IL100542A - Esters of 16, 17-alkylidene-dioxy-6-and/or 9-fluoro-11,21-dihydroxy-pregna-4-ene (and-1-4-diene)-3,20-diones - Google Patents
Esters of 16, 17-alkylidene-dioxy-6-and/or 9-fluoro-11,21-dihydroxy-pregna-4-ene (and-1-4-diene)-3,20-dionesInfo
- Publication number
- IL100542A IL100542A IL10054291A IL10054291A IL100542A IL 100542 A IL100542 A IL 100542A IL 10054291 A IL10054291 A IL 10054291A IL 10054291 A IL10054291 A IL 10054291A IL 100542 A IL100542 A IL 100542A
- Authority
- IL
- Israel
- Prior art keywords
- pregna
- diones
- dioxy
- alkylidene
- ene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9100342A SE9100342D0 (sv) | 1991-02-04 | 1991-02-04 | Novel steroid esters |
Publications (2)
Publication Number | Publication Date |
---|---|
IL100542A0 IL100542A0 (en) | 1992-09-06 |
IL100542A true IL100542A (en) | 1997-02-18 |
Family
ID=20381807
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10054291A IL100542A (en) | 1991-02-04 | 1991-12-27 | Esters of 16, 17-alkylidene-dioxy-6-and/or 9-fluoro-11,21-dihydroxy-pregna-4-ene (and-1-4-diene)-3,20-diones |
Country Status (38)
Country | Link |
---|---|
US (1) | US5614514A (de) |
EP (1) | EP0572451B1 (de) |
JP (1) | JP2947933B2 (de) |
KR (1) | KR100205835B1 (de) |
CN (3) | CN1039329C (de) |
AP (1) | AP365A (de) |
AT (1) | ATE164589T1 (de) |
BG (1) | BG61816B1 (de) |
CA (1) | CA2100453A1 (de) |
CZ (1) | CZ282057B6 (de) |
DE (1) | DE69224982T2 (de) |
DK (1) | DK0572451T3 (de) |
DZ (1) | DZ1554A1 (de) |
EE (1) | EE03110B1 (de) |
ES (1) | ES2114931T3 (de) |
FI (1) | FI933451A0 (de) |
HK (1) | HK1004335A1 (de) |
HU (1) | HU221168B1 (de) |
IE (1) | IE920167A1 (de) |
IL (1) | IL100542A (de) |
IS (1) | IS1653B (de) |
MA (1) | MA22407A1 (de) |
MX (1) | MX9200374A (de) |
MY (1) | MY111502A (de) |
NO (1) | NO304074B1 (de) |
NZ (1) | NZ241211A (de) |
PL (1) | PL170383B1 (de) |
PT (1) | PT100087B (de) |
RO (1) | RO111272B1 (de) |
RU (1) | RU2112775C1 (de) |
SE (1) | SE9100342D0 (de) |
SK (1) | SK281802B6 (de) |
TN (1) | TNSN92008A1 (de) |
TW (1) | TW287166B (de) |
UA (1) | UA43825C2 (de) |
WO (1) | WO1992013873A1 (de) |
YU (1) | YU48893B (de) |
ZA (1) | ZA92234B (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9100341D0 (sv) * | 1991-02-04 | 1991-02-04 | Astra Ab | Novel steroids |
HU221584B (hu) * | 1993-01-08 | 2002-11-28 | Aktiebolaget Astra | Új vastagbél- (colon) vagy csípőbél- (ileum) specifikus, cukortartalmú szteroidszármazékok, ezeket tartalmazó gyógyszerkészítmények és előállításuk |
US5983956A (en) * | 1994-10-03 | 1999-11-16 | Astra Aktiebolag | Formulation for inhalation |
US5980949A (en) * | 1994-10-03 | 1999-11-09 | Astra Aktiebolag | Formulation for inhalation |
SE9700133D0 (sv) * | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
SE9700135D0 (sv) | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
GB9923076D0 (en) | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
EP1079859B1 (de) | 1998-05-22 | 2010-07-14 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunktionelle moleküle sowie darauf basierende therapien. |
JP4937453B2 (ja) | 1999-05-27 | 2012-05-23 | ユーロ−セルティック エス. ア. | 抗感染剤および/または抗炎症剤を適用するための製剤 |
US7300667B1 (en) | 1999-05-27 | 2007-11-27 | Euro-Celtique, S.A. | Preparations for the application of anti-inflammatory, especially antiseptic agents and/or agents promoting the healing of wounds, to the lower respiratory tract |
HRP20010018A2 (en) | 2001-01-09 | 2002-12-31 | Pliva D D | Novel anti-inflammatory compounds |
