ES2150353B1 - Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos. - Google Patents

Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos.

Info

Publication number
ES2150353B1
ES2150353B1 ES009800793A ES9800793A ES2150353B1 ES 2150353 B1 ES2150353 B1 ES 2150353B1 ES 009800793 A ES009800793 A ES 009800793A ES 9800793 A ES9800793 A ES 9800793A ES 2150353 B1 ES2150353 B1 ES 2150353B1
Authority
ES
Spain
Prior art keywords
compounds
application
tienilazolilalcoxietanaminas
medicines
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES009800793A
Other languages
English (en)
Other versions
ES2150353A1 (es
Inventor
Ramon Merce-Vidal
Blas Andaluz-Mataro
Jordi Frigola-Constansa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Priority to ES009800793A priority Critical patent/ES2150353B1/es
Priority to CO99022015A priority patent/CO5011045A1/es
Priority to ARP990101712A priority patent/AR016210A1/es
Priority to SI9920030A priority patent/SI20473A/sl
Priority to PL99343512A priority patent/PL343512A1/xx
Priority to SK1528-2000A priority patent/SK285039B6/sk
Priority to NZ507573A priority patent/NZ507573A/en
Priority to PCT/ES1999/000098 priority patent/WO1999052525A1/es
Priority to GEAP19995625A priority patent/GEP20032913B/en
Priority to AT99913321T priority patent/ATE302604T1/de
Priority to UA2000105809A priority patent/UA58589C2/uk
Priority to EP99913321A priority patent/EP1072266B8/en
Priority to EEP200000596A priority patent/EE04739B1/xx
Priority to CNB998068098A priority patent/CN1189170C/zh
Priority to CZ20003764A priority patent/CZ298222B6/cs
Priority to KR10-2000-7011466A priority patent/KR100523366B1/ko
Priority to CA002328878A priority patent/CA2328878A1/en
Priority to US09/673,186 priority patent/US6410582B1/en
Priority to ROA200000995A priority patent/RO121690B1/ro
Priority to JP2000543135A priority patent/JP2002511412A/ja
Priority to RU2000128658/04A priority patent/RU2213743C2/ru
Priority to BR9910124-6A priority patent/BR9910124A/pt
Priority to AU31483/99A priority patent/AU754705B2/en
Priority to HU0102585A priority patent/HUP0102585A3/hu
Priority to TW088106199A priority patent/TW528756B/zh
Priority to CU20000215A priority patent/CU22960A3/es
Priority to LT2000097A priority patent/LT4830B/lt
Priority to BG104853A priority patent/BG64891B1/bg
Priority to IS5662A priority patent/IS5662A/is
Priority to NO20005146A priority patent/NO320313B1/no
Priority to LV000135A priority patent/LV12624B/xx
Publication of ES2150353A1 publication Critical patent/ES2150353A1/es
Application granted granted Critical
Publication of ES2150353B1 publication Critical patent/ES2150353B1/es
Priority to US10/139,674 priority patent/US20020188017A1/en
Priority to US10/779,287 priority patent/US7129361B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Tienilazolilalcoxietanaminas, su preparación y su aplicación como medicamentos. Las tienilazolilalcoxietanaminas (I) donde R1 es un átomo de hidrógeno, un halógeno o un radical alquilo inferior; R2, R3 y R4 representan, independientemente, un átomo de hidrógeno o un radical alquilo inferior; y Az representa un heterociclo aromático nitrogenado de 5 miembros, N-metilsustituido, que contiene de uno a tres átomos de nitrógeno, tienen actividad analgésico en mamíferos, incluido humanos. Los compuestos (I) pueden obtenerse, por ejemplo, por reacción de un derivado de hidroxi-tienilazol (IV) con un derivado de una N-(etil)amina apropiada. Los compuestos (IV) son intermedios útiles de síntesis de los compuestos (I). Los compuestos (I) tienen aplicación en Medicina humana y/o veterinaria.
ES009800793A 1998-04-15 1998-04-15 Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos. Expired - Fee Related ES2150353B1 (es)

Priority Applications (33)

Application Number Priority Date Filing Date Title
ES009800793A ES2150353B1 (es) 1998-04-15 1998-04-15 Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos.
ARP990101712A AR016210A1 (es) 1998-04-15 1999-04-14 Derivador de tienilazolilalcoxietanamina y sus sales fisiologicamente aceptables, procedimientos para obtener dichos derivados, sus enantiomeros puros ydichas sales, las composiciones farmaceuticas que los contienen, el empleo de dichos derivados para la preparacion de medicamentos, los compuestosin
CO99022015A CO5011045A1 (es) 1998-04-15 1999-04-14 Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos
RU2000128658/04A RU2213743C2 (ru) 1998-04-15 1999-04-15 Производное тиенилазолилалкоксиэтанамина, способ его получения (варианты), фармацевтическая композиция, промежуточный продукт и способ его получения (варианты)
SK1528-2000A SK285039B6 (sk) 1998-04-15 1999-04-15 Deriváty tienylazolylalkoxyetánamínu, spôsob ich prípravy a ich použitie na výrobu liečiv, farmaceutický prostriedok s ich obsahom, medziprodukty na ich prípravu a spôsob prípravy medziproduktov
NZ507573A NZ507573A (en) 1998-04-15 1999-04-15 Thienylazolylalkoxyethanamine derivatives, pharmaceutical compositions thereof, and their use as analgesics
PCT/ES1999/000098 WO1999052525A1 (es) 1998-04-15 1999-04-15 Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos
GEAP19995625A GEP20032913B (en) 1998-04-15 1999-04-15 Thienylazolylalcoxyethanamines, Their Preparation and Their Application as Medicaments
AT99913321T ATE302604T1 (de) 1998-04-15 1999-04-15 Thienylazolylalkoxyethanamine, deren herstellung und deren verwendung als medikamente
UA2000105809A UA58589C2 (uk) 1998-04-15 1999-04-15 Тієнілазолілалкоксіетанаміни, спосіб їх одержання, проміжні продукти для їх одержання та фармацевтична композиція
EP99913321A EP1072266B8 (en) 1998-04-15 1999-04-15 Thienylazolylalcoxyethanamines, their preparation and their application as medicaments
EEP200000596A EE04739B1 (et) 1998-04-15 1999-04-15 Tienüülasolüülalkoksüetaanamiinderivaadid, nende ja nende soolade valmistamismeetod ja kasutamine, farmatseutiline kompositsioon ning vaheühend ja selle valmistamismeetod
CNB998068098A CN1189170C (zh) 1998-04-15 1999-04-15 噻吩基唑基烷氧基乙胺,它们的制备以及它们作为药物的应用
CZ20003764A CZ298222B6 (cs) 1998-04-15 1999-04-15 Thienylazolylalkoxyethanaminy, jejich príprava a pouzití jako léciv
KR10-2000-7011466A KR100523366B1 (ko) 1998-04-15 1999-04-15 티에닐아졸일알콕시에탄아민, 이의 제조방법 및 이의 용도
CA002328878A CA2328878A1 (en) 1998-04-15 1999-04-15 Thienylazolylalcoxyethanamines, their preparation and their application as medicaments
SI9920030A SI20473A (sl) 1998-04-15 1999-04-15 Tienilazolilalkoksietanamini, njihova priprava in njihova uporaba kot zdravila
ROA200000995A RO121690B1 (ro) 1998-04-15 1999-04-15 Derivaţi de tienilazolilalcoxietanamină, procedeu de preparare a acestora şi utilizarea lor ca medicamente
JP2000543135A JP2002511412A (ja) 1998-04-15 1999-04-15 チエニルアゾリルアルコキシエタンアミン、その製造、および薬剤としてのその使用
PL99343512A PL343512A1 (en) 1998-04-15 1999-04-15 Thienylazolylalcoxyethanamines, their preparation and their application as medicaments
BR9910124-6A BR9910124A (pt) 1998-04-15 1999-04-15 Tienilazolilalcóxietanaminas, suas preparações e suas aplicações como medicamentos
AU31483/99A AU754705B2 (en) 1998-04-15 1999-04-15 Thienylazolylalcoxyethanamines, their preparation and their application as medicaments
HU0102585A HUP0102585A3 (en) 1998-04-15 1999-04-15 Thienylazolylalcoxyethanamin derivatives preparation the same and their use as medicaments
US09/673,186 US6410582B1 (en) 1998-04-15 1999-04-15 Thienylazolylalcoxyethanamines, their preparation and their application as medicaments
TW088106199A TW528756B (en) 1998-04-15 1999-04-19 Thienylazolylalkoxyethanamines, their preparation and their application as analgesic medicaments
CU20000215A CU22960A3 (es) 1998-04-15 2000-10-09 Tienilazolilalcoxietanaminas, su preparación y su aplicación como medicamentos
LT2000097A LT4830B (lt) 1998-04-15 2000-10-12 Tienilazolilalkoksietanaminai, jų gavimas ir jų pritaikymas vaistams
IS5662A IS5662A (is) 1998-04-15 2000-10-13 Þíenýlasólýlalkoxýetanamín, framleiðsla þeirra ognotkun sem lyf
NO20005146A NO320313B1 (no) 1998-04-15 2000-10-13 Tienylazolylalkoksyetanaminer, deres fremstilling og deres anvendelse som medikamenter, samt farmasoytisk sammensetning som innbefatter dem
BG104853A BG64891B1 (bg) 1998-04-15 2000-10-13 Тиенилазолилалкоксиетанамини, тяхното получаване и приложението им като лекарствени средства
LV000135A LV12624B (lv) 1998-04-15 2000-11-03 Tienilazolilalkosietanamini to iegusanas panemiens un pielietojums medikamentu legusana
US10/139,674 US20020188017A1 (en) 1998-04-15 2002-05-06 Thienylazolylalkoxyethanamines, their preparation and their application as medicaments
US10/779,287 US7129361B2 (en) 1998-04-15 2004-02-13 Thienylazolylalkoxyethanamines, their preparation and their application as medicaments

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009800793A ES2150353B1 (es) 1998-04-15 1998-04-15 Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos.

