IL117105A - Derivatives of tetrahydrocarbazole process for their preparation and pharmaceutical preparations containing them - Google Patents
Derivatives of tetrahydrocarbazole process for their preparation and pharmaceutical preparations containing themInfo
- Publication number
- IL117105A IL117105A IL117105A IL11710592A IL117105A IL 117105 A IL117105 A IL 117105A IL 117105 A IL117105 A IL 117105A IL 11710592 A IL11710592 A IL 11710592A IL 117105 A IL117105 A IL 117105A
- Authority
- IL
- Israel
- Prior art keywords
- formula
- compound
- tetrahydrocarbazole
- give
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919113802A GB9113802D0 (en) | 1991-06-26 | 1991-06-26 | Medicaments |
IL102322A IL102322A (en) | 1991-06-26 | 1992-06-25 | Tetrahydrocarbazole derivatives for use as 5-ht1-like agonist medicaments |
Publications (1)
Publication Number | Publication Date |
---|---|
IL117105A true IL117105A (en) | 1998-01-04 |
Family
ID=10697363
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL117105A IL117105A (en) | 1991-06-26 | 1992-06-25 | Derivatives of tetrahydrocarbazole process for their preparation and pharmaceutical preparations containing them |
IL11710596A IL117105A0 (en) | 1991-06-26 | 1992-06-25 | Tetrahydrocarbazole derivatives process for their preparation and pharmaceutical compositions containing them |
IL117104A IL117104A (en) | 1991-06-26 | 1992-06-25 | Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them |
IL102322A IL102322A (en) | 1991-06-26 | 1992-06-25 | Tetrahydrocarbazole derivatives for use as 5-ht1-like agonist medicaments |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11710596A IL117105A0 (en) | 1991-06-26 | 1992-06-25 | Tetrahydrocarbazole derivatives process for their preparation and pharmaceutical compositions containing them |
IL117104A IL117104A (en) | 1991-06-26 | 1992-06-25 | Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them |
IL102322A IL102322A (en) | 1991-06-26 | 1992-06-25 | Tetrahydrocarbazole derivatives for use as 5-ht1-like agonist medicaments |
Country Status (35)
Country | Link |
---|---|
US (2) | US5464864A (hu) |
EP (1) | EP0591280B1 (hu) |
JP (1) | JP3261502B2 (hu) |
KR (1) | KR100251571B1 (hu) |
CN (1) | CN1034072C (hu) |
AP (1) | AP344A (hu) |
AT (1) | ATE170746T1 (hu) |
BR (2) | BR9206237A (hu) |
CA (1) | CA2113726C (hu) |
CZ (3) | CZ282083B6 (hu) |
DE (2) | DE69226953T2 (hu) |
DK (1) | DK0591280T3 (hu) |
FI (1) | FI103967B1 (hu) |
GB (1) | GB9113802D0 (hu) |
HK (1) | HK1014669A1 (hu) |
HU (1) | HU218907B (hu) |
IE (1) | IE922062A1 (hu) |
IL (4) | IL117105A (hu) |
LU (1) | LU90939I2 (hu) |
MA (1) | MA22563A1 (hu) |
MX (1) | MX9203444A (hu) |
NL (1) | NL300103I2 (hu) |
NO (2) | NO304774B1 (hu) |
NZ (1) | NZ243288A (hu) |
PL (3) | PL171034B1 (hu) |
PT (1) | PT100620B (hu) |
RU (1) | RU2137474C1 (hu) |
SA (1) | SA92130141B1 (hu) |
SG (1) | SG47877A1 (hu) |
SI (1) | SI9200125B (hu) |
SK (3) | SK280906B6 (hu) |
TW (1) | TW214544B (hu) |
UA (1) | UA41254C2 (hu) |
WO (1) | WO1993000086A1 (hu) |
ZA (1) | ZA924658B (hu) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9211277D0 (en) | 1992-05-28 | 1992-07-15 | Glaxo Group Inc | Pharmaceutical compositions |
GB9226530D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
