HUP0203504A2 - Immunterápiás alkalmazásra szolgáló módosított peptidek és peptid-mimetikumok - Google Patents

Immunterápiás alkalmazásra szolgáló módosított peptidek és peptid-mimetikumok

Info

Publication number
HUP0203504A2
HUP0203504A2 HU0203504A HUP0203504A HUP0203504A2 HU P0203504 A2 HUP0203504 A2 HU P0203504A2 HU 0203504 A HU0203504 A HU 0203504A HU P0203504 A HUP0203504 A HU P0203504A HU P0203504 A2 HUP0203504 A2 HU P0203504A2
Authority
HU
Hungary
Prior art keywords
amino acids
ser
formula
thr
substitution
Prior art date
Application number
HU0203504A
Other languages
English (en)
Inventor
Anna Maria Helena Boots
Philippus Johannes Maric Galen Van
Rnaldus Marcellus Alphonsus Knegtel
Andreas Martinus Maria Miltenburg
Catherina Joanna Staveren
Cornelis Marius Timmers
Original Assignee
Akzo Nobel N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel N.V. filed Critical Akzo Nobel N.V.
Publication of HUP0203504A2 publication Critical patent/HUP0203504A2/hu
Publication of HUP0203504A3 publication Critical patent/HUP0203504A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rehabilitation Therapy (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány (II) általános képletű Q-A1-A2-A3-A4-A5-A6-A7- A8-A9-A10-A11-A12-A13-Z módosított peptid, amely H-Arg-Ser- Phe-Thr-Leu-Ala-Ser-Ser-Glu-Thr- Gly-Val-GIy-OH[(I) képlet] eredetű, melyben az A1-A13megfelel az (I) képletben megadott aminosavaknak, Q jelentése H és Zjelentése OH, amelyre jellemző, hogy 1- 6 olyan módosítást tartalmaz,melyet egy vagy több alábbi csoportból választanak ki: a) az A1-A13aminosavak közül 1-6, előnyösen 1-4 aminosavat nem természetes vagybéta-aminosavakkal helyettesítenek; b) egy vagy több amidkötéstredukált amidkötésekkel vagy etilén-izosztérekkel helyettesítenek; c)Q és/vagy Z csoporton helyettesítést végeznek, és adott esetben d)szubsztitúciót végeznek természetes aminosavakkal, legfeljebb 6módosítás erejéig. A találmány szerinti peptidek felhasználhatóktolerancia indukció előidézésére autoimun betegségekben szenvedőszervezetekben. Ó
HU0203504A 1999-10-18 2000-10-12 Modified peptides and peptidomimetics for use in immunotherapy HUP0203504A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99203427 1999-10-18
PCT/EP2000/010230 WO2001029081A1 (en) 1999-10-18 2000-10-12 Modified peptides and peptidomimetics for use in immunotherapy

Publications (2)

Publication Number Publication Date
HUP0203504A2 true HUP0203504A2 (hu) 2003-04-28
HUP0203504A3 HUP0203504A3 (en) 2005-03-29

Family

ID=8240756

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0203504A HUP0203504A3 (en) 1999-10-18 2000-10-12 Modified peptides and peptidomimetics for use in immunotherapy

Country Status (23)

Country Link
EP (1) EP1226167A1 (hu)
JP (1) JP2003512388A (hu)
KR (1) KR20020047245A (hu)
CN (1) CN1379786A (hu)
AR (1) AR026068A1 (hu)
AU (1) AU780238B2 (hu)
BR (1) BR0014803A (hu)
CA (1) CA2386398A1 (hu)
CO (1) CO5271650A1 (hu)
CZ (1) CZ20021356A3 (hu)
HK (1) HK1046693A1 (hu)
HU (1) HUP0203504A3 (hu)
IL (1) IL148778A0 (hu)
MX (1) MXPA02003520A (hu)
NO (1) NO20021763L (hu)
NZ (1) NZ518256A (hu)
PE (1) PE20010692A1 (hu)
PL (1) PL354590A1 (hu)
RU (1) RU2002113107A (hu)
SK (1) SK6842002A3 (hu)
TR (1) TR200201036T2 (hu)
WO (1) WO2001029081A1 (hu)
ZA (1) ZA200202577B (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002951212A0 (en) * 2002-09-04 2002-09-19 Monash University A method of modulating cellular activity and molecules for use therein
US20100240137A1 (en) * 2006-04-06 2010-09-23 Purdue Research Foundation Derivatization-enhanced analysis of amino acids and peptides
EP2114462B1 (en) * 2006-12-21 2013-06-05 Universite De Geneve Compounds for fluorescence imaging
WO2009092381A1 (en) 2008-01-23 2009-07-30 Herlev Hospital, Region Hovedstaden Ykl-40 as a general marker for non-specific disease
US8580520B2 (en) 2008-09-15 2013-11-12 Herlev Hospital YKL-40 as a marker for gastrointestinal cancers
AU2015342767B2 (en) * 2014-11-07 2021-05-13 Kineta Chronic Pain, Llc Modifications and uses of conotoxin peptides
EP3466963A1 (en) * 2017-10-05 2019-04-10 Suigeneris Farmacosmetics, S.L. Anticancer peptides and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL115744A (en) * 1994-10-27 2000-07-16 Akzo Nobel Nv Peptides comprising a subsequence of human cartilage glycoprotein - 39
TW575583B (en) * 1996-04-24 2004-02-11 Akzo Nobel Nv Novel peptides suitable for use in antigen specific immunosuppressive therapy
SK166798A3 (en) * 1996-06-07 1999-07-12 Zeneca Ltd Peptide derivatives, process for their preparation, pharmaceutical composition them containing, and their use
IL122233A (en) * 1996-12-06 2001-04-30 Akzo Nobel Nv Method of generating monoclonal antibodies to cell wall and pharmaceutical preparations and diagnostic agents containing them

Also Published As

Publication number Publication date
SK6842002A3 (en) 2002-09-10
MXPA02003520A (es) 2002-08-20
CN1379786A (zh) 2002-11-13
HK1046693A1 (zh) 2003-01-24
WO2001029081A1 (en) 2001-04-26
EP1226167A1 (en) 2002-07-31
NO20021763D0 (no) 2002-04-15
CO5271650A1 (es) 2003-04-30
IL148778A0 (en) 2002-09-12
CA2386398A1 (en) 2001-04-26
RU2002113107A (ru) 2004-01-10
AU780238B2 (en) 2005-03-10
JP2003512388A (ja) 2003-04-02
TR200201036T2 (tr) 2002-08-21
ZA200202577B (en) 2003-09-23
PL354590A1 (en) 2004-01-26
BR0014803A (pt) 2002-06-11
KR20020047245A (ko) 2002-06-21
AR026068A1 (es) 2002-12-26
NZ518256A (en) 2004-01-30
AU1139601A (en) 2001-04-30
NO20021763L (no) 2002-04-15
PE20010692A1 (es) 2001-07-06
HUP0203504A3 (en) 2005-03-29
CZ20021356A3 (cs) 2002-07-17

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