DK419086A - Heterocykliske substituerede indoler, mellemprodukter, fremgangsmaader til fremstilling heraf og laegemidler - Google Patents

Heterocykliske substituerede indoler, mellemprodukter, fremgangsmaader til fremstilling heraf og laegemidler Download PDF

Info

Publication number: DK419086A
Authority: DK; Denmark
Prior art keywords: intermediates; heteroatoms; alkyl; image; cyano
Prior art date: 1985-09-05

Application number

DK419086A

Other languages

English (en)

Other versions

DK419086D0 (da

Inventor

Alfred Mertens

Wolfgang Von Der Saal

Walter-Gunar Friebe

Bernd Mueller-Beckmann

Gisbert Sponer

Original Assignee

Boehringer Mannheim Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-09-05

Filing date

1986-09-02

Publication date

1987-03-06

1986-09-02 Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh

1986-09-02 Publication of DK419086D0 publication Critical patent/DK419086D0/da

1987-03-06 Publication of DK419086A publication Critical patent/DK419086A/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

DK419086A 1985-09-05 1986-09-02 Heterocykliske substituerede indoler, mellemprodukter, fremgangsmaader til fremstilling heraf og laegemidler DK419086A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19853531658 DE3531658A1 (de)	1985-09-05	1985-09-05	Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel

Publications (2)

Publication Number	Publication Date
DK419086D0 DK419086D0 (da)	1986-09-02
DK419086A true DK419086A (da)	1987-03-06

Family

ID=6280166

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK419086A DK419086A (da)	1985-09-05	1986-09-02	Heterocykliske substituerede indoler, mellemprodukter, fremgangsmaader til fremstilling heraf og laegemidler

Country Status (17)

Country	Link
US (1)	US4851406A (da)
EP (1)	EP0223937B1 (da)
JP (1)	JPS6256486A (da)
KR (1)	KR870003099A (da)
AT (1)	ATE73797T1 (da)
AU (1)	AU572405B2 (da)
DD (1)	DD258229A5 (da)
DE (2)	DE3531658A1 (da)
DK (1)	DK419086A (da)
ES (1)	ES2001936A6 (da)
FI (1)	FI863564A (da)
GR (1)	GR862248B (da)
HU (1)	HU197000B (da)
IL (1)	IL79911A (da)
NZ (1)	NZ217419A (da)
PT (1)	PT83310B (da)
ZA (1)	ZA866705B (da)

Families Citing this family (49)

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Publication number	Priority date	Publication date	Assignee	Title
FR2594438B1 (fr) *	1986-02-14	1990-01-26	Labaz Sanofi Nv	Derives d'indolizine, leur procede de preparation ainsi que les compositions en contenant
DE3631085A1 (de) *	1986-09-12	1988-03-24	Boehringer Mannheim Gmbh	Heterocyclisch substituierte indolinone, verfahren zu ihrer herstellung, arzneimittel sowie zwischenprodukte
DE3706427A1 (de) *	1987-02-27	1988-09-08	Boehringer Mannheim Gmbh	Neue substituierte 3h-indole, zwischenprodukte, verfahren zu ihrer herstellung sowie arzneimittel
US5225431A (en) *	1987-10-23	1993-07-06	Burroughs Wellcome Co.	Therapeutic substituted indole compounds and compositions thereof
JP2597893B2 (ja) *	1988-07-21	1997-04-09	自動車機器株式会社	流体給排用接続筒を備えたシリンダとその製造方法および製造装置
DE3826855A1 (de) *	1988-08-06	1990-02-15	Cassella Ag	4,5-dihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung und ihre verwendung
US5238938A (en) *	1989-02-10	1993-08-24	Otsuka Pharmaceutical Co., Ltd.	Indole derivatives
US5185332A (en) *	1989-02-11	1993-02-09	Orion-Yhtyma Oy	Thiadiazines and pharmaceutical compositions thereof as well as method of use
GB8903130D0 (en)	1989-02-11	1989-03-30	Orion Yhtymae Oy	Substituted pyridazinones
PT95899A (pt) *	1989-11-17	1991-09-13	Glaxo Group Ltd	Processo para a preparacao de derivados indole
MC2210A1 (fr) *	1990-06-07	1992-11-26	Wellcome Found	Composes heterocycliques therapeutiques,leur utilisation et procede pour les preparer
US5189054A (en) *	1990-11-02	1993-02-23	Merrell Dow Pharmaceuticals Inc.	3-amidoindolyl derivatives and pharmaceutical compositions thereof
US5317103A (en) *	1991-01-15	1994-05-31	Merck Sharp & Dohme Limited	Indole-substituted five-membered heteroaromatic compounds as 5-HT1 agonists
SK278998B6 (sk) *	1991-02-01	1998-05-06	Merck Sharp & Dohme Limited	Deriváty imidazolu, triazolu a tetrazolu, spôsob i
US5194435A (en) *	1992-04-07	1993-03-16	American Home Products Corporation	4-arylmethyl-5-alkyl-3h-pyrazol-3-ones
US5183825A (en) *	1992-04-07	1993-02-02	American Home Products Corporation	4-arylmethyl-5-alkyl-3H-pyrazol-3-ones and hypoglycemic use
IL106445A (en) *	1992-07-30	1998-01-04	Merck Sharp & Dohme	History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
EP0804434A1 (en) *	1994-08-02	1997-11-05	MERCK SHARP & DOHME LTD.	Azetidine, pyrrolidine and piperidine derivatives
US5523312A (en) *	1994-09-27	1996-06-04	Sterling Winthrop Inc.	Antipicornaviral agents
AU2720199A (en) *	1998-02-03	1999-08-23	Boehringer Ingelheim Pharma Kg	Five-membered, benzo-condensed heterocycles used as antithrombotic agents
US6114532A (en) *	1998-02-03	2000-09-05	Boehringer Ingelheim Pharma Kg	Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals
GB9926250D0 (en) *	1999-11-06	2000-01-12	Knoll Ag	Chemical process
FI20000577A0 (fi) *	2000-03-13	2000-03-13	Orion Yhtymae Oy	Pyridatsinyylifenyylihydratsoneja
TWI224101B (en) *	2001-06-20	2004-11-21	Wyeth Corp	Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
JP4399253B2 (ja) *	2001-06-20	2010-01-13	ワイス	プラスミノゲンアクチベーターインヒビター−１（ｐａｉ−１）のインヒビターとしての、置換されたインドール酸誘導体
ATE331709T1 (de) *	2002-12-10	2006-07-15	Wyeth Corp	Substituierte 3-carbonyl-1-yl essigsäure derivate als plasminogen aktivator inhibitor(pai-1) inhibitoren
US7056943B2 (en) *	2002-12-10	2006-06-06	Wyeth	Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
DE60306547T2 (de) *	2002-12-10	2007-06-28	Wyeth	Substituierte 3-alkyl- und 3-arylalkyl-1h-indol-1-yl-essigsäure-derivate als plasminogen-aktivator
EP1569901B1 (en) *	2002-12-10	2008-10-15	Wyeth	ARYL, ARYLOXY, AND ALKYLOXY SUBSTITUTED i 1H /i -INDOL-3-YL GLYOXYLIC ACID DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1)
UA80453C2 (en) *	2002-12-10	2007-09-25		Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1)
US7582773B2 (en) *	2003-09-25	2009-09-01	Wyeth	Substituted phenyl indoles
US7411083B2 (en)	2003-09-25	2008-08-12	Wyeth	Substituted acetic acid derivatives
US20050215626A1 (en) *	2003-09-25	2005-09-29	Wyeth	Substituted benzofuran oximes
US7163954B2 (en) *	2003-09-25	2007-01-16	Wyeth	Substituted naphthyl benzothiophene acids
US7446201B2 (en) *	2003-09-25	2008-11-04	Wyeth	Substituted heteroaryl benzofuran acids
US7265148B2 (en) *	2003-09-25	2007-09-04	Wyeth	Substituted pyrrole-indoles
US7351726B2 (en) *	2003-09-25	2008-04-01	Wyeth	Substituted oxadiazolidinediones
US7332521B2 (en) *	2003-09-25	2008-02-19	Wyeth	Substituted indoles
US7442805B2 (en) *	2003-09-25	2008-10-28	Wyeth	Substituted sulfonamide-indoles
US7420083B2 (en) *	2003-09-25	2008-09-02	Wyeth	Substituted aryloximes
US7141592B2 (en) *	2003-09-25	2006-11-28	Wyeth	Substituted oxadiazolidinediones
US7268159B2 (en) *	2003-09-25	2007-09-11	Wyeth	Substituted indoles
US7534894B2 (en) *	2003-09-25	2009-05-19	Wyeth	Biphenyloxy-acids
US7342039B2 (en) *	2003-09-25	2008-03-11	Wyeth	Substituted indole oximes
CA2577782A1 (en) *	2004-08-23	2006-03-02	Wyeth	Pyrrolo-naphthyl acids as pai-1 inhibitors
US7605172B2 (en)	2004-08-23	2009-10-20	Wyeth	Thiazolo-naphthyl acids
US7754747B2 (en) *	2004-08-23	2010-07-13	Wyeth Llc	Oxazolo-naphthyl acids
AU2006279496A1 (en) *	2005-08-17	2007-02-22	Wyeth	Substituted indoles and use thereof
EP2970145B1 (en)	2013-03-11	2020-05-06	The Broad Institute, Inc.	Compounds and compositions for the treatment of cancer

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3322786A (en) *	1965-10-07	1967-05-30	Merck & Co Inc	3-indolyl aliphatic acids
US3928380A (en) *	1973-03-29	1975-12-23	Sterling Drug Inc	1,1{40 -Spirobis(cyclopenta-{8 4,5-c{9 pyrroles)
DE2557341A1 (de) *	1975-12-19	1977-06-30	Hoechst Ag	Basisch substituierte indolderivate und verfahren zu ihrer herstellung
US4144338A (en) *	1977-02-17	1979-03-13	Merck & Co., Inc.	N-pyrimidinyl-N-dialkylaminoalkyl ureas
US4181665A (en) *	1977-10-31	1980-01-01	The Upjohn Company	Isochroman
DE2845220A1 (de) *	1978-10-17	1980-04-30	Yoshitomi Pharmaceutical	Pyridazinon-derivate, ihre salze mit saeuren, verfahren zu ihrer herstellung und ihre verwendung bei der behandlung von thrombosen und hypertonie
US4258185A (en) *	1978-10-17	1981-03-24	Yoshitomi Pharmaceutical Industries, Ltd.	Pyridazinone compounds
DE3172252D1 (en) *	1980-11-14	1985-10-17	Ici Plc	Heterocyclic compounds
JPS5785055A (en) *	1980-11-18	1982-05-27	Konishiroku Photo Ind Co Ltd	Silver halide photographic recording material
DE3131146A1 (de) *	1981-08-06	1983-02-24	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue heteroaryloxypropanolamine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
CA1199027A (en) *	1981-11-12	1986-01-07	Stuart D. Mills	Heterocyclic derivatives of pyridazinone, thiadiazinone, oxadiazinone and triazinone
FR2530246B1 (fr) *	1982-07-16	1985-06-14	Delalande Sa	Nouveaux derives pyrido indoliniques et pirido indoliques et leurs sels, ainsi que le procede de preparation et l'application en therapeutique de ces derives et sels
US4581356A (en) *	1983-03-22	1986-04-08	Fujisawa Pharmaceutical Co., Ltd.	Triazine derivatives, and pharmaceutical compositions comprising the same
US4666902A (en) *	1983-06-20	1987-05-19	Cassella Aktiengesellschaft	Tetrahydropyridazinone derivatives, processes for their preparation and their use
DE3421641A1 (de) *	1984-06-09	1985-12-12	Merck Patent Gmbh, 6100 Darmstadt	Indolderivate
DK623586A (da) *	1985-12-27	1987-06-28	Eisai Co Ltd	Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne

1985
- 1985-09-05 DE DE19853531658 patent/DE3531658A1/de not_active Withdrawn
1986
- 1986-09-01 EP EP86112068A patent/EP0223937B1/de not_active Expired - Lifetime
- 1986-09-01 DE DE8686112068T patent/DE3684415D1/de not_active Expired - Lifetime
- 1986-09-01 IL IL79911A patent/IL79911A/xx unknown
- 1986-09-01 AT AT86112068T patent/ATE73797T1/de not_active IP Right Cessation
- 1986-09-01 NZ NZ217419A patent/NZ217419A/xx unknown
- 1986-09-02 DD DD86294092A patent/DD258229A5/de not_active IP Right Cessation
- 1986-09-02 GR GR862248A patent/GR862248B/el unknown
- 1986-09-02 AU AU62166/86A patent/AU572405B2/en not_active Ceased
- 1986-09-02 DK DK419086A patent/DK419086A/da not_active Application Discontinuation
- 1986-09-04 PT PT83310A patent/PT83310B/pt not_active IP Right Cessation
- 1986-09-04 FI FI863564A patent/FI863564A/fi not_active Application Discontinuation
- 1986-09-04 ZA ZA866705A patent/ZA866705B/xx unknown
- 1986-09-04 HU HU863828A patent/HU197000B/hu not_active IP Right Cessation
- 1986-09-04 US US06/904,092 patent/US4851406A/en not_active Expired - Fee Related
- 1986-09-05 JP JP61208118A patent/JPS6256486A/ja active Pending
- 1986-09-05 ES ES8601651A patent/ES2001936A6/es not_active Expired
- 1986-09-05 KR KR1019860007440A patent/KR870003099A/ko not_active Application Discontinuation

Also Published As

Publication number	Publication date
ZA866705B (en)	1987-04-29
KR870003099A (ko)	1987-04-15
HUT41770A (en)	1987-05-28
DK419086D0 (da)	1986-09-02
EP0223937A1 (de)	1987-06-03
IL79911A (en)	1991-04-15
NZ217419A (en)	1989-03-29
ES2001936A6 (es)	1988-07-01
PT83310A (de)	1986-10-01
EP0223937B1 (de)	1992-03-18
DE3684415D1 (de)	1992-04-23
GR862248B (en)	1986-12-31
AU6216686A (en)	1987-03-12
FI863564A (fi)	1987-03-06
DD258229A5 (de)	1988-07-13
US4851406A (en)	1989-07-25
DE3531658A1 (de)	1987-03-12
AU572405B2 (en)	1988-05-05
JPS6256486A (ja)	1987-03-12
PT83310B (pt)	1989-01-17
HU197000B (en)	1989-02-28
ATE73797T1 (de)	1992-04-15
FI863564A0 (fi)	1986-09-04
IL79911A0 (en)	1986-12-31

Legal Events

Date	Code	Title	Description
1993-05-24	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
DK419086A (da)	1987-03-06	Heterocykliske substituerede indoler, mellemprodukter, fremgangsmaader til fremstilling heraf og laegemidler
IL88122A0 (en)	1989-06-30	Heterocyclic derivatives and pharmaceutical compositions containing them
RS50339B (sr)	2009-11-10	Jedinjenja indazola i farmaceutske kompozicije za inhibiranje protein kinaza i postupci za njihovu upotrebu
NO169286C (no)	1992-06-03	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzimidazolin-2-okso-1-karboksylsyrederivater
SE8303208D0 (sv)	1983-06-07	Heterocykliska foreningar
MX9206939A (es)	1993-06-01	Derivados de piperazina, procedimiento para su preparacion y composicion farmaceutica que los comprende
AR035111A1 (es)	2004-04-14	Procedimiento para preparar un compuesto de pirimidinona
DK0615549T3 (da)	1999-11-15	Fremgangsmåde til fremstilling af farmaceutisk aktive thiazolidin- eller oxazolidinforbindelser med en gærreduktase
DE3677857D1 (de)	1991-04-11	2,5-dimethylpyrrolderivative, ihre herstellung und ihre verwendung.
NO159269C (no)	1988-12-14	Analogifremgangsmaate for fremstilling av terapeutisk aktive heterocykliske fenylamidiner.
NO842921L (no)	1985-01-21	Fremgangsmaate for fremstilling av terapeutisk aktive amidin-derivater av 2-substituert 4-fenylimidazol
GB1008849A (en)	1965-11-03	Basically substituted triazolidines, processes for their manufacture and pharmaceutical preparations containing them
IL89682A0 (en)	1989-09-28	5,7-dihydropyrrolo(3,2-f)-benzoxazol-6-ones,processes for the preparation thereof and pharmaceutical compositions containing them
MX9305918A (es)	1994-05-31	Derivados de n-(2-amino-2-oxoetil)butanodiamida inhibidores de la renina procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
IT1210914B (it)	1989-09-29	Eterociclilfenilsolfonil e fosfonilamidine sostituite, procedimento per la loro preparazione e loro uso farmaceutico.
DK0618917T3 (da)	1997-10-13	1Amino-2- (benzothiazolyl)methyl spiro isoquinolin-4(1h),3-pyrrolidin -1,2,3,5(2h)-tetroner og analoger deraf, der kan anvendes som aldosereduktaseinhibitorer.
HUP0203921A2 (hu)	2003-03-28	Diazepin-karboxamid-származékok, eljárás a vegyületek előállítására, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk