DE69932812D1 - Epitope in der viralen hüllproteine und spezifische antikörper gegen diese epitope: verwendung für die detektion von hcv viralantigene im empfängergewebe - Google Patents
Epitope in der viralen hüllproteine und spezifische antikörper gegen diese epitope: verwendung für die detektion von hcv viralantigene im empfängergewebeInfo
- Publication number
- DE69932812D1 DE69932812D1 DE69932812T DE69932812T DE69932812D1 DE 69932812 D1 DE69932812 D1 DE 69932812D1 DE 69932812 T DE69932812 T DE 69932812T DE 69932812 T DE69932812 T DE 69932812T DE 69932812 D1 DE69932812 D1 DE 69932812D1
- Authority
- DE
- Germany
- Prior art keywords
- epitopes
- detection
- proteins
- viral
- hcv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000001514 detection method Methods 0.000 title abstract 3
- 230000003612 virological effect Effects 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 239000000344 soap Substances 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 101710091045 Envelope protein Proteins 0.000 abstract 1
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 abstract 1
- 101710188315 Protein X Proteins 0.000 abstract 1
- 102100021696 Syncytin-1 Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
- C07K16/109—Hepatitis C virus; Hepatitis G virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98870060A EP0947525A1 (de) | 1998-03-27 | 1998-03-27 | Epitope in der viralen Hüllproteine und spezifische Antikörper gegen diese Epitope: Verwendung für die detektion von viralantigene im empfängergewebe |
EP98870060 | 1998-03-27 | ||
PCT/EP1999/002154 WO1999050301A2 (en) | 1998-03-27 | 1999-03-29 | Epitopes in viral envelope proteins and specific antibodies directed against these epitopes: use for detection of hcv viral antigen in host tissue |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69932812D1 true DE69932812D1 (de) | 2006-09-28 |
DE69932812T2 DE69932812T2 (de) | 2007-04-12 |
Family
ID=8237012
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69932812T Expired - Fee Related DE69932812T2 (de) | 1998-03-27 | 1999-03-29 | Epitope in der viralen hüllproteine und spezifische antikörper gegen diese epitope: verwendung für die detektion von hcv viralantigene im empfängergewebe |
Country Status (19)
Country | Link |
---|---|
US (2) | US6521403B1 (de) |
EP (2) | EP0947525A1 (de) |
JP (1) | JP3657515B2 (de) |
KR (1) | KR20010042225A (de) |
CN (1) | CN1294598A (de) |
AT (1) | ATE336512T1 (de) |
AU (1) | AU756495B2 (de) |
BR (1) | BR9909026A (de) |
CA (1) | CA2321179A1 (de) |
DE (1) | DE69932812T2 (de) |
ES (1) | ES2272065T3 (de) |
HU (1) | HUP0103650A3 (de) |
IL (1) | IL138586A0 (de) |
NZ (1) | NZ506553A (de) |
PL (1) | PL343638A1 (de) |
PT (1) | PT1064309E (de) |
TR (1) | TR200002695T2 (de) |
WO (1) | WO1999050301A2 (de) |
ZA (1) | ZA200004383B (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09503396A (ja) * | 1994-07-29 | 1997-04-08 | インノジェネティクス・エヌ・ブイ | 診断用及び治療用の精製c型肝炎ウイルスエンベロープ蛋白 |
US20030180284A1 (en) * | 1998-11-05 | 2003-09-25 | Board Of Trustees Of Leland Stanford Junior University | Prevention and treatment of HCV infection employing antibodies directed against conformational and linear epitopes |
BR0015170A (pt) * | 1999-10-27 | 2002-06-25 | Innogenetics Nv | Proteìnas de hcv com oxirredução reversìvel e conformação similar à nativa |
EP1535628B1 (de) * | 1999-11-24 | 2013-07-31 | Novartis Vaccines and Diagnostics, Inc. | Hbv/hcv virus-ähnliche teilchen |
EP1178116A1 (de) * | 2000-08-03 | 2002-02-06 | Hybrigenics S.A. | Sid nukleische Saüre und aus einem pathogenischen Stamm des Hepatitis C Viruses selektierte Polypeptide und deren Verwendungenthereof |