US20050009798A1 (en) * | 2002-02-20 | 2005-01-13 | Sepracor Inc. | Carbonate and carbamate modified forms of glucocorticoids in combination with B2 adrenergic agonists |
WO2003070745A2 (en) * | 2002-02-20 | 2003-08-28 | Sepracor Inc. | Carbonate and carbamate modified forms of glucocorticoids |
CN100577681C (zh) | 2002-07-08 | 2010-01-06 | 葛兰素伊斯特拉齐瓦基森塔萨格勒布公司 | 用于治疗炎性疾病和病症的新化合物、组合物和方法 |
JP4530851B2 (ja) | 2002-07-08 | 2010-08-25 | グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ | ステロイド/非ステロイド抗炎症活性分子、抗新生物活性分子および抗ウイルス活性分子用担体としての新規な化合物、組成物 |
US20040157810A1 (en) * | 2002-08-23 | 2004-08-12 | Teicher Martin H. | Corticosteroid conjugates and uses thereof |
US20040235811A1 (en) * | 2002-10-08 | 2004-11-25 | Sepracor Inc. | Fatty acid modified forms of glucocorticoids |
HRP20030324A2 (en) | 2003-04-24 | 2005-02-28 | Pliva-Istra�iva�ki institut d.o.o. | Compounds of antiinflammatory effect |
HRP20030604A2 (en) | 2003-07-25 | 2005-04-30 | Pliva-Istra�iva�ki institut d.o.o. | Substituted furochromenes, preparation thereof andtheir antiinflammatory action |
HRP20030603A2 (en) | 2003-07-25 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | Substituted furochromene compounds of antiinflammatory action |
AU2003257154A1 (en) * | 2003-08-05 | 2005-03-07 | Sepracor Inc. | AMINO ACID AND PEPTIDE-MODIFIED FORMS OF GLUCOCORTICOIDS IN COMBINATION WITH ss2 ADRENERGIC AGONISTS |
CA2585711A1 (en) | 2004-10-27 | 2006-05-04 | Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. | Conjugates with anti-inflammatory activity |
SI1889198T1 (sl) | 2005-04-28 | 2015-02-27 | Proteus Digital Health, Inc. | Farma-informacijski sistem |
JP2009508494A (ja) | 2005-09-16 | 2009-03-05 | ラプトール ファーマシューティカル インコーポレイテッド | Crを含むタンパク質に対して特異的な受容体−結合タンパク質(rap)変異体を含む組成物およびその使用 |
DK2398500T3 (da) | 2009-02-20 | 2019-05-13 | 2 Bbb Medicines B V | Glutathion-baseret lægemiddelafgivelsessystem |
ES2942923T3 (es) | 2009-05-06 | 2023-06-07 | Laboratory Skin Care Inc | Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas |
US8737506B1 (en) | 2010-12-29 | 2014-05-27 | Sprint Communications Company L.P. | Determination of transmit diversity transmission delays |
US8437713B1 (en) | 2011-02-16 | 2013-05-07 | Sprint Communications Company L.P. | Wireless transmit diversity control by location of a wireless communication device |
US8565686B2 (en) | 2011-06-30 | 2013-10-22 | Sprint Communications Company L.P. | Power status multipath search window sizing for wireless communications |
CN104125830B (zh) | 2012-02-10 | 2018-01-16 | 台湾微脂体股份有限公司 | 用以减少眼用类固醇的并发症的药物组合物 |
JP5965187B2 (ja) * | 2012-03-30 | 2016-08-03 | 小林製薬株式会社 | 油性軟膏剤 |
CN109985048B (zh) * | 2017-12-29 | 2021-06-29 | 广州市赛普特医药科技股份有限公司 | 2β,3α,5α-三羟基雄甾-6-酮用于炎症反应的治疗 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3126375A (en) * | 1964-03-24 | Chioacyl | ||
US3197469A (en) * | 1958-08-06 | 1965-07-27 | Pharmaceutical Res Products In | 16, 17-acetals and ketals of 6-halo-16, 17-dihydroxy steroids of the pregnane seriesand intermediates therefor |
US3048581A (en) * | 1960-04-25 | 1962-08-07 | Olin Mathieson | Acetals and ketals of 16, 17-dihydroxy steroids |
US3357974A (en) * | 1965-12-28 | 1967-12-12 | Merck & Co Inc | Processes for preparing 16alpha, 17alpha-acetals and ketals of 16alpha, 17alpha, 21-trihydroxy-delta4-pregnene-3, 20-diones |
US3758686A (en) * | 1971-12-07 | 1973-09-11 | American Cyanamid Co | Method of using steroid acetonides |
SE378109B (de) * | 1972-05-19 | 1975-08-18 | Bofors Ab | |
US3796701A (en) * | 1973-02-26 | 1974-03-12 | Squibb & Sons Inc | 5alpha,9-oxazino steroids and 9-carboxamido steroids |
