IL131796A0 - Zinc free insulin crystals for use in pulmonary compositions - Google Patents
Zinc free insulin crystals for use in pulmonary compositionsInfo
- Publication number
- IL131796A0 IL131796A0 IL13179698A IL13179698A IL131796A0 IL 131796 A0 IL131796 A0 IL 131796A0 IL 13179698 A IL13179698 A IL 13179698A IL 13179698 A IL13179698 A IL 13179698A IL 131796 A0 IL131796 A0 IL 131796A0
- Authority
- IL
- Israel
- Prior art keywords
- free insulin
- zinc free
- insulin crystals
- crystals
- pulmonary compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK31797 | 1997-03-20 | ||
PCT/DK1998/000109 WO1998042749A1 (en) | 1997-03-20 | 1998-03-20 | Zinc free insulin crystals for use in pulmonary compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
IL131796A0 true IL131796A0 (en) | 2001-03-19 |
Family
ID=8092195
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13179698A IL131796A0 (en) | 1997-03-20 | 1998-03-20 | Zinc free insulin crystals for use in pulmonary compositions |
Country Status (17)
Country | Link |
---|---|
US (2) | US20070093411A1 (xx) |
EP (2) | EP1005490B1 (xx) |
JP (1) | JP3764174B2 (xx) |
KR (1) | KR20000076419A (xx) |
CN (1) | CN1259142A (xx) |
AT (1) | ATE321783T1 (xx) |
AU (1) | AU742591B2 (xx) |
BR (1) | BR9808285A (xx) |
CA (1) | CA2283705A1 (xx) |
DE (1) | DE69834028T2 (xx) |
ES (1) | ES2260832T3 (xx) |
HU (1) | HUP0000547A3 (xx) |
IL (1) | IL131796A0 (xx) |
NO (1) | NO994520D0 (xx) |
PL (1) | PL335777A1 (xx) |
RU (1) | RU2198181C2 (xx) |
WO (1) | WO1998042749A1 (xx) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6500933B1 (en) | 1997-09-05 | 2002-12-31 | Altus Biologics Inc. | Methods of preparing carbohydrate crosslinked glycoprotein crystals |
DK1009759T3 (da) | 1997-09-05 | 2008-08-04 | Altus Pharmaceuticals Inc | Carbohydrat-tværbundne glycoproteinkrystaller |
ZA989744B (en) * | 1997-10-31 | 2000-04-26 | Lilly Co Eli | Method for administering acylated insulin. |
US6541606B2 (en) | 1997-12-31 | 2003-04-01 | Altus Biologics Inc. | Stabilized protein crystals formulations containing them and methods of making them |
EP2311436A1 (en) | 1998-04-27 | 2011-04-20 | Altus Pharmaceuticals Inc. | Stabilized protein crystals, formulations containing them and methods of making them |
JP4965022B2 (ja) * | 1998-04-27 | 2012-07-04 | アルタス ファーマシューティカルズ インコーポレイテッド | 安定化されたタンパク質結晶、それを含む処方物、およびそれを作製する方法 |
DE19903125B4 (de) * | 1999-01-27 | 2006-01-05 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Trocknung von Kristallen von Insulin oder Insulinanaloga |
JP2002543092A (ja) * | 1999-04-27 | 2002-12-17 | イーライ・リリー・アンド・カンパニー | 肺投与用インスリン結晶 |
GB0011807D0 (en) * | 2000-05-16 | 2000-07-05 | Quadrant Holdings Cambridge | Formulation for inhalation |
DE10114178A1 (de) | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
DE10227232A1 (de) | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Saure Insulinzubereitungen mit verbesserter Stabilität |
US7193035B2 (en) | 2002-10-29 | 2007-03-20 | Sanofi-Aventis Deutschland Gmbh | Crystals of insulin analogs and processes for their preparation |
DE10250297A1 (de) * | 2002-10-29 | 2004-05-19 | Aventis Pharma Deutschland Gmbh | Kristalle von Insulinanaloga und Verfahren zu ihrer Herstellung |
EP2107069B1 (en) * | 2003-08-05 | 2013-01-16 | Novo Nordisk A/S | Novel insulin derivatives |
JP4601627B2 (ja) | 2004-01-16 | 2010-12-22 | バイオデル, インコーポレイテッド | 舌下薬物送達デバイス |
US20080090753A1 (en) | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
KR100798333B1 (ko) * | 2005-08-03 | 2008-01-28 | 고려대학교 산학협력단 | 락토오스 운반체와 혼합건조된 폐 전달용 인슐린미세결정분말 |
HUE037449T2 (hu) | 2008-10-17 | 2018-08-28 | Sanofi Aventis Deutschland | Egy inzulin és egy GLP-1 agonista kombinációja |
US9060927B2 (en) | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
MX346473B (es) * | 2009-08-11 | 2017-03-22 | Biocon Ltd | Procesos cromatograficos y compuestos purificados de los mismos. |
PE20121316A1 (es) | 2009-11-13 | 2012-10-05 | Sanofi Aventis Deutschland | Composicion farmaceutica que comprende un agonista de glp-1 y metionina |
RU2537239C2 (ru) | 2009-11-13 | 2014-12-27 | Санофи-Авентис Дойчланд Гмбх | Фармацевтическая композиция, включающая агонист glp-1, инсулин и метионин |
PT2611458T (pt) | 2010-08-30 | 2016-12-16 | Sanofi Aventis Deutschland | Utilização de ave0010 para o fabrico de um medicamento para o tratamento da diabetes mellitus tipo 2 |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
PT2750699E (pt) | 2011-08-29 | 2015-11-03 | Sanofi Aventis Deutschland | Acelerómetro pendular |
TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
AR099569A1 (es) | 2014-02-28 | 2016-08-03 | Novo Nordisk As | Derivados de insulina y los usos médicos de estos |
EP3166595B1 (en) * | 2014-07-08 | 2019-05-15 | Amphastar Pharmaceuticals, Inc. | Micronized insulin, micronized insulin analogues, and methods of manufacturing the same |
CA2970200A1 (en) | 2014-12-12 | 2016-06-16 | Sanofi-Aventis Deutschland Gmbh | Insulin glargine/lixisenatide fixed ratio formulation |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患之治療 |
CN104761632A (zh) * | 2015-04-14 | 2015-07-08 | 珠海联邦制药股份有限公司 | 一种地特胰岛素结晶的制备方法及应用 |
CN106117345B (zh) * | 2015-05-05 | 2020-11-24 | 宜昌东阳光长江药业股份有限公司 | 一种制备甘精胰岛素结晶的方法 |
JP2018531900A (ja) | 2015-08-25 | 2018-11-01 | ノヴォ ノルディスク アー/エス | 新規インスリン誘導体及びその医学的使用 |
US20180244743A1 (en) | 2015-08-25 | 2018-08-30 | Novo Nordisk A/S | Novel Insulin Derivatives and the Medical Uses Hereof |
JP2018531901A (ja) | 2015-08-25 | 2018-11-01 | ノヴォ ノルディスク アー/エス | 新規インスリン誘導体及びその医学的使用 |
US10322168B2 (en) | 2016-01-07 | 2019-06-18 | Amphastar Pharmaceuticals, Inc. | High-purity inhalable particles of insulin and insulin analogues, and high-efficiency methods of manufacturing the same |
CN106749616B (zh) * | 2016-12-19 | 2021-09-03 | 华润昂德生物药业有限公司 | B30位苏氨酸缺失人胰岛素晶体的制备方法 |
CN109957001B (zh) * | 2017-12-26 | 2022-11-18 | 甘李药业股份有限公司 | 甘赖脯胰岛素结晶的制备方法 |
PL238016B1 (pl) * | 2018-07-06 | 2021-06-28 | Bioton Spolka Akcyjna | Krystaliczna, bezcynkowa postać insuliny glargine i sposób jej otrzymywania |
AU2020402135A1 (en) | 2019-12-11 | 2022-06-02 | Novo Nordisk A/S | Novel insulin analogues and uses thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3719655A (en) * | 1969-12-05 | 1973-03-06 | Lilly Co Eli | Process for the crystallization of the ammonium and alkali metal salts in insulin |
DE3327928A1 (de) * | 1983-08-03 | 1985-02-21 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von insulin-derivaten |
US5506203C1 (en) * | 1993-06-24 | 2001-02-06 | Astra Ab | Systemic administration of a therapeutic preparation |
AU682061B2 (en) * | 1993-09-17 | 1997-09-18 | Novo Nordisk A/S | Acylated insulin |
PT748213E (pt) * | 1994-03-07 | 2004-08-31 | Nektar Therapeutics | Metodos e composicoes para administracao pulmonar de insulina |
JP3414539B2 (ja) * | 1994-05-11 | 2003-06-09 | 有限会社ドット | 経鼻吸収用組成物 |
US5597893A (en) * | 1994-10-31 | 1997-01-28 | Eli Lilly And Company | Preparation of stable insulin analog crystals |
US5700904A (en) * | 1995-06-07 | 1997-12-23 | Eli Lilly And Company | Preparation of an acylated protein powder |
US5898067A (en) * | 1997-02-07 | 1999-04-27 | Novo Nordisk A/S | Crystallization of proteins |
US6310038B1 (en) * | 1997-03-20 | 2001-10-30 | Novo Nordisk A/S | Pulmonary insulin crystals |
DE10114178A1 (de) * | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
-
1998
- 1998-03-20 EP EP98907916A patent/EP1005490B1/en not_active Expired - Lifetime
- 1998-03-20 JP JP54474798A patent/JP3764174B2/ja not_active Expired - Fee Related
- 1998-03-20 CA CA002283705A patent/CA2283705A1/en not_active Abandoned
- 1998-03-20 BR BR9808285-0A patent/BR9808285A/pt not_active IP Right Cessation
- 1998-03-20 ES ES98907916T patent/ES2260832T3/es not_active Expired - Lifetime
- 1998-03-20 KR KR1019997008523A patent/KR20000076419A/ko not_active Application Discontinuation
- 1998-03-20 DE DE69834028T patent/DE69834028T2/de not_active Expired - Lifetime
- 1998-03-20 IL IL13179698A patent/IL131796A0/xx unknown
- 1998-03-20 AU AU66120/98A patent/AU742591B2/en not_active Ceased
- 1998-03-20 PL PL98335777A patent/PL335777A1/xx unknown
- 1998-03-20 RU RU99122036/04A patent/RU2198181C2/ru not_active IP Right Cessation
- 1998-03-20 WO PCT/DK1998/000109 patent/WO1998042749A1/en active IP Right Grant
- 1998-03-20 EP EP05109987A patent/EP1627642A3/en not_active Withdrawn
- 1998-03-20 AT AT98907916T patent/ATE321783T1/de not_active IP Right Cessation
- 1998-03-20 CN CN98805938A patent/CN1259142A/zh active Pending
- 1998-03-20 HU HU0000547A patent/HUP0000547A3/hu unknown
-
1999
- 1999-09-17 NO NO994520A patent/NO994520D0/no unknown
-
2006
- 2006-01-23 US US11/337,855 patent/US20070093411A1/en not_active Abandoned
-
2007
- 2007-07-06 US US11/774,027 patent/US20090311326A9/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20070093411A1 (en) | 2007-04-26 |
AU742591B2 (en) | 2002-01-10 |
US20070292520A1 (en) | 2007-12-20 |
HUP0000547A3 (en) | 2002-11-28 |
DE69834028T2 (de) | 2006-12-07 |
CN1259142A (zh) | 2000-07-05 |
KR20000076419A (ko) | 2000-12-26 |
EP1005490B1 (en) | 2006-03-29 |
ATE321783T1 (de) | 2006-04-15 |
JP2001506272A (ja) | 2001-05-15 |
ES2260832T3 (es) | 2006-11-01 |
NO994520L (no) | 1999-09-17 |
WO1998042749A1 (en) | 1998-10-01 |
US20090311326A9 (en) | 2009-12-17 |
EP1627642A2 (en) | 2006-02-22 |
DE69834028D1 (de) | 2006-05-18 |
EP1627642A3 (en) | 2006-04-19 |
AU6612098A (en) | 1998-10-20 |
JP3764174B2 (ja) | 2006-04-05 |
NO994520D0 (no) | 1999-09-17 |
CA2283705A1 (en) | 1998-10-01 |
PL335777A1 (en) | 2000-05-22 |
HUP0000547A2 (hu) | 2000-08-28 |
BR9808285A (pt) | 2000-05-16 |
RU2198181C2 (ru) | 2003-02-10 |
EP1005490A1 (en) | 2000-06-07 |
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