HUP0102112A2 - Aril- (vagy heteroaril)-azolilkarbinol-származékok alkalmazása ideggyulladás kezelésére alkalmas gyógyszer előállítására - Google Patents

Aril- (vagy heteroaril)-azolilkarbinol-származékok alkalmazása ideggyulladás kezelésére alkalmas gyógyszer előállítására

Info

Publication number
HUP0102112A2
HUP0102112A2 HU0102112A HUP0102112A HUP0102112A2 HU P0102112 A2 HUP0102112 A2 HU P0102112A2 HU 0102112 A HU0102112 A HU 0102112A HU P0102112 A HUP0102112 A HU P0102112A HU P0102112 A2 HUP0102112 A2 HU P0102112A2
Authority
HU
Hungary
Prior art keywords
heteroaryl
aryl
treatment
medicament
utilization
Prior art date
Application number
HU0102112A
Other languages
English (en)
Inventor
Jordi Frigola-Constansa
Ramon Merce-Vidal
Original Assignee
Laboratorios Del Dr. Esteve, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Del Dr. Esteve, S.A. filed Critical Laboratorios Del Dr. Esteve, S.A.
Publication of HUP0102112A2 publication Critical patent/HUP0102112A2/hu
Publication of HUP0102112A3 publication Critical patent/HUP0102112A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Az (I) általános képletű aril- (vagy heteroaril-) azolilkarbonil-származékok, ahol a képletben R1 jelentése hidrogénatom vagy kevésszénatomos alkilcsoport, R2 jelentése dialkil-amino-alkil- vagyazaheterociklil-alkil-csoport; Ar jelentése adott esetbenhelyettesített fenil- vagy tienilcsoport; és Het jelentése 5 tagúnitrogéntartalmú aromás gyűrű, amely 1-3 nitrogénatomot tartalmaz ésadott esetben helyettesített, alkalmasak emlősökben, ezen belülemberekben különféle kórfolyamatokban, így a cukorbetegségben,asztmában, hólyaggyulladásban, ínygyulladásban, migrénben,bőrgyulladásban, náthában, pszoriázisban, az ülő- és csípőidegekgyulladásában, gasztrointesztinális kórfolyamatokban, szemgyulladásbanjelen levő ideggyulladás kezelésére. Ó
HU0102112A 1998-05-18 1999-05-18 Utilization of aryl(or heteroaryl)azolylcarbinol derivatives in the preparation of a medicament for the treatment of neurogenic inflammation HUP0102112A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009801021A ES2137136B1 (es) 1998-05-18 1998-05-18 Empleo de derivados de aril (o heteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion neurogenica.
PCT/ES1999/000142 WO1999059524A2 (es) 1998-05-18 1999-05-18 Empleo de derivados de aril(o heteroaril)azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion neurogenica

Publications (2)

Publication Number Publication Date
HUP0102112A2 true HUP0102112A2 (hu) 2002-03-28
HUP0102112A3 HUP0102112A3 (en) 2002-06-28

Family

ID=8303801

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0102112A HUP0102112A3 (en) 1998-05-18 1999-05-18 Utilization of aryl(or heteroaryl)azolylcarbinol derivatives in the preparation of a medicament for the treatment of neurogenic inflammation

Country Status (24)

Country Link
EP (1) EP1086682B1 (hu)
JP (1) JP2002515409A (hu)
KR (1) KR100572416B1 (hu)
CN (1) CN1221257C (hu)
AR (1) AR019555A1 (hu)
AT (1) ATE237328T1 (hu)
AU (1) AU759229B2 (hu)
BR (1) BR9910587A (hu)
CA (1) CA2332711A1 (hu)
CZ (1) CZ291593B6 (hu)
DE (1) DE69906969T2 (hu)
DK (1) DK1086682T3 (hu)
ES (2) ES2137136B1 (hu)
HU (1) HUP0102112A3 (hu)
IL (2) IL139744A0 (hu)
NO (1) NO20005837L (hu)
NZ (1) NZ508316A (hu)
PL (1) PL344742A1 (hu)
PT (1) PT1086682E (hu)
RU (1) RU2212237C2 (hu)
TR (1) TR200003434T2 (hu)
TW (1) TW570796B (hu)
WO (1) WO1999059524A2 (hu)
ZA (1) ZA200006732B (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2150353B1 (es) * 1998-04-15 2001-07-01 Esteve Labor Dr Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos.
ES2174756B2 (es) * 2001-04-06 2003-11-16 Esteve Labor Dr Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de enfermedades respiratorias.
ES2180449B1 (es) * 2001-07-06 2004-01-16 Esteve Labor Dr Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de la incontinencia urinaria.
EA008744B1 (ru) * 2002-08-12 2007-08-31 Актавис Груп Хф. Применение соединений антагонистов кальцитонин генсвязанного пептида (cgrp) для лечения псориаза
EP1784178A1 (en) * 2004-07-30 2007-05-16 Laboratorios Del Dr. Esteve, S.A. Aryl (or heteroaryl) azolylcarbinols
EP1632227A1 (en) * 2004-09-07 2006-03-08 Laboratorios del Dr. Esteve S.A. Derivatives of aryl (or heteroaryl) azolylcarbinols (in particular cizolirtin citrate) for the treatment of opioid addiction
EP1820502A1 (en) * 2006-02-10 2007-08-22 Laboratorios Del Dr. Esteve, S.A. Active substance combination comprising azolylcarbinol compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2613720B1 (fr) * 1987-04-10 1990-01-19 Esteve Labor Dr Derives d'aryl-heteroaryl carbinols avec activite analgesique
FR2681322B1 (fr) * 1991-09-12 1993-12-17 Laboratorios Dr Esteve Sa Derives d'aryl-heteroaryl-{n-[2-(3,4-dimethoxyphenyl)-ethyl]-n-methyl-3-aminopropoxy}-methane leur preparation et leur application en tant que medicaments .
ES2150353B1 (es) * 1998-04-15 2001-07-01 Esteve Labor Dr Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos.

Also Published As

Publication number Publication date
WO1999059524A3 (es) 2000-03-09
AR019555A1 (es) 2002-02-27
PT1086682E (pt) 2003-07-31
TR200003434T2 (tr) 2001-04-20
IL139744A (en) 2007-08-19
AU3711899A (en) 1999-12-06
DE69906969D1 (de) 2003-05-22
CZ291593B6 (cs) 2003-04-16
CN1306424A (zh) 2001-08-01
CA2332711A1 (en) 1999-11-25
ATE237328T1 (de) 2003-05-15
CZ20004282A3 (en) 2001-05-16
ES2137136A1 (es) 1999-12-01
NZ508316A (en) 2002-02-01
EP1086682B1 (en) 2003-04-16
DK1086682T3 (da) 2003-06-23
AU759229B2 (en) 2003-04-10
RU2212237C2 (ru) 2003-09-20
WO1999059524A2 (es) 1999-11-25
BR9910587A (pt) 2001-01-30
ZA200006732B (en) 2002-08-16
DE69906969T2 (de) 2003-12-11
HUP0102112A3 (en) 2002-06-28
ES2137136B1 (es) 2000-07-01
ES2196800T3 (es) 2003-12-16
JP2002515409A (ja) 2002-05-28
CN1221257C (zh) 2005-10-05
KR100572416B1 (ko) 2006-04-18
NO20005837D0 (no) 2000-11-17
IL139744A0 (en) 2002-03-10
TW570796B (en) 2004-01-11
KR20010034868A (ko) 2001-04-25
PL344742A1 (en) 2001-11-19
EP1086682A2 (en) 2001-03-28
NO20005837L (no) 2001-01-08

Similar Documents

Publication Publication Date Title
HUP0102187A2 (hu) Azolo-triazinok és -pirimidinek, ezeket tartalmazó gyógyászati készítmények, valamint e vegyületek alkalmazása
HUP0401086A2 (hu) 4-[(Fenil-piperazinil)-metil]-benzamid-származékok és alkalmazásuk fájdalom, szorongás vagy gasztrointesztinális zavarok kezelésére szolgáló gyógyszerkészítmények előállítására és eljárás a vegyületek előállítására
TR200100378T2 (tr) P-maddesi aşırısının aracılık ettiği hastalıkların tedavisindeki ilaç
DE69827785D1 (de) 1,4-substituierte cyclische aminderivate
FI941022A (fi) Spirosykliset piperidiinijohdannaiset
HUP0101372A2 (hu) Triszubsztituált 1,3,5-triazin-származékok HIV-fertőzések kezelésére
ES2150353A1 (es) Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos.
NO331068B1 (no) Benzazepinderivater for behandling av nevrologiske forstyrrelser.
BRPI0314344B8 (pt) composto 2,3-diidro-6-nitroimidazo[2,1-b]oxazol, composição farmacêutica compreendendo o mesmo e método para produzir um composto
TW200716528A (en) Cyclopropanecarboxamide derivatives
HUP0402317A2 (hu) Szulfonamidszármazékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
HUP0101192A2 (hu) Cikloalkénszármazékok, előállításuk és alkalmazásuk
NO20060146L (no) Benzimidazolderivater, sammensetninger som inneholder slike, fremstilling derav og anvendelse derav
IL132474A (en) 3,4-dihydrothienopyrimidine-4-(thi) ones for combating plant fungi and a novel such compound
DE60130119D1 (de) Phenylpyridazinderivate und diese enthaltende arzneimittel
TW200508221A (en) New azetidine compounds
SE9701304D0 (sv) Compounds
HUP0102112A2 (hu) Aril- (vagy heteroaril)-azolilkarbinol-származékok alkalmazása ideggyulladás kezelésére alkalmas gyógyszer előállítására
NO913331L (no) 4-substituerte dihydropyrido(4,3-d)pyrimidiner for behandling av hudforstyrrelser.
HUP0204217A2 (en) Novel a-500359 derivatives
DE502004007387D1 (de) Triazolverbindungen und ihre therapeutische verwendung
AU539177B2 (en) Amino alkoxy pyrazoles
AU8371691A (en) 3-(1H-indazol-3-yl)-4-pyridinamines
HUP9900895A2 (hu) Simaizom sejtburjánzást gátló 2-szubsztituált benzimidazolszármazékok
AR009144A1 (es) Compuestos heterociclicos guanidilamino, composicion farmaceutica que comprende dicho compuesto y uso del mismo para la fabricacion de un medicamento

Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished