HUP0303279A3 - Indolylopyrrolocarbazoles sugar derivatives as topoisomerase inhibitors and pharmaceutical compositions containing them - Google Patents
Indolylopyrrolocarbazoles sugar derivatives as topoisomerase inhibitors and pharmaceutical compositions containing themInfo
- Publication number
- HUP0303279A3 HUP0303279A3 HU0303279A HUP0303279A HUP0303279A3 HU P0303279 A3 HUP0303279 A3 HU P0303279A3 HU 0303279 A HU0303279 A HU 0303279A HU P0303279 A HUP0303279 A HU P0303279A HU P0303279 A3 HUP0303279 A3 HU P0303279A3
- Authority
- HU
- Hungary
- Prior art keywords
- indolylopyrrolocarbazoles
- pharmaceutical compositions
- compositions containing
- topoisomerase inhibitors
- sugar derivatives
- Prior art date
Links
- 239000003534 dna topoisomerase inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229940044693 topoisomerase inhibitor Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23872600P | 2000-10-06 | 2000-10-06 | |
| PCT/US2001/030640 WO2002030941A2 (en) | 2000-10-06 | 2001-10-01 | Topoisomerase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0303279A2 HUP0303279A2 (hu) | 2004-01-28 |
| HUP0303279A3 true HUP0303279A3 (en) | 2004-11-29 |
Family
ID=22899064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0303279A HUP0303279A3 (en) | 2000-10-06 | 2001-10-01 | Indolylopyrrolocarbazoles sugar derivatives as topoisomerase inhibitors and pharmaceutical compositions containing them |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6677450B2 (hu) |
| EP (1) | EP1326874A2 (hu) |
| JP (1) | JP2004523478A (hu) |
| AU (1) | AU2001296435A1 (hu) |
| CA (1) | CA2424971A1 (hu) |
| HU (1) | HUP0303279A3 (hu) |
| WO (1) | WO2002030941A2 (hu) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004025726B4 (de) * | 2004-05-26 | 2006-07-06 | Roder, Hanno, Dr. | Verwendung eines spezifischen K252a-Derivats zur Verhinderung oder Behandlung der Alzheimerschen Krankheit |
| JP2008504292A (ja) | 2004-06-24 | 2008-02-14 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス， インコーポレイテッド | 免疫増強用の化合物 |
| JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| AR060358A1 (es) | 2006-04-06 | 2008-06-11 | Novartis Vaccines & Diagnostic | Quinazolinas para la inhibicion de pdk 1 |
| WO2008076394A1 (en) * | 2006-12-14 | 2008-06-26 | Tautatis, Inc. | Compositions and methods for the treatment of cancer |
| JP2011506560A (ja) | 2007-12-20 | 2011-03-03 | ノバルティス アーゲー | Ｐｉ３キナーゼ阻害剤として用いられるチアゾール誘導体 |
| ES2326459B1 (es) * | 2008-04-08 | 2010-05-28 | Universidad De Oviedo | Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos. |
| US8293753B2 (en) | 2009-07-02 | 2012-10-23 | Novartis Ag | Substituted 2-carboxamide cycloamino ureas |
| AR082418A1 (es) | 2010-08-02 | 2012-12-05 | Novartis Ag | Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico |
| US8987257B2 (en) | 2011-01-31 | 2015-03-24 | Novartis Ag | Heterocyclic derivatives |
| EP2771342B1 (en) | 2011-10-28 | 2016-05-18 | Novartis AG | Purine derivatives and their use in the treatment of disease |
| US10213432B2 (en) | 2012-05-16 | 2019-02-26 | Novartis Ag | Dosage regimen for a PI-3 kinase inhibitor |
| PL3076969T3 (pl) | 2013-12-06 | 2022-01-17 | Novartis Ag | Schemat dawkowania selektywnego inhibitora 3-kinazy fosfatydynozytolu alfa-izoformy |
| CN104031052B (zh) * | 2014-05-20 | 2016-06-08 | 中国科学院南海海洋研究所 | 抗生素Indimicins A–E及其制备方法和在制备抗肿瘤药物中的应用 |
| CA3002954A1 (en) | 2015-11-02 | 2017-05-11 | Novartis Ag | Dosage regimen for a phosphatidylinositol 3-kinase inhibitor |