US5616603A (en) * | 1995-05-26 | 1997-04-01 | Smithkline Beecham Plc | Enantiomers of carbazole derivatives as 5-HT1 -like agonists |
GB9226566D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
US5618948A (en) * | 1995-05-26 | 1997-04-08 | Smithkline Beecham P.L.C. | Process for preparing an enantiomer of a carbazole derivative |
DE69610793T2 (de) * | 1995-06-23 | 2001-05-03 | Eli Lilly And Co., Indianapolis | 6-Subsitituierte-1,2,3,4-tetrahydro-9H-Carbazole und 7-substituierte-1OH-Cyclohepta(7,6-B)-Indole |
US5917054A (en) * | 1995-07-18 | 1999-06-29 | Smithkline Beecham P.L.C. | Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists |
US5708187A (en) * | 1996-06-27 | 1998-01-13 | Eli Lilly And Company | 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists |
US5891885A (en) * | 1996-10-09 | 1999-04-06 | Algos Pharmaceutical Corporation | Method for treating migraine |
GB9723061D0 (en) * | 1997-10-31 | 1998-01-07 | Vanguard Medica Ltd | Medicaments |
US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
US6066092A (en) * | 1997-11-06 | 2000-05-23 | Cady; Roger K. | Preemptive prophylaxis of migraine device and method |
GB9808069D0 (en) * | 1998-04-16 | 1998-06-17 | Vanguard Medica Ltd | Novel processes |
GB9817911D0 (en) * | 1998-08-17 | 1998-10-14 | Vanguard Medica Ltd | New use |
US20030198669A1 (en) * | 2001-07-05 | 2003-10-23 | R.T. Alamo Ventures I, Llc | Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine |
US20030017175A1 (en) * | 2001-07-05 | 2003-01-23 | R.T. Alamo Ventures I, Inc. | Sublingual administration of dihydroergotamine for the treatment of migraine |
US6685951B2 (en) | 2001-07-05 | 2004-02-03 | R. T. Alamo Ventures I, Inc. | Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine |
US7297711B2 (en) | 2002-06-21 | 2007-11-20 | Suven Life Sciences Limited | Arylalkyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them |
DE60317333T2 (de) | 2002-06-21 | 2008-08-28 | Suven Life Sciences Ltd. | Tetracyklische arylsulfonylindole mit affinität zum serotonin rezeptor |
JP4782425B2 (ja) | 2002-11-28 | 2011-09-28 | スベン ライフ サイエンシズ リミティド | N−アリールスルホニル−3−アミノアルコキシインドール |
WO2004048330A1 (en) | 2002-11-28 | 2004-06-10 | Suven Life Sciences Limited | N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them |
EA009367B1 (ru) | 2002-12-18 | 2007-12-28 | Сувен Лайф Сайенсиз Лимитед | ПРОИЗВОДНЫЕ 5-ТИА-5-ДИОКСО-4b-АЗАИНДЕНО[2,1-a]ИНДЕНА, ОБЛАДАЮЩИЕ АФФИННОСТЬЮ К РЕЦЕПТОРУ СЕРОТОНИНА |
KR101411820B1 (ko) * | 2006-08-07 | 2014-06-24 | 액테리온 파마슈티칼 리미티드 | (3-아미노-1,2,3,4-테트라하이드로-9h-카르바졸-9-일)-아세트산 유도체 |
US8653066B2 (en) | 2006-10-09 | 2014-02-18 | Charleston Laboratories, Inc. | Pharmaceutical compositions |
PT2425820E (pt) | 2007-02-11 | 2015-08-04 | Map Pharmaceuticals Inc | Método de administração terapêutica de dhe para permitir o rápido alívio das enxaquecas ao mesmo tempo que minimiza o perfil de efeitos secundários |
US20090069399A1 (en) * | 2007-09-12 | 2009-03-12 | Protia, Llc | Deuterium-enriched frovatriptan |
US8124126B2 (en) | 2008-01-09 | 2012-02-28 | Charleston Laboratories, Inc. | Pharmaceutical compositions |
WO2010073253A1 (en) * | 2008-12-22 | 2010-07-01 | Natco Pharma Limited | Method for preparing an optically active frovatriptan |
EP3311667A1 (en) | 2009-07-08 | 2018-04-25 | Charleston Laboratories, Inc. | Pharmaceutical compositions |
US9204906B2 (en) | 2009-10-22 | 2015-12-08 | Nuvasive, Inc. | Posterior cervical fusion system and techniques |
US10098674B2 (en) | 2009-10-22 | 2018-10-16 | Nuvasive, Inc. | System and method for posterior cervical fusion |
EP2734634B1 (en) | 2011-07-22 | 2019-08-21 | The University of Chicago | Igf-1 for use in the treatment of migraine |
US9394314B2 (en) | 2012-12-21 | 2016-07-19 | Map Pharmaceuticals, Inc. | 8′-hydroxy-dihydroergotamine compounds and compositions |
EP2816030A1 (en) | 2013-06-20 | 2014-12-24 | Duke Chem, S. A. | Process for the preparation of frovatriptan and its enantiomer |
GB201312768D0 (en) * | 2013-07-17 | 2013-08-28 | Ge Healthcare Ltd | Work-up procedure |
WO2017152130A1 (en) | 2016-03-04 | 2017-09-08 | Charleston Laboratories, Inc. | Pharmaceutical compositions |
EP3766483A1 (en) | 2019-07-19 | 2021-01-20 | BioPharma Synergies, S. L. | Orodispersible powder composition comprising a triptan |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3642816A (en) * | 1967-08-10 | 1972-02-15 | Sterling Drug Inc | 3-acetamido-1 2 3 4-tetrahydrocarbazole |
US3959309A (en) * | 1968-01-24 | 1976-05-25 | Sterling Drug Inc. | 3-Amido-1,2,3,4-tetrahydrocarbazoles |
US4062864A (en) * | 1968-01-24 | 1977-12-13 | Sterling Drug Inc. | 3-Hydroxy carbazole derivatives |
US3592824A (en) * | 1970-03-12 | 1971-07-13 | Miles Lab | 3-substituted amino-1,2,3,4-tetrahydrocarbazoles |
US4172834A (en) * | 1971-08-16 | 1979-10-30 | Sterling Drug Inc. | 3-Amino-tetrahydrocarbazoles |
BE787537A (fr) * | 1971-08-16 | 1973-02-14 | Sterling Drug Inc | Tetrahydrocarbazoles |
US4257952A (en) * | 1977-06-06 | 1981-03-24 | Sterling Drug Inc. | 3-Amino-tetrahydrocarbazoles |
US4254134A (en) * | 1978-03-17 | 1981-03-03 | Endo Laboratories, Inc. | Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles |
EP0115607A1 (de) * | 1983-01-04 | 1984-08-15 | MERCK PATENT GmbH | Tetrahydrocarbazolderivate |
-
1991
- 1991-06-26 GB GB919113802A patent/GB9113802D0/en active Pending
-
1992
- 1992-06-17 UA UA93002251A patent/UA41254C2/uk unknown
- 1992-06-17 EP EP92912379A patent/EP0591280B1/en not_active Expired - Lifetime
- 1992-06-17 PL PL92311304A patent/PL171034B1/pl unknown
- 1992-06-17 CZ CS932861A patent/CZ282083B6/cs not_active IP Right Cessation
- 1992-06-17 SK SK1054-98A patent/SK280906B6/sk not_active IP Right Cessation
- 1992-06-17 US US08/167,846 patent/US5464864A/en not_active Expired - Lifetime
- 1992-06-17 CZ CZ961506A patent/CZ282327B6/cs not_active IP Right Cessation
- 1992-06-17 SK SK1319-93A patent/SK280905B6/sk not_active IP Right Cessation
- 1992-06-17 SK SK1685-98A patent/SK280907B6/sk not_active IP Right Cessation
- 1992-06-17 PL PL92301883A patent/PL169392B1/pl unknown
- 1992-06-17 DK DK92912379T patent/DK0591280T3/da active
- 1992-06-17 BR BR9206237A patent/BR9206237A/pt not_active Application Discontinuation
- 1992-06-17 DE DE69226953T patent/DE69226953T2/de not_active Expired - Lifetime
- 1992-06-17 RU RU93058534A patent/RU2137474C1/ru active Protection Beyond IP Right Term
- 1992-06-17 DE DE2002199042 patent/DE10299042I2/de active Active
- 1992-06-17 PL PL92307118A patent/PL169410B1/pl unknown
- 1992-06-17 HU HU9303731A patent/HU218907B/hu active IP Right Revival
