IL100542A - Esters of 16, 17-alkylidene-dioxy-6-and/or 9-fluoro-11,21-dihydroxy-pregna-4-ene (and-1-4-diene)-3,20-diones - Google Patents

Esters of 16, 17-alkylidene-dioxy-6-and/or 9-fluoro-11,21-dihydroxy-pregna-4-ene (and-1-4-diene)-3,20-diones

Info

Publication number
IL100542A
IL100542A IL10054291A IL10054291A IL100542A IL 100542 A IL100542 A IL 100542A IL 10054291 A IL10054291 A IL 10054291A IL 10054291 A IL10054291 A IL 10054291A IL 100542 A IL100542 A IL 100542A
Authority
IL
Israel
Prior art keywords
pregna
diones
dioxy
alkylidene
ene
Prior art date
Application number
IL10054291A
Other languages
English (en)
Other versions
IL100542A0 (en
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of IL100542A0 publication Critical patent/IL100542A0/xx
Publication of IL100542A publication Critical patent/IL100542A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL10054291A 1991-02-04 1991-12-27 Esters of 16, 17-alkylidene-dioxy-6-and/or 9-fluoro-11,21-dihydroxy-pregna-4-ene (and-1-4-diene)-3,20-diones IL100542A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9100342A SE9100342D0 (sv) 1991-02-04 1991-02-04 Novel steroid esters

Publications (2)

Publication Number Publication Date
IL100542A0 IL100542A0 (en) 1992-09-06
IL100542A true IL100542A (en) 1997-02-18

Family

ID=20381807

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10054291A IL100542A (en) 1991-02-04 1991-12-27 Esters of 16, 17-alkylidene-dioxy-6-and/or 9-fluoro-11,21-dihydroxy-pregna-4-ene (and-1-4-diene)-3,20-diones

Country Status (38)

