ES2180449B1 - Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de la incontinencia urinaria. - Google Patents
Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de la incontinencia urinaria.Info
- Publication number
- ES2180449B1 ES2180449B1 ES200101587A ES200101587A ES2180449B1 ES 2180449 B1 ES2180449 B1 ES 2180449B1 ES 200101587 A ES200101587 A ES 200101587A ES 200101587 A ES200101587 A ES 200101587A ES 2180449 B1 ES2180449 B1 ES 2180449B1
- Authority
- ES
- Spain
- Prior art keywords
- treatment
- derivatives
- urinary incontinence
- azolilcarbinoles
- heteroaril
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 206010046543 Urinary incontinence Diseases 0.000 title abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- PLIKAWJENQZMHA-UHFFFAOYSA-N 4-aminophenol Chemical class NC1=CC=C(O)C=C1 PLIKAWJENQZMHA-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de la incontinencia urinaria. Los derivados de aril(o heteroaril) azolilcarbinoles de fórmula general (I), en la cual Ar representa un radical fenilo o un radical tienilo, opcionalmente sustituidos, R1 representa un átomo de hidrógeno o un grupo alquilo inferior, R2 representa un radical dialquilaminoalquilo o azaheterociclilalquil y Het representa un azol no sustituido u opcionalmente sustituido por uno o dos sustituyentes, así como sus sales fisiológicamente aceptables; son útiles como medicamentos en terapéutica humana y/o veterinaria para el tratamiento de la incontinencia urinaria, en mamíferos, incluido el hombre.
Priority Applications (27)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200101587A ES2180449B1 (es) | 2001-07-06 | 2001-07-06 | Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de la incontinencia urinaria. |
UA2004020880A UA79238C2 (en) | 2001-07-06 | 2002-01-07 | Use of derivatives of aryl (or heteroaryl) azolylcarbinoles |
AT02745440T ATE327752T1 (de) | 2001-07-06 | 2002-07-01 | Aryl- (oder heteroaryl-) azolylcarbynolderivatve zur behandlung von harninkontinenz |
KR10-2004-7000056A KR20040030788A (ko) | 2001-07-06 | 2002-07-01 | 요실금 치료를 위한 아릴(또는 헤테로아릴)아졸릴카르비놀 유도체 |
PCT/ES2002/000326 WO2003004022A1 (es) | 2001-07-06 | 2002-07-01 | Derivados de aril(o heteroaril)azolilcarbinoles para el tratamiento de la incontinencia urinaria |
DE60211913T DE60211913T2 (de) | 2001-07-06 | 2002-07-01 | Aryl- (oder heteroaryl-) azolylcarbynolderivatve zur behandlung von harninkontinenz |
ARP020102482A AR034679A1 (es) | 2001-07-06 | 2002-07-01 | Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de la incontinencia urinaria |
SI200230346T SI1413305T1 (sl) | 2001-07-06 | 2002-07-01 | Aril (ali heteroaril) azolikarbonil derivati za zdravljenje urinske inkontinence |
DK02745440T DK1413305T3 (da) | 2001-07-06 | 2002-07-01 | Aryl(eller heteroaryl)-azolylcarbinolderivater til behandling af urininkontinens |
CNA028161009A CN1543344A (zh) | 2001-07-06 | 2002-07-01 | 治疗尿失禁的芳基(或杂芳基)氮杂茂甲醇衍生物 |
ES02745440T ES2263792T3 (es) | 2001-07-06 | 2002-07-01 | Derivados de aril(o heteroaril) azolilcarbinoles para el tratamiento de la incontinencia urinaria. |
JP2003510033A JP2004521150A (ja) | 2001-07-06 | 2002-07-01 | 尿失禁治療用アリール(またはヘテロアリール)アゾリルカルビノール誘導体 |
BR0211237-0A BR0211237A (pt) | 2001-07-06 | 2002-07-01 | Uso de derivados de aril (ou heteroaril) azolil-carbinóis para o tratamento de incontinência urinária e composição farmacêutica |
