HUT56071A - Process for producing substituted 2-hydroxymethyl-4-pyridone derivatives - Google Patents

Process for producing substituted 2-hydroxymethyl-4-pyridone derivatives

Info

Publication number
HUT56071A
HUT56071A HU908257A HU825787A HUT56071A HU T56071 A HUT56071 A HU T56071A HU 908257 A HU908257 A HU 908257A HU 825787 A HU825787 A HU 825787A HU T56071 A HUT56071 A HU T56071A
Authority
HU
Hungary
Prior art keywords
group
substituted
hydroxymethyl
heterocyclic ring
unsubstituted
Prior art date
Application number
HU908257A
Other languages
English (en)
Other versions
HU908257D0 (en
Inventor
Yoshiyuki Zama
Nobuo Ishiyama
Tsuneo Saita
Takanobu Naito
Masao Hirose
Masaaki Yokoyama
Taiji Asano
Hisato Senda
Keiji Sekine
Shigeru Sanai
Original Assignee
Kaken Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaken Pharma Co Ltd filed Critical Kaken Pharma Co Ltd
Publication of HU908257D0 publication Critical patent/HU908257D0/hu
Publication of HUT56071A publication Critical patent/HUT56071A/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HU908257A 1986-07-01 1987-06-25 Process for producing substituted 2-hydroxymethyl-4-pyridone derivatives HUT56071A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15270686 1986-07-01
JP19159086 1986-08-18

Publications (2)

Publication Number Publication Date
HU908257D0 HU908257D0 (en) 1991-06-28
HUT56071A true HUT56071A (en) 1991-07-29

Family

ID=26481559

Family Applications (3)

Application Number Title Priority Date Filing Date
HU872882A HU198500B (en) 1986-07-01 1987-06-25 Process for producing cefemcarboxylic acid derivatives and pharmaceutical composition comprising same
HU892782A HUT56099A (en) 1986-07-01 1987-06-25 Process for producing 2-(2-amino-thiazol-4-yl)-2-(4-pyridon-2-yl-methoxy-imino)-acetic acid derivatives
HU908257A HUT56071A (en) 1986-07-01 1987-06-25 Process for producing substituted 2-hydroxymethyl-4-pyridone derivatives

Family Applications Before (2)

Application Number Title Priority Date Filing Date
HU872882A HU198500B (en) 1986-07-01 1987-06-25 Process for producing cefemcarboxylic acid derivatives and pharmaceutical composition comprising same
HU892782A HUT56099A (en) 1986-07-01 1987-06-25 Process for producing 2-(2-amino-thiazol-4-yl)-2-(4-pyridon-2-yl-methoxy-imino)-acetic acid derivatives

Country Status (10)

Country Link
US (2) US4822786A (hu)
EP (1) EP0251299B1 (hu)
KR (1) KR930007418B1 (hu)
CN (1) CN1022036C (hu)
AT (1) ATE110729T1 (hu)
AU (3) AU597676B2 (hu)
CA (1) CA1283404C (hu)
DE (1) DE3750443T2 (hu)
ES (1) ES2062974T3 (hu)
HU (3) HU198500B (hu)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028601A (en) * 1987-04-30 1991-07-02 Meiji Saika Kaisha, Ltd. Cephalosporin compounds and antibacterial agents
JPH0633281B2 (ja) * 1987-11-11 1994-05-02 明治製菓株式会社 新規セファロスポリン化合物及び抗菌剤
JPH0686463B2 (ja) * 1988-07-01 1994-11-02 明治製菓株式会社 新規セフェム化合物、その製造法及び抗菌剤
DE3826846A1 (de) * 1988-08-06 1990-02-08 Goedecke Ag Alkoxy-4(1h)-pyridon-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
JPH0248580A (ja) * 1988-08-10 1990-02-19 Meiji Seika Kaisha Ltd 新規セファロスポリン系化合物及び抗菌剤
EP0400805A1 (en) * 1989-04-25 1990-12-05 Toshiyasu Ishimaru Cephalosporin compounds and their use
JPH03176473A (ja) * 1989-12-01 1991-07-31 Kaken Pharmaceut Co Ltd ピリジン―ｎ―オキシド誘導体及びその製法
CA2100623A1 (en) * 1992-07-17 1994-01-18 Michiyuki Sendai Cephem compounds, their production and use
JPH11124384A (ja) 1997-10-17 1999-05-11 Otsuka Chem Co Ltd ３−セフェム化合物の製造法
US6352770B1 (en) 1999-01-15 2002-03-05 Bic Corporation Correction tape having dye migration blocking properties
CN102988362B (zh) 2005-12-07 2014-11-05 巴斯利尔药物股份公司 单环-内酰胺类抗生素与β-内酰胺酶抑制剂的有效的联合应用
KR101320718B1 (ko) 2007-03-23 2013-10-21 바실리어 파마슈티카 아게 세균 감염 치료용 조합 약제
SG187757A1 (en) 2010-08-10 2013-03-28 Rempex Pharmaceuticals Inc Cyclic boronic acid ester derivatives and therapeutic uses thereof
US9012491B2 (en) 2011-08-31 2015-04-21 Rempex Pharmaceuticals, Inc. Heterocyclic boronic acid ester derivatives and therapeutic uses thereof
US9156858B2 (en) 2012-05-23 2015-10-13 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US10561675B2 (en) 2012-06-06 2020-02-18 Rempex Pharmaceuticals, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
CN104981239B (zh) 2013-01-04 2019-01-04 莱姆派克斯制药公司 硼酸衍生物及其治疗用途
US9241947B2 (en) 2013-01-04 2016-01-26 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US9101638B2 (en) 2013-01-04 2015-08-11 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
KR20150103269A (ko) 2013-01-04 2015-09-09 렘펙스 파머수티클스 인코퍼레이티드 보론산 유도체 및 그의 치료적 용도
EP3139930A4 (en) 2014-05-05 2018-01-17 Rempex Pharmaceuticals, Inc. Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof
LT3140310T (lt) 2014-05-05 2019-11-25 Rempex Pharmaceuticals Inc Boronato druskų sintezė ir jų panaudojimas
EP3145936B1 (en) 2014-05-19 2020-09-30 Qpex Biopharma, Inc. Boronic acid derivatives and therapeutic uses thereof
JP6700203B2 (ja) 2014-07-01 2020-05-27 レンペックス・ファーマシューティカルズ・インコーポレイテッド ボロン酸誘導体およびその治療的使用
WO2016081297A1 (en) 2014-11-18 2016-05-26 Rempex Pharmaceuticals, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
US10364257B2 (en) 2014-12-19 2019-07-30 Rempex Pharmaceuticals, Inc. Apparatus and continuous flow process for production of boronic acid derivatives
US20180051041A1 (en) 2015-03-17 2018-02-22 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
MY196909A (en) 2016-06-30 2023-05-09 Qpex Biopharma Inc Boronic acid derivatives and therapeutic uses thereof
CN107641119B (zh) 2016-07-21 2019-11-08 中国科学院上海药物研究所 单环β-内酰胺-铁载体轭合物及其制备方法和用途
EP3694864A4 (en) 2017-10-11 2021-10-13 Qpex Biopharma, Inc. BORONIC ACID DERIVATIVES AND THEIR SYNTHESIS
CN112424209A (zh) 2018-04-20 2021-02-26 Qpex生物制药有限公司 硼酸衍生物及其治疗用途
CN112409383A (zh) * 2020-11-30 2021-02-26 上海交通大学医学院 一种氨噻肟哌啶酮头孢菌素的制备及应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
ZA806977B (en) * 1979-11-19 1981-10-28 Fujisawa Pharmaceutical Co 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
JPS5849382A (ja) * 1981-09-18 1983-03-23 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物
US4616081A (en) * 1982-07-07 1986-10-07 Asahi Kasei Kogyo Kabushiki Kaisha Cephalosporin compounds
JPS59167576A (ja) * 1983-03-15 1984-09-21 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物
JPS59219282A (ja) * 1983-05-28 1984-12-10 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物およびその中間体
GB8329043D0 (en) * 1983-10-31 1983-11-30 Hider R C Pharmaceutical compositions
GB8410289D0 (en) * 1984-04-19 1984-05-31 Callingham B A Pharmaceutical compositions
NZ215527A (en) * 1985-04-01 1989-06-28 Mochida Pharm Co Ltd Cephalosporin derivatives and pharmaceutical compositions
DE3826846A1 (de) * 1988-08-06 1990-02-08 Goedecke Ag Alkoxy-4(1h)-pyridon-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel

Also Published As

Publication number Publication date
AU6214390A (en) 1990-12-20
AU597676B2 (en) 1990-06-07
US4822786A (en) 1989-04-18
EP0251299B1 (en) 1994-08-31
AU627067B2 (en) 1992-08-13
KR930007418B1 (ko) 1993-08-10
US4883879A (en) 1989-11-28
DE3750443T2 (de) 1995-04-20
AU7493187A (en) 1988-01-07
ATE110729T1 (de) 1994-09-15
ES2062974T3 (es) 1995-01-01
EP0251299A3 (en) 1989-10-11
DE3750443D1 (de) 1994-10-06
CN1022036C (zh) 1993-09-08
HUT44259A (en) 1988-02-29
AU1962892A (en) 1992-09-10
EP0251299A2 (en) 1988-01-07
AU635174B2 (en) 1993-03-11
HU908257D0 (en) 1991-06-28
HUT56099A (en) 1991-07-29
CA1283404C (en) 1991-04-23
HU198500B (en) 1989-10-30
KR880001674A (ko) 1988-04-26
CN87104590A (zh) 1988-01-13

Similar Documents

Publication Publication Date Title
HUT56071A (en) Process for producing substituted 2-hydroxymethyl-4-pyridone derivatives
PL292101A1 (en) Method of obtaining novel derivatives of cyclopentylpurine and cyclopentylpyrimidine
GR3020369T3 (en) Xanthine derivatives
HUT45984A (en) Process for production of quinoline-derivatives and of their medically acceptable acid-additioned salts
AU1811988A (en) A process for the preparation of substituted indolin-2-one derivatives
AU572994B2 (en) Cephalosporin derivatives
NO875002D0 (no) Imidazolderivater, samt fremgangsmaate for fremstilling av slike.
EP0214600A3 (en) Cephalosporin derivatives
YU40388A (en) Process for making imidazole derivatives
AU576887B2 (en) 1,6-naphthyridine derivatives
GR3015314T3 (en) Penem derivatives, production and use thereof.
NZ240404A (en) Oxysulphonyl (thio)carbamate derivatives and pharmaceutical
HU913293D0 (en) Process for the production of pierazine derivatives and medical preparations containing them
IE893533L (en) Substituted 3-aminosydnonimines, processes for their¹preparation and their use
YU108987A (en) Process for preparing 6-/d(-)-alpha(4-ethyl-2,3-dioxo-1-piperazincarboxamido)-phenylacetamido/phenicilanic acid
HU912216D0 (en) Process for the production of purinyl-and pirimidinyl - tetrahydrofurane derivatives and medical preparations containing them
ES8506725A1 (es) Procedimiento para la preparacion de un derivado de cefalosporina