HUP0301887A2 - Több részecskébżl álló gyógyszerforma, amely legalább két különbözżen bevont pelletformát tartalmaz - Google Patents
Több részecskébżl álló gyógyszerforma, amely legalább két különbözżen bevont pelletformát tartalmazInfo
- Publication number
- HUP0301887A2 HUP0301887A2 HU0301887A HUP0301887A HUP0301887A2 HU P0301887 A2 HUP0301887 A2 HU P0301887A2 HU 0301887 A HU0301887 A HU 0301887A HU P0301887 A HUP0301887 A HU P0301887A HU P0301887 A2 HUP0301887 A2 HU P0301887A2
- Authority
- HU
- Hungary
- Prior art keywords
- pellet
- active ingredient
- medicament
- polymer
- hours
- Prior art date
Links
- 239000008188 pellet Substances 0.000 title abstract 5
- 239000003814 drug Substances 0.000 title 1
- 238000000576 coating method Methods 0.000 abstract 4
- 239000004480 active ingredient Substances 0.000 abstract 3
- 229920000642 polymer Polymers 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- 239000011248 coating agent Substances 0.000 abstract 2
- 239000002552 dosage form Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 210000002429 large intestine Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000000813 small intestine Anatomy 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/606—Salicylic acid; Derivatives thereof having amino groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány több részecskéből álló gyógyszerformára vonatkozik, amelyegy hatóanyagnak a vékonybélben és a vastagbélben való egyenletesleadására alkalmas, és amely legalább két, A és B pelletformát foglalmagában, amelyek a magban gyógyhatású komponenst tartalmaznak éseltérő polimer bevonattal vannak ellátva, amely bevonatok ahatóanyagnak különböző pH-értékeknél való leadását határozzák meg, agyógyszerformára jellemző, hogy az A pelletforma egy belső polimerbevonattal, amely lehetővé teszi a hatóanyag folyamatos leadását, ésegy külső, enterális bevonattal van ellátva, amely kb. 5,5 feletti pH-n gyorsan feloldódik, és a B pelletforma egy olyan polimer bevonattalvan ellátva, amely a USP hatóanyag-felszabadulási tesztben a hatóanyagkevesebb, mint 20%-át adja le 6,8-es pH-n 6 óra alatt, és a hatóanyagtöbb, mint 50%-át adja le 7,2-es pH-n 6 óra alatt. A találmány tárgyátképezi a több részecskéből álló gyógyszerforma előállítására alkalmaseljárás és az A és B pelletforma gyógyszerforma előállítására valóalkalmazása is. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10104504 | 2001-01-31 | ||
DE10104880A DE10104880A1 (de) | 2001-01-31 | 2001-02-01 | Multipartikuläre Arzneiform, enthaltend mindestens zwei unterschiedlich überzogene Pelletformen |
PCT/EP2001/002679 WO2002060415A1 (de) | 2001-01-31 | 2001-03-09 | Multipartikuläre arzneiform, enthaltend mindestens zwei unterschiedlich überzogene pelletformen |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP0301887A2 true HUP0301887A2 (hu) | 2003-09-29 |
HUP0301887A3 HUP0301887A3 (en) | 2006-07-28 |
HU229291B1 HU229291B1 (en) | 2013-10-28 |
Family
ID=26008387
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0301887A HU229291B1 (en) | 2001-01-31 | 2001-03-09 | Multi-particulate form of medicament, comprising at least two differently coated forms of pellet |
Country Status (14)
Country | Link |
---|---|
US (2) | US6897205B2 (hu) |
EP (1) | EP1248599B1 (hu) |
JP (1) | JP5502254B2 (hu) |
KR (1) | KR100507946B1 (hu) |
AT (1) | ATE380022T1 (hu) |
CA (1) | CA2403670C (hu) |
DE (1) | DE50113344D1 (hu) |
ES (1) | ES2298236T3 (hu) |
HU (1) | HU229291B1 (hu) |
IL (1) | IL151150A0 (hu) |
MX (1) | MXPA02009478A (hu) |
PL (1) | PL201766B1 (hu) |
SK (1) | SK287902B6 (hu) |
WO (1) | WO2002060415A1 (hu) |
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2001
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- 2001-03-09 EP EP01933676A patent/EP1248599B1/de not_active Expired - Lifetime
- 2001-03-09 DE DE50113344T patent/DE50113344D1/de not_active Expired - Lifetime
- 2001-03-09 ES ES01933676T patent/ES2298236T3/es not_active Expired - Lifetime
- 2001-03-09 US US10/239,209 patent/US6897205B2/en not_active Expired - Lifetime
- 2001-03-09 PL PL356962A patent/PL201766B1/pl unknown
- 2001-03-09 HU HU0301887A patent/HU229291B1/hu unknown
- 2001-03-09 MX MXPA02009478A patent/MXPA02009478A/es active IP Right Grant
- 2001-03-09 CA CA2403670A patent/CA2403670C/en not_active Expired - Lifetime
- 2001-03-09 SK SK1374-2002A patent/SK287902B6/sk not_active IP Right Cessation
- 2001-03-09 AT AT01933676T patent/ATE380022T1/de active
- 2001-03-09 WO PCT/EP2001/002679 patent/WO2002060415A1/de active IP Right Grant
- 2001-03-09 JP JP2002560608A patent/JP5502254B2/ja not_active Expired - Lifetime
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JP5502254B2 (ja) | 2014-05-28 |
US7438929B2 (en) | 2008-10-21 |
US20050053660A1 (en) | 2005-03-10 |
CA2403670A1 (en) | 2002-08-08 |
JP2004517156A (ja) | 2004-06-10 |
KR100507946B1 (ko) | 2005-08-17 |
PL201766B1 (pl) | 2009-05-29 |
US6897205B2 (en) | 2005-05-24 |
CA2403670C (en) | 2010-02-09 |
IL151150A0 (en) | 2003-04-10 |
HU229291B1 (en) | 2013-10-28 |
DE50113344D1 (de) | 2008-01-17 |
PL356962A1 (en) | 2004-07-12 |
EP1248599B1 (de) | 2007-12-05 |
KR20030009407A (ko) | 2003-01-29 |
MXPA02009478A (es) | 2003-03-10 |
SK13742002A3 (sk) | 2004-05-04 |
EP1248599A1 (de) | 2002-10-16 |
ES2298236T3 (es) | 2008-05-16 |
HUP0301887A3 (en) | 2006-07-28 |
ATE380022T1 (de) | 2007-12-15 |
WO2002060415A1 (de) | 2002-08-08 |
SK287902B6 (sk) | 2012-03-02 |
US20030152627A1 (en) | 2003-08-14 |
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