IL121000A - Process for preparing sildenafil - Google Patents

Process for preparing sildenafil

Info

Publication number: IL121000A
Authority: IL; Israel
Prior art keywords: preparing sildenafil; sildenafil; preparing
Prior art date: 1996-06-14

Application number

IL12100097A

Other languages

English (en)

Other versions

IL121000A0 (en

Original Assignee

Pfizer Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-14

Filing date

1997-06-05

Publication date

2000-02-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10795332&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL121000(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-06-05 Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev

1997-06-05 Priority to IL12541197A priority Critical patent/IL125411A/xx

1997-11-20 Publication of IL121000A0 publication Critical patent/IL121000A0/xx

2000-02-29 Publication of IL121000A publication Critical patent/IL121000A/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Gynecology & Obstetrics (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Steroid Compounds (AREA)

IL12100097A 1996-06-14 1997-06-05 Process for preparing sildenafil IL121000A (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
IL12541197A IL125411A (en)	1996-06-14	1997-06-05	Preparation of the sildenafil precursor 4-¬2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)-benzamido¾-1-methyl 3-n-propylpyrazole-5-carboxamide and the 2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)-benzoic acid intermediate therefor

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9612514.1A GB9612514D0 (en)	1996-06-14	1996-06-14	Novel process

Publications (2)

Publication Number	Publication Date
IL121000A0 IL121000A0 (en)	1997-11-20
IL121000A true IL121000A (en)	2000-02-29

Family

ID=10795332

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
IL12541197A IL125411A (en)	1996-06-14	1997-06-05	Preparation of the sildenafil precursor 4-¬2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)-benzamido¾-1-methyl 3-n-propylpyrazole-5-carboxamide and the 2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)-benzoic acid intermediate therefor
IL12100097A IL121000A (en)	1996-06-14	1997-06-05	Process for preparing sildenafil
IL12541198A IL125411A0 (en)	1996-06-14	1998-07-20	Sildenafil precursor and process for preparing it

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
IL12541197A IL125411A (en)	1996-06-14	1997-06-05	Preparation of the sildenafil precursor 4-¬2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)-benzamido¾-1-methyl 3-n-propylpyrazole-5-carboxamide and the 2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)-benzoic acid intermediate therefor

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL12541198A IL125411A0 (en)	1996-06-14	1998-07-20	Sildenafil precursor and process for preparing it

Country Status (48)

Country	Link
US (2)	US5955611A (ru)
EP (2)	EP0916675B1 (ru)
JP (2)	JP2866841B2 (ru)
KR (1)	KR100207352B1 (ru)
CN (2)	CN1106399C (ru)
AP (1)	AP717A (ru)
AR (1)	AR003401A1 (ru)
AT (2)	ATE246194T1 (ru)
AU (1)	AU697684B2 (ru)
BG (1)	BG62554B1 (ru)
BR (1)	BR9703580A (ru)
CA (1)	CA2207694C (ru)
CO (1)	CO4780028A1 (ru)
CZ (1)	CZ290942B6 (ru)
DE (2)	DE69700321T2 (ru)
DK (2)	DK0812845T3 (ru)
DZ (1)	DZ2247A1 (ru)
EA (1)	EA000102B1 (ru)
EG (1)	EG24123A (ru)
ES (2)	ES2134051T3 (ru)
GB (1)	GB9612514D0 (ru)
GR (1)	GR3031087T3 (ru)
HK (1)	HK1033459A1 (ru)
HN (1)	HN1997000072A (ru)
HR (1)	HRP970326B1 (ru)
HU (1)	HU224497B1 (ru)
ID (1)	ID18745A (ru)
IL (3)	IL125411A (ru)
IN (5)	IN187350B (ru)
IS (2)	IS1922B (ru)
MA (1)	MA24205A1 (ru)
MX (1)	MX9704433A (ru)
NO (2)	NO304551B1 (ru)
NZ (1)	NZ328084A (ru)
OA (1)	OA10426A (ru)
PE (2)	PE20011303A1 (ru)
PL (1)	PL189333B1 (ru)
PT (1)	PT916675E (ru)
RS (2)	RS49924B (ru)
SA (1)	SA97180124B1 (ru)
SG (1)	SG50024A1 (ru)
SI (2)	SI0916675T1 (ru)
SK (5)	SK283893B6 (ru)
TN (1)	TNSN97102A1 (ru)
TR (1)	TR199700470A2 (ru)
UA (1)	UA27085C2 (ru)
UY (2)	UY24585A1 (ru)
ZA (1)	ZA975259B (ru)

