HUT64298A - Method for producing 9-amino-7-(substituted)-6-demethyl-6-desoxy-0tetracycline derivatives and medical preparatives containing them - Google Patents

Method for producing 9-amino-7-(substituted)-6-demethyl-6-desoxy-0tetracycline derivatives and medical preparatives containing them

Info

Publication number
HUT64298A
HUT64298A HU9203143A HU9203143A HUT64298A HU T64298 A HUT64298 A HU T64298A HU 9203143 A HU9203143 A HU 9203143A HU 9203143 A HU9203143 A HU 9203143A HU T64298 A HUT64298 A HU T64298A
Authority
HU
Hungary
Prior art keywords
amino
demethyl
substituted
desoxy
derivatives
Prior art date
Application number
HU9203143A
Other languages
English (en)
Other versions
HU211214B (en
HU9203143D0 (en
Inventor
Joseph John Hlavka
Phaik-Eng Sum
Yakov Gluzman
Ving J Lee
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Priority to HU9302833A priority Critical patent/HU212267B/hu
Publication of HU9203143D0 publication Critical patent/HU9203143D0/hu
Publication of HUT64298A publication Critical patent/HUT64298A/hu
Publication of HU211214B publication Critical patent/HU211214B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
  • Peptides Or Proteins (AREA)
  • Luminescent Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Moulding By Coating Moulds (AREA)
  • Tires In General (AREA)
  • Spinning Or Twisting Of Yarns (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HU9203143A 1991-10-04 1992-10-02 Method for producing novel 9-amino-7-(substituted)-6-demethyl-6-desoxy-tetracycline derivatives and medical preparatives containing them HU211214B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HU9302833A HU212267B (en) 1991-10-04 1992-10-02 Process for preparing 9-nitro-7-(substituted)-6-demethyl-6-desoxytetracyclin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/771,697 US5281628A (en) 1991-10-04 1991-10-04 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines

Publications (3)

Publication Number Publication Date
HU9203143D0 HU9203143D0 (en) 1992-12-28
HUT64298A true HUT64298A (en) 1993-12-28
HU211214B HU211214B (en) 1995-11-28

Family

ID=25092681

Family Applications (2)

Application Number Title Priority Date Filing Date
HU9203143A HU211214B (en) 1991-10-04 1992-10-02 Method for producing novel 9-amino-7-(substituted)-6-demethyl-6-desoxy-tetracycline derivatives and medical preparatives containing them
HU95P/P00602P HU211922A9 (en) 1991-10-04 1995-06-29 Novel 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines

Family Applications After (1)

Application Number Title Priority Date Filing Date
HU95P/P00602P HU211922A9 (en) 1991-10-04 1995-06-29 Novel 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines

Country Status (25)

Country Link
US (3) US5281628A (hu)
EP (1) EP0535346B1 (hu)
JP (1) JP3183729B2 (hu)
KR (1) KR100261528B1 (hu)
CN (1) CN1053182C (hu)
AT (1) ATE129697T1 (hu)
AU (1) AU651734B2 (hu)
CA (1) CA2079703C (hu)
CZ (1) CZ285015B6 (hu)
DE (1) DE69205792T2 (hu)
DK (1) DK0535346T3 (hu)
ES (1) ES2081005T3 (hu)
FI (1) FI111716B (hu)
GR (1) GR3017978T3 (hu)
HK (1) HK1000319A1 (hu)
HU (2) HU211214B (hu)
IL (1) IL103319A (hu)
MX (1) MX9205573A (hu)
NO (1) NO300129B1 (hu)
NZ (1) NZ244556A (hu)
PH (1) PH30343A (hu)
PL (2) PL170939B1 (hu)
SK (1) SK281113B6 (hu)
TW (1) TW222616B (hu)
ZA (1) ZA927608B (hu)