- 1992-06-17 WO PCT/GB1992/001082 patent/WO1993000086A1/en active IP Right Grant
- 1992-06-17 AT AT92912379T patent/ATE170746T1/de active
- 1992-06-17 SG SG1996004938A patent/SG47877A1/en unknown
- 1992-06-17 CA CA002113726A patent/CA2113726C/en not_active Expired - Lifetime
- 1992-06-17 KR KR1019930704055A patent/KR100251571B1/ko not_active IP Right Cessation
- 1992-06-17 CZ CZ961505A patent/CZ282061B6/cs not_active IP Right Cessation
- 1992-06-17 JP JP51108692A patent/JP3261502B2/ja not_active Expired - Lifetime
- 1992-06-24 PT PT100620A patent/PT100620B/pt not_active IP Right Cessation
- 1992-06-24 NZ NZ243288A patent/NZ243288A/en not_active IP Right Cessation
- 1992-06-24 MA MA22853A patent/MA22563A1/fr unknown
- 1992-06-24 ZA ZA924658A patent/ZA924658B/xx unknown
- 1992-06-25 IL IL117105A patent/IL117105A/en not_active IP Right Cessation
- 1992-06-25 CN CN92108831A patent/CN1034072C/zh not_active Expired - Lifetime
- 1992-06-25 TW TW081104991A patent/TW214544B/zh not_active IP Right Cessation
- 1992-06-25 IL IL11710596A patent/IL117105A0/xx unknown
- 1992-06-25 IL IL117104A patent/IL117104A/xx not_active IP Right Cessation
- 1992-06-25 AP APAP/P/1992/000403A patent/AP344A/en active
- 1992-06-25 IL IL102322A patent/IL102322A/xx not_active IP Right Cessation
- 1992-06-26 MX MX9203444A patent/MX9203444A/es unknown
- 1992-06-26 SI SI9200125A patent/SI9200125B/sl unknown
- 1992-07-01 IE IE206292A patent/IE922062A1/en not_active IP Right Cessation
- 1992-10-04 SA SA92130141A patent/SA92130141B1/ar unknown
-
1993
- 1993-12-23 FI FI935842A patent/FI103967B1/fi not_active IP Right Cessation
- 1993-12-23 NO NO934759A patent/NO304774B1/no not_active IP Right Cessation
-
1995
- 1995-05-15 US US08/442,719 patent/US5637611A/en not_active Expired - Lifetime
-
1997
- 1997-05-06 BR BR1100460-6A patent/BR1100460A/pt active IP Right Grant
-
1998
- 1998-12-28 HK HK98116054A patent/HK1014669A1/xx not_active IP Right Cessation
-
2002
- 2002-07-24 LU LU90939C patent/LU90939I2/fr unknown
- 2002-10-14 NL NL300103C patent/NL300103I2/nl unknown
-
2005
- 2005-05-03 NO NO2005011C patent/NO2005011I2/no unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2113726C (en) | Use of tetrahydrocarbazone derivatives as 5ht1 receptor agonists | |
US5618947A (en) | Process of preparing enantiomers of carbazole derivatives | |
US5827871A (en) | Medicaments 1,2,3,4-tetrahydrocarbazoles and 5-HT1 agonist use thereof | |
US5612331A (en) | Tetrahydrocarbazole derivatives as 5-HT1-like agonists | |
EP0603432B1 (en) | Tetrahydrocarbazole derivatives for the manufacture of a medicament for the treatment of a disease where a 5-HT1-like agonist is indicated | |
US5616603A (en) | Enantiomers of carbazole derivatives as 5-HT1 -like agonists | |
US5618948A (en) | Process for preparing an enantiomer of a carbazole derivative | |
AU652842C (en) | Use of tetrahydrocarbazone derivatives as 5HT1 receptor agonists | |
CA2756876A1 (en) | A process for the preparation of frovatriptan and frovatriptan succinate and their synthetic intermediates | |
AU707990B2 (en) | Enantiomers of carbazole derivatives as 5-HT1-like agonists | |
NZ299232A (en) | (+)-6-carboxamido-3-n-ethylamino-1,2,3,4- tetrahydrocarbazoles; medicaments thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
EXP | Patent expired |