ID25469A - Komposisi sefalosporin amorf yang stabil secara kristalografi dan proses pembuatannya - Google Patents
Komposisi sefalosporin amorf yang stabil secara kristalografi dan proses pembuatannyaInfo
- Publication number
- ID25469A ID25469A IDW20001303A ID20001303A ID25469A ID 25469 A ID25469 A ID 25469A ID W20001303 A IDW20001303 A ID W20001303A ID 20001303 A ID20001303 A ID 20001303A ID 25469 A ID25469 A ID 25469A
- Authority
- ID
- Indonesia
- Prior art keywords
- sefalosporine
- christalography
- amorf
- stories
- making
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP192098 | 1998-01-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
ID25469A true ID25469A (id) | 2000-10-05 |
Family
ID=11515039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IDW20001303A ID25469A (id) | 1998-01-07 | 1999-01-07 | Komposisi sefalosporin amorf yang stabil secara kristalografi dan proses pembuatannya |
Country Status (23)
Country | Link |
---|---|
US (2) | US6342493B1 (id) |
EP (1) | EP1051978B1 (id) |
JP (1) | JP3413406B2 (id) |
KR (1) | KR100435315B1 (id) |
CN (1) | CN1151845C (id) |
AU (1) | AU736555B2 (id) |
BR (1) | BRPI9907084B8 (id) |
CA (1) | CA2316841C (id) |
CZ (1) | CZ302082B6 (id) |
EA (1) | EA002881B1 (id) |
ES (1) | ES2393972T3 (id) |
HK (1) | HK1035148A1 (id) |
HU (1) | HU230295B1 (id) |
ID (1) | ID25469A (id) |
IL (2) | IL137004A0 (id) |
NZ (1) | NZ505871A (id) |
PL (1) | PL194097B1 (id) |
PT (1) | PT1051978E (id) |
SK (1) | SK286631B6 (id) |
TR (1) | TR200001903T2 (id) |
TW (1) | TW587946B (id) |
UA (1) | UA70311C2 (id) |
WO (1) | WO1999034832A1 (id) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ302082B6 (cs) * | 1998-01-07 | 2010-09-29 | Meiji Seika Kaisha Ltd. | Prostredek zahrnující krystalograficky stabilní amorfní cefalosporin a zpusob jeho výroby |
PE20010635A1 (es) | 1999-10-08 | 2001-08-15 | Smithkline Beecham Corp | Inhibidores de fab i utiles para el tratamiento de infecciones bacterianas |
DE60230934D1 (de) | 2001-04-06 | 2009-03-05 | Affinium Pharm Inc | Fab-i-inhibitoren |
AU2002253642B2 (en) * | 2001-04-26 | 2007-05-24 | Meiji Seika Kaisha, Ltd. | Amorphous cefditoren pivoxil composition and process for producing the same |
EP1555024B1 (en) * | 2002-10-02 | 2010-09-29 | Meiji Seika Kaisha Ltd. | Antibacterial medicinal composition of enhanced oral absorptivity |
ES2518316T3 (es) | 2002-12-06 | 2014-11-05 | Debiopharm International Sa | Compuestos heterocíclicos, métodos de fabricación de los mismos y su uso en terapia |
DE602004016831D1 (de) * | 2003-03-17 | 2008-11-13 | Affinium Pharm Inc | Pharmazeutische zusammensetzungen inhibitoren von fab i und weitere antibiotika enthaltend |
US20070167402A1 (en) * | 2003-06-20 | 2007-07-19 | Meiji Seika Kaisha, Ltd. | Product of coprecipitation of sparingly soluble substance and water-soluble polymer and process for producing the same |
PT1671635E (pt) * | 2003-10-08 | 2012-01-17 | Meiji Seika Pharma Co Ltd | Composição de antibiótico amorfo contendo cefditoreno pivoxil |
EP1689755A2 (en) * | 2003-11-07 | 2006-08-16 | Ranbaxy Laboratories Limited | Processes for the preparation of highly pure 3-(2-substituted vinyl) cephalosporin |
JP2005162696A (ja) * | 2003-12-04 | 2005-06-23 | Nichiko Pharmaceutical Co Ltd | 溶出性に優れたセフジトレンピボキシル製剤 |
WO2005082330A2 (en) * | 2004-02-19 | 2005-09-09 | Ranbaxy Laboratories Limited | Co-precipitated amorphous cefditoren pivoxil and dosage forms comprising the same |
CA2568914C (en) | 2004-06-04 | 2013-09-24 | Affinium Pharmaceuticals, Inc. | Therapeutic agents, and methods of making and using the same |
US20080069879A1 (en) * | 2006-05-02 | 2008-03-20 | Ravishekhar Bhiwgade | Stable solid dosage form containing amorphous cefditoren pivoxil and process for preparation thereof |
EP2687533B1 (en) | 2006-07-20 | 2017-07-19 | Debiopharm International SA | Acrylamide derivatives as FAB I inhibitors |
WO2008057058A1 (en) * | 2006-11-10 | 2008-05-15 | Nobel Ilac Sanayii Ve Ticaret As | Oral pharmaceutical compositions |
EP2125802A4 (en) | 2007-02-16 | 2014-08-20 | Debiopharm Int Sa | SALTS, PRODRUGS AND POLYMORPHES OF FAB I INHIBITORS |