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USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
AU666372B2 (en) * 1992-05-28 1996-02-08 Centre For Molecular Biology And Medicine Therapeutic compositions
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5371076A (en) * 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
CA2183565A1 (en) * 1994-02-17 1995-08-24 Wei-Guo Su 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
AU753370B2 (en) * 1998-01-23 2002-10-17 Trustees Of Tufts College Pharmaceutically active compounds and methods of use thereof
ATE323671T1 (de) * 1999-09-14 2006-05-15 Tufts College Verfahren zur herstellung von substituierten tetracyclinen mit hilfe von auf übergangsmetalle basierten chemien
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6686365B2 (en) * 2000-02-04 2004-02-03 Eli Lilly And Company Pharmaceutical composition
WO2001098236A2 (en) * 2000-06-16 2001-12-27 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
CZ2003343A3 (cs) * 2000-07-07 2003-05-14 Trustees Of Tufts College 7-Substituované tetracyklinové sloučeniny
ATE544745T1 (de) * 2000-07-07 2012-02-15 Tufts College 9-substituierte minocyclinverbindungen
US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
CZ20032780A3 (cs) * 2001-03-13 2004-01-14 Paratek Pharmaceuticals, Inc. 7,9- Substituované tetracyklinové sloučeniny
EP1241160A1 (en) * 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
AU2002250331A1 (en) * 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
EP2332548A1 (en) 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Tetracyclines for the treatment of stroke
AU2002365120A1 (en) 2001-08-02 2003-07-15 Paratek Pharmaceuticals, Inc. Medicaments
US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
AU2003235759A1 (en) * 2002-01-08 2003-07-24 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
EP1482926A4 (en) * 2002-03-08 2006-04-12 Paratek Pharm Innc AMINO METHYL SUBSTITUTED TETRACYCLINE COMPOUNDS
KR101025400B1 (ko) 2002-03-21 2011-03-28 파라테크 파마슈티컬스, 인크. 치환된 테트라시클린 화합물
AU2003261161B2 (en) 2002-07-12 2009-09-10 Paratek Pharmaceuticals, Inc 3, 10, and 12a substituted tetracycline compounds
CN1732023A (zh) * 2002-12-27 2006-02-08 血管技术国际股份公司 组合物和使用collajolie的方法
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EP2319829A1 (en) * 2003-07-09 2011-05-11 Paratek Pharmaceuticals, Inc. 9-substituted tetracycline compounds
CA2553510C (en) 2004-01-15 2012-09-25 Paratek Pharmaceuticals, Inc. Aromatic a-ring derivatives of tetracycline compounds
EP2284151A3 (en) 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
CA2585418A1 (en) 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
EP1848685A1 (en) 2005-02-04 2007-10-31 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
AR057034A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Metodos para purificar tigeciclina
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AU2006272698B2 (en) * 2005-07-21 2012-11-01 Paratek Pharmaceuticals, Inc. 10-substituted tetracyclines and methods of use thereof
JP2009521456A (ja) * 2005-12-22 2009-06-04 ワイス チゲサイクリンでの胃腸管感染症の治療法
CA2632213A1 (en) * 2005-12-22 2007-07-05 Wyeth Oral formulations comprising tigecycline
US20070244335A1 (en) * 2006-04-17 2007-10-18 Teva Pharmaceutical Industries Ltd. Isolation of tetracycline derivatives
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
PT2016045E (pt) * 2006-04-24 2015-02-05 Teva Pharma Forma cristalina de tigeciclina e processos para a sua preparação
EP2016043A1 (en) * 2006-05-10 2009-01-21 Teva Pharmaceutical Industries Ltd. Methods for reducing 7/9-nitrotetracycline derivatives
EP2537934A3 (en) 2006-05-15 2013-04-10 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
MX2008009520A (es) 2006-11-29 2009-02-26 Teva Pharma Formas cristalinas de tigeciclina y procesos de preparacion de ellas.
EP2084126A1 (en) * 2006-11-30 2009-08-05 Teva Pharmaceutical Industries Ltd. Processes for preparation of 9-haloacetamidominocyclines
WO2008106234A1 (en) * 2007-03-01 2008-09-04 Teva Pharmaceutical Industries Ltd. Processes for purification of tigecycline
CA2706475C (en) 2007-11-29 2016-05-03 Actelion Pharmaceuticals Ltd Phosphonic acid derivates and their use as p2y12 receptor antagonists
WO2010032219A1 (en) * 2008-09-18 2010-03-25 Ranbaxy Laboratories Limited Process for the preparation of tigecycline
WO2010114680A1 (en) * 2009-03-12 2010-10-07 Wyeth Llc Nitration of tetracyclines
SI2327676T1 (sl) * 2009-11-26 2014-07-31 Sandoz Ag Reakcije organskih spojin z nizkimi količinami vodika

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US2482055A (en) * 1948-02-11 1949-09-13 American Cyanamid Co Aureomycin and preparation of same
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Also Published As

Publication number Publication date
PL170939B1 (pl) 1997-02-28
FI111716B (fi) 2003-09-15
CA2079703C (en) 2004-07-20
PL296140A1 (en) 1993-11-02
PH30343A (en) 1997-04-02
ES2081005T3 (es) 1996-02-16
DE69205792D1 (de) 1995-12-07
NZ244556A (en) 1994-06-27
NO923856D0 (no) 1992-10-02
HU211922A9 (en) 1996-01-29
CN1053182C (zh) 2000-06-07
ZA927608B (en) 1993-04-13
FI924453A0 (fi) 1992-10-02
SK297292A3 (en) 1994-12-07
FI924453A (fi) 1993-04-05
KR100261528B1 (ko) 2000-07-15
CN1071415A (zh) 1993-04-28
AU651734B2 (en) 1994-07-28
CA2079703A1 (en) 1993-04-05
MX9205573A (es) 1993-05-01
NO923856L (no) 1993-04-05
PL170933B1 (pl) 1997-02-28
GR3017978T3 (en) 1996-02-29
ATE129697T1 (de) 1995-11-15
DK0535346T3 (da) 1995-12-04
US5326759A (en) 1994-07-05
AU2618292A (en) 1993-04-08
EP0535346A1 (en) 1993-04-07
IL103319A0 (en) 1993-03-15
CZ297292A3 (en) 1993-04-14
EP0535346B1 (en) 1995-11-02
JP3183729B2 (ja) 2001-07-09
DE69205792T2 (de) 1996-06-20
NO300129B1 (no) 1997-04-14
US5401863A (en) 1995-03-28
TW222616B (hu) 1994-04-21
SK281113B6 (sk) 2000-12-11
HK1000319A1 (en) 1998-02-27
HU211214B (en) 1995-11-28
JPH05239006A (ja) 1993-09-17
HU9203143D0 (en) 1992-12-28
KR930007895A (ko) 1993-05-20
CZ285015B6 (cs) 1999-05-12
US5281628A (en) 1994-01-25
IL103319A (en) 1996-07-23

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Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees