HUP0101356A2 - Eljárás 1,3-diszubsztituált-4-oxo-ciklikus karbamidok előállítására - Google Patents
Eljárás 1,3-diszubsztituált-4-oxo-ciklikus karbamidok előállításáraInfo
- Publication number
- HUP0101356A2 HUP0101356A2 HU0101356A HUP0101356A HUP0101356A2 HU P0101356 A2 HUP0101356 A2 HU P0101356A2 HU 0101356 A HU0101356 A HU 0101356A HU P0101356 A HUP0101356 A HU P0101356A HU P0101356 A2 HUP0101356 A2 HU P0101356A2
- Authority
- HU
- Hungary
- Prior art keywords
- disubstituted
- oxo
- substituted
- amino
- cyclic urea
- Prior art date
Links
- 235000013877 carbamide Nutrition 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000003672 ureas Chemical class 0.000 title 1
- -1 amino- Chemical class 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000006323 alkenyl amino group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005257 alkyl acyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 150000002829 nitrogen Chemical class 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Catalysts (AREA)
Abstract
A találmány tárgya eljárás általános képletű 1,3-diszubsztituált-9-oxo-ciklikus karbamidok előállítására - ahol R1, R2 és R3 egymástólfüggetlenül hidrogénatom, amino-, nitro-, karboxi-, mezil-amino-,szulfo-, hidroxi, alkoxi-, alkil-, alkoxi-karbonil-, hidroxi-alkil-,karboxi-alkil- vagy aciloxicsoport; R4 szubsztituált vagyszubsztituálatlan alkil-, alkenil-, alkinil-, alkil-acil- vagyheteroalkilcsoport; és A szubsztituált vagy szubsztituálatlan,telített vagy telítetlen, egyenes vagy elágazó szénláncú alkil- vagyalkenil-aminocsoport; vagy legalább egy nitrogénatomot tartalmazóheterociklusos csoport, és R4 ehhez a nitrogénatomhoz kapcsolódik. Az1,3-diszubsztituált-4-oxo-ciklikus karbamidot úgy állítják elő, hogyia) egy 1-szubsztituált-4-oxo-ciklikus karbamidot gyenge bázis ésoldószer jelenlétében egy legalább két kilépőcsoportot tartalmazószénlánc-reagenssel egy legalább egy kilépőcsoportot tartalmazóadduktummá reagáltatnak; majd ib) az adduktumot egy aminnal 1,3-diszubsztituált-4-oxo-ciklikus karbamiddá kondenzálják; és ii) aterméket a reakcióelegyből kinyerik. Ó
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8340698P | 1998-04-29 | 1998-04-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0101356A2 true HUP0101356A2 (hu) | 2002-05-29 |
| HUP0101356A3 HUP0101356A3 (en) | 2003-08-28 |
Family
ID=22178103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0101356A HUP0101356A3 (en) | 1998-04-29 | 1999-04-27 | Process for making 1,3-disubstituted-4-oxocyclic ureas |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6420568B1 (hu) |
| EP (1) | EP1075474B1 (hu) |
| JP (1) | JP4514950B2 (hu) |
| KR (1) | KR100400051B1 (hu) |
| CN (1) | CN1298402A (hu) |
| AR (1) | AR019120A1 (hu) |
| AT (1) | ATE275563T1 (hu) |
| AU (1) | AU747237B2 (hu) |
| BR (1) | BR9910078A (hu) |
| CA (1) | CA2330685A1 (hu) |
| CO (1) | CO5050358A1 (hu) |
| DE (1) | DE69920003T2 (hu) |
| HU (1) | HUP0101356A3 (hu) |
| ID (1) | ID27316A (hu) |
| IL (1) | IL138405A (hu) |
| MY (1) | MY133752A (hu) |
| NO (1) | NO20005425L (hu) |
| NZ (1) | NZ506773A (hu) |
| PE (1) | PE20000439A1 (hu) |
| PL (1) | PL198951B1 (hu) |
| RU (1) | RU2194705C2 (hu) |
| SK (1) | SK15832000A3 (hu) |
| TR (1) | TR200003136T2 (hu) |
| TW (1) | TW492965B (hu) |
| WO (1) | WO1999055701A1 (hu) |
| ZA (1) | ZA200004714B (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9910074A (pt) * | 1998-04-29 | 2000-12-26 | Procter & Gamble | Processo para fabricação de uréias 1,3-di-substituìdas-4-oxocìclicas |
| CN100443473C (zh) * | 2005-04-30 | 2008-12-17 | 中国药科大学 | 1-氨基-3-(氮杂环基烷基)-2,4-咪唑二酮的合成方法 |
| US20120178762A1 (en) | 2006-12-15 | 2012-07-12 | Warner Chilcott Company, Llc | Compositions of azimilide dihydrochloride |
| TW200840578A (en) * | 2006-12-15 | 2008-10-16 | Procter & Gamble | Compositions of azimilide dihydrochloride |
| US8123815B2 (en) | 2008-11-24 | 2012-02-28 | Biomet Manufacturing Corp. | Multiple bearing acetabular prosthesis |
| US8308810B2 (en) | 2009-07-14 | 2012-11-13 | Biomet Manufacturing Corp. | Multiple bearing acetabular prosthesis |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL272960A (hu) * | 1960-12-27 | |||
| US3906010A (en) | 1974-06-17 | 1975-09-16 | Morton Norwich Products Inc | Series of 5-aryl-2-furamidines |
| US3919231A (en) | 1974-06-17 | 1975-11-11 | Morton Norwich Products Inc | Series of 5-aryl-2-furamidines |
| US3946049A (en) | 1975-04-03 | 1976-03-23 | Morton-Norwich Products, Inc. | 5-phenyl-2-furamidoximes |
| US4001222A (en) | 1975-10-14 | 1977-01-04 | Morton-Norwich Products, Inc. | 3-(Aminoacyl)-1-{[5-(substituted phenyl)furfurylidene]amino}hydantoins and process for their preparation thereof |
| JPS5726653A (en) | 1980-05-09 | 1982-02-12 | Ciba Geigy Ag | Substituted phenyl ether |
| IL82856A0 (en) | 1986-06-26 | 1987-12-20 | Norwich Eaton Pharma | Pharmaceutical compositions containing 2-(5-phenyl-2-furanyl)imidazoles and certain such novel compounds |
| US4882354A (en) | 1987-12-16 | 1989-11-21 | Norwich Eaton Pharmaceuticals, Inc. | N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents |
| US5019651A (en) | 1990-06-20 | 1991-05-28 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof |
| JP3031973B2 (ja) * | 1990-08-16 | 2000-04-10 | 富士レビオ株式会社 | フェニトイン誘導体 |
| HU221317B1 (en) * | 1991-08-14 | 2002-09-28 | Procter & Gamble Pharma | 2,4-imidazolidinedione derivatives and antiarrhythmic and antifibrillatory compositions containing them, and process for producing them |
| PL171280B1 (pl) | 1991-08-14 | 1997-03-28 | Procter & Gamble Pharma | Sposób wytwarzania nowych cyklicznych uretanów PL PL |
| BR9910074A (pt) * | 1998-04-29 | 2000-12-26 | Procter & Gamble | Processo para fabricação de uréias 1,3-di-substituìdas-4-oxocìclicas |
-
1999
- 1999-04-27 HU HU0101356A patent/HUP0101356A3/hu unknown
- 1999-04-27 AT AT99920062T patent/ATE275563T1/de not_active IP Right Cessation
- 1999-04-27 JP JP2000545861A patent/JP4514950B2/ja not_active Expired - Fee Related
- 1999-04-27 KR KR10-2000-7011922A patent/KR100400051B1/ko not_active IP Right Cessation
- 1999-04-27 WO PCT/US1999/009093 patent/WO1999055701A1/en not_active Application Discontinuation
- 1999-04-27 SK SK1583-2000A patent/SK15832000A3/sk unknown
- 1999-04-27 CA CA002330685A patent/CA2330685A1/en not_active Abandoned
- 1999-04-27 CN CN99805365A patent/CN1298402A/zh active Pending
- 1999-04-27 US US09/674,228 patent/US6420568B1/en not_active Expired - Lifetime
- 1999-04-27 DE DE69920003T patent/DE69920003T2/de not_active Expired - Lifetime
- 1999-04-27 NZ NZ506773A patent/NZ506773A/xx not_active Application Discontinuation
- 1999-04-27 ID IDW20002480A patent/ID27316A/id unknown
- 1999-04-27 RU RU2000129802/04A patent/RU2194705C2/ru not_active IP Right Cessation
- 1999-04-27 TR TR2000/03136T patent/TR200003136T2/xx unknown
- 1999-04-27 BR BR9910078-9A patent/BR9910078A/pt not_active IP Right Cessation
- 1999-04-27 PL PL343733A patent/PL198951B1/pl not_active IP Right Cessation
- 1999-04-27 IL IL13840599A patent/IL138405A/xx not_active IP Right Cessation
- 1999-04-27 EP EP99920062A patent/EP1075474B1/en not_active Expired - Lifetime
- 1999-04-27 AU AU37644/99A patent/AU747237B2/en not_active Ceased
- 1999-04-29 CO CO99025955A patent/CO5050358A1/es unknown
- 1999-04-29 PE PE1999000354A patent/PE20000439A1/es not_active Application Discontinuation
- 1999-04-29 AR ARP990101995A patent/AR019120A1/es not_active Application Discontinuation
- 1999-04-29 MY MYPI99001689A patent/MY133752A/en unknown
- 1999-07-28 TW TW088106940A patent/TW492965B/zh not_active IP Right Cessation
-
2000
- 2000-09-07 ZA ZA200004714A patent/ZA200004714B/en unknown
- 2000-10-27 NO NO20005425A patent/NO20005425L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200004714B (en) | 2002-01-30 |
| ID27316A (id) | 2001-03-22 |
| RU2194705C2 (ru) | 2002-12-20 |
| DE69920003T2 (de) | 2005-09-15 |
| ATE275563T1 (de) | 2004-09-15 |
| TR200003136T2 (tr) | 2001-03-21 |
| PE20000439A1 (es) | 2000-07-13 |
| PL343733A1 (en) | 2001-09-10 |
| WO1999055701A1 (en) | 1999-11-04 |
| KR100400051B1 (ko) | 2003-09-29 |
| US6420568B1 (en) | 2002-07-16 |
| IL138405A0 (en) | 2001-10-31 |
| KR20010043053A (ko) | 2001-05-25 |
| NO20005425D0 (no) | 2000-10-27 |
| CO5050358A1 (es) | 2001-06-27 |
| JP2002513022A (ja) | 2002-05-08 |
| CN1298402A (zh) | 2001-06-06 |
| AU3764499A (en) | 1999-11-16 |
| HUP0101356A3 (en) | 2003-08-28 |
| NO20005425L (no) | 2000-10-27 |
| AR019120A1 (es) | 2001-12-26 |
| IL138405A (en) | 2005-03-20 |
| AU747237B2 (en) | 2002-05-09 |
| EP1075474A1 (en) | 2001-02-14 |
| TW492965B (en) | 2002-07-01 |
| EP1075474B1 (en) | 2004-09-08 |
| PL198951B1 (pl) | 2008-08-29 |
| SK15832000A3 (sk) | 2001-06-11 |
| BR9910078A (pt) | 2000-12-26 |
| MY133752A (en) | 2007-11-30 |
| CA2330685A1 (en) | 1999-11-04 |
| JP4514950B2 (ja) | 2010-07-28 |
| DE69920003D1 (de) | 2004-10-14 |
| NZ506773A (en) | 2004-03-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB9A | Succession in title |
Owner name: WARNER CHILCOTT COMPANY, LLC, US Free format text: FORMER OWNER(S): THE PROCTER & GAMBLE CO., US |
|
| FD9A | Lapse of provisional protection due to non-payment of fees |