| WO2018060833A1 (en) | 2016-09-27 | 2018-04-05 | Novartis Ag | Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4487925A (en) | 1983-01-28 | 1984-12-11 | Bristol-Myers Company | Rebeccamycin and process for its preparation |
| US4552842A (en) | 1983-01-28 | 1985-11-12 | Bristol-Myers Company | Process for producing rebeccamycin |
| US4567143A (en) | 1984-09-04 | 1986-01-28 | Bristol-Myers Company | Process for preparing 4'-deschlororebeccamycin |
| US4785085A (en) | 1986-11-21 | 1988-11-15 | Bristol-Myers Company | Rebeccamycin analogs |
| JP2766360B2 (ja) * | 1988-02-04 | 1998-06-18 | 協和醗酵工業株式会社 | スタウロスポリン誘導体 |
| DE3924538A1 (de) | 1989-07-25 | 1991-01-31 | Goedecke Ag | Indolocarbazol und dessen verwendung |
| US5618809A (en) * | 1989-12-14 | 1997-04-08 | Schering Corporation | Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov SCC 1951 ATCC 53856 |
| IL97233A (en) | 1990-03-06 | 1995-03-30 | Bristol Myers Squibb Co | Analogs of rabamycin, their manufacture and pharmaceutical preparations containing them |
| US5478813A (en) | 1990-05-11 | 1995-12-26 | Banyu Pharmaceutical Co., Ltd. | Antitumor substance BE-13793C derivatives |
| US5668271A (en) | 1991-11-29 | 1997-09-16 | Banyu Pharmaceutical Co., Ltd. | Indolopyrrolocarbazole derivatives |
| US5589365A (en) | 1991-11-29 | 1996-12-31 | Banyu Pharmaceutical Co., Ltd. | Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms |
| NZ245203A (en) | 1991-11-29 | 1997-07-27 | Banyu Pharma Co Ltd | 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates |
| DE69331228D1 (en) * | 1992-09-21 | 2002-01-10 | Kyowa Hakko Kogyo Kk | Heilmittel für thrombozytopenia |
| FR2696465B1 (fr) | 1992-10-02 | 1994-12-23 | Adir | Nouveaux dérivés d'ellipticine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| JP3603322B2 (ja) | 1992-12-14 | 2004-12-22 | 萬有製薬株式会社 | インドロピロロカルバゾール誘導体の製造法 |
| US5468872A (en) | 1993-09-16 | 1995-11-21 | Cephalon, Inc. | K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders |
| WO1995030682A1 (fr) | 1994-05-09 | 1995-11-16 | Banyu Pharmaceutical Co., Ltd. | Derive d'indolopyrolocarbazole antitumoral |
| WO1996004293A1 (fr) | 1994-08-02 | 1996-02-15 | Banyu Pharmaceutical Co., Ltd. | Indolopyrrolocarbazoles antitumoraux |
| US5475110A (en) | 1994-10-14 | 1995-12-12 | Cephalon, Inc. | Fused Pyrrolocarbazoles |
| US5705511A (en) | 1994-10-14 | 1998-01-06 | Cephalon, Inc. | Fused pyrrolocarbazoles |
| WO1997007081A2 (en) * | 1995-08-11 | 1997-02-27 | Yale University | Glycosylated indolocarbazole synthesis |
| BR9711306A (pt) | 1996-08-22 | 1999-08-17 | Bristol Myers Squibb Co | Amino a-Úcar citotÄxico e derivados de a-Úcar correlatos de indolopirrolocarbazÄis |
| CO4940430A1 (es) * | 1997-07-07 | 2000-07-24 | Novartis Ag | Compuestos policiclicos que contienen estaurosporina hidrogenada con propiedades farmacologicas convenientes y un efecto inhibidor sobre el crecimiento de las celulas tumorales |
| FR2801054B1 (fr) | 1999-11-17 | 2003-06-13 | Adir | Nouveaux derives de 12,13-(pyranosyl)-indolo[2,3-a]pyrrolo [3,4-c]carbazole et 12,13-(pyranosyl)-furo[3,4-c]indolo [2,3-a]carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2001
- 2001-09-27 US US09/965,976 patent/US6677450B2/en not_active Expired - Fee Related
- 2001-10-01 HU HU0303279A patent/HUP0303279A3/hu unknown
- 2001-10-01 AU AU2001296435A patent/AU2001296435A1/en not_active Abandoned
- 2001-10-01 WO PCT/US2001/030640 patent/WO2002030941A2/en not_active Application Discontinuation
- 2001-10-01 JP JP2002534326A patent/JP2004523478A/ja not_active Withdrawn
- 2001-10-01 CA CA002424971A patent/CA2424971A1/en not_active Abandoned
- 2001-10-01 EP EP01977305A patent/EP1326874A2/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1326874A2 (en) | 2003-07-16 |
| CA2424971A1 (en) | 2002-04-18 |
| US6677450B2 (en) | 2004-01-13 |
| WO2002030941A2 (en) | 2002-04-18 |
| JP2004523478A (ja) | 2004-08-05 |
| AU2001296435A1 (en) | 2002-04-22 |
| HUP0303279A2 (hu) | 2004-01-28 |
| WO2002030941A3 (en) | 2002-10-03 |
| US20020107237A1 (en) | 2002-08-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0500173A3 (en) | Alpha-sulphonamido-acetamide derivatives as beta-amyloid inhibitors and pharmaceutical compositions containing them | |
| HUP0302485A3 (en) | Arylmethylamine derivatives for use as tryptase inhibitors and pharmaceutical compositions containing them | |
| HUP0400451A3 (en) | Pyrrole derivatives and pharmaceutical compositions containing them | |
| IL165119A0 (en) | C-aryl glucoside derivatives and pharmaceutical compositions containing the same | |
| HUP0302412A3 (en) | Betha-carboline derivatives useful as inhibitors of phosphodiesterase and pharmaceutical compositions containing the same | |
| IL152490A0 (en) | Pyridine derivatives and pharmaceutical compositions containing the same | |
| IL148806A0 (en) | C-aryl glucoside derivatives and pharmaceutical compositions containing the same | |
| IL151209A0 (en) | Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation | |
| IL150734A0 (en) | Azaindole derivatives and pharmaceutical compositions containing the same | |
| HUP0301178A3 (en) | Glucopyranosyloxybenzylbenzene derivatives and pharmaceutical compositions containing the same | |
| HUP0300565A3 (en) | 8-quinolinxanthine and 8-isoquinolinxanthine derivatives as pde 5 inhibitors, their use, process for their preparation and pharmaceutical compositions containing them | |
| HUP0400837A3 (en) | 2-phenyl-thiazole derivatives, their use and pharmaceutical compositions containing them | |
| HUP0204474A3 (en) | 1h-imidazopyridine derivatives, pharmaceutical compositions containing them and their use | |
| HUP0303279A3 (en) | Indolylopyrrolocarbazoles sugar derivatives as topoisomerase inhibitors and pharmaceutical compositions containing them | |
| HUP0203288A3 (en) | Pyrrole derivatives as phosphodiesterase vii inhibitors, pharmaceutical compositions containing them and their use | |
| HUP0400011A3 (en) | Dihydro isoquinoline derivatives as phosphodiesterase inhibitors and pharmaceutical compositions containing them | |
| HUP0203245A3 (en) | Imidazopyridine derivatives as phosphodiesterase vii inhibitors and pharmaceutical compositions containing them | |
| HUP0001632A3 (en) | Pharmaceutical compositions comprising selective phosphodiestherase inhibitors | |
| HUP0301713A3 (en) | Pharmaceutical compositions containing propenone derivatives and their use | |
| HUP0303184A3 (en) | Substituted c-cyclohexylmethylamine derivatives and pharmaceutical compositions containing them | |
| IL176077A0 (en) | 1-n-phenyl-amino-1h-imidazole derivatives and pharmaceutical compositions containing them | |
| IL151912A0 (en) | Pyrolidine derivatives, their preparation and pharmaceutical compositions containing them | |
| PL356911A1 (en) | Novel heterocyclic derivatives, preparation method and pharmaceutical compositions containing same | |
| HUP0303204A3 (en) | 1-methylcarbapenem derivatives and pharmaceutical compositions containing them | |
| IL151715A0 (en) | N-deacetylthiocolchicine derivatives and pharmaceutical compositions containing them |