CN101560216B (zh) * | 2009-05-27 | 2011-06-15 | 上海交通大学 | 头孢妥仑酯的制备方法 |
US20130143857A1 (en) * | 2010-07-23 | 2013-06-06 | Lupin Limited | Pharmaceutical compositions of cefditoren pivoxil |
JPWO2012043700A1 (ja) | 2010-09-30 | 2014-02-24 | 富山化学工業株式会社 | 6−フルオロ−3−ヒドロキシ−2−ピラジンカルボキサミドのナトリウム塩 |
EP2623497B1 (en) | 2010-09-30 | 2016-01-20 | Toyama Chemical Co., Ltd. | Meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide |
PL2861608T3 (pl) | 2012-06-19 | 2019-09-30 | Debiopharm International Sa | Pochodne prolekowe (e)-n-metylo-n-((3-metylobenzofuran-2-ylo)metylo)-3-(7-okso-5,6,7,8-tetrahydro-1,8-naftyrydyn-3-ylo)akryloamidu |
MX371021B (es) * | 2013-08-29 | 2020-01-13 | Cadila Healthcare Ltd | Procedimiento para preparar saroglitazar o sus sales farmaceuticamente aceptables. |
WO2016114727A1 (en) | 2015-01-16 | 2016-07-21 | Öğün Yusuf Toktamiş | Cefditoren pivoxil compositions with improved stability and production methods thereof |
US10751351B2 (en) | 2016-02-26 | 2020-08-25 | Debiopharm International S.A. | Medicament for treatment of diabetic foot infections |
CN109053768A (zh) * | 2018-08-07 | 2018-12-21 | 中国医药集团总公司四川抗菌素工业研究所 | 一种无定型头孢妥仑酯的制备方法 |
CN110251467A (zh) * | 2019-06-26 | 2019-09-20 | 北京济美堂医药研究有限公司 | 一种无定形态头孢妥仑匹酯组合物的制备方法 |
CN112190539B (zh) * | 2020-11-10 | 2021-11-02 | 深圳立健药业有限公司 | 一种头孢妥仑匹酯组合物及其应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0678234B2 (ja) * | 1988-04-19 | 1994-10-05 | 明治製菓株式会社 | 経口投与用抗菌組成物 |
JPH05306227A (ja) * | 1992-04-27 | 1993-11-19 | Lion Corp | 徐放性口腔内疾患治療剤 |
JP2576927B2 (ja) * | 1992-05-15 | 1997-01-29 | ファイザー製薬株式会社 | 細粒核 |
JPH06316517A (ja) * | 1993-02-22 | 1994-11-15 | Grelan Pharmaceut Co Ltd | 放出制御製剤 |
JPH0717866A (ja) * | 1993-06-16 | 1995-01-20 | Meiji Seika Kaisha Ltd | 医薬組成物 |
AR004014A1 (es) * | 1995-10-13 | 1998-09-30 | Meiji Seika Kaisha | Una composicion antibacteriana de cefditoren pivoxilo para administracion oral y metodo para obtener dicha composicion |
DE69721290T2 (de) * | 1996-09-20 | 2004-01-22 | Meiji Seika Kaisha Ltd. | Kristalline substanz von pivoxilcefditoren und verfahren zu ihrer herstellung |
CZ302082B6 (cs) * | 1998-01-07 | 2010-09-29 | Meiji Seika Kaisha Ltd. | Prostredek zahrnující krystalograficky stabilní amorfní cefalosporin a zpusob jeho výroby |
-
1999
- 1999-01-07 CZ CZ20002542A patent/CZ302082B6/cs not_active IP Right Cessation
- 1999-01-07 ID IDW20001303A patent/ID25469A/id unknown
- 1999-01-07 HU HU0101272A patent/HU230295B1/hu unknown
- 1999-01-07 EA EA200000742A patent/EA002881B1/ru not_active IP Right Cessation
- 1999-01-07 CA CA002316841A patent/CA2316841C/en not_active Expired - Lifetime
- 1999-01-07 BR BRPI9907084A patent/BRPI9907084B8/pt not_active IP Right Cessation
- 1999-01-07 PL PL99341589A patent/PL194097B1/pl unknown
- 1999-01-07 NZ NZ505871A patent/NZ505871A/xx not_active IP Right Cessation
- 1999-01-07 CN CNB998027855A patent/CN1151845C/zh not_active Expired - Lifetime
- 1999-01-07 AU AU17845/99A patent/AU736555B2/en not_active Ceased
- 1999-01-07 WO PCT/JP1999/000020 patent/WO1999034832A1/ja active IP Right Grant
- 1999-01-07 IL IL13700499A patent/IL137004A0/xx unknown
- 1999-01-07 SK SK1026-2000A patent/SK286631B6/sk not_active IP Right Cessation
- 1999-01-07 KR KR10-2000-7007546A patent/KR100435315B1/ko not_active IP Right Cessation
- 1999-01-07 ES ES99900136T patent/ES2393972T3/es not_active Expired - Lifetime
- 1999-01-07 PT PT99900136T patent/PT1051978E/pt unknown
- 1999-01-07 EP EP99900136A patent/EP1051978B1/en not_active Expired - Lifetime
- 1999-01-07 US US09/582,937 patent/US6342493B1/en not_active Expired - Lifetime
- 1999-01-07 TR TR2000/01903T patent/TR200001903T2/xx unknown
- 1999-01-07 JP JP2000527279A patent/JP3413406B2/ja not_active Expired - Lifetime
- 1999-06-28 TW TW088110903A patent/TW587946B/zh not_active IP Right Cessation
- 1999-07-01 UA UA2000084638A patent/UA70311C2/uk unknown
-
2000
- 2000-06-26 IL IL137004A patent/IL137004A/en not_active IP Right Cessation
-
2001
- 2001-08-22 HK HK01105914A patent/HK1035148A1/xx not_active IP Right Cessation
- 2001-11-26 US US09/991,694 patent/US6486149B2/en not_active Expired - Lifetime
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