HUP9800520A2 - Génexpresszió emlős sejtekben - Google Patents
Génexpresszió emlős sejtekbenInfo
- Publication number
- HUP9800520A2 HUP9800520A2 HU9800520A HUP9800520A HUP9800520A2 HU P9800520 A2 HUP9800520 A2 HU P9800520A2 HU 9800520 A HU9800520 A HU 9800520A HU P9800520 A HUP9800520 A HU P9800520A HU P9800520 A2 HUP9800520 A2 HU P9800520A2
- Authority
- HU
- Hungary
- Prior art keywords
- proteins
- hüman
- vectors
- various
- genes
- Prior art date
Links
- 230000014509 gene expression Effects 0.000 title abstract 2
- 210000004962 mammalian cell Anatomy 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 9
- 102000004169 proteins and genes Human genes 0.000 abstract 6
- 239000013598 vector Substances 0.000 abstract 4
- 210000004027 cell Anatomy 0.000 abstract 3
- 102000014150 Interferons Human genes 0.000 abstract 2
- 108010050904 Interferons Proteins 0.000 abstract 2
- 229940079322 interferon Drugs 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 241000725619 Dengue virus Species 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000013595 glycosylation Effects 0.000 abstract 1
- 238000006206 glycosylation reaction Methods 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000002054 inoculum Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány tárgyát különböző gének emlős sejtekben történőexpresszáltatására alkalmas vektőrők képezik. A találmány szerintivektőrők közelebbről őlyan fehérjékért felelős génekexpresszáltatására alkalmasak, amelyek in vivő biőlógiai aktivitásátkülönöböző faktőrők befőlyásőlják, beleértve a specifikűsglikőzilációt. Ilyen gének példáűl a hűmán -interferőn (IFN), a hűmáneritrőpőietin (EPO), a hűmán chőriőnikűs gőnadőtrőpin, különböző máscitőkinek és növekedési faktőrők épp úgy, mint egyes vírűseredetűantigének, mint példáűl Dengűe vírűsfehérjék, amelyek szerkezetelényeges lehet az őltóanyagők kifejlesztésében. A találmány tárgyát képezik tővábbá a találmány szerinti vektőrőkkaltranszfőrmált sejtek, eljárásők a találmány szerinti sejtek és kívántfehérjék előállítására, a találmány szerinti vektőrőkkal transzfőrmáltsejtek, eljárásők a találmány szerinti eljárással előállítőttfehérjék, valamint a találmány szerinti fehérjéket tartalmazógyógyászati készítmények. A találmány szerinti megőldás alkalmasbizőnyős gyógyászatilag főntős hűmán fehérjék hatékőny előállítására. ŕ
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9506051.3A GB9506051D0 (en) | 1995-03-24 | 1995-03-24 | Gene expression |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP9800520A2 true HUP9800520A2 (hu) | 1998-06-29 |
HUP9800520A3 HUP9800520A3 (en) | 1999-09-28 |
Family
ID=10771834
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9800520A HUP9800520A3 (en) | 1995-03-24 | 1996-03-22 | Gene expression in mammalian cells |
Country Status (16)
Country | Link |
---|---|
US (1) | US6207146B1 (hu) |
EP (1) | EP0815251A1 (hu) |
JP (1) | JPH11502705A (hu) |
KR (1) | KR19980703275A (hu) |
CN (1) | CN1185180A (hu) |
AP (1) | AP730A (hu) |
AU (1) | AU722341B2 (hu) |
BR (1) | BR9607831A (hu) |
CA (1) | CA2216174A1 (hu) |
GB (2) | GB9506051D0 (hu) |
HK (1) | HK1005248A1 (hu) |
HU (1) | HUP9800520A3 (hu) |
IL (1) | IL117594A (hu) |
NO (1) | NO974367L (hu) |
NZ (1) | NZ303133A (hu) |
WO (1) | WO1996030531A1 (hu) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002089828A2 (en) * | 2001-05-04 | 2002-11-14 | Institute Of Molecular And Cell Biology | Interferons in the treatment of ischemia |
FR2843973B1 (fr) * | 2002-08-30 | 2006-07-07 | Agronomique Inst Nat Rech | Cassettes d'expression procaryotes regulees par le zinc |
GB0524782D0 (en) * | 2005-12-05 | 2006-01-11 | Chiron Srl | Analysis of samples |
CN100432230C (zh) * | 2006-05-11 | 2008-11-12 | 南京大学 | 一种金属硫蛋白融合表达方法及其应用 |
US8936936B2 (en) * | 2007-10-25 | 2015-01-20 | Sangamo Biosciences, Inc. | Methods and compositions for targeted integration |
SG11202009009UA (en) * | 2018-03-21 | 2020-10-29 | Nature Tech Corporation | Viral and non-viral nanoplasmid vectors with improved production |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5514567A (en) | 1979-01-30 | 1996-05-07 | Juridical Foundation, Japanese Foundation For Cancer Research | DNA and recombinant plasmid |
AU538665B2 (en) | 1979-10-30 | 1984-08-23 | Juridical Foundation, Japanese Foundation For Cancer Research | Human interferon dna |
US4966843A (en) | 1982-11-01 | 1990-10-30 | Cetus Corporation | Expression of interferon genes in Chinese hamster ovary cells |
WO1986004920A1 (en) * | 1985-02-13 | 1986-08-28 | Biotechnology Research Partners, Limited | Human metallothionein-ii promoter in mammalian expression system |
GB2177914B (en) | 1985-06-04 | 1989-10-25 | Chugai Pharmaceutical Co Ltd | A pharmaceutical composition containing human erythropoietin and a surface active agent for nasal administration for the treatment of anemia |
US4954437A (en) * | 1986-09-15 | 1990-09-04 | Integrated Genetics, Inc. | Cell encoding recombinant human erythropoietin |
CA1294215C (en) * | 1986-10-27 | 1992-01-14 | Ze'ev Shaked | Pharmaceutical compositions of recombinant beta-interferon and formulation processes |
DE3712564A1 (de) | 1987-04-14 | 1988-11-24 | Bioferon Biochem Substanz | Verfahren zur konstruktion einer animalen zellinie fuer die herstellung von humanem interferon-beta |
DD287531A5 (de) * | 1988-06-16 | 1991-02-28 | Akademie Der Wissenschaften,De | Verfahren zur herstellung von humanem wachstumshormon (sth) in tierischen zellen |
DE4128319A1 (de) * | 1991-08-27 | 1993-03-04 | Bioferon Biochem Substanz | Neues rekombinantes human-ifn-beta, verfahren zu dessen herstellung und dieses enthaltende pharmazeutische zubereitungen |
EP0551535A1 (en) * | 1992-01-13 | 1993-07-21 | SCLAVO S.p.A. | Process for the purification of recombinant human beta interferon, beta interferon thus purified, and pharmaceutical compositions which contain them |
-
1995
- 1995-03-24 GB GBGB9506051.3A patent/GB9506051D0/en active Pending
-
1996
- 1996-03-21 IL IL11759496A patent/IL117594A/en not_active IP Right Cessation
- 1996-03-22 EP EP96905646A patent/EP0815251A1/en not_active Withdrawn
- 1996-03-22 WO PCT/CA1996/000174 patent/WO1996030531A1/en not_active Application Discontinuation
- 1996-03-22 AP APAP/P/1997/001091A patent/AP730A/en active
- 1996-03-22 AU AU49358/96A patent/AU722341B2/en not_active Ceased
- 1996-03-22 NZ NZ303133A patent/NZ303133A/xx unknown
- 1996-03-22 BR BR9607831-6A patent/BR9607831A/pt not_active Application Discontinuation
- 1996-03-22 CN CN96194053A patent/CN1185180A/zh active Pending
- 1996-03-22 US US08/913,778 patent/US6207146B1/en not_active Expired - Fee Related
- 1996-03-22 HU HU9800520A patent/HUP9800520A3/hu unknown
- 1996-03-22 KR KR1019970706679A patent/KR19980703275A/ko not_active Application Discontinuation
- 1996-03-22 CA CA002216174A patent/CA2216174A1/en not_active Abandoned
- 1996-03-22 JP JP8528730A patent/JPH11502705A/ja not_active Withdrawn
- 1996-03-22 GB GB9720467A patent/GB2314332B/en not_active Expired - Fee Related
-
1997
- 1997-09-22 NO NO974367A patent/NO974367L/no not_active Application Discontinuation
-
1998
- 1998-05-25 HK HK98104482A patent/HK1005248A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
BR9607831A (pt) | 1999-11-30 |
IL117594A (en) | 2002-11-10 |
AP9701091A0 (en) | 1997-10-31 |
EP0815251A1 (en) | 1998-01-07 |
HUP9800520A3 (en) | 1999-09-28 |
AU722341B2 (en) | 2000-07-27 |
JPH11502705A (ja) | 1999-03-09 |
GB2314332B (en) | 1999-06-30 |
WO1996030531A1 (en) | 1996-10-03 |
GB9720467D0 (en) | 1997-11-26 |
CN1185180A (zh) | 1998-06-17 |
IL117594A0 (en) | 1996-07-23 |
GB9506051D0 (en) | 1995-05-10 |
MX9707244A (es) | 1998-08-30 |
NO974367D0 (no) | 1997-09-22 |
NO974367L (no) | 1997-11-24 |
NZ303133A (en) | 1999-11-29 |
AP730A (en) | 1999-02-04 |
KR19980703275A (ko) | 1998-10-15 |
HK1005248A1 (en) | 1998-12-31 |
US6207146B1 (en) | 2001-03-27 |
CA2216174A1 (en) | 1996-10-03 |
GB2314332A (en) | 1997-12-24 |
AU4935896A (en) | 1996-10-16 |
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