HUP0400350A2 - Új ciano-szubsztituált dihidropirimidin-vegyületek, eljárás előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Új ciano-szubsztituált dihidropirimidin-vegyületek, eljárás előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0400350A2 HUP0400350A2 HU0400350A HUP0400350A HUP0400350A2 HU P0400350 A2 HUP0400350 A2 HU P0400350A2 HU 0400350 A HU0400350 A HU 0400350A HU P0400350 A HUP0400350 A HU P0400350A HU P0400350 A2 HUP0400350 A2 HU P0400350A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- heteroarylalkyl
- cycloalkyl
- heterocycloalkylalkyl
- arylalkyl
- Prior art date
Links
- -1 cyano-substituted dihydropyrimidine compounds Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 5
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 5
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- XYMVZPOXZCDCNP-UHFFFAOYSA-N sulfamoyl cyanide Chemical group NS(=O)(=O)C#N XYMVZPOXZCDCNP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 125000004001 thioalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A találmány tárgyát az általános képletű, rákellenes hatású vegyületek- amely képletben R1 hidrogénatom, alkil- és cikloalkilcsoport; R2 ésR3 egymástól függetlenül hidrogénatom, alkil-, aril-, heteroaril-,aril-alkil-, cikloalkil-, heterocikloalkil-, cikloalkil-alkil-,heterocikloalkil-alkil- és heteroaril-alkil-csoport; vagy R2 és R3összekapcsolódhatnak karbociklusos- vagy heterociklusos gyűrűvé; R4alkil-, aril-alkil-, cikloalkil-alkil-, heteroaril-alkil-,heterocikloalkil-alkil-, amino-alkil-, ciano-, R5OC-, R5O2C ésR6R5NOC- csoport; R5 és R6 egymástól függetlenül hidrogénatom, alkil-,cikloalkil-, hidroxi-alkil-, alkenil-, alkoxi-, tioalkoxi-, alkoxi-alkil-, halogén-alkil-, aril-, heteroaril-, aril-alkil-, cikloalkil-alkil-, heteroaril-alkil- és heterocikloalkil-alkil-csoport vagy -NR5R6 együtt heterocikloalkil-csoportot alkot; Z oxigén-, kénatom és -R8N- csoport; R8 hidrogénatom, ciano-, szulfonamid-, R7O-, alkil-,cikloalkil-, aril-, aril-alkil-, heterociklusos-, heteroaril- ésheteroaril-alkil-csoport; és R6 halogénatom, alkil-, aril-alkil-,cikloalkil-alkil-, heterocikloalkil-alkil- és heteroaril-alkil-csoportés gyógyszerészetileg elfogadható sóik és ezeket tartalmazógyógyszerkészítmények képezik. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27995601P | 2001-03-29 | 2001-03-29 | |
| PCT/US2002/009497 WO2002079149A2 (en) | 2001-03-29 | 2002-03-26 | Novel cyano-substituted dihydropyrimidine compounds and their use to treat diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0400350A2 true HUP0400350A2 (hu) | 2005-01-28 |
| HUP0400350A3 HUP0400350A3 (en) | 2005-06-28 |
Family
ID=23071059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0400350A HUP0400350A3 (en) | 2001-03-29 | 2002-03-26 | Novel cyano-substituted dihydropyrimidine compounds, process for producing them, their use and pharmaceutical compositions containing them |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6809102B2 (hu) |
| EP (1) | EP1373221A4 (hu) |
| JP (1) | JP2005504725A (hu) |
| KR (1) | KR20030086327A (hu) |
| CN (1) | CN1507435A (hu) |
| AR (1) | AR034585A1 (hu) |
| BG (1) | BG108180A (hu) |
| BR (1) | BR0208405A (hu) |
| CA (1) | CA2442482A1 (hu) |
| CZ (1) | CZ20032645A3 (hu) |
| EE (1) | EE200300474A (hu) |
| HR (1) | HRP20030875A2 (hu) |
| HU (1) | HUP0400350A3 (hu) |
| IL (1) | IL157441A0 (hu) |
| IS (1) | IS6967A (hu) |
| MX (1) | MXPA03008634A (hu) |
| NO (1) | NO20034300L (hu) |
| PE (1) | PE20021013A1 (hu) |
| PL (1) | PL373759A1 (hu) |
| RU (1) | RU2003130961A (hu) |
| SK (1) | SK11062003A3 (hu) |
| TW (1) | TWI228416B (hu) |
| UY (1) | UY27232A1 (hu) |
| WO (1) | WO2002079149A2 (hu) |
| YU (1) | YU75803A (hu) |
| ZA (2) | ZA200306648B (hu) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6900214B2 (en) * | 2001-03-29 | 2005-05-31 | Bristol-Myers Squibb Company | Cyano-substituted dihydropyrimidine compounds and their use to treat diseases |
| EP1454903B9 (en) * | 2001-12-11 | 2011-10-05 | Kyowa Hakko Kirin Co., Ltd. | Thiadiazoline derivatives for treating cancer |
| AR050920A1 (es) * | 2003-03-07 | 2006-12-06 | Astrazeneca Ab | Enantiomeros de heterociclos fusionados seleccionados y usos de los mismos |
| MXPA05009577A (es) * | 2003-03-07 | 2005-12-12 | Astrazeneca Ab | Heterociclos fundidos novedosos y sus usos. |
| ES2377498T3 (es) * | 2003-04-18 | 2012-03-28 | Kyowa Hakko Kirin Co., Ltd. | Inhibidor de quinesina en etapa M |
| KR20060014071A (ko) * | 2003-06-10 | 2006-02-14 | 교와 핫꼬 고교 가부시끼가이샤 | 티아디아졸린 유도체 |
| WO2005007124A2 (en) | 2003-07-23 | 2005-01-27 | Bristol-Myers Squibb Company | Substituted dihydropyrimidine inhibitors of calcium channel function |
| US7166603B2 (en) | 2003-07-23 | 2007-01-23 | Bristol-Myers Squibb Co. | Dihydropyrimidone inhibitors of calcium channel function |
| WO2005037799A1 (en) * | 2003-10-16 | 2005-04-28 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| KR20070044458A (ko) * | 2004-07-22 | 2007-04-27 | 아스트라제네카 아베 | 암의 예방 및 치료에 유용한 융합 피리미돈 |
| US20060041128A1 (en) * | 2004-08-18 | 2006-02-23 | Astrazeneca Ab | Selected fused heterocyclics and uses thereof |
| CA2575188A1 (en) * | 2004-08-18 | 2006-02-23 | Astrazeneca Ab | Enantiomers of selected fused pyrimidones and uses in the treatment and preventi on of cancer |
| US20100093767A1 (en) * | 2004-12-03 | 2010-04-15 | Takeda San Diego, Inc. | Mitotic Kinase Inhibitors |
| EP1870404A4 (en) * | 2005-03-22 | 2010-07-14 | Kyowa Hakko Kirin Co Ltd | MEANS FOR THE TREATMENT OF A HEMATOPOIETIC TUMOR |
| KR20070113300A (ko) * | 2005-03-22 | 2007-11-28 | 교와 핫꼬 고교 가부시끼가이샤 | 고형종양 치료제 |
| EP1908755A4 (en) * | 2005-06-24 | 2009-06-24 | Kyowa Hakko Kirin Co Ltd | THERAPEUTIC AGENT AGAINST RESTENOSIS |
| DE102006002065B4 (de) * | 2006-01-16 | 2007-11-29 | Infineon Technologies Austria Ag | Kompensationsbauelement mit reduziertem und einstellbarem Einschaltwiderstand |
| CN110464722B (zh) * | 2019-06-06 | 2023-05-23 | 暨南大学 | 一类小分子化合物或其药学上可接受的盐在制备抗肿瘤转移药物中的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6211198B1 (en) | 1993-04-05 | 2001-04-03 | Synaptic Pharmaceutical Corporation | Dihydropyridines and new uses thereof |
| EE9700209A (et) | 1994-11-16 | 1998-04-15 | Synaptic Pharmaceutical Corporation | Dihüdropürimidiinid ja nende kasutamine |
| WO1997017969A1 (en) | 1995-11-16 | 1997-05-22 | Synaptic Pharmaceutical Corporation | Dihydropyrimidines and uses thereof |
| US6172066B1 (en) | 1996-05-16 | 2001-01-09 | Synaptic Pharmaceutical Corporation | Dihydropyrimidines and uses thereof |
| JP2000506904A (ja) | 1996-05-16 | 2000-06-06 | シナプティック・ファーマスーティカル・コーポレーション | ジヒドロピリミジン類およびその使用 |
| US6080760A (en) | 1997-06-18 | 2000-06-27 | Merck & Co., Inc. | Alpha 1A adrenergic receptor antagonists |
| CA2294349A1 (en) | 1997-06-18 | 1998-12-23 | Michael A. Patane | Alpha 1aadrenergic receptor antagonists |
| WO1999025345A1 (en) | 1997-11-14 | 1999-05-27 | Merck & Co., Inc. | Alpha-1a adrenergic receptor antagonists |
| WO1999050440A2 (en) | 1998-04-01 | 1999-10-07 | Yale University | Method to identify modulators of survivin - tubulin interaction |
| US6300084B1 (en) | 1998-10-08 | 2001-10-09 | The Regents Of The University Of California | Anti-mitotic agent screening process |
| AUPQ171999A0 (en) | 1999-07-20 | 1999-08-12 | University Of Sydney, The | Neurotropic virus transport |
| DE19935303A1 (de) | 1999-07-28 | 2001-02-08 | Aventis Pharma Gmbh | Oligonukleotide zur Inhibierung der Expression von humanem eg5 |
| US6617115B1 (en) | 1999-10-27 | 2003-09-09 | Cytokinetics, Inc. | Methods of screening for modulators of cell proliferation |
| ES2263501T3 (es) | 1999-10-27 | 2006-12-16 | Cytokinetics, Inc. | Procedimiento y composiciones que utilizan quinazolinonas. |
| US6284480B1 (en) | 2000-04-03 | 2001-09-04 | Cytokinetics, Inc. | Antifungal assay |
| US6900214B2 (en) | 2001-03-29 | 2005-05-31 | Bristol-Myers Squibb Company | Cyano-substituted dihydropyrimidine compounds and their use to treat diseases |
-
2002
- 2002-03-22 US US10/104,257 patent/US6809102B2/en not_active Expired - Lifetime
- 2002-03-25 PE PE2002000232A patent/PE20021013A1/es not_active Application Discontinuation
- 2002-03-25 TW TW091105771A patent/TWI228416B/zh not_active IP Right Cessation
- 2002-03-26 PL PL02373759A patent/PL373759A1/xx not_active Application Discontinuation
- 2002-03-26 BR BR0208405-8A patent/BR0208405A/pt not_active IP Right Cessation
- 2002-03-26 RU RU2003130961/04A patent/RU2003130961A/ru not_active Application Discontinuation
- 2002-03-26 WO PCT/US2002/009497 patent/WO2002079149A2/en active Search and Examination
- 2002-03-26 HU HU0400350A patent/HUP0400350A3/hu unknown
- 2002-03-26 KR KR10-2003-7012604A patent/KR20030086327A/ko not_active Application Discontinuation
- 2002-03-26 IL IL15744102A patent/IL157441A0/xx unknown
- 2002-03-26 EE EEP200300474A patent/EE200300474A/xx unknown
- 2002-03-26 JP JP2002577776A patent/JP2005504725A/ja not_active Withdrawn
- 2002-03-26 YU YU75803A patent/YU75803A/sh unknown
- 2002-03-26 CN CNA028074556A patent/CN1507435A/zh active Pending
- 2002-03-26 EP EP02728592A patent/EP1373221A4/en not_active Withdrawn
- 2002-03-26 CA CA002442482A patent/CA2442482A1/en not_active Abandoned
- 2002-03-26 SK SK1106-2003A patent/SK11062003A3/sk unknown
- 2002-03-26 CZ CZ20032645A patent/CZ20032645A3/cs unknown
- 2002-03-26 MX MXPA03008634A patent/MXPA03008634A/es unknown
- 2002-03-27 AR ARP020101168A patent/AR034585A1/es unknown
- 2002-03-27 UY UY27232A patent/UY27232A1/es not_active Application Discontinuation
-
2003
- 2003-08-26 ZA ZA200306648A patent/ZA200306648B/en unknown
- 2003-09-17 BG BG108180A patent/BG108180A/xx unknown
- 2003-09-18 ZA ZA200307320A patent/ZA200307320B/en unknown
- 2003-09-24 IS IS6967A patent/IS6967A/is unknown
- 2003-09-26 NO NO20034300A patent/NO20034300L/no not_active Application Discontinuation
- 2003-10-28 HR HR20030875A patent/HRP20030875A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2442482A1 (en) | 2002-10-10 |
| HUP0400350A3 (en) | 2005-06-28 |
| EP1373221A4 (en) | 2004-09-29 |
| HRP20030875A2 (en) | 2004-08-31 |
| MXPA03008634A (es) | 2003-12-08 |
| KR20030086327A (ko) | 2003-11-07 |
| IS6967A (is) | 2003-09-24 |
| EP1373221A2 (en) | 2004-01-02 |
| ZA200307320B (en) | 2004-12-20 |
| YU75803A (sh) | 2006-05-25 |
| BG108180A (en) | 2004-09-30 |
| US20030008888A1 (en) | 2003-01-09 |
| UY27232A1 (es) | 2002-11-29 |
| SK11062003A3 (sk) | 2004-08-03 |
| IL157441A0 (en) | 2004-03-28 |
| CN1507435A (zh) | 2004-06-23 |
| NO20034300L (no) | 2003-11-07 |
| BR0208405A (pt) | 2004-03-30 |
| TWI228416B (en) | 2005-03-01 |
| PE20021013A1 (es) | 2002-11-10 |
| AR034585A1 (es) | 2004-03-03 |
| EE200300474A (et) | 2003-12-15 |
| US6809102B2 (en) | 2004-10-26 |
| CZ20032645A3 (cs) | 2004-06-16 |
| JP2005504725A (ja) | 2005-02-17 |
| ZA200306648B (en) | 2004-11-26 |
| NO20034300D0 (no) | 2003-09-26 |
| WO2002079149A3 (en) | 2003-02-27 |
| WO2002079149A2 (en) | 2002-10-10 |
| RU2003130961A (ru) | 2005-04-10 |
| PL373759A1 (en) | 2005-09-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0400350A2 (hu) | Új ciano-szubsztituált dihidropirimidin-vegyületek, eljárás előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények | |
| HUP0203841A2 (en) | 5-membered heteroaromatic compounds and use thereof for preparation of pharmaceutical compositions, and pharmaceutical compositions containing them | |
| HUP0402320A2 (hu) | Ariloxifenil- és arilszulfanilfenil-piperazin-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| HUP0302153A2 (hu) | Kemokin receptor aktívitás modulátoraiként hatásos piperidinszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények | |
| HUP0401481A2 (hu) | Kinolinszármazékok, mint neuropeptid Y antagonisták, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| HUP0303756A2 (hu) | 1-Aril- vagy 1-alkilszulfonil-heterociklobenzazolok és eljárás ezek elõállítására és ezeket tartalmazó gyógyszerkészítmények | |
| HUP0203316A2 (hu) | Amino-triazolopiridin-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| ZA200505273B (en) | Novel compound | |
| HUP0203971A2 (hu) | Imidazoimidazolok és -triazolok mint gyulladásellenes szerek és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| HUP0300497A2 (hu) | Humán foszfatidilinozit-3-kináz-delta inhibitorok és alkalmazásuk | |
| HUP0000914A2 (hu) | 3-Aril-4 (3H)-kinazolinon-származékok atropizomerjei és ezeket a vegyületeket tartalmazó gyógyszerkészítmények | |
| BRPI0707491B8 (pt) | compostos úteis como agentes moduladores de receptores de mineralocorticóides, os referidos agentes compreendendo os mesmos e composições farmacêuticas | |
| HUP0402019A2 (hu) | CCR5 antagonistaként alkalmazható piperidinszármazékok és ezeket tartalmazó gyógyszerkészítmények | |
| HUP0104959A2 (hu) | 4-Kinolinkarboxamid-származékok, előállításuk, neurokinin-2 (NK-2) és neurokinin-3 (NK-3) receptor antagonistákként történő felhasználásuk, valamint a vegyületeket tartalmazó gyógyszerkészítmények | |
| MY123193A (en) | Novel 2-(iminomethyl)amino-phenyl derivatives,preparation,application as medicines and compositions containing same | |
| HUP0400341A2 (hu) | Ciano-szubsztituált dihidropirimidin-vegyületek és alkalmazásuk | |
| EA200601194A1 (ru) | Новые производные бензофурана, используемые для профилактики или лечения нарушений, связанных с 5-ht-рецептором | |
| HUP0402261A2 (hu) | Piperidinszármazékok és alkalmazásuk kemokin receptor aktivitás modulátoraiként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| HUP0402675A2 (hu) | HIV integráz inhibitor hatású hidroxilaminszármazékok, az ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| ATE233754T1 (de) | Diphenyl-piperidin derivate | |
| HUP0204347A2 (en) | Compounds having antitumor activity: process for their preparation and pharmaceutical compositions containing them and their use | |
| HUP0400806A2 (hu) | Heterokondenzált (gamma)-laktám-származékok, alkalmazásuk és az ezeket tartalmazó gyógyászati készítmények | |
| HUP0402567A2 (hu) | Piperidinszármazékok és alkalmazásuk kemokin receptor (különösen CCR5) aktivitás modulátoraiként | |
| HUP0303593A2 (hu) | Biguanidszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| HUP0402585A2 (hu) | Új benzotiazin- benzotiadiazin-származékok, előállításuk, alkalmazásuk és az ezeket tartalmazó gyógyászati készítmények |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |