
DE (1) | DE60034061T2 (xx) |
DK (1) | DK1237878T3 (xx) |
EG (1) | EG24361A (xx) |
ES (1) | ES2282162T3 (xx) |
HK (1) | HK1054384B (xx) |
HR (1) | HRP20020468B1 (xx) |
HU (1) | HU229105B1 (xx) |
IL (2) | IL149617A0 (xx) |
JO (1) | JO2283B1 (xx) |
MA (1) | MA26850A1 (xx) |
MX (1) | MXPA02005564A (xx) |
MY (1) | MY126972A (xx) |
NO (1) | NO322866B1 (xx) |
NZ (1) | NZ518828A (xx) |
PE (1) | PE20010961A1 (xx) |
PL (1) | PL207160B1 (xx) |
PT (1) | PT1237878E (xx) |
RS (1) | RS50371B (xx) |
RU (1) | RU2266901C2 (xx) |
SI (1) | SI1237878T1 (xx) |
TW (1) | TWI256387B (xx) |
WO (1) | WO2001042225A2 (xx) |
ZA (1) | ZA200203533B (xx) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6960597B2 (en) | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
JP3440469B2 (ja) * | 2000-08-18 | 2003-08-25 | 味の素株式会社 | 新規フェニルアラニン誘導体 |
AR033765A1 (es) * | 2001-05-22 | 2004-01-07 | Syngenta Participations Ag | Procedimiento para la preparacion de derivados 3-alquil-3h-isobenzofuran-1-ona 7-sustituidos. |
EP1454898A4 (en) * | 2001-12-13 | 2006-12-13 | Ajinomoto Kk | NEW PHENYL ALANIDE DERIVATIVES |
US7345049B2 (en) | 2003-12-22 | 2008-03-18 | Ajinomoto Co., Inc. | Phenylalanine derivatives |
US7618981B2 (en) * | 2004-05-06 | 2009-11-17 | Cytokinetics, Inc. | Imidazopyridinyl-benzamide anti-cancer agents |
AU2005277634B2 (en) * | 2004-08-16 | 2011-02-17 | Merck Sharp & Dohme Corp. | VLA-4 antagonists |
JP4784224B2 (ja) | 2004-09-24 | 2011-10-05 | 味の素株式会社 | 糖鎖転移方法および糖鎖転移酵素 |
EP2091916A2 (en) * | 2005-11-23 | 2009-08-26 | AstraZeneca AB | L-phenylalanine derivatives and their use as integrin antagonists |
AR059224A1 (es) * | 2006-01-31 | 2008-03-19 | Jerini Ag | Compuestos para la inhibicion de integrinas y uso de estas |
US20090203663A1 (en) * | 2006-02-09 | 2009-08-13 | Astrazeneca Ab | Chemical compounds |
CN101472900B (zh) * | 2006-06-19 | 2011-07-27 | 东丽株式会社 | 多发性硬化症的治疗或预防药 |
DK2203430T3 (da) | 2007-09-17 | 2011-09-26 | Abbott Lab | N-phenyl-dioxo-hydropyrimidiner anvendelige som inhibitorer for hepatitis C virus (HCV) |
CN101842360B (zh) | 2007-09-17 | 2014-12-17 | 艾伯维巴哈马有限公司 | 抗感染嘧啶及其用途 |
TWI437994B (zh) | 2007-09-17 | 2014-05-21 | Abbvie Bahamas Ltd | 抗感染劑及其用途 |
EP2382222B1 (en) * | 2008-12-22 | 2013-05-01 | Icl-ip America Inc. | Water miscible solvent based process for purifying a bisphosphate |
US9216952B2 (en) | 2010-03-23 | 2015-12-22 | Abbvie Inc. | Process for preparing antiviral compound |
US9255074B2 (en) | 2010-07-16 | 2016-02-09 | Abbvie Inc. | Process for preparing antiviral compounds |
US8975443B2 (en) | 2010-07-16 | 2015-03-10 | Abbvie Inc. | Phosphine ligands for catalytic reactions |
NZ704603A (en) | 2010-07-16 | 2016-06-24 | Abbvie Inc | Phosphine ligands for catalytic reactions |
US8895737B2 (en) | 2010-07-16 | 2014-11-25 | Shashank Shekhar | Process for preparing antiviral compounds |
US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
US9447035B2 (en) * | 2012-01-27 | 2016-09-20 | Hoffmann-La Roche Inc. | Integrin antagonist conjugates for targeted delivery to cells expressing VLA-4 |
KR20140127234A (ko) * | 2012-01-27 | 2014-11-03 | 에프. 호프만-라 로슈 아게 | Vla-4 발현 세포로의 표적화된 전달을 위한 인테그린 안타고니스트 접합체 |
WO2015048819A1 (en) | 2013-09-30 | 2015-04-02 | The Regents Of The University Of California | Anti-alphavbeta1 integrin compounds and methods |
CN109053723B (zh) * | 2013-10-29 | 2021-09-03 | Ea制药株式会社 | 磺酰胺衍生物及其药物用途 |
AU2016228852A1 (en) | 2015-03-10 | 2017-10-19 | The Regents Of The University Of California | Anti-alphavbeta1 integrin inhibitors and methods of use |
AU2019373242B2 (en) | 2018-10-30 | 2023-07-13 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
CN112969687A (zh) | 2018-10-30 | 2021-06-15 | 吉利德科学公司 | 作为α4β7整合素抑制剂的喹啉衍生物 |