Families Citing this family (53)

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US20060222647A1 (en) *	1993-05-27	2006-10-05	Beavo Joseph A	Methods and compositions for modulating the activity of PDE5
ID22834A (id) *	1997-04-25	1999-12-09	Pfizer	Pirazolopimidinona untuk kelainan seksual
CN1309561A (zh) *	1997-05-29	2001-08-22	持田制药株式会社	***机能障碍治疗剂
US6399618B1 (en)	1997-07-09	2002-06-04	Cardiome Pharma Corp	Compositions and methods for modulating sexual activity
GB9722520D0 (en)	1997-10-24	1997-12-24	Pfizer Ltd	Compounds
PT1049695E (pt)	1997-11-12	2002-07-31	Bayer Ag	Imidazotriazinonas 2-fenil substituidas enquanto inibidores de fosfodiesterase
DK1073658T3 (da) *	1998-04-20	2003-12-08	Pfizer	Pyrazolopyrimidinon-cGMP PDE5-inhibitorer til behandling af sexualforstyrrelse
CA2235642C (en)	1998-05-15	2007-11-13	Torcan Chemical Ltd.	Processes for preparing sildenafil
DK1109814T3 (da) *	1998-09-04	2004-08-02	Ortho Mcneil Pharm Inc	5-Heterocyclylpyrazolo[4,3-d]pyrimidin-7-oner til behandling af mandlig erektil dysfunktion
GB9822238D0 (en) *	1998-10-12	1998-12-09	Pfizer Ltd	Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof
GB9823102D0 (en)	1998-10-23	1998-12-16	Pfizer Ltd	Pharmaceutically active compounds
GB9823103D0 (en)	1998-10-23	1998-12-16	Pfizer Ltd	Pharmaceutically active compounds
GB9823101D0 (en)	1998-10-23	1998-12-16	Pfizer Ltd	Pharmaceutically active compounds
KR100353014B1 (ko) *	1998-11-11	2002-09-18	동아제약 주식회사	발기부전 치료에 효과를 갖는 피라졸로피리미디논 화합물
US6087362A (en) *	1999-03-16	2000-07-11	Pentech Pharmaceuticals, Inc.	Apomorphine and sildenafil composition
AU5204800A (en) *	1999-06-21	2001-01-09	Biochemical Pharmaceutical Factory of Zhuhai Sez, The	Process for preparing sildenafil, and troche which comprises sildenafil and apomorphine
CN1094492C (zh) *	1999-06-21	2002-11-20	杭州神鹰医药化工有限公司	西地那非的制备方法
CN1077108C (zh) *	1999-07-13	2002-01-02	成都地奥制药集团有限公司	用于制备药物昔多芬的前体化合物
WO2001019827A1 (en) *	1999-09-13	2001-03-22	Cipla Ltd.	A novel process for the synthesis of sildenafil citrate
US6075028A (en) *	1999-09-23	2000-06-13	Graham; Richard	Method of treating Tourette's syndrome and related CNS disorders
TWI265925B (en) *	1999-10-11	2006-11-11	Pfizer	Pyrazolo[4,3-d]pyrimidin-7-ones useful in inhibiting type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases(cGMP PDE5), process and intermediates for their preparation, their uses and composition comprising them
NZ517324A (en)	1999-10-11	2003-09-26	Pfizer	5-(2-substituted-5-heterocyclylsulphonylpyrid-3-YL)- dihydropyrazolo[4,3-d]pyrimidin-7-ones as phosphodiesterase inhibitors
WO2001098303A1 (en) *	2000-06-22	2001-12-27	Pfizer Limited	Novel process for the preparation of pyrazolopyrimidinones
US6667398B2 (en)	2000-06-22	2003-12-23	Pfizer Inc	Process for the preparation of pyrazolopyrimidinones
US6730786B2 (en)	2000-06-22	2004-05-04	Pfizer Inc	Process for the preparation of pyrazolopyrimidinones
GB0015462D0 (en) *	2000-06-22	2000-08-16	Pfizer Ltd	Novel process for the preparation of pyrazolopyrimidinones
EP1176147A1 (en) *	2000-07-28	2002-01-30	Pfizer Limited	Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-ones and intermediates thereof
EP1176142A1 (en) *	2000-07-28	2002-01-30	Pfizer Inc.	Process for the preparation of pyrazoles
US6407259B1 (en)	2000-07-28	2002-06-18	Pfizer Inc.	Process for the preparation of pyrazoles
US6821978B2 (en)	2000-09-19	2004-11-23	Schering Corporation	Xanthine phosphodiesterase V inhibitors
CN1127506C (zh) *	2001-06-29	2003-11-12	刘宝顺	一种治疗阳痿的新化合物
CN1315835C (zh) *	2001-08-28	2007-05-16	先灵公司	多环鸟嘌呤磷酸二酯酶v抑制剂
SI1509525T1 (sl)	2002-05-31	2006-12-31	Schering Corp	Postopek priprave inhibitorjev ksantinske fosfodiesteraze V in njihovih prekurzorjev
DE10232113A1 (de)	2002-07-16	2004-01-29	Bayer Ag	Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
CN100374441C (zh)	2003-06-06	2008-03-12	天津倍方科技发展有限公司	二氢吡咯[2，3-d]嘧啶-4-酮衍生物，其制备方法及其制药用途
CN100360531C (zh) *	2003-12-18	2008-01-09	中国人民解放军军事医学科学院放射与辐射医学研究所	用于预防或治疗阳萎和***的新吡唑并嘧啶类化合物
ATE387203T1 (de) *	2004-01-05	2008-03-15	Teva Pharma	Prozesse zur herstellung von sildenafil-base und zitratsalz
EP1779852A3 (en) *	2004-01-05	2007-05-09	Teva Pharmaceutical Industries Ltd.	Processes for the production of sildenafil base and citrate salt
DE102005009240A1 (de)	2005-03-01	2006-09-07	Bayer Healthcare Ag	Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
WO2008074194A1 (fr) *	2006-12-21	2008-06-26	Topharman Shanghai Co., Ltd.	Procédé de préparation du sildénafil et de ses intermédiaires
ES2310144B1 (es)	2007-06-15	2010-01-12	Galenicum Health, S.L.	Intermedios para la preparacion de un inhibidor de la fosfodiesterasa tipo 5.
EP2374460A4 (en)	2008-12-12	2013-08-21	Rhein Siegfried Sa De Cv	SILDENAFIL COMPOSITION WITH PULSED RELEASE AND METHOD FOR PRODUCING THIS COMPOSITION
MX2010006227A (es)	2010-06-07	2011-12-14	World Trade Imp Exp Wtie Ag	Nuevos derivados 1,4-diazepanos, inhibidores de pde-5.
CN102993205B (zh) *	2012-12-27	2015-04-15	华润赛科药业有限责任公司	一种高收率制备高纯度西地那非游离碱的纯化方法
CN103044330B (zh) *	2013-01-14	2018-11-13	常州亚邦制药有限公司	西地那非中间体4-氨基-1-甲基-3-正丙基吡唑-5-甲酰胺的绿色合成新工艺
CN105085526B (zh) *	2014-05-15	2017-08-01	重庆圣华曦药业股份有限公司	一种改进的西地那非制备方法
CN105753870B (zh) *	2016-04-01	2018-05-22	重庆康刻尔制药有限公司	一种西地那非杂质f及其制备方法和应用
WO2017168174A1 (en)	2016-04-02	2017-10-05	N4 Pharma Uk Limited	New pharmaceutical forms of sildenafil
CN105837578A (zh) *	2016-04-05	2016-08-10	重庆康刻尔制药有限公司	一种西地那非杂质d的合成方法
WO2018069316A2 (en)	2016-10-10	2018-04-19	Transgene Sa	Immunotherapeutic product and mdsc modulator combination therapy
CN113493459B (zh) *	2020-04-07	2022-12-13	广州白云山医药集团股份有限公司白云山制药总厂	Pde5抑制剂化合物及其制备方法和应用
CN112961160A (zh) *	2021-03-05	2021-06-15	遂成药业股份有限公司	一种西地那非的改良合成工艺
CN113754612B (zh) *	2021-10-26	2023-09-26	山东安舜制药有限公司	一种西地那非中间体的制备方法

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US4871843A (en) *	1983-10-18	1989-10-03	Dropic-Societe Civile De Gestion De Droits De Propriete Industrielle	Cyclic benzenesulfonamides, process for their preparation and their use as active substance of pharmaceutical compositions
GB9013750D0 (en) *	1990-06-20	1990-08-08	Pfizer Ltd	Therapeutic agents
GB9114760D0 (en) *	1991-07-09	1991-08-28	Pfizer Ltd	Therapeutic agents
GB9301192D0 (en) *	1993-06-09	1993-06-09	Trott Francis W	Flower shaped mechanised table
ID22834A (id) *	1997-04-25	1999-12-09	Pfizer	Pirazolopimidinona untuk kelainan seksual
US6087368A (en) *	1998-06-08	2000-07-11	Bristol-Myers Squibb Company	Quinazolinone inhibitors of cGMP phosphodiesterase

1996
- 1996-06-14 GB GBGB9612514.1A patent/GB9612514D0/en active Pending
1997
- 1997-05-14 HN HN1997000072A patent/HN1997000072A/es unknown
- 1997-05-30 NO NO972481A patent/NO304551B1/no not_active IP Right Cessation
- 1997-06-02 AP APAP/P/1997/001009A patent/AP717A/en active
- 1997-06-04 EP EP98123740A patent/EP0916675B1/en not_active Expired - Lifetime
- 1997-06-04 SI SI9730577T patent/SI0916675T1/xx unknown
- 1997-06-04 DK DK97303832T patent/DK0812845T3/da active
- 1997-06-04 PT PT98123740T patent/PT916675E/pt unknown
- 1997-06-04 EP EP97303832A patent/EP0812845B1/en not_active Expired - Lifetime
- 1997-06-04 DK DK98123740T patent/DK0916675T3/da active
- 1997-06-04 ES ES97303832T patent/ES2134051T3/es not_active Expired - Lifetime
- 1997-06-04 ES ES98123740T patent/ES2201397T3/es not_active Expired - Lifetime
- 1997-06-04 AT AT98123740T patent/ATE246194T1/de active
- 1997-06-04 DE DE69700321T patent/DE69700321T2/de not_active Expired - Lifetime
- 1997-06-04 SI SI9730005T patent/SI0812845T1/xx not_active IP Right Cessation
- 1997-06-04 DE DE69723846T patent/DE69723846T2/de not_active Expired - Lifetime
- 1997-06-04 AT AT97303832T patent/ATE182150T1/de active
- 1997-06-05 IL IL12541197A patent/IL125411A/xx not_active IP Right Cessation
- 1997-06-05 IL IL12100097A patent/IL121000A/xx not_active IP Right Cessation
- 1997-06-05 TR TR97/00470A patent/TR199700470A2/xx unknown
- 1997-06-05 BG BG101569A patent/BG62554B1/bg unknown
- 1997-06-06 US US08/869,532 patent/US5955611A/en not_active Expired - Lifetime
- 1997-06-10 SK SK743-97A patent/SK283893B6/sk not_active IP Right Cessation
- 1997-06-10 SK SK1786-2001A patent/SK283896B6/sk not_active IP Right Cessation
- 1997-06-10 SK SK1787-2001A patent/SK283897B6/sk not_active IP Right Cessation
- 1997-06-10 SK SK1784-2001A patent/SK283895B6/sk not_active IP Right Cessation
- 1997-06-10 SK SK1783-2001A patent/SK283894B6/sk not_active IP Right Cessation
- 1997-06-10 SA SA97180124A patent/SA97180124B1/ar unknown
- 1997-06-10 IN IN1548DE1997 patent/IN187350B/en unknown
- 1997-06-10 IS IS4503A patent/IS1922B/is unknown
- 1997-06-11 MA MA24655A patent/MA24205A1/fr unknown
- 1997-06-11 PE PE2001000983A patent/PE20011303A1/es not_active IP Right Cessation
- 1997-06-11 EA EA199700061A patent/EA000102B1/ru not_active IP Right Cessation
- 1997-06-11 PE PE1997000483A patent/PE1299A1/es not_active IP Right Cessation
- 1997-06-11 TN TNTNSN97102A patent/TNSN97102A1/fr unknown
- 1997-06-11 DZ DZ970097A patent/DZ2247A1/fr active
- 1997-06-12 SG SG1997002037A patent/SG50024A1/en unknown
- 1997-06-12 CA CA002207694A patent/CA2207694C/en not_active Expired - Lifetime
- 1997-06-12 UA UA97062802A patent/UA27085C2/ru unknown
- 1997-06-12 ID IDP972004A patent/ID18745A/id unknown
- 1997-06-12 CZ CZ19971811A patent/CZ290942B6/cs not_active IP Right Cessation
- 1997-06-12 AR ARP970102564A patent/AR003401A1/es unknown
- 1997-06-12 EG EG54097A patent/EG24123A/xx active
- 1997-06-13 HU HU9701048A patent/HU224497B1/hu not_active IP Right Cessation
- 1997-06-13 JP JP9156422A patent/JP2866841B2/ja not_active Expired - Lifetime
- 1997-06-13 PL PL97320555A patent/PL189333B1/pl not_active IP Right Cessation
- 1997-06-13 KR KR1019970024457A patent/KR100207352B1/ko not_active IP Right Cessation
- 1997-06-13 CN CN97113261A patent/CN1106399C/zh not_active Expired - Lifetime
- 1997-06-13 AU AU24878/97A patent/AU697684B2/en not_active Ceased
- 1997-06-13 NZ NZ328084A patent/NZ328084A/en not_active IP Right Cessation
- 1997-06-13 ZA ZA9705259A patent/ZA975259B/xx unknown
- 1997-06-13 RS YUP-2006/0484A patent/RS49924B/sr unknown
- 1997-06-13 CO CO97032741A patent/CO4780028A1/es unknown
- 1997-06-13 HR HR970326A patent/HRP970326B1/xx not_active IP Right Cessation
- 1997-06-13 OA OA70024A patent/OA10426A/en unknown
- 1997-06-13 UY UY24585A patent/UY24585A1/es not_active IP Right Cessation
- 1997-06-13 MX MX9704433A patent/MX9704433A/es unknown
- 1997-06-13 RS YUP-254/97A patent/RS49653B/sr unknown
- 1997-06-16 BR BR9703580A patent/BR9703580A/pt not_active IP Right Cessation
- 1997-07-09 UY UY24612A patent/UY24612A1/es not_active IP Right Cessation
1998
- 1998-07-20 IL IL12541198A patent/IL125411A0/xx unknown
- 1998-09-25 JP JP10271067A patent/JP3058863B2/ja not_active Expired - Lifetime
- 1998-10-30 NO NO985064A patent/NO306115B1/no not_active IP Right Cessation
1999
- 1999-07-23 US US09/360,128 patent/US6066735A/en not_active Expired - Lifetime
- 1999-08-26 GR GR990402170T patent/GR3031087T3/el unknown
2000
- 2000-07-05 CN CNB001200542A patent/CN1149206C/zh not_active Expired - Lifetime
2001
- 2001-04-24 IN IN517DE2001 patent/IN187317B/en unknown
- 2001-04-24 IN IN519DE2001 patent/IN187319B/en unknown
- 2001-04-24 IN IN520DE2001 patent/IN187320B/en unknown
- 2001-04-24 IN IN518DE2001 patent/IN187318B/en unknown
- 2001-06-15 HK HK01104141A patent/HK1033459A1/xx not_active IP Right Cessation
2002
- 2002-11-25 IS IS6634A patent/IS1923B/is unknown

Also Published As

Publication number	Publication date
EP0916675B1 (en)	2003-07-30
IN187318B (ru)	2002-03-23
AU2487897A (en)	1997-12-18
CO4780028A1 (es)	1999-05-26
DK0916675T3 (da)	2003-10-27
ATE246194T1 (de)	2003-08-15
DE69700321T2 (de)	1999-11-04
IS1922B (is)	2004-03-15
TNSN97102A1 (fr)	2005-03-15
RS20060484A (en)	2007-04-10
DE69723846D1 (de)	2003-09-04
TR199700470A2 (xx)	1998-01-21
HU9701048D0 (en)	1997-08-28
PL189333B1 (pl)	2005-07-29
RS49653B (sr)	2007-09-21
JP3058863B2 (ja)	2000-07-04
SA97180124A (ar)	2005-12-03
HK1033459A1 (en)	2001-08-31
AU697684B2 (en)	1998-10-15
DZ2247A1 (fr)	2002-12-18
IN187317B (ru)	2002-03-23
US5955611A (en)	1999-09-21
IS1923B (is)	2004-03-15
SI0812845T1 (en)	1999-12-31
MA24205A1 (fr)	1997-12-31
DE69700321D1 (de)	1999-08-19
EG24123A (en)	2008-07-06
CZ290942B6 (cs)	2002-11-13
ES2134051T3 (es)	1999-09-16
GB9612514D0 (en)	1996-08-14
IS6634A (is)	2002-11-25
HRP970326B1 (en)	2000-10-31
JP2866841B2 (ja)	1999-03-08
SK283896B6 (sk)	2004-04-06
EA000102B1 (ru)	1998-08-27
IL125411A0 (en)	1999-03-12
SK283893B6 (sk)	2004-04-06
JPH1081688A (ja)	1998-03-31
PT916675E (pt)	2003-11-28
ATE182150T1 (de)	1999-07-15
NO972481D0 (no)	1997-05-30
GR3031087T3 (en)	1999-12-31
CN1106399C (zh)	2003-04-23
EA199700061A1 (ru)	1997-12-30
SG50024A1 (en)	1998-06-15
BG62554B1 (bg)	2000-02-29
HN1997000072A (es)	1997-12-26
CN1282740A (zh)	2001-02-07
EP0812845A1 (en)	1997-12-17
SK283897B6 (sk)	2004-04-06
MX9704433A (es)	1998-11-30
PE20011303A1 (es)	2001-12-25
PE1299A1 (es)	1999-01-13
NZ328084A (en)	1998-08-26
NO985064L (no)	1997-12-15
IS4503A (is)	1997-12-15
CZ181197A3 (cs)	1998-03-18
BG101569A (en)	1998-01-30
CA2207694C (en)	1999-11-23
HUP9701048A2 (hu)	1998-12-28
EP0916675A3 (en)	1999-07-14
AR003401A1 (es)	1998-08-05
SI0916675T1 (en)	2003-12-31
HUP9701048A3 (en)	2000-10-30
EP0812845B1 (en)	1999-07-14
JPH11171879A (ja)	1999-06-29
NO972481L (no)	1997-12-15
ID18745A (id)	1998-05-07
YU25497A (sh)	1998-12-23
HRP970326A2 (en)	1998-06-30
AP717A (en)	1999-01-04
IN187350B (ru)	2002-03-30
SK283895B6 (sk)	2004-04-06
SA97180124B1 (ar)	2006-02-08
BR9703580A (pt)	1998-11-10
KR100207352B1 (en)	1999-07-15
IN187320B (ru)	2002-03-23
DE69723846T2 (de)	2004-03-04
UA27085C2 (ru)	2000-02-28
HU224497B1 (hu)	2005-10-28
PL320555A1 (en)	1997-12-22
EP0916675A2 (en)	1999-05-19
NO985064D0 (no)	1998-10-30
ZA975259B (en)	1997-12-15
IL125411A (en)	2000-02-29
DK0812845T3 (da)	1999-11-29
CN1149206C (zh)	2004-05-12
UY24612A1 (es)	2000-09-29
SK74397A3 (en)	1998-06-03
SK283894B6 (sk)	2004-04-06
UY24585A1 (es)	1997-12-02
IL121000A0 (en)	1997-11-20
NO304551B1 (no)	1999-01-11
NO306115B1 (no)	1999-09-20
AP9701009A0 (en)	1997-07-31
US6066735A (en)	2000-05-23
CN1168376A (zh)	1997-12-24
OA10426A (en)	2001-12-07
IN187319B (ru)	2002-03-23
KR980002051A (ko)	1998-03-30
RS49924B (sr)	2008-09-29
CA2207694A1 (en)	1997-12-14
ES2201397T3 (es)	2004-03-16

Legal Events

Date	Code	Title
2000-06-29	FF	Patent granted
2000-12-06	KB	Patent renewed
2004-02-19	HP	Change in proprietorship
2018-01-31	EXP	Patent expired

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