HUP0004855A2 - Eljárás kinolinszármazékok előállítására és az eljárás intermedierjei - Google Patents

Eljárás kinolinszármazékok előállítására és az eljárás intermedierjei

Info

Publication number
HUP0004855A2
HUP0004855A2 HU0004855A HUP0004855A HUP0004855A2 HU P0004855 A2 HUP0004855 A2 HU P0004855A2 HU 0004855 A HU0004855 A HU 0004855A HU P0004855 A HUP0004855 A HU P0004855A HU P0004855 A2 HUP0004855 A2 HU P0004855A2
Authority
HU
Hungary
Prior art keywords
alkyl
group
carbonyl
cycloalkyl
alkoxy
Prior art date
Application number
HU0004855A
Other languages
English (en)
Inventor
Conrad Kowalski
Mark Mellinger
Joseph Sisko
Original Assignee
Smithkline Beecham Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp. filed Critical Smithkline Beecham Corp.
Publication of HUP0004855A2 publication Critical patent/HUP0004855A2/hu
Publication of HUP0004855A3 publication Critical patent/HUP0004855A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2

Abstract

A találmány tárgya új eljárás (I) általános képletű vegyületek -amelyek képletében Ar adott esetben szubsztituált fenil-, naftil-,cikloalkadienil- vagy heterociklusos csoport; R alkil-, cikloalkil-,cikloalkil-alkil-, adott esetben szubsztituált fenil- vagy fenil-alkil-, heteroaril-, hidroxi-alkil-, (dialkil-amino)-alkil-, (acil-amino)-alkil-, alkoxi-alkil-, alkil-karbonil-, karboxi-, alkoxi-karbonil-, (alkoxi-karbonil)-alkil-, karbamoil-, (alkil-amino)-karbonil-, (dialkil-amino)-karbonil-csoport, vagy egy, az Ar csoportraciklizált - (CH2)p-csoport, R1 és R2 hidrogénatom, alkilcsoport, vagyegyütt egy -(CH2)n- csoportot képez, vagy R1 és R együtt egy -(CH2)q-csoportot képez, R3 és R4 hidrogén-, halogénatom, alkil-, alkenil-,aril-, alkoxi-, hidroxi-, nitro-, ciano-, karboxi-, karbamoil-,szulfonil-amino-, trifluor-metil-, amino-, mono- vagy dialkil-amino-,-O(CH2)r-NT2 csoport, R4 az aromás R5 csoportra ciklizálva egy -(CH2)t-csoportot képez, R5 alkil-, cikloalkil-, cikloalkil-alkil-,adott esetben szubsztituált aril- vagy heterociklusos csoport - vagygyógyászatilag elfogadható sóik előállítására. A találmány kiterjed az eljárás új intermedierjeire is. Ó
HU0004855A 1997-09-17 1998-09-17 Method for the synthesis of quinoline derivatives and intermediates HUP0004855A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5930397P 1997-09-17 1997-09-17
PCT/US1998/019434 WO1999014196A1 (en) 1997-09-17 1998-09-17 Method for the synthesis of quinoline derivatives

Publications (2)

Publication Number Publication Date
HUP0004855A2 true HUP0004855A2 (hu) 2001-06-28
HUP0004855A3 HUP0004855A3 (en) 2001-08-28

Family

ID=22022126

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004855A HUP0004855A3 (en) 1997-09-17 1998-09-17 Method for the synthesis of quinoline derivatives and intermediates

Country Status (32)