CA3115830C (en) | 2018-10-30 | 2023-09-12 | Gilead Sciences, Inc. | Compounds for inhibition of .alpha.4.beta.7 integrin |
KR102641718B1 (ko) | 2018-10-30 | 2024-02-29 | 길리애드 사이언시즈, 인코포레이티드 | 알파4베타7 인테그린 억제제로서의 이미다조피리딘 유도체 |
CN114222730A (zh) | 2019-08-14 | 2022-03-22 | 吉利德科学公司 | 用于抑制α4β7整合素的化合物 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998053817A1 (en) * | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Biarylalkanoic acids as cell adhesion inhibitors |
EP1001764A4 (en) * | 1997-05-29 | 2005-08-24 | Merck & Co Inc | Heterocyclic amides as cell adhesion inhibitors |
NZ502813A (en) * | 1997-08-22 | 2002-10-25 | F | N-aroylphenylalanine derivatives as inhibitors of the interaction between a4 containing integrins and VCAM-1 |
DE69821950T2 (de) * | 1997-08-22 | 2004-12-16 | F. Hoffmann-La Roche Ag | N-aroylphenylalaninderivate |
DE60021251D1 (de) * | 1999-01-22 | 2005-08-18 | Elan Pharm Inc | Multizyklische verbindungen zur hemmung der durch vla-4 vermittelten leukozytenadhäsion |
-
2000
- 2000-11-28 PL PL357601A patent/PL207160B1/pl unknown
- 2000-11-28 AT AT00989906T patent/ATE357433T1/de active
- 2000-11-28 SI SI200030948T patent/SI1237878T1/sl unknown
- 2000-11-28 BR BR0016195-0A patent/BR0016195A/pt active Search and Examination
- 2000-11-28 AU AU26696/01A patent/AU783348B2/en not_active Ceased
- 2000-11-28 DE DE60034061T patent/DE60034061T2/de not_active Expired - Lifetime
- 2000-11-28 NZ NZ518828A patent/NZ518828A/en not_active IP Right Cessation
- 2000-11-28 HU HU0204081A patent/HU229105B1/hu not_active IP Right Cessation
- 2000-11-28 PT PT00989906T patent/PT1237878E/pt unknown
- 2000-11-28 CA CA2392570A patent/CA2392570C/en not_active Expired - Fee Related
- 2000-11-28 CN CNB008167958A patent/CN1218943C/zh not_active Expired - Fee Related
- 2000-11-28 MX MXPA02005564A patent/MXPA02005564A/es active IP Right Grant
- 2000-11-28 RS YUP-404/02A patent/RS50371B/sr unknown
- 2000-11-28 KR KR10-2002-7007175A patent/KR100522344B1/ko not_active IP Right Cessation
- 2000-11-28 JP JP2001543526A patent/JP3824935B2/ja not_active Expired - Fee Related
- 2000-11-28 IL IL14961700A patent/IL149617A0/xx active IP Right Grant
- 2000-11-28 CZ CZ20022351A patent/CZ303435B6/cs not_active IP Right Cessation
- 2000-11-28 EP EP00989906A patent/EP1237878B1/en not_active Expired - Lifetime
- 2000-11-28 RU RU2002117422/04A patent/RU2266901C2/ru not_active IP Right Cessation
- 2000-11-28 DK DK00989906T patent/DK1237878T3/da active
- 2000-11-28 WO PCT/EP2000/011884 patent/WO2001042225A2/en active IP Right Grant
- 2000-11-28 ES ES00989906T patent/ES2282162T3/es not_active Expired - Lifetime
- 2000-11-29 JO JO2000190A patent/JO2283B1/en active
- 2000-12-03 EG EG20001502A patent/EG24361A/xx active
- 2000-12-04 AR ARP000106415A patent/AR034401A1/es not_active Application Discontinuation
- 2000-12-04 MY MYPI20005690A patent/MY126972A/en unknown
- 2000-12-05 CO CO00092691A patent/CO5080772A1/es unknown
- 2000-12-05 PE PE2000001293A patent/PE20010961A1/es not_active Application Discontinuation
- 2000-12-05 TW TW089125890A patent/TWI256387B/zh not_active IP Right Cessation
-
2002
- 2002-05-03 ZA ZA200203533A patent/ZA200203533B/en unknown
- 2002-05-13 IL IL149617A patent/IL149617A/en not_active IP Right Cessation
- 2002-05-28 HR HR20020468A patent/HRP20020468B1/xx not_active IP Right Cessation
- 2002-06-04 NO NO20022633A patent/NO322866B1/no not_active IP Right Cessation
- 2002-06-05 MA MA26673A patent/MA26850A1/fr unknown
-
2003
- 2003-09-16 HK HK03106628.4A patent/HK1054384B/zh not_active IP Right Cessation
-
2007
- 2007-05-29 CY CY20071100715T patent/CY1106626T1/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed |