IL136681A0 - Biodegradable mixed polymeric micelles for gene delivery - Google Patents

Biodegradable mixed polymeric micelles for gene delivery

Info

Publication number
IL136681A0
IL136681A0 IL13668198A IL13668198A IL136681A0 IL 136681 A0 IL136681 A0 IL 136681A0 IL 13668198 A IL13668198 A IL 13668198A IL 13668198 A IL13668198 A IL 13668198A IL 136681 A0 IL136681 A0 IL 136681A0
Authority
IL
Israel
Prior art keywords
gene delivery
polymeric micelles
mixed polymeric
biodegradable mixed
biodegradable
Prior art date
Application number
IL13668198A
Other languages
English (en)
Original Assignee
Samyang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samyang Corp filed Critical Samyang Corp
Publication of IL136681A0 publication Critical patent/IL136681A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/06Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906Drug delivery
    • Y10S977/907Liposome
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915Therapeutic or pharmaceutical composition
    • Y10S977/916Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL13668198A 1997-12-12 1998-12-11 Biodegradable mixed polymeric micelles for gene delivery IL136681A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6955197P 1997-12-12 1997-12-12
PCT/US1998/026403 WO1999029303A1 (en) 1997-12-12 1998-12-11 Biodegradable mixed polymeric micelles for gene delivery

Publications (1)

Publication Number Publication Date
IL136681A0 true IL136681A0 (en) 2001-06-14

Family

ID=22089740

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13668198A IL136681A0 (en) 1997-12-12 1998-12-11 Biodegradable mixed polymeric micelles for gene delivery

Country Status (13)

