HUP0500037A2 - Eljárás inzulinvegyületek előállítására - Google Patents

Eljárás inzulinvegyületek előállítására

Info

Publication number
HUP0500037A2
HUP0500037A2 HU0500037A HUP0500037A HUP0500037A2 HU P0500037 A2 HUP0500037 A2 HU P0500037A2 HU 0500037 A HU0500037 A HU 0500037A HU P0500037 A HUP0500037 A HU P0500037A HU P0500037 A2 HUP0500037 A2 HU P0500037A2
Authority
HU
Hungary
Prior art keywords
insulin compounds
preparing insulin
insulin
preparing
converting
Prior art date
Application number
HU0500037A
Other languages
English (en)
Inventor
Are Bogsnes
Ingun Christiansen
Per Balschmidt
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of HUP0500037A2 publication Critical patent/HUP0500037A2/hu
Publication of HUP0500037A3 publication Critical patent/HUP0500037A3/hu
Publication of HU228934B1 publication Critical patent/HU228934B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A találmány tárgya az inzulin prekurzor inzulinná alakításánakelőnyben részesített módja, azaz enzimatikus hidrolízis vizesközegben, ezt követően a reakcióelegyhez a keletkezett közti termékeltávolítása nélkül, a kapcsolási reakcióhoz szükséges aminosavésztertvagy peptidésztert, valamint szerves oldószert adagolnak. Ó
HU0500037A 2001-11-19 2002-11-15 Eljárás inzulinvegyületek elõállítására HU228934B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200101716 2001-11-19
PCT/DK2002/000765 WO2003044210A2 (en) 2001-11-19 2002-11-15 Process for preparing insulin compounds

Publications (3)

Publication Number Publication Date
HUP0500037A2 true HUP0500037A2 (hu) 2005-03-29
HUP0500037A3 HUP0500037A3 (en) 2010-01-28
HU228934B1 HU228934B1 (hu) 2013-06-28

Family

ID=8160841

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0500037A HU228934B1 (hu) 2001-11-19 2002-11-15 Eljárás inzulinvegyületek elõállítására

Country Status (15)

Country Link
EP (1) EP1448786B1 (hu)
JP (1) JP4404631B2 (hu)
KR (1) KR100925381B1 (hu)
CN (1) CN100424179C (hu)
AT (1) ATE464390T1 (hu)
AU (1) AU2002342597A1 (hu)
BR (1) BR0213583A (hu)
CA (1) CA2464616C (hu)
DE (1) DE60236014D1 (hu)
ES (1) ES2344448T3 (hu)
HU (1) HU228934B1 (hu)
IL (2) IL161358A0 (hu)
PL (1) PL210437B1 (hu)
RU (1) RU2376379C2 (hu)
WO (1) WO2003044210A2 (hu)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006031955A1 (de) * 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
DE102006031962A1 (de) * 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidiertes Insulin Glargin
TW200902708A (en) * 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
CA2740685C (en) 2008-10-17 2018-09-11 Sanofi-Aventis Deutschland Gmbh Combination of an insulin and a glp-1 agonist
MX346473B (es) * 2009-08-11 2017-03-22 Biocon Ltd Procesos cromatograficos y compuestos purificados de los mismos.
AU2010317995B2 (en) 2009-11-13 2014-04-17 Sanofi-Aventis Deutschland Gmbh Pharmaceutical composition comprising a GLP-1 agonist, an insulin, and methionine
JP5973918B2 (ja) 2009-11-13 2016-08-23 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Ｇｌｐ−１アゴニスト及びメチオニンを含む薬学的組成物
JP6199186B2 (ja) 2010-08-30 2017-09-20 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ２型糖尿病の治療用の医薬の製造のためのａｖｅ００１０の使用
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
RU2650616C2 (ru) 2011-08-29 2018-04-16 Санофи-Авентис Дойчланд Гмбх Фармацевтическая комбинация для применения при гликемическом контроле у пациентов с сахарным диабетом 2 типа
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
CN102703552B (zh) * 2012-05-15 2014-10-29 山东阿华生物药业有限公司 重组人胰岛素的制备方法及其产品
CN102816819B (zh) * 2012-08-13 2014-10-29 山东阿华生物药业有限公司 提高人胰岛素前体融合蛋白酶切转换成b30缺苏氨酸人胰岛素产率的方法
CN103305581B (zh) * 2013-07-04 2015-05-27 珠海联邦制药股份有限公司 一种重组人胰岛素的制备方法
US10611813B2 (en) * 2013-12-23 2020-04-07 Biocon Research Limited Method of production of human insulin methyl ester
HRP20230470T1 (hr) 2014-12-12 2023-07-21 Sanofi-Aventis Deutschland Gmbh Formulacija fiksnog omjera inzulin glargin/liksisenatid
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
KR20170036643A (ko) * 2015-09-24 2017-04-03 한미약품 주식회사 인슐린의 제조 방법

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50892B1 (en) 1980-02-11 1986-08-06 Novo Industri As Process for preparing insulin esters
WO1983001074A1 (en) 1981-09-15 1983-03-31 Andresen, Finn, Hede Enzymatic preparation of human insulin or b-30 esters thereof
WO1983000504A1 (en) 1981-08-10 1983-02-17 Andresen, Finn, Hede Enzymatic preparation of human insulin
DK149824C (da) 1982-01-22 1987-03-16 Carlsberg Biotechnology Ltd Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner
EP0087238A1 (en) 1982-02-08 1983-08-31 Biogen N.V. Am improved method for preparing human insulin from non-human insulin
DK347086D0 (da) 1986-07-21 1986-07-21 Novo Industri As Novel peptides
PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
IL84110A (en) * 1986-10-14 1992-11-15 Lilly Co Eli Process for transforming a human insulin precursor to a human insulin
CA1339416C (en) 1987-02-25 1997-09-02 Liselotte Langkjaer Insulin derivatives
US6011007A (en) 1993-09-17 2000-01-04 Novo Nordisk A/S Acylated insulin
RO112873B1 (ro) 1993-09-17 1998-01-30 Novo Nordisk As Derivati de insulina
HUP0203475A3 (en) 1999-12-29 2005-11-28 Novo Nordisk As Method for making insulin precursors and insulin precursor analogs
WO2001049870A1 (en) 1999-12-29 2001-07-12 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
ATE381573T1 (de) 2000-04-14 2008-01-15 Univ Maryland Biotech Inst Verbesserte thermostabilität und temperaturresistenz von proteinen
US20040198960A1 (en) 2001-03-29 2004-10-07 Janoff Edward N Human monoclonal antibodies against capsular polysaccharides of streptococcus pneumoniae

Also Published As

Publication number Publication date
DE60236014D1 (de) 2010-05-27
HUP0500037A3 (en) 2010-01-28
CA2464616A1 (en) 2003-05-30
ATE464390T1 (de) 2010-04-15
CN100424179C (zh) 2008-10-08
KR20050044855A (ko) 2005-05-13
RU2376379C2 (ru) 2009-12-20
CN1589328A (zh) 2005-03-02
WO2003044210A3 (en) 2004-03-25
WO2003044210A2 (en) 2003-05-30
JP4404631B2 (ja) 2010-01-27
ES2344448T3 (es) 2010-08-27
AU2002342597A1 (en) 2003-06-10
IL161358A (en) 2011-05-31
AU2002342597A8 (en) 2003-06-10
CA2464616C (en) 2012-07-24
KR100925381B1 (ko) 2009-11-09
RU2004118503A (ru) 2005-06-10
EP1448786B1 (en) 2010-04-14
IL161358A0 (en) 2004-09-27
EP1448786A2 (en) 2004-08-25
BR0213583A (pt) 2004-08-24
PL369447A1 (en) 2005-04-18
PL210437B1 (pl) 2012-01-31
HU228934B1 (hu) 2013-06-28
JP2005509687A (ja) 2005-04-14

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Legal Events

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MM4A Lapse of definitive patent protection due to non-payment of fees