Publications (2)

Publication Number Publication Date
ES2150353A1 ES2150353A1 (es) 2000-11-16
ES2150353B1 true ES2150353B1 (es) 2001-07-01

Family

ID=8303465

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009800793A Expired - Fee Related ES2150353B1 (es) 1998-04-15 1998-04-15 Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos.

Country Status (31)

Country Link
US (3) US6410582B1 (es)
EP (1) EP1072266B8 (es)
JP (1) JP2002511412A (es)
KR (1) KR100523366B1 (es)
CN (1) CN1189170C (es)
AR (1) AR016210A1 (es)
AT (1) ATE302604T1 (es)
AU (1) AU754705B2 (es)
BG (1) BG64891B1 (es)
BR (1) BR9910124A (es)
CA (1) CA2328878A1 (es)
CO (1) CO5011045A1 (es)
CU (1) CU22960A3 (es)
CZ (1) CZ298222B6 (es)
EE (1) EE04739B1 (es)
ES (1) ES2150353B1 (es)
GE (1) GEP20032913B (es)
HU (1) HUP0102585A3 (es)
IS (1) IS5662A (es)
LT (1) LT4830B (es)
LV (1) LV12624B (es)
NO (1) NO320313B1 (es)
NZ (1) NZ507573A (es)
PL (1) PL343512A1 (es)
RO (1) RO121690B1 (es)
RU (1) RU2213743C2 (es)
SI (1) SI20473A (es)
SK (1) SK285039B6 (es)
TW (1) TW528756B (es)
UA (1) UA58589C2 (es)
WO (1) WO1999052525A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2150353B1 (es) * 1998-04-15 2001-07-01 Esteve Labor Dr Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos.
ES2137136B1 (es) * 1998-05-18 2000-07-01 Esteve Labor Dr Empleo de derivados de aril (o heteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion neurogenica.
ES2150378B1 (es) * 1998-08-07 2001-07-01 Esteve Labor Dr Empleo de derivados de aril(o heteroaril)azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de los trastornos mediados por un exceso de substancia p.
US6432954B1 (en) * 2000-07-14 2002-08-13 Targacept, Inc. Pharmaceutical compositions and methods for use
ES2174756B2 (es) * 2001-04-06 2003-11-16 Esteve Labor Dr Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de enfermedades respiratorias.
ES2180449B1 (es) * 2001-07-06 2004-01-16 Esteve Labor Dr Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de la incontinencia urinaria.
US20040142929A1 (en) * 2001-07-06 2004-07-22 Ramon Merce-Vidal Derivatives of aryl (or heteroaryl) azolylcarbinoles for the treatment of urinary incontinence
CL2004001034A1 (es) 2003-05-14 2005-03-28 Teijin Pharma Ltd Formas cristalinas de acido 4-(1-((,etilbenzotiofen-3-il)me til)benzimidazol-2-iltio)butanoico; procedimiento de preparacion de las formas cristalinas; composicion farmaceutica; y su uso para el tratamiento de enfermedades inflamatorias, alergicas, r
TW200533657A (en) * 2004-02-17 2005-10-16 Esteve Labor Dr Substituted pyrazoline compounds, their preparation and use as medicaments
EP1584335A3 (en) * 2004-04-05 2006-02-22 Laboratorios Del Dr. Esteve, S.A. Active substance combination comprising a carbinol composition and an opioid
US20060040924A1 (en) * 2004-06-22 2006-02-23 Laboratorios Dr. Esteve S.A. Derivatives of aryl (or heteroaryl) azolylcarbinols for the treatment of renal colic
WO2006010627A1 (en) * 2004-07-30 2006-02-02 Laboratorios Del Dr. Esteve, S.A. Aryl (or heteroaryl) azolylcarbinols
EP1632227A1 (en) * 2004-09-07 2006-03-08 Laboratorios del Dr. Esteve S.A. Derivatives of aryl (or heteroaryl) azolylcarbinols (in particular cizolirtin citrate) for the treatment of opioid addiction
EP1671968A1 (en) * 2004-12-17 2006-06-21 Laboratorios Del Dr. Esteve, S.A. Process for obtaining enantiomers of thienylazolylalcoxyethanamines
WO2006063860A2 (en) * 2004-12-17 2006-06-22 Laboratorios Del Dr. Esteve, S.A. Process for obtaining enantiomers of thienylazolylalcoxyethanamines
EP1674465A1 (en) * 2004-12-27 2006-06-28 Laboratorios Del Dr. Esteve, S.A. Process for obtaining enantiomers of thienylazolylalcoxyethanamines
WO2006069767A1 (en) * 2004-12-27 2006-07-06 Laboratorios Del Dr. Esteve, S.A. Process for obtaining enantiomers of thienylazolylalcoxyethanamines
ES2303795B1 (es) * 2004-12-27 2009-06-12 Laboratorios Del Dr. Esteve, S.A. Procedimiento para obtener enantiomeros de tienilazolilalcoxietanaminas.
EP1757587A1 (en) * 2005-07-15 2007-02-28 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds, their preparation and use as medicaments
EP1743892A1 (en) * 2005-07-15 2007-01-17 Laboratorios del Dr. Esteve S.A. Substituted pyrazoline compounds, their preparation and use as medicaments
US7897589B2 (en) * 2005-07-15 2011-03-01 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds, their preparation and use as medicaments
EP1743890A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. 4,5-Dihydro-1H-pyrazole derivatives, their preparation and use as medicaments
US20070149590A1 (en) * 2005-08-05 2007-06-28 Garcia Francisco J L Controlled release dosage form of pirazole compounds
EP1820502A1 (en) 2006-02-10 2007-08-22 Laboratorios Del Dr. Esteve, S.A. Active substance combination comprising azolylcarbinol compounds
EP2151234A1 (en) * 2008-07-28 2010-02-10 Laboratorios Del. Dr. Esteve, S.A. Pharmaceutical formulation comprising a CB1-receptor compound in a solid solution and/or solid dispersion
CN102432845B (zh) * 2011-08-22 2013-03-13 电子科技大学 聚3,4-双乙基羟基噻吩气敏材料及其制备方法
ES2725977T3 (es) * 2014-12-15 2019-10-01 Esteve Pharmaceuticals Sa Compuestos metil-1H-pirazolalquilamínicos que tienen actividad multimodal contra el dolor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2613720B1 (fr) * 1987-04-10 1990-01-19 Esteve Labor Dr Derives d'aryl-heteroaryl carbinols avec activite analgesique
ES2150353B1 (es) * 1998-04-15 2001-07-01 Esteve Labor Dr Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos.
ES2137136B1 (es) * 1998-05-18 2000-07-01 Esteve Labor Dr Empleo de derivados de aril (o heteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion neurogenica.

Also Published As

Publication number Publication date
WO1999052525A1 (es) 1999-10-21
HUP0102585A3 (en) 2002-04-29
ATE302604T1 (de) 2005-09-15
CN1189170C (zh) 2005-02-16
IS5662A (is) 2000-10-13
US6410582B1 (en) 2002-06-25
CZ298222B6 (cs) 2007-07-25
NZ507573A (en) 2002-07-26
JP2002511412A (ja) 2002-04-16
RO121690B1 (ro) 2008-02-28
HUP0102585A2 (hu) 2001-12-28
US20020188017A1 (en) 2002-12-12
CO5011045A1 (es) 2001-02-28
SI20473A (sl) 2001-08-31
KR20010042739A (ko) 2001-05-25
BG64891B1 (bg) 2006-08-31
CU22960A3 (es) 2004-06-21
EP1072266B1 (en) 2005-08-24
BR9910124A (pt) 2001-01-09
GEP20032913B (en) 2003-03-25
PL343512A1 (en) 2001-08-27
CA2328878A1 (en) 1999-10-21
LV12624B (lv) 2001-09-20
LV12624A (lv) 2001-03-20
EE04739B1 (et) 2006-12-15
AU3148399A (en) 1999-11-01
SK285039B6 (sk) 2006-05-04
NO20005146D0 (no) 2000-10-13
EP1072266A1 (en) 2001-01-31
CN1303283A (zh) 2001-07-11
RU2213743C2 (ru) 2003-10-10
US20040162324A1 (en) 2004-08-19
EE200000596A (et) 2002-06-17
LT4830B (lt) 2001-08-27
TW528756B (en) 2003-04-21
SK15282000A3 (sk) 2001-12-03
CZ20003764A3 (en) 2001-05-16
ES2150353A1 (es) 2000-11-16
AR016210A1 (es) 2001-06-20
AU754705B2 (en) 2002-11-21
BG104853A (en) 2001-04-30
KR100523366B1 (ko) 2005-10-20
NO20005146L (no) 2000-12-14
EP1072266B8 (en) 2006-10-18
LT2000097A (en) 2001-03-26
US7129361B2 (en) 2006-10-31
NO320313B1 (no) 2005-11-21
UA58589C2 (uk) 2003-08-15

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