IL122242A - Combination of an angiotensin II receptor antigen and an epoxy-steroidal aldosterone receptor antigen - Google Patents

Combination of an angiotensin II receptor antigen and an epoxy-steroidal aldosterone receptor antigen

Info

Publication number
IL122242A
IL122242A IL12224296A IL12224296A IL122242A IL 122242 A IL122242 A IL 122242A IL 12224296 A IL12224296 A IL 12224296A IL 12224296 A IL12224296 A IL 12224296A IL 122242 A IL122242 A IL 122242A
Authority
IL
Israel
Prior art keywords
angiotensin
epoxy
receptor antagonist
compound
oxo
Prior art date
Application number
IL12224296A
Other languages
English (en)
Hebrew (he)
Other versions
IL122242A0 (en
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of IL122242A0 publication Critical patent/IL122242A0/xx
Publication of IL122242A publication Critical patent/IL122242A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL12224296A 1995-06-07 1996-06-05 Combination of an angiotensin II receptor antigen and an epoxy-steroidal aldosterone receptor antigen IL122242A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48645695A 1995-06-07 1995-06-07
PCT/US1996/009335 WO1996040257A1 (fr) 1995-06-07 1996-06-05 Therapie mixte a base d'un antagoniste epoxy-steroidien de l'aldosterone et d'un antagoniste de l'angiotensine ii pour le traitement de l'insuffisance cardiaque globale

Publications (2)

Publication Number Publication Date
IL122242A0 IL122242A0 (en) 1998-04-05
IL122242A true IL122242A (en) 2001-07-24

Family

ID=23931955

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12224296A IL122242A (en) 1995-06-07 1996-06-05 Combination of an angiotensin II receptor antigen and an epoxy-steroidal aldosterone receptor antigen

Country Status (21)

Country Link
US (1) US6653306B1 (fr)
EP (1) EP0831910B1 (fr)
JP (1) JPH11507627A (fr)
KR (1) KR100618466B1 (fr)
CN (2) CN1522701A (fr)
AT (1) ATE209047T1 (fr)
AU (1) AU725689B2 (fr)
BR (1) BR9609066A (fr)
CA (1) CA2224079A1 (fr)
CZ (1) CZ297975B6 (fr)
DE (1) DE69617235T2 (fr)
DK (1) DK0831910T3 (fr)
ES (1) ES2167571T3 (fr)
IL (1) IL122242A (fr)
NO (1) NO318184B1 (fr)
NZ (1) NZ310730A (fr)
PL (1) PL185150B1 (fr)
PT (1) PT831910E (fr)
RO (1) RO118046B1 (fr)
RU (1) RU2166330C2 (fr)
WO (1) WO1996040257A1 (fr)

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US6201002B1 (en) 1997-01-10 2001-03-13 Merck & Co., Inc. Method for reducing mortality with an angiotensin II antagonist
IL130599A0 (en) * 1997-01-10 2000-06-01 Merck & Co Inc Use of angiotensin II antagonists to treat symptomatic heart failure
US6306826B1 (en) 1997-06-04 2001-10-23 The Regents Of The University Of California Treatment of heart failure with growth hormone
NZ514205A (en) * 1999-03-05 2004-07-30 G Combination therapy of angiotensin converting enzyme inhibitor and the epoxy-steroidal aldosterone antagonist eplerenone for treatment of cardiovascular disease
US6211217B1 (en) 1999-03-16 2001-04-03 Novartis Ag Method for reducing pericardial fibrosis and adhesion formation
US20030083342A1 (en) * 2002-08-27 2003-05-01 Steele Ronald Edward Combination of organic compounds
CA2409437A1 (fr) * 2000-05-11 2001-11-22 Pharmacia Corporation Composition antagoniste de l'aldosterone destinee a etre liberee durant l'acrophase de l'aldosterone
AU2001278045B2 (en) * 2000-07-27 2006-08-03 Pharmacia Corporation Epoxy-steroidal aldosterone antagonist and calcium channel blocker combination therapy for treatment of congestive heart failure
AU2001282990A1 (en) * 2000-07-27 2002-02-13 Pharmacia Corporation Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
JP5082033B2 (ja) 2001-12-21 2012-11-28 エグゼリクシス パテント カンパニー エルエルシー Ｌｘｒのモジュレーター
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US20070123498A1 (en) * 2003-10-17 2007-05-31 Shetty Suraj S Combination of organic compounds
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WO2006068760A2 (fr) 2004-11-19 2006-06-29 The Regents Of The University Of California Pyrazolopyrimidines anti-inflammatoires
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US7585868B2 (en) 2006-04-04 2009-09-08 The Regents Of The University Of California Substituted pyrazolo[3,4-D]pyrimidines as kinase antagonists
US20110160232A1 (en) 2007-10-04 2011-06-30 Pingda Ren Certain chemical entities and therapeutic uses thereof
WO2009088990A1 (fr) 2008-01-04 2009-07-16 Intellikine, Inc. Entités chimiques, compositions et procédés
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
US8637542B2 (en) 2008-03-14 2014-01-28 Intellikine, Inc. Kinase inhibitors and methods of use
WO2009114874A2 (fr) 2008-03-14 2009-09-17 Intellikine, Inc. Inhibiteurs de kinases (benzothiazole) et procédés d’utilisation associés
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WO2010006072A2 (fr) 2008-07-08 2010-01-14 The Regents Of The University Of California Modulateurs de mtor et leurs utilisations
WO2010036380A1 (fr) 2008-09-26 2010-04-01 Intellikine, Inc. Inhibiteurs hétérocycliques de kinases
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US8476282B2 (en) 2008-11-03 2013-07-02 Intellikine Llc Benzoxazole kinase inhibitors and methods of use
PE20120593A1 (es) 2009-01-30 2012-05-21 Takeda Pharmaceutical Derivados fusionados de pirimidin-4-ona como antagonistas del receptor de angiotensina ii y como agonistas del receptor ppar gamma
WO2010129816A2 (fr) 2009-05-07 2010-11-11 Intellikine, Inc. Composés hétérocycliques et leurs utilisations
WO2011047384A2 (fr) 2009-10-16 2011-04-21 The Regents Of The University Of California Procédés d'inhibition de l'activité ire1
WO2011146882A1 (fr) 2010-05-21 2011-11-24 Intellikine, Inc. Composés chimiques, compositions et procédés pour modulation de kinases
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CA2943075C (fr) 2014-03-19 2023-02-28 Infinity Pharmaceuticals, Inc. Composes heterocycliques destines a etre utilises dans le traitement de troubles medies par pi3k-gamma
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US5529992A (en) * 1992-04-21 1996-06-25 Curators Of The University Of Missouri Method for inhibiting myocardial fibrosis by administering an aldosterone antagonist which suppresses aldoster one receptors
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Also Published As

Publication number Publication date
AU725689B2 (en) 2000-10-19
JPH11507627A (ja) 1999-07-06
AU6157796A (en) 1996-12-30
CA2224079A1 (fr) 1996-12-19
NO318184B1 (no) 2005-02-14
DE69617235D1 (de) 2002-01-03
CZ297975B6 (cs) 2007-05-09
PL324001A1 (en) 1998-04-27
PL185150B1 (pl) 2003-03-31
PT831910E (pt) 2002-05-31
CN1192697A (zh) 1998-09-09
RO118046B1 (ro) 2003-01-30
ES2167571T3 (es) 2002-05-16
ATE209047T1 (de) 2001-12-15
NO975741D0 (no) 1997-12-05
CZ385097A3 (cs) 1998-06-17
NO975741L (no) 1998-01-29
DE69617235T2 (de) 2002-07-25
EP0831910A1 (fr) 1998-04-01
US6653306B1 (en) 2003-11-25
BR9609066A (pt) 1999-01-26
IL122242A0 (en) 1998-04-05
RU2166330C2 (ru) 2001-05-10
EP0831910B1 (fr) 2001-11-21
DK0831910T3 (da) 2002-05-21
NZ310730A (en) 2001-01-26
KR100618466B1 (ko) 2006-12-13
CN1142793C (zh) 2004-03-24
KR19990022548A (ko) 1999-03-25
CN1522701A (zh) 2004-08-25
WO1996040257A1 (fr) 1996-12-19

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