CA2429946A1 (en) * | 2000-12-01 | 2002-07-18 | The Government Of The United States Of America, As Represented By The Se Cretary, Department Of Health And Human Services | Monoclonal antibodies specific for the e2 glycoprotein of hepatitis c virus and their use in the diagnosis, treatment, and prevention of hepatitis c |
EP1355948B1 (de) * | 2001-01-12 | 2009-03-11 | Molecules of Man AB | Materialien und methoden zur behandlung von hepatitis c |
EP2062590A1 (de) * | 2003-09-22 | 2009-05-27 | Green Peptide Co., Ltd. | Von Hepatitis-C-Virus abgeleitetes Peptid |
EP1602664A1 (de) * | 2004-03-08 | 2005-12-07 | Innogenetics N.V. | HCV E1 beinhaltend spezifische Disulfidbrücken |
EP1574517A1 (de) * | 2004-03-09 | 2005-09-14 | Innogenetics N.V. | HCV E1 beinhaltend spezifische Disulfidbrücken |
US7309589B2 (en) * | 2004-08-20 | 2007-12-18 | Vironix Llc | Sensitive detection of bacteria by improved nested polymerase chain reaction targeting the 16S ribosomal RNA gene and identification of bacterial species by amplicon sequencing |
WO2006033012A2 (en) * | 2004-09-24 | 2006-03-30 | Pfizer Limited | Method of screening for modulators of hepatitis c virus infection |
US20090220490A1 (en) * | 2006-02-23 | 2009-09-03 | Martina Buck | Compositions and Assays for Inhibiting HCV Infection |
WO2007111965A2 (en) * | 2006-03-22 | 2007-10-04 | Genimmune N.V. | Hepatitis c virus neutralizing antibodies |
WO2007137456A1 (fr) * | 2006-06-01 | 2007-12-06 | Yun Cheng | Peptide pour la prévention ou le traitement d'atteinte hépatique et son dérivé ainsi que son utilisation |
US8551484B2 (en) | 2007-02-21 | 2013-10-08 | University Of Massachusetts | Human antibodies against hepatitis C virus (HCV) and uses thereof |
CN102227445B (zh) | 2008-09-30 | 2014-12-17 | 东丽株式会社 | 结合丙型肝炎病毒的包膜蛋白2的抗体以及利用所述抗体鉴定丙型肝炎病毒的基因型的方法 |
US20100104555A1 (en) * | 2008-10-24 | 2010-04-29 | The Scripps Research Institute | HCV neutralizing epitopes |
WO2014065822A1 (en) * | 2012-10-26 | 2014-05-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hepatitis c virus neutralizing epitopes, antibodies, and methods |
EP3274707B1 (de) * | 2015-03-23 | 2022-11-30 | Sartorius BioAnalytical Instruments, Inc. | Beurteilung von biologischem material für freie partikel in virusgrösse vom virustyp eines adenovirus oder adeno-assoziierten virus |
CN109160942B (zh) * | 2018-09-26 | 2021-06-29 | 广州市第八人民医院 | Hcv包膜蛋白高度保守区域的肽段502-518及其用途 |
CN109232722B (zh) * | 2018-09-26 | 2021-06-29 | 广州市第八人民医院 | Hcv包膜蛋白高度保守区域的肽段317-325及其用途 |
KR20230050761A (ko) | 2021-10-08 | 2023-04-17 | 김민준 | 과제기한 자동알림 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5308750A (en) | 1989-12-22 | 1994-05-03 | Abbott Laboratories | Monoclonal antibodies to putative HCV E2/NS1 proteins and methods for using same |
CZ289006B6 (cs) | 1990-11-08 | 2001-10-17 | Chiron Corporation | Asialoglykoprotein hepatitis C viru, farmaceutická kompozice s jeho obsahem a jeho pouľití |
KR930703361A (ko) * | 1991-01-31 | 1993-11-29 | 찰스 엠. 브룩 | 추정의 c형 간염 바이러스(hcv) 외막 영역에 대한 모노클로날 항체 및 이의 사용 방법 |
FR2677372B1 (fr) | 1991-06-06 | 1994-11-10 | Pasteur Institut | Sequences nucleotidiques et peptidiques d'un isolat de virus de l'hepatite c, applications diagnostiques et therapeutiques. |
DE4209215A1 (de) * | 1991-07-04 | 1993-01-07 | Boehringer Mannheim Gmbh | Hcv peptidantigene und verfahren zur bestimmung von hcv |
IT1249684B (it) | 1991-07-19 | 1995-03-09 | Sorin Biomedica Spa | Epitopi della proteina env del virus dell'epatite c. |
JP3439209B2 (ja) | 1992-01-31 | 2003-08-25 | アボツト・ラボラトリーズ | Hcv蛋白のための哺乳動物発現システム |
US6165730A (en) * | 1992-03-06 | 2000-12-26 | N.V. Innogenetics S.A. | Hepatitis C virus peptides obtained from the NS4 coding region and their use in diagnostic assays |
JPH05344899A (ja) | 1992-06-11 | 1993-12-27 | Kokuritsu Yobou Eisei Kenkyusho | C型肝炎ウイルス外被タンパク質の産生法 |
HUT71860A (en) * | 1992-08-27 | 1996-02-28 | Deakin Res Ltd | Retro-, inverso-, and retro-inverso synthetic peptide analogues |
US5514539A (en) | 1993-06-29 | 1996-05-07 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines |
US5610009A (en) | 1994-01-28 | 1997-03-11 | Abbott Laboratories | Mammalian expression systems for hepatitis C virus envelope genes |
JPH09503396A (ja) | 1994-07-29 | 1997-04-08 | インノジェネティクス・エヌ・ブイ | 診断用及び治療用の精製c型肝炎ウイルスエンベロープ蛋白 |
US6110465A (en) * | 1995-06-07 | 2000-08-29 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of hypervariable region 1 of the envelope 2 gene of isolates of hepatitis C virus and the use of reagents derived from these hypervariable sequences in diagnostic methods and vaccines |
-
1998
- 1998-03-27 EP EP98870060A patent/EP0947525A1/de not_active Withdrawn
-
1999
- 1999-03-29 EP EP99917909A patent/EP1064309B1/de not_active Expired - Lifetime
- 1999-03-29 AT AT99917909T patent/ATE336512T1/de not_active IP Right Cessation
- 1999-03-29 PL PL99343638A patent/PL343638A1/xx not_active Application Discontinuation
- 1999-03-29 TR TR2000/02695T patent/TR200002695T2/xx unknown
- 1999-03-29 DE DE69932812T patent/DE69932812T2/de not_active Expired - Fee Related
- 1999-03-29 BR BR9909026-0A patent/BR9909026A/pt not_active Application Discontinuation
- 1999-03-29 CA CA002321179A patent/CA2321179A1/en not_active Abandoned
- 1999-03-29 AU AU36022/99A patent/AU756495B2/en not_active Ceased
- 1999-03-29 PT PT99917909T patent/PT1064309E/pt unknown
- 1999-03-29 NZ NZ506553A patent/NZ506553A/xx unknown
- 1999-03-29 CN CN99804420A patent/CN1294598A/zh active Pending
- 1999-03-29 HU HU0103650A patent/HUP0103650A3/hu unknown
- 1999-03-29 IL IL13858699A patent/IL138586A0/xx unknown
- 1999-03-29 JP JP2000541203A patent/JP3657515B2/ja not_active Expired - Fee Related
- 1999-03-29 ES ES99917909T patent/ES2272065T3/es not_active Expired - Lifetime
- 1999-03-29 WO PCT/EP1999/002154 patent/WO1999050301A2/en active IP Right Grant
- 1999-03-29 KR KR1020007010746A patent/KR20010042225A/ko not_active Application Discontinuation
-
2000
- 2000-08-24 ZA ZA200004383A patent/ZA200004383B/xx unknown
- 2000-08-24 US US09/645,470 patent/US6521403B1/en not_active Expired - Fee Related
-
2002
- 2002-12-13 US US10/318,200 patent/US6841353B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
PT1064309E (pt) | 2006-12-29 |
EP1064309B1 (de) | 2006-08-16 |
IL138586A0 (en) | 2001-10-31 |
TR200002695T2 (tr) | 2000-12-21 |
HUP0103650A3 (en) | 2005-10-28 |
PL343638A1 (en) | 2001-08-27 |
EP0947525A1 (de) | 1999-10-06 |
BR9909026A (pt) | 2000-12-05 |
DE69932812T2 (de) | 2007-04-12 |
US6841353B2 (en) | 2005-01-11 |
US6521403B1 (en) | 2003-02-18 |
JP3657515B2 (ja) | 2005-06-08 |
KR20010042225A (ko) | 2001-05-25 |
ZA200004383B (en) | 2003-01-28 |
HUP0103650A2 (hu) | 2002-01-28 |
JP2002510038A (ja) | 2002-04-02 |
WO1999050301A2 (en) | 1999-10-07 |
CA2321179A1 (en) | 1999-10-07 |
ATE336512T1 (de) | 2006-09-15 |
AU756495B2 (en) | 2003-01-16 |
US20030129746A1 (en) | 2003-07-10 |
CN1294598A (zh) | 2001-05-09 |
EP1064309A2 (de) | 2001-01-03 |
AU3602299A (en) | 1999-10-18 |
WO1999050301A3 (en) | 1999-11-25 |
ES2272065T3 (es) | 2007-04-16 |
NZ506553A (en) | 2002-11-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |