IL149256A0 - Resolution of intermediates in the synthesis of substantially pure bicalutamide - Google Patents

Resolution of intermediates in the synthesis of substantially pure bicalutamide

Info

Publication number: IL149256A0
Authority: IL; Israel
Prior art keywords: intermediates; resolution; synthesis; substantially pure; pure bicalutamide
Prior art date: 1999-10-27

Application number

IL14925600A

Other languages

English (en)

Original Assignee

Nobex Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-27

Filing date

2000-10-25

Publication date

2002-11-10

2000-10-25 Application filed by Nobex Corp filed Critical Nobex Corp

2002-11-10 Publication of IL149256A0 publication Critical patent/IL149256A0/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/06—Separation; Purification; Stabilisation; Use of additives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
- C07C319/28—Separation; Purification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL14925600A 1999-10-27 2000-10-25 Resolution of intermediates in the synthesis of substantially pure bicalutamide IL149256A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US16188499P	1999-10-27	1999-10-27
PCT/US2000/041609 WO2001034563A1 (en)	1999-10-27	2000-10-25	Resolution of intermediates in the synthesis of substantially pure bicalutamide

Publications (1)

Publication Number	Publication Date
IL149256A0 true IL149256A0 (en)	2002-11-10

Family

ID=22583193

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL14925600A IL149256A0 (en)	1999-10-27	2000-10-25	Resolution of intermediates in the synthesis of substantially pure bicalutamide
IL149256A IL149256A (en)	1999-10-27	2002-04-22	Resolution of intermediates in the synthesis of essentially pure bicalotamide

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL149256A IL149256A (en)	1999-10-27	2002-04-22	Resolution of intermediates in the synthesis of essentially pure bicalotamide

Country Status (19)