SE8008524L (sv) * | 1980-12-04 | 1982-06-05 | Draco Ab | 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand |
US4304727A (en) * | 1980-12-05 | 1981-12-08 | The Upjohn Company | 9α-Debromination |
JPS58176485A (ja) * | 1982-04-08 | 1983-10-15 | Nippon Denso Co Ltd | 可変容量圧縮機 |
US4749649A (en) * | 1983-05-16 | 1988-06-07 | The Upjohn Company | Microbial Δ1-dehydrogenation process using a scavenger of toxic oxygen |
JPS6067496A (ja) * | 1983-09-26 | 1985-04-17 | Ota Seiyaku Kk | フルオシノロン16,17−アセトニド21−ブチレ−トおよびその製造法 |
IT1196142B (it) * | 1984-06-11 | 1988-11-10 | Sicor Spa | Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti |
SE8403905D0 (sv) * | 1984-07-30 | 1984-07-30 | Draco Ab | Liposomes and steroid esters |
-
1991
- 1991-02-04 SE SE9100342A patent/SE9100342D0/xx unknown
- 1991-12-27 IL IL10054291A patent/IL100542A/xx not_active IP Right Cessation
- 1991-12-30 TW TW080110262A patent/TW287166B/zh active
-
1992
- 1992-01-06 NZ NZ241211A patent/NZ241211A/xx unknown
- 1992-01-13 ZA ZA92234A patent/ZA92234B/xx unknown
- 1992-01-21 IE IE016792A patent/IE920167A1/en not_active IP Right Cessation
- 1992-01-22 YU YU6492A patent/YU48893B/sh unknown
- 1992-01-22 DZ DZ920006A patent/DZ1554A1/fr active
- 1992-01-27 AP APAP/P/1992/000354A patent/AP365A/en active
- 1992-01-29 MX MX9200374A patent/MX9200374A/es unknown
- 1992-01-29 UA UA93004296A patent/UA43825C2/uk unknown
- 1992-01-29 RO RO93-01094A patent/RO111272B1/ro unknown
- 1992-01-29 CZ CS931495A patent/CZ282057B6/cs not_active IP Right Cessation
- 1992-01-29 DE DE69224982T patent/DE69224982T2/de not_active Expired - Fee Related
- 1992-01-29 ES ES92904423T patent/ES2114931T3/es not_active Expired - Lifetime
- 1992-01-29 WO PCT/SE1992/000056 patent/WO1992013873A1/en active IP Right Grant
- 1992-01-29 US US08/094,100 patent/US5614514A/en not_active Expired - Fee Related
- 1992-01-29 HU HU9302243A patent/HU221168B1/hu not_active IP Right Cessation
- 1992-01-29 EP EP92904423A patent/EP0572451B1/de not_active Expired - Lifetime
- 1992-01-29 DK DK92904423T patent/DK0572451T3/da active
- 1992-01-29 SK SK797-93A patent/SK281802B6/sk unknown
- 1992-01-29 RU RU93053632A patent/RU2112775C1/ru active
- 1992-01-29 CA CA002100453A patent/CA2100453A1/en not_active Abandoned
- 1992-01-29 PL PL92300351A patent/PL170383B1/pl unknown
- 1992-01-29 KR KR1019930702299A patent/KR100205835B1/ko not_active IP Right Cessation
- 1992-01-29 JP JP4504217A patent/JP2947933B2/ja not_active Expired - Fee Related
- 1992-01-29 AT AT92904423T patent/ATE164589T1/de not_active IP Right Cessation
- 1992-01-31 MY MYPI92000158A patent/MY111502A/en unknown
- 1992-02-03 PT PT100087A patent/PT100087B/pt not_active IP Right Cessation
- 1992-02-03 CN CN92100797A patent/CN1039329C/zh not_active Expired - Fee Related
- 1992-02-03 MA MA22693A patent/MA22407A1/fr unknown
- 1992-02-03 IS IS3809A patent/IS1653B/is unknown
- 1992-02-04 TN TNTNSN92008A patent/TNSN92008A1/fr unknown
-
1993
- 1993-08-02 NO NO932762A patent/NO304074B1/no not_active IP Right Cessation
- 1993-08-02 BG BG98011A patent/BG61816B1/bg unknown
- 1993-08-03 FI FI933451A patent/FI933451A0/fi unknown
-
1994
- 1994-11-23 EE EE9400330A patent/EE03110B1/xx not_active IP Right Cessation
-
1996
- 1996-10-22 CN CN96122759A patent/CN1076607C/zh not_active Expired - Fee Related
- 1996-11-01 CN CN96114411A patent/CN1076606C/zh not_active Expired - Fee Related
-
1998
- 1998-04-24 HK HK98103446A patent/HK1004335A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
RH | Patent void | ||
MM9K | Patent not in force due to non-payment of renewal fees |