HUP0302771A2 - Nitrozo-difenilamin-származékok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents

Nitrozo-difenilamin-származékok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk

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Publication number
HUP0302771A2
HUP0302771A2 HU0302771A HUP0302771A HUP0302771A2 HU P0302771 A2 HUP0302771 A2 HU P0302771A2 HU 0302771 A HU0302771 A HU 0302771A HU P0302771 A HUP0302771 A HU P0302771A HU P0302771 A2 HUP0302771 A2 HU P0302771A2
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Hungary
Prior art keywords
group
atom
saturated
aliphatic hydrocarbon
general formula
Prior art date
Application number
HU0302771A
Other languages
English (en)
Inventor
Lidia Caputo
Jacques Decerprit
Didier Festal
Daniel Guerrier
Claude Lardy
Jean-Yves Nioche
Jean-Yves Ortholand
Original Assignee
Merck Patent Gmbh
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Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of HUP0302771A2 publication Critical patent/HUP0302771A2/hu

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07C243/04—N-nitroso compounds
    • C07C243/08—N-nitroso-carboxamides
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Abstract

A találmány szerinti vegyületek (I) általános képletében X jelentésehidrogénatom, telített vagy telítetlen alifás szénhidrogénen alapulócsoport, vagy -A-Y általános képletű csoport, A jelentése -CO-, -SO2-vagy -CO-NRa- képletű csoport, ahol a karbonilcsoport az NX-csoportnitrogénatomjához kapcsolódik, Ra jelentése hidrogénatom vagy telítettvagy telítetlen alifás szénhidrogénen alapuló csoport; vagy Ajelentése -CO-NRa-SO2- képletű csoport, ahol a karbonilcsoport az NX-csoport nitrogénatomjához kapcsolódik, Ra jelentése a fenti, Tjelentése hidrogénatom, halogénatom, telített vagy telítetlen alifásszénhidrogénen alapuló csoport, amely adott esetben oxigénatomotés/vagy kénatomot tartalmaz, és adott esetben halogénatommalszubsztituálva lehet vagy nitrocsoport, vagy cianocsoport, Y jelentéseszerves szubsztituens. és ezek sztereoizomer formái, savakkal vagybázisokkal képzett addíciós sói, hidrátjai, és szolvátjai. A találmánykiterjed egyes új nitrozocsoport nélküli difenilaminoszármazékra. Atalálmány kiterjed továbbá az (I) általános képletű vegyületekelőállítására, és ezeket és új nitrozocsoport nélkülidifenilaminoszármazékokat tartalmazó gyógyszerkészítményekre. Ó
HU0302771A 2000-10-05 2001-09-18 Nitrozo-difenilamin-származékok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk HUP0302771A2 (hu)

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FR0012749A FR2815030A1 (fr) 2000-10-05 2000-10-05 Derives nitroso de la diphenylamine, compositions pharmaceutiques les contenant et leur utilisation pour la preparation de medicaments
PCT/EP2001/010761 WO2002028820A1 (en) 2000-10-05 2001-09-18 Nitroso diphenylamine derivatives

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WO2002028820A1 (en) 2002-04-11
PL359821A1 (en) 2004-09-06
KR20030059179A (ko) 2003-07-07
EP1322598A1 (en) 2003-07-02
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AR030857A1 (es) 2003-09-03

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