Country Link
US (1) US6210717B1 (xx)
EP (1) EP1037611B1 (xx)
JP (1) JP4570776B2 (xx)
KR (1) KR20010032878A (xx)
CN (1) CN1281355A (xx)
AR (1) AR018528A1 (xx)
AT (1) ATE412403T1 (xx)
AU (1) AU740342B2 (xx)
BR (1) BR9813548A (xx)
DE (1) DE69840175D1 (xx)
IL (1) IL136681A0 (xx)
WO (1) WO1999029303A1 (xx)
ZA (1) ZA9811376B (xx)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2317549C (en) * 1998-01-05 2006-04-11 University Of Washington Composition for enhancing transport through lipid-containing membranes, and uses thereof
SE9904581D0 (sv) * 1999-12-15 1999-12-15 A & Science Invest Ab A novel helicobacter pylori-binding substance and use thereof
US7737108B1 (en) * 2000-01-07 2010-06-15 University Of Washington Enhanced transport using membrane disruptive agents
US20030134420A1 (en) * 2000-02-18 2003-07-17 Lollo Charles Peter Methods and compositions for gene delivery
US20030072794A1 (en) * 2000-06-09 2003-04-17 Teni Boulikas Encapsulation of plasmid DNA (lipogenes™) and therapeutic agents with nuclear localization signal/fusogenic peptide conjugates into targeted liposome complexes
JP2003535832A (ja) * 2000-06-09 2003-12-02 ブリカス,テニ ポリヌクレオチドおよび薬物の標的化リポソームへのカプセル化
US7265186B2 (en) * 2001-01-19 2007-09-04 Nektar Therapeutics Al, Corporation Multi-arm block copolymers as drug delivery vehicles
TWI246524B (en) * 2001-01-19 2006-01-01 Shearwater Corp Multi-arm block copolymers as drug delivery vehicles
WO2002072150A2 (en) * 2001-03-13 2002-09-19 Angiotech Pharmaceuticals Inc. Micellar drug delivery vehicles and uses thereof
US20030157170A1 (en) * 2001-03-13 2003-08-21 Richard Liggins Micellar drug delivery vehicles and precursors thereto and uses thereof
ATE363898T1 (de) 2001-04-20 2007-06-15 Univ British Columbia Mizellares arzneistoffverabreichungssystem für hydrophobe arzneistoffe
KR100566911B1 (ko) * 2001-06-25 2006-04-03 주식회사 삼양사 약물 전달체용 음이온기-함유 양친성 블록 공중합체 및 그의 양이온성 약물과의 복합체
US6967234B2 (en) 2002-12-18 2005-11-22 Ethicon, Inc. Alkyd-lactone copolymers for medical applications
US7030127B2 (en) 2001-06-29 2006-04-18 Ethicon, Inc. Composition and medical devices utilizing bioabsorbable polymeric waxes
US7034037B2 (en) 2001-06-29 2006-04-25 Ethicon, Inc. Compositions and medical devices utilizing bioabsorbable polymeric waxes and rapamycin
US20030186916A1 (en) * 2002-03-12 2003-10-02 Lei Yu Vector for transfection of eukaryotic cells
US7005136B2 (en) 2002-03-29 2006-02-28 Ethicon, Inc. Bone replacement materials utilizing bioabsorbable liquid polymers
US7326426B2 (en) 2002-03-29 2008-02-05 Ethicon, Inc. Compositions and medical devices utilizing bioabsorbable liquid polymers
WO2003090807A1 (en) * 2002-04-24 2003-11-06 Poly-Med, Inc. Multifaceted endovascular stent coating for preventing restenosis
US7368125B2 (en) 2002-06-05 2008-05-06 Ethicon, Inc. Amphiphilic polymers for medical applications
AR037006A1 (es) * 2002-06-20 2004-10-20 S I G Sist S De Identificacion Marcador de objetos a identificar consistente en al menos un fragmento de adn.
US7026374B2 (en) 2002-06-25 2006-04-11 Aruna Nathan Injectable microdispersions for medical applications
US7101566B2 (en) 2002-06-28 2006-09-05 Ethicon, Inc. Polymer coated microparticles for sustained release
MY148805A (en) 2002-10-16 2013-05-31 Takeda Pharmaceutical Controlled release preparation
GB0228525D0 (en) * 2002-12-06 2003-01-15 Univ Cambridge Tech Polymers and their use
US20040115226A1 (en) * 2002-12-12 2004-06-17 Wenji Li Free-flowing solid formulations with improved bio-availability of poorly water soluble drugs and process for making the same
US6872799B2 (en) 2002-12-18 2005-03-29 Ethicon, Inc. Functionalized polymers for medical applications
US6866860B2 (en) 2002-12-19 2005-03-15 Ethicon, Inc. Cationic alkyd polyesters for medical applications
US7135523B2 (en) * 2003-03-14 2006-11-14 Industrial Technology Research Institute Nanoscale helical microstructures and channels from chiral poly(L-lactide) block containing block copolymers
WO2004086046A1 (en) * 2003-03-25 2004-10-07 Biacore Ab Immobilization method and kit therefor
SE0300805D0 (sv) * 2003-03-25 2003-03-25 Biacore Ab Immobilization method and kit therefor
US7309757B2 (en) * 2003-06-20 2007-12-18 Agency For Science, Technology And Research Polymers for the delivery of bioactive agents and methods of their preparation
ES2411962T3 (es) 2003-10-24 2013-07-09 Gencia Corporation Métodos y composiciones para suministrar polinucleótidos
US8507277B2 (en) 2003-10-24 2013-08-13 Gencia Corporation Nonviral vectors for delivering polynucleotides
US20090208478A1 (en) * 2003-10-24 2009-08-20 Gencia Corporation Transducible polypeptides for modifying metabolism
US8062891B2 (en) 2003-10-24 2011-11-22 Gencia Corporation Nonviral vectors for delivering polynucleotides to plants
US20090123468A1 (en) 2003-10-24 2009-05-14 Gencia Corporation Transducible polypeptides for modifying metabolism
US8133733B2 (en) 2003-10-24 2012-03-13 Gencia Corporation Nonviral vectors for delivering polynucleotides to target tissues
WO2005105040A2 (en) * 2004-04-26 2005-11-10 Micelle Products, Inc. Water-soluble formulations of fat soluble vitamins and pharmaceutical agents and their applications
EP1765403A4 (en) * 2004-05-10 2011-03-30 Univ Utah Res Found COMBINED ACTIVE AND PASSIVE TARGETING OF BIOLOGICALLY ACTIVE ACTIVE SUBSTANCES
AU2006214655A1 (en) * 2005-02-17 2006-08-24 Medivas, Llc. Polymer particle delivery compositions and methods of use
US8568705B2 (en) 2005-07-18 2013-10-29 Nektar Therapeutics Method for preparing branched functionalized polymers using branched polyol cores
CN101331173A (zh) 2005-10-05 2008-12-24 东京Cro株式会社 生物相容性嵌段共聚物、其用途和制造方法
WO2007109584A1 (en) * 2006-03-16 2007-09-27 University Of Washington Temperature-and ph-responsive polymer compositions
DK2089516T3 (da) * 2006-11-29 2012-02-20 Novozymes Inc Fremgangsmåder til at forbedre indføringen af DNA i bakterielle celler
US7981688B2 (en) 2007-03-08 2011-07-19 University Of Washington Stimuli-responsive magnetic nanoparticles and related methods
JP5270884B2 (ja) * 2007-09-03 2013-08-21 大阪瓦斯株式会社 分散剤およびこの分散剤を含むポリ乳酸系複合樹脂粒子
WO2009100645A1 (en) * 2008-01-25 2009-08-20 Tuo Jin Polycationic gene carriers formed of endogenous amino group-bearing monomers
MX2010012239A (es) 2008-05-13 2011-05-24 Univ Washington Montajes micelares.
AU2009246321A1 (en) 2008-05-13 2009-11-19 Phaserx, Inc. Polymeric carrier
EP2620161A1 (en) 2008-05-13 2013-07-31 University of Washington Diblock copolymers and polynucleotide complexes thereof for delivery into cells
CA2734917A1 (en) 2008-08-22 2010-02-25 University Of Washington Heterogeneous polymeric micelles for intracellular delivery
WO2010053596A1 (en) 2008-11-06 2010-05-14 University Of Washington Bispecific intracellular delivery vehicles
KR20110095292A (ko) 2008-11-06 2011-08-24 유니버시티 오브 워싱톤 다중블록 공중합체
JP2012511053A (ja) 2008-12-08 2012-05-17 ユニヴァーシティ オブ ワシントン オメガ機能性化ポリマー、ジャンクション機能性化ブロック共重合体、およびラジカル連鎖延長重合
EP2201935B1 (en) * 2008-12-26 2020-07-08 Samyang Biopharmaceuticals Corporation Polymeric micelle composition containing a poorly soluble drug and preparation method of the same
NZ593735A (en) * 2008-12-26 2013-08-30 Samyang Biopharmaceuticals Preparation method of polymeric micellar nanoparticles composition containing a poorly water-soluble drug
WO2010114770A1 (en) * 2009-03-30 2010-10-07 Cerulean Pharma Inc. Polymer-agent conjugates, particles, compositions, and related methods of use
CA2756072A1 (en) * 2009-03-30 2010-10-14 Cerulean Pharma Inc. Polymer-agent conjugates, particles, compositions, and related methods of use
WO2010114768A1 (en) * 2009-03-30 2010-10-07 Cerulean Pharma Inc. Polymer-epothilone conjugates, particles, compositions, and related methods of use
US8426214B2 (en) * 2009-06-12 2013-04-23 University Of Washington System and method for magnetically concentrating and detecting biomarkers
US9080933B2 (en) 2009-11-09 2015-07-14 University Of Washington Through Its Center For Commercialization Stimuli-responsive polymer diagnostic assay comprising magnetic nanoparticles and capture conjugates
US20110117668A1 (en) * 2009-11-09 2011-05-19 University Of Washington Through Its Center For Commercialization Self-powered smart diagnostic devices
US9415113B2 (en) 2009-11-18 2016-08-16 University Of Washington Targeting monomers and polymers having targeting blocks
US8765098B2 (en) 2010-03-30 2014-07-01 International Business Machines Corporation Star polymers, methods of preparation thereof, and uses thereof
US9163107B2 (en) * 2010-07-26 2015-10-20 Shanghai Jiao Tong University Cationic polymers formed from amino group-bearing monomers and heterocyclic linkers
EP2658567A4 (en) 2010-12-28 2014-09-24 Univ Rochester METHOD FOR MODIFYING INSULIN SIGNAL TRANSMISSION BY BILIVERDINREDUCTASE (BVR) AND BVR-DERIVED PEPTIDES
US9963549B2 (en) 2011-06-23 2018-05-08 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
CN102516534B (zh) * 2011-11-14 2013-11-20 上海交通大学 可降解为精胺的聚阳离子及其合成方法、纳米颗粒
US9694050B2 (en) 2012-10-21 2017-07-04 University Of Rochester THY1 (CD90) as a novel therapy to control adipose tissue accumulation
CA3160394C (en) 2013-07-30 2023-11-07 Genevant Sciences Gmbh Block copolymers and their conjugates or complexes with oligonucleotides
EP3033108B1 (en) 2013-08-16 2021-03-24 University Of Rochester Designed peptides for tight junction barrier modulation
CA2931547A1 (en) 2013-12-09 2015-06-18 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
CN106102777B (zh) * 2013-12-27 2019-12-17 林希龙 用于生物体内及体外递送核酸系药物的新颖糖醇系组成物
EP3233067B1 (en) 2014-12-18 2019-11-06 DSM IP Assets B.V. Drug delivery system for delivery of acid sensitive drugs
CN107530436B (zh) 2015-01-21 2022-03-29 菲泽尔克斯公司 用于将治疗剂和诊断剂递送到细胞中的方法、组合物和***
CN104829786A (zh) * 2015-05-04 2015-08-12 中国科学院上海有机化学研究所 侧挂天然半乳糖和赖氨酸的阳离子大分子、制备方法及其用途
CA2999756A1 (en) 2015-09-24 2017-03-30 The University Of North Carolina At Chapel Hill Methods and compositions for reducing metastases
WO2017105138A1 (ko) * 2015-12-18 2017-06-22 주식회사 삼양바이오팜 음이온성 약물을 함유하는 고분자 미셀의 제조방법
EP3562510A4 (en) 2016-12-30 2021-01-06 Genevant Sciences GmbH BRANCHED PEG MOLECULES AND ASSOCIATED COMPOSITIONS AND PROCEDURES
WO2019049862A1 (ja) * 2017-09-05 2019-03-14 味の素株式会社 ポリリジン誘導体
WO2019129657A1 (en) 2017-12-28 2019-07-04 Fundació Hospital Universitari Vall D'hebron - Institut De Recerca Actively targeted polymeric micelles for drug and gene delivery
WO2020247347A1 (en) 2019-06-05 2020-12-10 University Of Rochester New designed inhibitors of tight junction formation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3808531C1 (xx) 1988-03-15 1989-07-13 Eppendorf - Netheler - Hinz Gmbh, 2000 Hamburg, De
US5501662A (en) 1992-05-22 1996-03-26 Genetronics, Inc. Implantable electroporation method and apparatus for drug and gene delivery
US5273525A (en) 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
CA2167920A1 (en) * 1993-07-23 1995-02-02 Abraham J. Domb Nonoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
DK0754032T3 (da) * 1994-04-08 2002-04-02 Atrix Lab Inc Flydende frigivelsessammensætninger
US5752974A (en) * 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body

Also Published As

Publication number Publication date
ZA9811376B (en) 1999-06-28
CN1281355A (zh) 2001-01-24
AU740342B2 (en) 2001-11-01
JP2001525357A (ja) 2001-12-11
EP1037611A1 (en) 2000-09-27
EP1037611A4 (en) 2006-09-20
DE69840175D1 (de) 2008-12-11
WO1999029303A1 (en) 1999-06-17
BR9813548A (pt) 2000-10-10
AU1910899A (en) 1999-06-28
KR20010032878A (ko) 2001-04-25
AR018528A1 (es) 2001-11-28
ATE412403T1 (de) 2008-11-15
US6210717B1 (en) 2001-04-03
JP4570776B2 (ja) 2010-10-27
EP1037611B1 (en) 2008-10-29

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