Country Link
US (1) US5614514A (de)
EP (1) EP0572451B1 (de)
JP (1) JP2947933B2 (de)
KR (1) KR100205835B1 (de)
CN (3) CN1039329C (de)
AP (1) AP365A (de)
AT (1) ATE164589T1 (de)
BG (1) BG61816B1 (de)
CA (1) CA2100453A1 (de)
CZ (1) CZ282057B6 (de)
DE (1) DE69224982T2 (de)
DK (1) DK0572451T3 (de)
DZ (1) DZ1554A1 (de)
EE (1) EE03110B1 (de)
ES (1) ES2114931T3 (de)
FI (1) FI933451A0 (de)
HK (1) HK1004335A1 (de)
HU (1) HU221168B1 (de)
IE (1) IE920167A1 (de)
IL (1) IL100542A (de)
IS (1) IS1653B (de)
MA (1) MA22407A1 (de)
MX (1) MX9200374A (de)
MY (1) MY111502A (de)
NO (1) NO304074B1 (de)
NZ (1) NZ241211A (de)
PL (1) PL170383B1 (de)
PT (1) PT100087B (de)
RO (1) RO111272B1 (de)
RU (1) RU2112775C1 (de)
SE (1) SE9100342D0 (de)
SK (1) SK281802B6 (de)
TN (1) TNSN92008A1 (de)
TW (1) TW287166B (de)
UA (1) UA43825C2 (de)
WO (1) WO1992013873A1 (de)
YU (1) YU48893B (de)
ZA (1) ZA92234B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
HU221584B (hu) * 1993-01-08 2002-11-28 Aktiebolaget Astra Új vastagbél- (colon) vagy csípőbél- (ileum) specifikus, cukortartalmú szteroidszármazékok, ezeket tartalmazó gyógyszerkészítmények és előállításuk
US5983956A (en) * 1994-10-03 1999-11-16 Astra Aktiebolag Formulation for inhalation
US5980949A (en) * 1994-10-03 1999-11-09 Astra Aktiebolag Formulation for inhalation
SE9700133D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
SE9700135D0 (sv) 1997-01-20 1997-01-20 Astra Ab New formulation
GB9923076D0 (en) 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
EP1079859B1 (de) 1998-05-22 2010-07-14 The Board Of Trustees Of The Leland Stanford Junior University Bifunktionelle moleküle sowie darauf basierende therapien.
JP4937453B2 (ja) 1999-05-27 2012-05-23 ユーロ−セルティック エス． ア． 抗感染剤および／または抗炎症剤を適用するための製剤
US7300667B1 (en) 1999-05-27 2007-11-27 Euro-Celtique, S.A. Preparations for the application of anti-inflammatory, especially antiseptic agents and/or agents promoting the healing of wounds, to the lower respiratory tract
HRP20010018A2 (en) 2001-01-09 2002-12-31 Pliva D D Novel anti-inflammatory compounds
US20050009798A1 (en) * 2002-02-20 2005-01-13 Sepracor Inc. Carbonate and carbamate modified forms of glucocorticoids in combination with B2 adrenergic agonists
WO2003070745A2 (en) * 2002-02-20 2003-08-28 Sepracor Inc. Carbonate and carbamate modified forms of glucocorticoids
CN100577681C (zh) 2002-07-08 2010-01-06 葛兰素伊斯特拉齐瓦基森塔萨格勒布公司 用于治疗炎性疾病和病症的新化合物、组合物和方法
JP4530851B2 (ja) 2002-07-08 2010-08-25 グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ ステロイド／非ステロイド抗炎症活性分子、抗新生物活性分子および抗ウイルス活性分子用担体としての新規な化合物、組成物
US20040157810A1 (en) * 2002-08-23 2004-08-12 Teicher Martin H. Corticosteroid conjugates and uses thereof
US20040235811A1 (en) * 2002-10-08 2004-11-25 Sepracor Inc. Fatty acid modified forms of glucocorticoids
HRP20030324A2 (en) 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect
HRP20030604A2 (en) 2003-07-25 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. Substituted furochromenes, preparation thereof andtheir antiinflammatory action
HRP20030603A2 (en) 2003-07-25 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Substituted furochromene compounds of antiinflammatory action
AU2003257154A1 (en) * 2003-08-05 2005-03-07 Sepracor Inc. AMINO ACID AND PEPTIDE-MODIFIED FORMS OF GLUCOCORTICOIDS IN COMBINATION WITH ss2 ADRENERGIC AGONISTS
CA2585711A1 (en) 2004-10-27 2006-05-04 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Conjugates with anti-inflammatory activity
SI1889198T1 (sl) 2005-04-28 2015-02-27 Proteus Digital Health, Inc. Farma-informacijski sistem
JP2009508494A (ja) 2005-09-16 2009-03-05 ラプトール ファーマシューティカル インコーポレイテッド Ｃｒを含むタンパク質に対して特異的な受容体−結合タンパク質（ｒａｐ）変異体を含む組成物およびその使用
DK2398500T3 (da) 2009-02-20 2019-05-13 2 Bbb Medicines B V Glutathion-baseret lægemiddelafgivelsessystem
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US8737506B1 (en) 2010-12-29 2014-05-27 Sprint Communications Company L.P. Determination of transmit diversity transmission delays
US8437713B1 (en) 2011-02-16 2013-05-07 Sprint Communications Company L.P. Wireless transmit diversity control by location of a wireless communication device
US8565686B2 (en) 2011-06-30 2013-10-22 Sprint Communications Company L.P. Power status multipath search window sizing for wireless communications
CN104125830B (zh) 2012-02-10 2018-01-16 台湾微脂体股份有限公司 用以减少眼用类固醇的并发症的药物组合物
JP5965187B2 (ja) * 2012-03-30 2016-08-03 小林製薬株式会社 油性軟膏剤
CN109985048B (zh) * 2017-12-29 2021-06-29 广州市赛普特医药科技股份有限公司 2β,3α,5α-三羟基雄甾-6-酮用于炎症反应的治疗

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3126375A (en) * 1964-03-24 Chioacyl
US3197469A (en) * 1958-08-06 1965-07-27 Pharmaceutical Res Products In 16, 17-acetals and ketals of 6-halo-16, 17-dihydroxy steroids of the pregnane seriesand intermediates therefor
US3048581A (en) * 1960-04-25 1962-08-07 Olin Mathieson Acetals and ketals of 16, 17-dihydroxy steroids
US3357974A (en) * 1965-12-28 1967-12-12 Merck & Co Inc Processes for preparing 16alpha, 17alpha-acetals and ketals of 16alpha, 17alpha, 21-trihydroxy-delta4-pregnene-3, 20-diones
US3758686A (en) * 1971-12-07 1973-09-11 American Cyanamid Co Method of using steroid acetonides
SE378109B (de) * 1972-05-19 1975-08-18 Bofors Ab
US3796701A (en) * 1973-02-26 1974-03-12 Squibb & Sons Inc 5alpha,9-oxazino steroids and 9-carboxamido steroids
SE8008524L (sv) * 1980-12-04 1982-06-05 Draco Ab 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
US4304727A (en) * 1980-12-05 1981-12-08 The Upjohn Company 9α-Debromination
JPS58176485A (ja) * 1982-04-08 1983-10-15 Nippon Denso Co Ltd 可変容量圧縮機
US4749649A (en) * 1983-05-16 1988-06-07 The Upjohn Company Microbial Δ1-dehydrogenation process using a scavenger of toxic oxygen
JPS6067496A (ja) * 1983-09-26 1985-04-17 Ota Seiyaku Kk フルオシノロン１６，１７−アセトニド２１−ブチレ−トおよびその製造法
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8403905D0 (sv) * 1984-07-30 1984-07-30 Draco Ab Liposomes and steroid esters

Also Published As

Publication number Publication date
IL100542A0 (en) 1992-09-06
AP9200354A0 (en) 1992-01-31
TW287166B (de) 1996-10-01
SK79793A3 (en) 1994-03-09
EE03110B1 (et) 1998-08-17
IE920167A1 (en) 1992-08-12
MX9200374A (es) 1992-08-01
EP0572451A1 (de) 1993-12-08
IS3809A (is) 1992-08-05
DE69224982T2 (de) 1998-07-30
KR100205835B1 (ko) 1999-07-01
NO932762D0 (no) 1993-08-02
JPH06505233A (ja) 1994-06-16
AP365A (en) 1994-10-21
DZ1554A1 (fr) 2002-02-17
CZ149593A3 (en) 1994-03-16
RO111272B1 (ro) 1996-08-30
FI933451A (fi) 1993-08-03
ZA92234B (en) 1992-10-28
SK281802B6 (sk) 2001-08-06
MA22407A1 (fr) 1992-10-01
CN1158726A (zh) 1997-09-10
HK1004335A1 (en) 1998-11-20
AU1235892A (en) 1992-09-07
PT100087A (pt) 1993-05-31
CN1076606C (zh) 2001-12-26
DE69224982D1 (de) 1998-05-07
CZ282057B6 (cs) 1997-05-14
CN1155418A (zh) 1997-07-30
HUT64972A (en) 1994-03-28
RU2112775C1 (ru) 1998-06-10
SE9100342D0 (sv) 1991-02-04
YU48893B (sh) 2002-10-18
JP2947933B2 (ja) 1999-09-13
TNSN92008A1 (fr) 1993-06-08
CN1064078A (zh) 1992-09-02
NZ241211A (en) 1993-08-26
YU6492A (sh) 1994-12-28
EP0572451B1 (de) 1998-04-01
HU9302243D0 (en) 1993-10-28
FI933451A0 (fi) 1993-08-03
PT100087B (pt) 1999-09-30
NO932762L (no) 1993-08-02
ES2114931T3 (es) 1998-06-16
PL170383B1 (pl) 1996-12-31
CN1076607C (zh) 2001-12-26
CN1039329C (zh) 1998-07-29
BG61816B1 (bg) 1998-06-30
US5614514A (en) 1997-03-25
ATE164589T1 (de) 1998-04-15
DK0572451T3 (da) 1998-10-19
HU221168B1 (en) 2002-08-28
AU661472B2 (en) 1995-07-27
BG98011A (bg) 1994-04-29
IS1653B (is) 1997-06-20
NO304074B1 (no) 1998-10-19
CA2100453A1 (en) 1992-08-05
WO1992013873A1 (en) 1992-08-20
UA43825C2 (uk) 2002-01-15
MY111502A (en) 2000-07-31

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
RH Patent void
MM9K Patent not in force due to non-payment of renewal fees