Country	Link
US (1)	US6593492B1 (de)
EP (1)	EP1224167A1 (de)
JP (1)	JP4778178B2 (de)
KR (1)	KR20020067509A (de)
CN (1)	CN1413188A (de)
AU (1)	AU2619501A (de)
BR (1)	BR0015124A (de)
CA (1)	CA2389100A1 (de)
CZ (1)	CZ20021434A3 (de)
HK (1)	HK1048299A1 (de)
HU (1)	HUP0203186A2 (de)
IL (2)	IL149256A0 (de)
MX (1)	MXPA02004225A (de)
NO (1)	NO20021999L (de)
NZ (1)	NZ518552A (de)
PL (1)	PL360059A1 (de)
TW (1)	TWI271397B (de)
WO (1)	WO2001034563A1 (de)
ZA (1)	ZA200203228B (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6995284B2 (en)	2000-08-24	2006-02-07	The University Of Tennessee Research Foundation	Synthesis of selective androgen receptor modulators
US6071957A (en)	1996-11-27	2000-06-06	The University Of Tennessee Research Corporation	Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer
US7622503B2 (en)	2000-08-24	2009-11-24	University Of Tennessee Research Foundation	Selective androgen receptor modulators and methods of use thereof
US6998500B2 (en)	2000-08-24	2006-02-14	University Of Tennessee Research Foundation	Selective androgen receptor modulators and methods of use thereof
US6838484B2 (en)	2000-08-24	2005-01-04	University Of Tennessee Research Foundation	Formulations comprising selective androgen receptor modulators
US7026500B2 (en)	2000-08-24	2006-04-11	University Of Tennessee Research Foundation	Halogenated selective androgen receptor modulators and methods of use thereof
US8445534B2 (en)	2000-08-24	2013-05-21	University Of Tennessee Research Foundation	Treating androgen decline in aging male (ADAM)-associated conditions with SARMs
US8008348B2 (en)	2001-12-06	2011-08-30	University Of Tennessee Research Foundation	Treating muscle wasting with selective androgen receptor modulators
AU2002312431A1 (en) *	2001-06-13	2002-12-23	Biogal Gyogyszergyar Rt.	Novel process for preparing rac-bicalutamide and its intermediates
US8853266B2 (en)	2001-12-06	2014-10-07	University Of Tennessee Research Foundation	Selective androgen receptor modulators for treating diabetes
MXPA04005519A (es)	2001-12-06	2005-06-20	Gtx Inc	Tratamiento del desgaste muscular con moduladores receptores de androgeno selectivos.
AU2002354475B2 (en) *	2001-12-13	2008-08-14	Sumitomo Chemical Company, Limited	Crystals of bicalutamide and process for their production
RS69704A (en)	2002-02-07	2006-12-15	Gtx Inc.	Treating bening prostate hyperplasia with sarms
US7705182B2 (en)	2002-02-28	2010-04-27	University Of Tennessee Research Foundation	Multi-substituted selective androgen receptor modulators and methods of use thereof
WO2003074450A2 (en)	2002-02-28	2003-09-12	The University Of Tennessee Research Corporation	Radiolabeled selective androgen receptor modulators and their use in prostate cancer imaging and therapy
US7772433B2 (en)	2002-02-28	2010-08-10	University Of Tennessee Research Foundation	SARMS and method of use thereof
US7803970B2 (en)	2002-02-28	2010-09-28	University Of Tennessee Research Foundation	Multi-substitued selective androgen receptor modulators and methods of use thereof
TW200407280A (en)	2002-06-17	2004-05-16	Univ Tennessee Res Foundation	N-bridged selective androgen receptor modulators and methods of use thereof
US7741371B2 (en)	2002-06-17	2010-06-22	University Of Tennessee Research Foundation	Selective androgen receptor modulators and methods of use thereof
US6818766B2 (en)	2002-10-02	2004-11-16	Synthon Bv	Process for making bicalutamide and intermediates thereof
US8309603B2 (en)	2004-06-07	2012-11-13	University Of Tennessee Research Foundation	SARMs and method of use thereof
US9889110B2 (en)	2004-06-07	2018-02-13	University Of Tennessee Research Foundation	Selective androgen receptor modulator for treating hormone-related conditions
US9884038B2 (en)	2004-06-07	2018-02-06	University Of Tennessee Research Foundation	Selective androgen receptor modulator and methods of use thereof
EP1669347A1 (de) *	2004-12-10	2006-06-14	Helm AG	Verfahren zur Herstellung von 3-¬(4-Fluorphenyl)sulfonyl\|-2-hydroxy-2-methylpropionsäure
US20060269596A1 (en) *	2005-01-12	2006-11-30	Gary Liversidge	Controlled release compositions comprising an acylanilide
US20080177109A1 (en) *	2005-03-29	2008-07-24	Usv Limited	Novel Process for Preparation of Bicalutamide
WO2008013791A2 (en) *	2006-07-24	2008-01-31	University Of Delaware	Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
US10010521B2 (en)	2006-08-24	2018-07-03	University Of Tennessee Research Foundation	SARMs and method of use thereof
US9844528B2 (en)	2006-08-24	2017-12-19	University Of Tennessee Research Foundation	SARMs and method of use thereof
US9730908B2 (en)	2006-08-24	2017-08-15	University Of Tennessee Research Foundation	SARMs and method of use thereof
DK2054049T3 (en)	2006-08-24	2016-08-01	Univ Tennessee Res Found	SUBSTITUTED ACYLANILIDES AND PROCEDURES FOR USING THEREOF
US7968603B2 (en)	2007-09-11	2011-06-28	University Of Tennessee Research Foundation	Solid forms of selective androgen receptor modulators
WO2011008543A2 (en) *	2009-06-29	2011-01-20	University Of Delaware	Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
WO2012042532A1 (en)	2010-09-29	2012-04-05	Shilpa Medicare Limited	Process for preparing bicalutamide
CN103539710A (zh) *	2012-07-02	2014-01-29	国药一心制药有限公司	一种（r）-比卡鲁胺的合成方法
US10258596B2 (en)	2012-07-13	2019-04-16	Gtx, Inc.	Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US10987334B2 (en)	2012-07-13	2021-04-27	University Of Tennessee Research Foundation	Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)
US9622992B2 (en)	2012-07-13	2017-04-18	Gtx, Inc.	Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10314807B2 (en)	2012-07-13	2019-06-11	Gtx, Inc.	Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9969683B2 (en)	2012-07-13	2018-05-15	Gtx, Inc.	Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
KR102238970B1 (ko)	2012-07-13	2021-04-09	지티엑스, 인코포레이티드	선택적 안드로겐 수용체 조절자(sarms)를 이용한 안드로겐 수용체(ar) 양성 유방암의 치료 방법
US9744149B2 (en)	2012-07-13	2017-08-29	Gtx, Inc.	Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
CN104897818A (zh) *	2015-06-19	2015-09-09	重庆医药高等专科学校	一种同时测定比卡鲁胺中6种有关物质的uplc方法
CN108069887B (zh) *	2016-11-17	2021-04-20	山西振东制药股份有限公司	一种(r)-比卡鲁胺中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS58183669A (ja) *	1982-04-19	1983-10-26	Teikoku Chem Ind Corp Ltd	光学活性なプロピオン酸誘導体の製造方法
DE3372965D1 (en) *	1982-07-23	1987-09-17	Ici Plc	Amide derivatives
GB8617652D0 (en) *	1986-07-18	1986-08-28	Ici Plc	Acylanilide derivatives
WO1994008986A1 (en) *	1992-10-21	1994-04-28	Pfizer, Inc.	Enantiomeric cis-3-(4,6-dihydroxychroman-3-yl-methyl)benzoic acids
JPH09508125A (ja)	1994-01-21	1997-08-19	セプラコー，インコーポレイテッド	光学的純正ｒ−（−）−カソデックスを使用した男性ホルモン依存疾患治療のための方法と組成
AU7723198A (en)	1997-06-04	1998-12-21	University Of Tennessee Research Corporation, The	Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging

2000
- 2000-10-25 IL IL14925600A patent/IL149256A0/xx unknown
- 2000-10-25 PL PL36005900A patent/PL360059A1/xx unknown
- 2000-10-25 EP EP00989719A patent/EP1224167A1/de not_active Withdrawn
- 2000-10-25 AU AU26195/01A patent/AU2619501A/en not_active Abandoned
- 2000-10-25 BR BR0015124-6A patent/BR0015124A/pt not_active Application Discontinuation
- 2000-10-25 HU HU0203186A patent/HUP0203186A2/hu unknown
- 2000-10-25 CZ CZ20021434A patent/CZ20021434A3/cs unknown
- 2000-10-25 CA CA002389100A patent/CA2389100A1/en not_active Abandoned
- 2000-10-25 KR KR1020027005357A patent/KR20020067509A/ko not_active Application Discontinuation
- 2000-10-25 US US09/695,884 patent/US6593492B1/en not_active Expired - Lifetime
- 2000-10-25 CN CN00817760A patent/CN1413188A/zh active Pending
- 2000-10-25 JP JP2001536512A patent/JP4778178B2/ja not_active Expired - Fee Related
- 2000-10-25 MX MXPA02004225A patent/MXPA02004225A/es not_active Application Discontinuation
- 2000-10-25 WO PCT/US2000/041609 patent/WO2001034563A1/en not_active Application Discontinuation
- 2000-10-25 NZ NZ518552A patent/NZ518552A/en unknown
- 2000-10-26 TW TW089122556A patent/TWI271397B/zh not_active IP Right Cessation
2002
- 2002-04-22 IL IL149256A patent/IL149256A/en not_active IP Right Cessation
- 2002-04-23 ZA ZA200203228A patent/ZA200203228B/en unknown
- 2002-04-26 NO NO20021999A patent/NO20021999L/no unknown
2003
- 2003-01-16 HK HK03100398.5A patent/HK1048299A1/zh unknown

Also Published As

Publication number	Publication date
CA2389100A1 (en)	2001-05-17
NO20021999L (no)	2002-06-20
MXPA02004225A (es)	2002-10-17
KR20020067509A (ko)	2002-08-22
US6593492B1 (en)	2003-07-15
EP1224167A1 (de)	2002-07-24
PL360059A1 (en)	2004-09-06
JP2003513955A (ja)	2003-04-15
HUP0203186A2 (hu)	2003-01-28
IL149256A (en)	2011-05-31
BR0015124A (pt)	2002-07-02
ZA200203228B (en)	2003-07-23
AU2619501A (en)	2001-06-06
CN1413188A (zh)	2003-04-23
NZ518552A (en)	2003-10-31
NO20021999D0 (no)	2002-04-26
HK1048299A1 (zh)	2003-03-28
WO2001034563A1 (en)	2001-05-17
CZ20021434A3 (cs)	2002-11-13
TWI271397B (en)	2007-01-21
JP4778178B2 (ja)	2011-09-21

Publication	Publication Date	Title
IL149256A0 (en)	2002-11-10	Resolution of intermediates in the synthesis of substantially pure bicalutamide
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