Country Link
US (6) US6335448B1 (hu)
EP (1) EP1017676B1 (hu)
JP (1) JP2001516744A (hu)
KR (1) KR20010024031A (hu)
CN (1) CN1125815C (hu)
AP (1) AP1201A (hu)
AR (1) AR015445A1 (hu)
AT (1) ATE353879T1 (hu)
AU (1) AU744538B2 (hu)
BG (1) BG104243A (hu)
BR (1) BR9812085A (hu)
CA (1) CA2303026A1 (hu)
DE (1) DE69837100T2 (hu)
DZ (1) DZ2607A1 (hu)
EA (1) EA002633B1 (hu)
ES (1) ES2283072T3 (hu)
HU (1) HUP0004855A3 (hu)
ID (1) ID24140A (hu)
IL (1) IL134991A0 (hu)
MA (1) MA24644A1 (hu)
MY (1) MY120237A (hu)
NO (1) NO314303B1 (hu)
NZ (1) NZ503307A (hu)
OA (1) OA11340A (hu)
PE (1) PE129299A1 (hu)
PL (1) PL339340A1 (hu)
SK (1) SK3672000A3 (hu)
TR (1) TR200000720T2 (hu)
TW (1) TW509678B (hu)
UY (2) UY25174A1 (hu)
WO (1) WO1999014196A1 (hu)
ZA (1) ZA988455B (hu)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP1201A (en) * 1997-09-17 2003-09-01 Smithkline Beecham Corp Method for the synthesis of quinoline derivatives.
DE60004654T2 (de) 1999-03-29 2004-06-24 Neurogen Corp., Branford 4-substituierte chinolinderivate als nk-3 und/oder gaba(a) rezeptor liganden
AP2006003685A0 (en) 2004-02-04 2006-08-31 Pfizer Prod Inc Substituted quinoline compounds
KR20080016591A (ko) * 2005-06-03 2008-02-21 아스트라제네카 아베 Ｎｋ3 길항제로서의 퀴놀린 유도체
US20080194623A1 (en) * 2005-08-02 2008-08-14 Labaw Clifford S Method for the Synthesis of Quinoline Derivatives
US20080280949A1 (en) * 2005-08-11 2008-11-13 Astrazeneca Ab Oxopyridyl Quinoline Amides as Nk3 Receptor Modulators
AR057130A1 (es) * 2005-09-21 2007-11-14 Astrazeneca Ab Quinolinas de alquilsulfoxido y una composicion farmaceutica
WO2007035156A1 (en) * 2005-09-21 2007-03-29 Astrazeneca Ab N-oxo-heterocycle and n-oxo-alkyl quinoline-4-carboxamides as nk-3 receptor ligands
WO2007086799A1 (en) * 2006-01-27 2007-08-02 Astrazeneca Ab Amide substituted quinolines
CN102702099A (zh) * 2012-06-21 2012-10-03 江苏恩华药业股份有限公司 (s)-3-羟基-2-苯基-n-(1-苯基丙基)喹啉-4-甲酰胺的制备方法
CN102924375B (zh) * 2012-06-21 2015-02-18 江苏恩华药业股份有限公司 Talnetant中间体及其制备方法和应用
CN103214416A (zh) * 2013-04-26 2013-07-24 扬州大学 一种合成多取代喹啉类化合物的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776290A (en) * 1957-01-01 Hydroxy cevchoninates and carboxylic
CZ291476B6 (cs) * 1994-05-27 2003-03-12 Smithkline Beecham S. P. A. N-(alfa-Ethylbenzyl)-3-hydroxy-2-fenylchinolin-4-karboxamid, farmaceutický prostředek s jeho obsahem a použití
US5627193A (en) * 1995-02-09 1997-05-06 Mitsui Toatsu Chemicals, Inc. Quinoline-4-carbonylguanidine derivatives, process for producing the same and pharmaceutical preparations containing the compounds
AP1201A (en) * 1997-09-17 2003-09-01 Smithkline Beecham Corp Method for the synthesis of quinoline derivatives.

Also Published As

Publication number Publication date
WO1999014196A1 (en) 1999-03-25
PE129299A1 (es) 2000-02-19
NO314303B1 (no) 2003-03-03
ID24140A (id) 2000-07-06
US20020038029A1 (en) 2002-03-28
AU744538B2 (en) 2002-02-28
DZ2607A1 (fr) 2003-03-01
BR9812085A (pt) 2000-09-26
JP2001516744A (ja) 2001-10-02
PL339340A1 (en) 2000-12-18
ATE353879T1 (de) 2007-03-15
HUP0004855A3 (en) 2001-08-28
NO20001387L (no) 2000-03-16
IL134991A0 (en) 2001-05-20
AP2000001767A0 (en) 2000-03-31
ES2283072T3 (es) 2007-10-16
KR20010024031A (ko) 2001-03-26
AP1201A (en) 2003-09-01
UY25407A1 (es) 1999-11-17
CN1125815C (zh) 2003-10-29
BG104243A (en) 2001-05-31
US6335448B1 (en) 2002-01-01
ZA988455B (en) 1999-02-17
US20020173657A1 (en) 2002-11-21
MA24644A1 (fr) 1999-04-01
UY25174A1 (es) 2001-07-31
NO20001387D0 (no) 2000-03-16
EA002633B1 (ru) 2002-08-29
EA200000322A1 (ru) 2000-10-30
US20050171152A1 (en) 2005-08-04
NZ503307A (en) 2002-04-26
EP1017676A4 (en) 2002-12-04
MY120237A (en) 2005-09-30
US20060189809A1 (en) 2006-08-24
TR200000720T2 (tr) 2000-08-21
US20040049031A1 (en) 2004-03-11
AR015445A1 (es) 2001-05-02
AU9395898A (en) 1999-04-05
DE69837100D1 (de) 2007-03-29
TW509678B (en) 2002-11-11
CN1278796A (zh) 2001-01-03
CA2303026A1 (en) 1999-03-25
SK3672000A3 (en) 2000-09-12
EP1017676B1 (en) 2007-02-14
DE69837100T2 (de) 2007-11-22
EP1017676A1 (en) 2000-07-12
OA11340A (en) 2003-12-09

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