RU2004103475/15A RU2308268C2 (ru) | 2001-07-06 | 2002-07-01 | Производные арил- или гетероарилазолилкарбинолов для лечения недержания мочи |
PT02745440T PT1413305E (pt) | 2001-07-06 | 2002-07-01 | Derivados aril (ou heteroaril) azolilcabrinol para o tratamento de incontinencia urinaria |
CA002452646A CA2452646A1 (en) | 2001-07-06 | 2002-07-01 | Derivatives of aryl(or heteroaryl) azolylcarbinols for the treatement ofurinary incontinence |
MXPA04000065A MXPA04000065A (es) | 2001-07-06 | 2002-07-01 | Derivados de aril(o ehteroaril)azolilcarbinoles para el tratamiento de la incontinencia urinaria. |
NZ530817A NZ530817A (en) | 2001-07-06 | 2002-07-01 | Aryl (or heteroaryl) azolylcarbynol derivatives for the treatment of urinary incontinence |
EP02745440A EP1413305B1 (en) | 2001-07-06 | 2002-07-01 | Aryl (or heteroaryl) azolylcarbynol derivatives for the treatment of urinary incontinence |
PL02369062A PL369062A1 (en) | 2001-07-06 | 2002-07-01 | Aryl (or heteroaryl) azolylcarbynol derivatives for the treatment of urinary incontinence |
US10/189,915 US20030022925A1 (en) | 2001-07-06 | 2002-07-03 | Derivatives of aryl (or heteroaryl) azolylcarbinoles for the treatment of urinary incontinence |
NO20040031A NO20040031L (no) | 2001-07-06 | 2004-01-05 | Aryl-(eller heteroaryl)azolylkarbynolderivater for behandlingen av urininkontinens |
US10/753,161 US20040142929A1 (en) | 2001-07-06 | 2004-01-06 | Derivatives of aryl (or heteroaryl) azolylcarbinoles for the treatment of urinary incontinence |
ZA200400780A ZA200400780B (en) | 2001-07-06 | 2004-01-30 | Aryl (or heteroaryl) azolylcarbynol derivatives for the treatment of urinary incontinence. |
MA27514A MA27056A1 (fr) | 2001-07-06 | 2004-02-04 | Derives d'azolylcarbinols d'aryle (ou d'heteroaryle) pour le traitement de l'incontinence d'urine. |
US11/045,708 US20050131049A1 (en) | 2001-07-06 | 2005-01-28 | Derivatives of aryl (or heteroaryl) azolylcarbinoles for the treatment of urinary incontinence |
CY20061101049T CY1105113T1 (el) | 2001-07-06 | 2006-07-28 | Παραγωγα της αρυλικης (ή ετepοαρυλικης) αζολυλκαρβυνολης για την αντιμετωπιση της ακρατειας ουρων |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200101587A ES2180449B1 (es) | 2001-07-06 | 2001-07-06 | Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de la incontinencia urinaria. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2180449A1 ES2180449A1 (es) | 2003-02-01 |
ES2180449B1 true ES2180449B1 (es) | 2004-01-16 |
Family
ID=8498326
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200101587A Expired - Fee Related ES2180449B1 (es) | 2001-07-06 | 2001-07-06 | Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de la incontinencia urinaria. |
ES02745440T Expired - Lifetime ES2263792T3 (es) | 2001-07-06 | 2002-07-01 | Derivados de aril(o heteroaril) azolilcarbinoles para el tratamiento de la incontinencia urinaria. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES02745440T Expired - Lifetime ES2263792T3 (es) | 2001-07-06 | 2002-07-01 | Derivados de aril(o heteroaril) azolilcarbinoles para el tratamiento de la incontinencia urinaria. |
Country Status (23)
Country | Link |
---|---|
US (2) | US20030022925A1 (es) |
EP (1) | EP1413305B1 (es) |
JP (1) | JP2004521150A (es) |
KR (1) | KR20040030788A (es) |
CN (1) | CN1543344A (es) |
AR (1) | AR034679A1 (es) |
AT (1) | ATE327752T1 (es) |
BR (1) | BR0211237A (es) |
CA (1) | CA2452646A1 (es) |
CY (1) | CY1105113T1 (es) |
DE (1) | DE60211913T2 (es) |
DK (1) | DK1413305T3 (es) |
ES (2) | ES2180449B1 (es) |
MA (1) | MA27056A1 (es) |
MX (1) | MXPA04000065A (es) |
NO (1) | NO20040031L (es) |
NZ (1) | NZ530817A (es) |
PL (1) | PL369062A1 (es) |
PT (1) | PT1413305E (es) |
RU (1) | RU2308268C2 (es) |
UA (1) | UA79238C2 (es) |
WO (1) | WO2003004022A1 (es) |
ZA (1) | ZA200400780B (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040142929A1 (en) * | 2001-07-06 | 2004-07-22 | Ramon Merce-Vidal | Derivatives of aryl (or heteroaryl) azolylcarbinoles for the treatment of urinary incontinence |
DE10335566A1 (de) * | 2003-07-31 | 2005-02-24 | Grünenthal GmbH | Arzneimittel enthaltend Derivate von Aryl( oder Heteroaryl)azolylcarbinolen |
TW200533657A (en) * | 2004-02-17 | 2005-10-16 | Esteve Labor Dr | Substituted pyrazoline compounds, their preparation and use as medicaments |
ES2244326B1 (es) * | 2004-04-05 | 2007-02-16 | Laboratorios Del Dr. Esteve, S.A. | Combinacion de substancias activas. |
EP1584335A3 (en) * | 2004-04-05 | 2006-02-22 | Laboratorios Del Dr. Esteve, S.A. | Active substance combination comprising a carbinol composition and an opioid |
US20060040924A1 (en) * | 2004-06-22 | 2006-02-23 | Laboratorios Dr. Esteve S.A. | Derivatives of aryl (or heteroaryl) azolylcarbinols for the treatment of renal colic |
WO2006010627A1 (en) * | 2004-07-30 | 2006-02-02 | Laboratorios Del Dr. Esteve, S.A. | Aryl (or heteroaryl) azolylcarbinols |
EP1743892A1 (en) * | 2005-07-15 | 2007-01-17 | Laboratorios del Dr. Esteve S.A. | Substituted pyrazoline compounds, their preparation and use as medicaments |
EP1743890A1 (en) * | 2005-07-15 | 2007-01-17 | Laboratorios Del Dr. Esteve, S.A. | 4,5-Dihydro-1H-pyrazole derivatives, their preparation and use as medicaments |
US7897589B2 (en) * | 2005-07-15 | 2011-03-01 | Laboratorios Del Dr. Esteve, S.A. | Substituted pyrazoline compounds, their preparation and use as medicaments |
EP1757587A1 (en) * | 2005-07-15 | 2007-02-28 | Laboratorios Del Dr. Esteve, S.A. | Substituted pyrazoline compounds, their preparation and use as medicaments |
US20070021485A1 (en) * | 2005-07-22 | 2007-01-25 | Gomis Antonio F | Aryl (or heteroaryl) azolylcarbinols |
ES2334548B1 (es) * | 2005-07-29 | 2010-10-27 | Laboratorios Del Dr. Esteve, S.A | Forma de dosificacion de liberacion controlada de compuestos de pirazol para el tratamiento de la incontinencia urinaria. |
US8722079B2 (en) | 2008-04-18 | 2014-05-13 | Warsaw Orthopedic, Inc. | Methods for treating conditions such as dystonia and post-stroke spasticity with clonidine |
EP2151234A1 (en) * | 2008-07-28 | 2010-02-10 | Laboratorios Del. Dr. Esteve, S.A. | Pharmaceutical formulation comprising a CB1-receptor compound in a solid solution and/or solid dispersion |
US20100291151A1 (en) * | 2009-04-21 | 2010-11-18 | Auspex Pharmaceuticals, Inc. | 1-methylpyrazole modulators of substance p, calcitonin gene-related peptide, adrenergic receptor, and/or 5-ht receptor |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE891865A (fr) * | 1981-01-30 | 1982-07-22 | Sandoz Sa | Nouveaux medicaments a base de derives condenses de l'imidazole pour le traitement des troubles urinaires |
ES2150353B1 (es) * | 1998-04-15 | 2001-07-01 | Esteve Labor Dr | Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos. |
ES2137136B1 (es) * | 1998-05-18 | 2000-07-01 | Esteve Labor Dr | Empleo de derivados de aril (o heteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion neurogenica. |
ES2150378B1 (es) * | 1998-08-07 | 2001-07-01 | Esteve Labor Dr | Empleo de derivados de aril(o heteroaril)azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de los trastornos mediados por un exceso de substancia p. |
-
2001
- 2001-07-06 ES ES200101587A patent/ES2180449B1/es not_active Expired - Fee Related
-
2002
- 2002-01-07 UA UA2004020880A patent/UA79238C2/uk unknown
- 2002-07-01 PL PL02369062A patent/PL369062A1/xx not_active Application Discontinuation
- 2002-07-01 KR KR10-2004-7000056A patent/KR20040030788A/ko not_active Application Discontinuation
- 2002-07-01 WO PCT/ES2002/000326 patent/WO2003004022A1/es active IP Right Grant
- 2002-07-01 AR ARP020102482A patent/AR034679A1/es not_active Application Discontinuation
- 2002-07-01 MX MXPA04000065A patent/MXPA04000065A/es unknown
- 2002-07-01 EP EP02745440A patent/EP1413305B1/en not_active Expired - Lifetime
- 2002-07-01 CN CNA028161009A patent/CN1543344A/zh active Pending
- 2002-07-01 BR BR0211237-0A patent/BR0211237A/pt not_active IP Right Cessation
- 2002-07-01 AT AT02745440T patent/ATE327752T1/de not_active IP Right Cessation
- 2002-07-01 CA CA002452646A patent/CA2452646A1/en not_active Abandoned
- 2002-07-01 DE DE60211913T patent/DE60211913T2/de not_active Expired - Fee Related
- 2002-07-01 JP JP2003510033A patent/JP2004521150A/ja active Pending
- 2002-07-01 NZ NZ530817A patent/NZ530817A/en unknown
- 2002-07-01 PT PT02745440T patent/PT1413305E/pt unknown
- 2002-07-01 RU RU2004103475/15A patent/RU2308268C2/ru not_active IP Right Cessation
- 2002-07-01 ES ES02745440T patent/ES2263792T3/es not_active Expired - Lifetime
- 2002-07-01 DK DK02745440T patent/DK1413305T3/da active
- 2002-07-03 US US10/189,915 patent/US20030022925A1/en not_active Abandoned
-
2004
- 2004-01-05 NO NO20040031A patent/NO20040031L/no not_active Application Discontinuation
- 2004-01-30 ZA ZA200400780A patent/ZA200400780B/en unknown
- 2004-02-04 MA MA27514A patent/MA27056A1/fr unknown
-
2005
- 2005-01-28 US US11/045,708 patent/US20050131049A1/en not_active Abandoned
-
2006
- 2006-07-28 CY CY20061101049T patent/CY1105113T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
JP2004521150A (ja) | 2004-07-15 |
RU2308268C2 (ru) | 2007-10-20 |
KR20040030788A (ko) | 2004-04-09 |
RU2004103475A (ru) | 2005-06-10 |
NZ530817A (en) | 2005-07-29 |
PL369062A1 (en) | 2005-04-18 |
NO20040031L (no) | 2004-03-02 |
ES2263792T3 (es) | 2006-12-16 |
ATE327752T1 (de) | 2006-06-15 |
EP1413305B1 (en) | 2006-05-31 |
US20030022925A1 (en) | 2003-01-30 |
CA2452646A1 (en) | 2003-01-16 |
BR0211237A (pt) | 2004-08-10 |
DE60211913D1 (de) | 2006-07-06 |
ZA200400780B (en) | 2005-01-31 |
MXPA04000065A (es) | 2004-05-21 |
EP1413305A1 (en) | 2004-04-28 |
DK1413305T3 (da) | 2006-09-18 |
MA27056A1 (fr) | 2004-12-20 |
ES2180449A1 (es) | 2003-02-01 |
CN1543344A (zh) | 2004-11-03 |
UA79238C2 (en) | 2007-06-11 |
CY1105113T1 (el) | 2010-03-03 |
DE60211913T2 (de) | 2007-05-24 |
US20050131049A1 (en) | 2005-06-16 |
WO2003004022A1 (es) | 2003-01-16 |
PT1413305E (pt) | 2006-09-29 |
AR034679A1 (es) | 2004-03-03 |
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